Monoclonal antibodies with selective specificity for Alzheimer Tau are directed against phosphatase-sensitive epitopes

Cleavage of Structural Proteins during the Assembly of the Head of Bacteriophage T4

1970 • 253,849 citations

Short-Term Effects of Nose-Only Cigarette Smoke Exposure on Glutathione Redox Homeostasis, Cytochrome P450 1A1/2 and Respiratory Enzyme Activities in Mice Tissues

2013 • 47,043 citations

Continuous cultures of fused cells secreting antibody of predefined specificity

1975 • 17,037 citations

Use of avidin-biotin-peroxidase complex (ABC) in immunoperoxidase techniques: a comparison between ABC and unlabeled antibody (PAP) procedures.

1981 • 14,396 citations

Abnormal phosphorylation of the microtubule-associated protein tau (tau) in Alzheimer cytoskeletal pathology.

1986 • 3,430 citations

Multiple isoforms of human microtubule-associated protein tau: sequences and localization in neurofibrillary tangles of Alzheimer's disease

1989 • 2,308 citations

The distribution of tau in the mammalian central nervous system.

1985 • 1,518 citations

A68: a Major Subunit of Paired Helical Filaments and Derivatized Forms of Normal Tau

1991 • 1,397 citations

Monoclonal antibodies distinguish phosphorylated and nonphosphorylated forms of neurofilaments in situ.

1983 • 1,162 citations

Isolation of a fragment of tau derived from the core of the paired helical filament of Alzheimer disease.

1988 • 920 citations

A preparation of Alzheimer paired helical filaments that displays distinct tau proteins by polyacrylamide gel electrophoresis.

1990 • 715 citations

Phosphorylated Tau Protein Is Integrated into Paired Helical Filaments in Alzheimer's Disease1

1986 • 504 citations

Epitopes that span the tau molecule are shared with paired helical filaments

1988 • 494 citations

ALZHEIMER’S DISEASE —AN ELECTRON MICROSCOPICAL STUDY

1964 • 440 citations

Abnormal phosphorylation of the microtubule-associated protein? (tau) in Alzheimer cytoskeletal pathology

1987 • 393 citations

The car☐yl third of tau is tightly bound to paired helical filaments

1988 • 342 citations

Distribution of tau proteins in the normal human central and peripheral nervous system.

1989 • 314 citations

Identification and localization of a tau peptide to paired helical filaments of Alzheimer disease.

1989 • 255 citations

Difference between the tau protein of Alzheimer paired helical filament core and normal tau revealed by epitope analysis of monoclonal antibodies 423 and 7.51.

1991 • 214 citations

Recognition of Alzheimer paired helical filaments by monoclonal neurofilament antibodies is due to crossreaction with tau protein.

1987 • 200 citations

Recognition of tau epitopes by anti-neurofilament antibodies that bind to Alzheimer neurofibrillary tangles.

1987 • 181 citations

Tau in Alzheimer neurofibrillary tangles. N- and C-terminal regions are differentially associated with paired helical filaments and the location of a putative abnormal phosphorylation site

1991 • 160 citations

Alzheimer's neurofibrillary tangles contain unique epitopes and epitopes in common with the heat-stable microtubule associated proteins tau and MAP2.

1987 • 147 citations

Pathological proteins Tau 64 and 69 are specifically expressed in the somatodendritic domain of the degenerating cortical neurons during Alzheimer's disease

1990 • 122 citations

Alzheimer disease proteins (A68) share epitopes with tau but show distinct biochemical properties

1990 • 115 citations

Characterization of two pathological Tau protein variants in Alzheimer brain cortices

1989 • 100 citations

Biochemical Assay of Alzheimer's Disease—Associated Protein(s) in Human Brain Tissue

1990 • 50 citations

Affinity Purification of Human τ Proteins and the Construction of a Sensitive Sandwich Enzyme‐Linked Immunosorbent Assay for Human τ Detection

1992 • 48 citations

Phosphorylation characteristics of the A68 protein in Alzheimer's disease

1990 • 36 citations

Differential sensitivity of the microtubule-associated protein, tau, in Alzheimer's disease tissue to formalin fixation.

1988 • 33 citations

A sandwich enzyme immunoassay for detecting and measuring alzheimer's disease‐associated proteins in human brain tissue

1990 • 19 citations

Demonstration of a novel neurofilament associated antigen with the neurofibrillary pathology of Alzheimer and related diseases

1991 • 18 citations

Specific monoclonal antibodies against normal microtubule-associated protein-2 (MAP2) epitopes present in Alzheimer pathological structures do not recognize paired helical filaments

1992 • 11 citations

Separation and purification of individual neurofilament proteins by reverse-phase high-performance liquid chromatography

1986 • 10 citations