The ezrin protein family: membrane-cytoskeleton interactions and disease associations

A novel moesin-, ezrin-, radixin-like gene is a candidate for the neurofibromatosis 2 tumor suppressor

1993 • 1,376 citations

Alteration in a new gene encoding a putative membrane-organizing protein causes neuro-fibromatosis type 2

1993 • 1,360 citations

Regulation mechanism of ERM (ezrin/radixin/moesin) protein/plasma membrane association: possible involvement of phosphatidylinositol turnover and Rho-dependent signaling pathway.

1996 • 601 citations

Regulation of vinculin binding to talin and actin by phosphatidyl-inositol-4-5-bisphosphate

1996 • 522 citations

Ezrin contains cytoskeleton and membrane binding domains accounting for its proposed role as a membrane-cytoskeletal linker.

1993 • 427 citations

Ezrin is concentrated in the apical microvilli of a wide variety of epithelial cells whereas moesin is found primarily in endothelial cells

1993 • 426 citations

Ezrin self-association involves binding of an N-terminal domain to a normally masked C-terminal domain that includes the F-actin binding site.

1995 • 422 citations

Ezrin has a COOH-terminal actin-binding site that is conserved in the ezrin protein family.

1994 • 395 citations

Rapid phosphorylation and reorganization of ezrin and spectrin accompany morphological changes induced in A-431 cells by epidermal growth factor.

1989 • 385 citations

ERM (ezrin/radixin/moesin) family: from cytoskeleton to signal transduction

1997 • 363 citations

Perturbation of cell adhesion and microvilli formation by antisense oligonucleotides to ERM family members.

1994 • 347 citations

ERM proteins: head-to-tail regulation of actin-plasma membrane interaction

1997 • 312 citations

Ezrin is a cyclic AMP-dependent protein kinase anchoring protein

1997 • 309 citations

Neurofibromatosis type 2 (NF2) gene is somatically mutated in mesothelioma but not in lung cancer

1995 • 296 citations

Purification of an 80,000-dalton protein that is a component of the isolated microvillus cytoskeleton, and its localization in nonmuscle cells.

1983 • 294 citations

Microfilament Structure and Function in the Cortical Cytoskeleton

1991 • 276 citations

cDNA cloning and sequencing of the protein-tyrosine kinase substrate, ezrin, reveals homology to band 4.1.

1989 • 253 citations

Comparative analysis of 1196 orthologous mouse and human full-length mRNA and protein sequences.

1996 • 234 citations

ICAM-2 redistributed by ezrin as a target for killer cells

1996 • 233 citations

A new 82-kD barbed end-capping protein (radixin) localized in the cell-to-cell adherens junction: purification and characterization.

1989 • 211 citations

Ezrin oligomers are major cytoskeletal components of placental microvilli: a proposal for their involvement in cortical morphogenesis.

1995 • 208 citations

Phosphorylation of Threonine 558 in the Carboxyl-terminal Actin-binding Domain of Moesin by Thrombin Activation of Human Platelets

1995 • 205 citations

Identification of a phosphatidylinositol‐4,5‐bisphosphate‐binding domain in the N‐terminal region of ezrin

1995 • 198 citations

Identification of the two major epidermal growth factor-induced tyrosine phosphorylation sites in the microvillar core protein ezrin.

1992 • 189 citations

The secretion-stimulated 80K phosphoprotein of parietal cells is ezrin, and has properties of a membrane cytoskeletal linker in the induced apical microvilli.

1991 • 182 citations

Moesin, ezrin, and p205 are actin-binding proteins associated with neutrophil plasma membranes.

1995 • 169 citations

Neurofibromatosis 2 tumor suppressor protein colocalizes with ezrin and CD44 and associates with actin-containing cytoskeleton

1997 • 168 citations

An anti-Ras function of neurofibromatosis type 2 gene product (NF2/Merlin).

1994 • 153 citations

Distinct cellular and subcellular patterns of expression imply distinct functions for the Drosophila homologues of moesin and the neurofibromatosis 2 tumor suppressor, merlin.

1996 • 153 citations

Ezrin NH2-terminal domain inhibits the cell extension activity of the COOH-terminal domain.

1995 • 135 citations

Ezrin has properties to self-associate at the plasma membrane

1994 • 133 citations

Biochemical Characterization of Ezrin-Actin Interaction

1996 • 125 citations

Indirect association of ezrin with F-actin: isoform specificity and calcium sensitivity.

1995 • 120 citations

Two independent domains of hDlg are sufficient for subcellular targeting: the PDZ1-2 conformational unit and an alternatively spliced domain.

1996 • 118 citations

The merlin tumor suppressor localizes preferentially in membrane ruffles.

1996 • 116 citations

Dephosphorylation of ezrin as an early event in renal microvillar breakdown and anoxic injury.

1995 • 107 citations

Heterotypic and homotypic associations between ezrin and moesin, two putative membrane-cytoskeletal linking proteins.

1993 • 107 citations

Molecular dissection of radixin: distinct and interdependent functions of the amino- and carboxy-terminal domains.

1995 • 106 citations

The neurofibromatosis type 2 gene product, schwannomin, suppresses growth of NIH 3T3 cells.

1995 • 99 citations

Interdomain Interactions of Radixin in Vitro

1995 • 93 citations

Cytovillin, a Microvillar Mr 75,000 Protein

1989 • 92 citations

Soluble ezrin purified from placenta exists as stable monomers and elongated dimers with masked C-terminal ezrin-radixin-moesin association domains

1995 • 87 citations

Characterization of an 80-kDa phosphoprotein involved in parietal cell stimulation

1989 • 80 citations

Physical association of moesin and CD46 as a receptor complex for measles virus

1995 • 80 citations

Ezrin expression in stromal cells of capillary hemangioblastoma. An immunohistochemical survey of brain tumors.

1996 • 80 citations

Microvillus-specific Mr 75,000 plasma membrane protein of human choriocarcinoma cells.

1987 • 80 citations

Expression of the neurofibromatosis 2 tumor suppressor gene product, merlin, in Schwann cells

1996 • 76 citations

Rho regulates association of both the ERM family and vinculin with the plasma membrane in MDCK cells

1997 • 75 citations

The cytoskeletal linking proteins, moesin and radixin, are upregulated by platelet-derived growth factor, but not basic fibroblast growth factor in experimental mesangial proliferative glomerulonephritis.

1996 • 69 citations

Identification of Drosophila cytoskeletal proteins by induction of abnormal cell shape in fission yeast.

1994 • 66 citations

Induction of Tyrosine Phosphorylation and Translocation of Ezrin by Hepatocyte Growth Factor/Scatter Factor (HGF/SF)

1995 • 66 citations

Defining of the Minimal Domain of Protein 4.1 Involved in Spectrin-Actin Binding

1995 • 61 citations

Neurofibromatosis 2 antisense oligodeoxynucleotides induce reversible inhibition of schwannomin synthesis and cell adhesion in STS26T and T98G cells.

1996 • 55 citations

βCAP73: A novel β actin-specific binding protein

1996 • 55 citations

Detection of cellular proteins that interact with the NF2 tumor suppressor gene product.

1994 • 51 citations

Molecular Cloning, cDNA Sequence, and Chromosomal Assignment of the Human Radixin Gene and Two Dispersed Pseudogenes

1993 • 51 citations

Human placental syncytiotrophoblastic Mr 75,000 polypeptide defined by antibodies to a synthetic peptide based on a cloned human endogenous retroviral DNA sequence.

1984 • 50 citations

A highly expressed 81 kDa protein in immortalized mouse fibroblast: its proliferative function and identity with ezrin.

1996 • 50 citations

Phosphorylation of558T of Moesin Detected by Site-Specific Antibodies in RAW264.7 Macrophages

1996 • 44 citations

Molecular Insights into Neurofibromatosis 2

1997 • 44 citations

Ligation of CD4 Surface Antigen Induces Rapid Tyrosine Phosphorylation of the Cytoskeletal Protein Ezrin

1994 • 42 citations

Deregulation of genes encoding microfilament-associated proteins during Fos-induced morphological transformation.

1995 • 41 citations

Neurofibromatosis type 2 protein co-localizes with elements of the cytoskeleton.

1995 • 41 citations

Widespread but cell type-specific expression of the mouse neurofibromatosis type 2 gene

1995 • 37 citations

Cytovillin and other microvillar proteins of human choriocarcinoma cells

1989 • 28 citations

Redistribution of Mr 75,000 plasma membrane protein, cytovillin, into newly formed microvilli in herpes simplex and Semliki Forest virus infected human embryonal fibroblasts.

1988 • 27 citations

Subregional mapping of 8 single copy loci to chromosome 6 by fluorescence in situ hybridization

1994 • 23 citations

Characterization of the 78 kDa mast cell protein phosphorylated by the antiallergic drug cromolyn and homology to moesin

1996 • 20 citations

Structure and Localization on the X Chromosome of the Gene Coding for the Human Filopodial Protein Moesin (MSN)

1994 • 14 citations