Transforming Growth Factor β1 Induces Hypoxia-inducible Factor-1 Stabilization through Selective Inhibition of PHD2 Expression

Hypoxia-inducible factor 1 is a basic-helix-loop-helix-PAS heterodimer regulated by cellular O2 tension.

1995 • 5,971 citations

Targeting of HIF-α to the von Hippel-Lindau Ubiquitylation Complex by O ₂ -Regulated Prolyl Hydroxylation

2001 • 5,255 citations

The tumour suppressor protein VHL targets hypoxia-inducible factors for oxygen-dependent proteolysis

1999 • 4,973 citations

HIFα Targeted for VHL-Mediated Destruction by Proline Hydroxylation: Implications for O ₂ Sensing

2001 • 4,537 citations

Activation of Vascular Endothelial Growth Factor Gene Transcription by Hypoxia-Inducible Factor 1

1996 • 3,851 citations

C. elegans EGL-9 and Mammalian Homologs Define a Family of Dioxygenases that Regulate HIF by Prolyl Hydroxylation

2001 • 3,215 citations

A reagent for the single-step simultaneous isolation of RNA, DNA and proteins from cell and tissue samples.

1993 • 2,807 citations

A nuclear factor induced by hypoxia via de novo protein synthesis binds to the human erythropoietin gene enhancer at a site required for transcriptional activation.

1992 • 2,420 citations

Overexpression of hypoxia-inducible factor 1alpha in common human cancers and their metastases.

1999 • 2,168 citations

Regulation of hypoxia-inducible factor 1α is mediated by an O ₂ -dependent degradation domain via the ubiquitin-proteasome pathway

1998 • 2,044 citations

NEW EMBO MEMBERS REVIEW: Transcriptional control by the TGF-beta/Smad signaling system

2000 • 1,935 citations

Hypoxia-inducible Factor 1α (HIF-1α) Protein Is Rapidly Degraded by the Ubiquitin-Proteasome System under Normoxic Conditions

1997 • 1,610 citations

TGFβ signals through a heteromeric protein kinase receptor complex

1992 • 1,519 citations

Endothelial PAS domain protein 1 (EPAS1), a transcription factor selectively expressed in endothelial cells.

1997 • 1,325 citations

HIF prolyl-hydroxylase 2 is the key oxygen sensor setting low steady-state levels of HIF-1 in normoxia

2003 • 1,276 citations

Regulation of tumor angiogenesis by p53-induced degradation of hypoxia-inducible factor 1alpha.

2000 • 1,087 citations

Hypoxia-inducible factor-1 modulates gene expression in solid tumors and influences both angiogenesis and tumor growth

1997 • 1,059 citations

Independent function of two destruction domains in hypoxia-inducible factor-α chains activated by prolyl hydroxylation

2001 • 994 citations

Regulation of tumor angiogenesis by p53-induced degradation of hypoxia-inducible factor 1α

2000 • 893 citations

Insulin-like Growth Factor 1 Induces Hypoxia-inducible Factor 1-mediated Vascular Endothelial Growth Factor Expression, Which is Dependent on MAP Kinase and Phosphatidylinositol 3-Kinase Signaling in Colon Cancer Cells

2002 • 807 citations

Desferrioxamine induces erythropoietin gene expression and hypoxia- inducible factor 1 DNA-binding activity: implications for models of hypoxia signal transduction

1993 • 740 citations

IL‐1β mediated up‐regulation of HIF‐lα via an NFkB/COX‐2 pathway identifies HIF‐1 as a critical link between inflammation and oncogenesis

2003 • 650 citations

Inhibition of Transforming Growth Factor (TGF)-β1–Induced Extracellular Matrix with a Novel Inhibitor of the TGF-β Type I Receptor Kinase Activity: SB-431542

2002 • 609 citations

Non-hypoxic pathway mediates the induction of hypoxia inducible factor 1 alpha (HIF-1 alpha ) in vascular smooth muscle cells

2000 • 592 citations

Insulin Stimulates Hypoxia-inducible Factor 1 through a Phosphatidylinositol 3-Kinase/Target of Rapamycin-dependent Signaling Pathway

2002 • 527 citations

Induction of HIF-1alpha in response to hypoxia is instantaneous.

2001 • 507 citations

Suppression of tumor growth through disruption of hypoxia-inducible transcription

2000 • 501 citations

Nonhypoxic Pathway Mediates the Induction of Hypoxia-inducible Factor 1α in Vascular Smooth Muscle Cells

2000 • 465 citations

YC-1: A Potential Anticancer Drug Targeting Hypoxia-Inducible Factor 1

2003 • 454 citations

Interleukin-1β and Tumor Necrosis Factor- Stimulate DNA Binding of Hypoxia-Inducible Factor-1

1999 • 443 citations

Hypoxic gene activation by lipopolysaccharide in macrophages: implication of hypoxia-inducible factor 1α

2003 • 428 citations

Induction of HIF–1α in response to hypoxia is instantaneous

2001 • 416 citations

Thrombin Activates the Hypoxia-Inducible Factor-1 Signaling Pathway in Vascular Smooth Muscle Cells

2001 • 415 citations

Processing of Transforming Growth Factor β1 Precursor by Human Furin Convertase

1995 • 395 citations

Nitric Oxide Impairs Normoxic Degradation of HIF-1α by Inhibition of Prolyl Hydroxylases

2003 • 390 citations

Induction of Hypoxia-inducible Factor-1α by Transcriptional and Translational Mechanisms

2002 • 380 citations

Interleukin-1β and Tumor Necrosis Factor- Stimulate DNA Binding of Hypoxia-Inducible Factor-1

1999 • 355 citations

Hypoxia-inducible factor-1 (HIF-1) promotes its degradation by induction of HIF-α-prolyl-4-hydroxylases

2004 • 344 citations

Tumour-associated macrophages as a prototypic type II polarised phagocyte population: role in tumour progression

2004 • 312 citations

Depletion of Intracellular Ascorbate by the Carcinogenic Metals Nickel and Cobalt Results in the Induction of Hypoxic Stress

2004 • 311 citations

α ₁ -Antitrypsin Portland, a bioengineered serpin highly selective for furin: Application as an antipathogenic agent

1998 • 265 citations

Transforming growth factor-?1 level correlates with angiogenesis, tumor progression, and prognosis in patients with nonsmall cell lung carcinoma

2001 • 242 citations

c-myc Is a Downstream Target of the Smad Pathway

2002 • 238 citations

Role of Hypoxia-Inducible Factor 1 in Gastric Cancer Cell Growth, Angiogenesis, and Vessel Maturation

2004 • 235 citations

Role of transforming growth factor beta in cancer

2001 • 232 citations

Increased expression of hypoxia inducible factor-1alpha in rat and human prostate cancer.

1998 • 231 citations

Evidence that Furin Is an Authentic Transforming Growth Factor-β1-Converting Enzyme

2001 • 230 citations

Differential prognostic impact of hypoxia induced and diffuse HIF-1 expression in invasive breast cancer

2005 • 226 citations

Relationship of hypoxia-inducible factor (HIF)-1alpha and HIF-2alpha expression to vascular endothelial growth factor induction and hypoxia survival in human breast cancer cell lines.

2000 • 224 citations

TGF-β-induced upregulation of MMP-2 and MMP-9 depends on p38 MAPK, but not ERK signaling in MCF10A human breast epithelial cells

2004 • 214 citations

Regulation of HIF prolyl hydroxylases by hypoxia‐inducible factors

2004 • 205 citations

Regulation of the prolyl hydroxylase domain protein 2 (phd2/egln-1) gene: identification of a functional hypoxia-responsive element

2005 • 193 citations

Overexpression of Transforming Growth Factor β1 in Head and Neck Epithelia Results in Inflammation, Angiogenesis, and Epithelial Hyperproliferation

2004 • 191 citations

MammalianEGLNgenes have distinct patterns of mRNA expression and regulation

2002 • 188 citations

Snail and E47 repressors ofE-cadherininduce distinct invasive and angiogenic properties in vivo

2004 • 170 citations

Tumor Necrosis Factor-α Causes Accumulation of a Ubiquitinated Form of Hypoxia Inducible Factor-1α through a Nuclear Factor-κB-Dependent Pathway

2003 • 168 citations

Processing of viral glycoproteins by the subtilisin-like endoprotease furin and its inhibition by specific peptidylchloroalkylketones

1994 • 166 citations

Hypoxia-enhanced Expression of the Proprotein Convertase Furin Is Mediated by Hypoxia-inducible Factor-1

2004 • 165 citations

Differential regulation of HIF-1α prolyl-4-hydroxylase genes by hypoxia in human cardiovascular cells

2003 • 165 citations

Transforming growth factor beta 1 stimulates vascular endothelial growth factor gene transcription in human cholangiocellular carcinoma cells.

2003 • 161 citations

Expression of hypoxia‐inducible factor‐1α is associated with tumor vascularization in human colorectal carcinoma

2003 • 159 citations

Role of Transforming Growth Factor-β1 in Invasion and Metastasis in Gastric Carcinoma

1999 • 157 citations

TGFβ-induced downregulation of E-cadherin-based cell-cell adhesion depends on PI3-kinase and PTEN

2005 • 154 citations

Pro-protein convertase gene expression in human breast cancer

1997 • 146 citations

Inhibitory effect of YC-1 on the hypoxic induction of erythropoietin and vascular endothelial growth factor in Hep3B cells11Abbreviations: EPO, erythropoietin; VEGF, vascular endothelial growth factor; HIF, hypoxia-inducible factor; NO, nitric oxide; NOS, nitric oxide synthase; CO, carbon monoxide; sGC, soluble guanylate cyclase; cGMP, cyclic GMP; YC-1, 3-(5′-hydroxymethyl-2′-furyl)-1-benzylindazole; SNP, sodium nitroprusside; ODQ, 1H-(1,2,4)oxadiazole (4,3a)quinoxatin-1-one; MB, methylene blue…

2001 • 146 citations

Pc2-mediated Sumoylation of Smad-interacting Protein 1 Attenuates Transcriptional Repression of E-cadherin

2005 • 144 citations

Source of early reactive oxygen species in the apoptosis induced by transforming growth factor-β in fetal rat hepatocytes

2003 • 135 citations

TGFbeta1 regulates gene expression of its own converting enzyme furin.

1997 • 128 citations

Comparative analysis of expression of the proprotein convertases furin, PACE4, PC1 and PC2 in human lung tumours

1997 • 126 citations

Cross-talk between the p42/p44 MAP Kinase and Smad Pathways in Transforming Growth Factor β1-induced Furin Gene Transactivation

2001 • 124 citations

Mechanisms by which oxygen regulates gene expression and cell-cell interaction in the vasculature

1997 • 119 citations

Regulation of Hypoxia-Inducible Factor (HIF)-1 Activity and Expression of HIF Hydroxylases in Response to Insulin-Like Growth Factor I

2005 • 117 citations

HIF-1α, pimonidazole, and iododeoxyuridine to estimate hypoxia and perfusion in human head-and-neck tumors

2002 • 117 citations

Hepatocyte growth factor-activated NF- B regulates HIF-1 activity and ODC expression, implicated in survival, differently in different carcinoma cell lines

2004 • 113 citations

Role of AP-1 and HIF-1 Transcription Factors in TGF-β Activation of VEGF Expression

2001 • 107 citations

A Unique Role of the β-2 Thyroid Hormone Receptor Isoform in Negative Regulation by Thyroid Hormone

1997 • 106 citations

Stable overexpression of Smad7 in human melanoma cells inhibits their tumorigenicity in vitro and in vivo

2005 • 102 citations

TGFβ-1 regulation of VEGF production by breast cancer cells

1997 • 99 citations

Transforming growth factor‐β and Ras regulate the VEGF/VEGF‐receptor system during tumor angiogenesis

2001 • 91 citations

Hypoxia-inducible factor-1alpha is an intrinsic marker for hypoxia in cervical cancer xenografts.

2001 • 88 citations

The proteolytic processing of pro-platelet-derived growth factor-A at RRKR(86) by members of the proprotein convertase family is functionally correlated to platelet-derived growth factor-A-induced functions and tumorigenicity.

2003 • 83 citations

Transforming growth factor-β1 modulates matrix metalloproteinase-9 production through the Ras/MAPK signaling pathway in transformed keratinocytes

2002 • 82 citations

Mechanism of transforming growth factor-β1-induced expression of vascular endothelial growth factor in murine osteoblastic MC3T3-E1 cells

2000 • 57 citations

TGF-β-induced p38 activation is mediated by Rac1-regulated generation of reactive oxygen species in cultured human keratinocytes

2001 • 51 citations

Involvement of transforming growth factor beta1 in autocrine enhancement of gelatinase B secretion by murine metastatic colon carcinoma cells.

1996 • 51 citations

Growth factor expression in Breast tissue

1990 • 43 citations

Role of Smad3 in the regulation of rat telomerase reverse transcriptase by TGFβ

2005 • 42 citations

Distortion of autocrine transforming growth factor β signal accelerates malignant potential by enhancing cell growth as well as PAI-1 and VEGF production in human hepatocellular carcinoma cells

2003 • 41 citations

Plasma Level of Transforming Growth Factor β1 Measured from the Azygos Vein Predicts Prognosis in Patients with Esophageal Cancer

2004 • 40 citations

Alternative pathway for the role of furin in tumor cell invasion processEnhanced MMP-2 levels through bioactive TGFβ

2003 • 29 citations

Furin gene (fur) regulation in differentiating human megakaryoblastic Dami cells: involvement of the proximal GATA recognition motif in the P1 promoter and impact on the maturation of furin substrates

2002 • 25 citations