Immunogold labelling of paired helical filaments and amyloid fibrils by specific monoclonal and polyclonal antibodies

Clinical diagnosis of Alzheimer's disease

1984 • 27,279 citations

Alzheimer's disease: Initial report of the purification and characterization of a novel cerebrovascular amyloid protein

1984 • 5,166 citations

Amyloid plaque core protein in Alzheimer disease and Down syndrome.

1985 • 4,276 citations

Abnormal phosphorylation of the microtubule-associated protein tau (tau) in Alzheimer cytoskeletal pathology.

1986 • 3,430 citations

Microtubule-associated protein tau. A component of Alzheimer paired helical filaments.

1986 • 1,709 citations

The Clinical Diagnosis of Alzheimer's Disease

1987 • 1,381 citations

Uber eine eigenartige Erkrankung der Hirnrinde

1907 • 1,332 citations

Tau proteins of alzheimer paired helical filaments: Abnormal phosphorylation of all six brain isoforms

1992 • 1,058 citations

Cloning and sequencing of the cDNA encoding an isoform of microtubule-associated protein tau containing four tandem repeats: differential expression of tau protein mRNAs in human brain.

1989 • 989 citations

Paired Helical Filaments in Electron Microscopy of Alzheimer's Disease

1963 • 956 citations

Isolation of a fragment of tau derived from the core of the paired helical filament of Alzheimer disease.

1988 • 920 citations

Purification of tau, a microtubule-associated protein that induces assembly of microtubules from purified tubulin

1977 • 878 citations

Accumulation of abnormally phosphorylated τ precedes the formation of neurofibrillary tangles in Alzheimer's disease

1989 • 783 citations

A preparation of Alzheimer paired helical filaments that displays distinct tau proteins by polyacrylamide gel electrophoresis.

1990 • 715 citations

Advanced Maillard reaction end products are associated with Alzheimer disease pathology.

1994 • 712 citations

Structural characterization of the core of the paired helical filament of Alzheimer disease.

1988 • 566 citations

Biopsy-derived adult human brain tau is phosphorylated at many of the same sites as Alzheimer's disease paired helical filament tau

1994 • 561 citations

Identification of cDNA clones for the human microtubule-associated protein tau and chromosomal localization of the genes for tau and microtubule-associated protein 2

1986 • 535 citations

Phosphorylated Tau Protein Is Integrated into Paired Helical Filaments in Alzheimer's Disease1

1986 • 504 citations

Tau Consists of a Set of Proteins with Repeated C-Terminal Microtubule-Binding Domains and Variable N-Terminal Domains

1989 • 478 citations

Abnormal phosphorylation of the microtubule-associated protein? (tau) in Alzheimer cytoskeletal pathology

1987 • 393 citations

The car☐yl third of tau is tightly bound to paired helical filaments

1988 • 342 citations

Tau consists of a set of proteins with repeated C-terminal microtubule-binding domains and variable N-terminal domains.

1989 • 321 citations

Straight and paired helical filaments in Alzheimer disease have a common structural unit.

1991 • 310 citations

Alzheimer's disease: Tau proteins, the promoting factors of microtubule assembly, are major components of paired helical filaments

1986 • 310 citations

Abnormal phosphorylation of tau precedes ubiquitination in neurofibrillary pathology of Alzheimer disease

1991 • 177 citations

Ultrastructural morphology of amyloid fibrils from neuritic and amyloid plaques

1983 • 173 citations

Studies on the expression of the microtubule-associated protein, tau, during mouse brain development, with newly isolated complementary DNA probes.

1984 • 164 citations

Neurofibrillary degeneration in amyotrophic lateral sclerosis/parkinsonism-dementia complex of Guam. Immunochemical characterization of tau proteins.

1995 • 124 citations

Pathological proteins Tau 64 and 69 are specifically expressed in the somatodendritic domain of the degenerating cortical neurons during Alzheimer's disease

1990 • 122 citations

Characterization of two pathological Tau protein variants in Alzheimer brain cortices

1989 • 100 citations

Ultrastructural localization of beta-amyloid, tau, and ubiquitin epitopes in extracellular neurofibrillary tangles.

1991 • 98 citations

Beta protein immunoreactivity is found in the majority of neurofibrillary tangles of Alzheimer's disease.

1992 • 67 citations

Senile Dementia of the Alzheimer Type: Morphological and Immunocytochemical Studies

1985 • 66 citations

Ultrastructure of Senile Dementia and of Experimental Analogs

1972 • 61 citations

The relationship between quantitative measures of dementia and of degenerative changes in the cerebral grey matter of elderly subjects.

1967 • 59 citations

Coexistence of substances related to enkephalin and somatostatin in granules of the guinea-pig median eminence: demonstration by use of colloidal gold immunocytochemical methods

1984 • 50 citations

Alzheimer's disease: A new evidence for common epitopes between microtubule associated protein Tau and paired helical filaments (PHF): Demonstration at the electron microscope level by a double immunogold labelling

1988 • 38 citations

Topographic heterogeneity of amyloid B-protein epitopes in brains with various forms of neuronal ceroid lipofuscinoses suggesting defective processing of amyloid precursor protein

1990 • 38 citations

The organization of the microtubule associated protein tau in Alzheimer paired helical filaments

1993 • 35 citations

Alzheimer neurofibrillary tangles contain 2.1 nm filaments structurally identical to the microtubule-associated protein τ: a high-resolution transmission electron microscope study of tangles and senile plaque core amyloid

1992 • 30 citations

Immunogold labeling of cerebrovascular and neuritic plaque amyloid fibrils in Alzheimer's disease with an anti-beta protein monoclonal antibody.

1987 • 29 citations

Anti-PHF antibodies: An immunohistochemical marker of the lesions of the Alzheimer's disease

1985 • 18 citations

Alzheimer's paired helical filaments: Amyloid precursor protein epitope mapping

1994 • 7 citations