Alzheimer's neurofibrillary tangles contain unique epitopes and epitopes in common with the heat-stable microtubule associated proteins tau and MAP2.

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Microtubule-associated protein tau (tau) is a major antigenic component of paired helical filaments in Alzheimer disease.

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Physical and chemical properties of purified tau factor and the role of tau in microtubule assembly

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Neurofibrillary tangles of Alzheimer disease share antigenic determinants with the axonal microtubule-associated protein tau (tau)

1986 • 729 citations

A Neuronal Antigen in the Brains of Alzheimer Patients

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Monoclonal antibodies show that neurofibrillary tangles and neurofilaments share antigenic determinants

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Alzheimer's Disease: Insolubility of Partially Purified Paired Helical Filaments in Sodium Dodecyl Sulfate and Urea

1982 • 398 citations

Distribution of microtubule-associated protein 2 in the nervous system of the rat studied by immunofluorescence

1984 • 378 citations

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Aberrant neurofilament phosphorylation in Alzheimer disease.

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Fractionation of Brain Microtubule‐Associated Proteins

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Antibodies to paired helical filaments in Alzheimer's disease do not recognize normal brain proteins

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Microtubule-associated protein 2: monoclonal antibodies demonstrate the selective incorporation of certain epitopes into Alzheimer neurofibrillary tangles.

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1984 • 227 citations

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EVIDENCE THAT ALZHEIMER NEUROFIBRILLARY TANGLES ORIGINATE FROM NEUROTUBULES

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Microheterogeneity of Micro tubule‐Associated τ Proteins Is Due to Differences in Phosphorylation

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Alzheimer neurofibrillary tangles: Monoclonal antibodies to inherent antigen(s)

1984 • 106 citations

Neurofibrillary Changes in Human Brain

1983 • 103 citations

Neurofibrillary tangles in senile dementia of the Alzheimer type share an antigenic determinant with intermediate filaments of the vimentin class.

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The Biochemistry of Microtubules

1984 • 32 citations

Amyloid-like (Congophilic) neurofibrillary tangles do not react with neurofilament antisera in Alzheimer's cerebral cortex

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