Source of early reactive oxygen species in the apoptosis induced by transforming growth factor-β in fetal rat hepatocytes

Single-Step Method of RNA Isolation by Acid Guanidinium Thiocyanate–Phenol–Chloroform Extraction

1987 • 64,270 citations

Single-step method of RNA isolation by acid guanidinium thiocyanate-phenol-chloroform extraction

1987 • 45,673 citations

Mitochondrial control of cell death

2000 • 3,098 citations

Reactive oxygen species in cell signaling

2000 • 2,844 citations

Superoxide dismutase multigene family: a comparison of the CuZn-SOD (SOD1), Mn-SOD (SOD2), and EC-SOD (SOD3) gene structures, evolution, and expression

2002 • 2,020 citations

Effects of antioxidant enzymes in the molecular control of reactive oxygen species toxicology

2000 • 1,461 citations

Oxidant signals and oxidative stress

2003 • 1,378 citations

Signal Transduction by the TGF-β Superfamily

2002 • 1,255 citations

The Neutrophil NADPH Oxidase

2002 • 904 citations

Voltage-dependent Anion Channels Control the Release of the Superoxide Anion from Mitochondria to Cytosol

2003 • 682 citations

Studies on the inhibitory mechanism of iodonium compounds with special reference to neutrophil NADPH oxidase

1993 • 586 citations

Regulation and measurement of oxidative stress in apoptosis

2002 • 567 citations

Vitamin E and its function in membranes

1999 • 537 citations

VDAC-dependent permeabilization of the outer mitochondrial membrane by superoxide induces rapid and massive cytochrome c release

2001 • 507 citations

Production of hydrogen peroxide by transforming growth factor-beta 1 and its involvement in induction of egr-1 in mouse osteoblastic cells.

1994 • 478 citations

Diphenyleneiodonium, an NAD(P)H Oxidase Inhibitor, also Potently Inhibits Mitochondrial Reactive Oxygen Species Production

1998 • 470 citations

Caspase-mediated loss of mitochondrial function and generation of reactive oxygen species during apoptosis

2003 • 468 citations

Activation of an H2O2-generating NADH Oxidase in Human Lung Fibroblasts by Transforming Growth Factor β1

1995 • 426 citations

Mechanisms of TGF-β-mediated apoptosis

2002 • 397 citations

Inhibitors of oxidative stress mimic the ability of follicle-stimulating hormone to suppress apoptosis in cultured rat ovarian follicles.

1995 • 334 citations

Reactive oxygen species (ROS) mediates the mitochondrial‐dependent apoptosis induced by transforming growth factor ß in fetal hepatocytes

2001 • 290 citations

Contribution of mitochondria to oxidative stress associated with alcoholic liver disease1 1This article is part of a series of reviews on “Alcohol, Oxidative Stress and Cell Injury”. The full list of papers may be found on the homepage of the journal.

2002 • 289 citations

Apoptosis Induced by Transforming Growth Factor-β in Fetal Hepatocyte Primary Cultures

1996 • 262 citations

Transforming growth factor β₁induces the expression of α1(i) procollagen mRNA by a hydrogen peroxide-C/EBPβ-dependent mechanism in rat hepatic stellate cells

1999 • 237 citations

Ethanol stimulates the production of reactive oxygen species at mitochondrial complexes I and III

1999 • 218 citations

Inhibition of NADPH Oxidase Activation by 4-(2-Aminoethyl)-benzenesulfonyl Fluoride and Related Compounds

1997 • 196 citations

The NADPH Oxidase of Endothelial Cells

2000 • 177 citations

Suppression of antioxidative enzyme expression by transforming growth factor-beta 1 in rat hepatocytes.

1994 • 166 citations

NADPH oxidase: a universal oxygen sensor?

2000 • 165 citations

On the Measurement of Protein Turnover in Animal Cells

1972 • 162 citations

Ras‐dependent and ‐independent regulation of reactive oxygen species by mitogenic growth factors and TGF‐β1

2000 • 147 citations

The NADPH Oxidase of Endothelial Cells

2000 • 138 citations

Involvement of phenyl radicals in iodonium inhibition of flavoenzymes.

1994 • 137 citations

Inhibitors of oxidative stress mimic the ability of follicle- stimulating hormone to suppress apoptosis in cultured rat ovarian follicles

1995 • 118 citations

Activation of caspases occurs downstream from radical oxygen species production, Bcl-xL down-regulation, and early cytochrome C release in apoptosis induced by transforming growth factor β in rat fetal hepatocytes

2001 • 117 citations

TGF-β1 Triggers Oxidative Modifications and Enhances Apoptosis in Hit Cells Through Accumulation of Reactive Oxygen Species by Suppression of Catalase and Glutathione Peroxidase

1997 • 108 citations

Cycloheximide prevents apoptosis, reactive oxygen species production, and glutathione depletion induced by transforming growth factor ? in fetal rat hepatocytes in primary culture

1997 • 105 citations

Transforming growth factor beta 1-induced apoptosis in human ovarian carcinoma cells: protection by the antioxidant N-acetylcysteine and bcl-2.

1996 • 103 citations

Molecular Mechanism of Transforming Growth Factor (TGF)-β1-induced Glutathione Depletion in Alveolar Epithelial Cells

2002 • 102 citations

Measurement of Cellular Oxidation, Reactive Oxygen Species, and Antioxidant Enzymes during Apoptosis

2000 • 101 citations

TGFβ1‐induced suppression of glutathione antioxidant defenses in hepatocytes: caspase‐dependent posttranslational and caspase‐independent transcriptional regulatory mechanisms

2003 • 87 citations

NADPH oxidase(s): new source(s) of reactive oxygen species in the vascular system?

2002 • 86 citations

Role of NAD(P)H oxidase in the tamoxifen-induced generation of reactive oxygen species and apoptosis in HepG2 human hepatoblastoma cells

2000 • 79 citations

Mitochondrial proton leak: a role for uncoupling proteins 2 and 3?

2001 • 76 citations

Therapeutics against Mitochondrial Oxidative Stress in Animal Models of Aging

2002 • 69 citations

Oxygen toxicity: Unique cytoprotective properties of vitamin E succinate in hepatocytes

1990 • 67 citations

Source of oxygen free radicals produced by rat hepatocytes during postanoxic reoxygenation

1995 • 63 citations

Induction of free radicals in hepatocytes, mitochondria and microsomes of rats by ochratoxin A and its analogs

1997 • 57 citations

Characterization of the Transforming Growth Factor-β1-induced Apoptotic Transcriptome in FaO Hepatoma Cells

2003 • 37 citations

Rates of lipogenesis in fetal hepatocytes in suspension and in primary culture: hormonal effects

1989 • 32 citations

Cycloheximide prevents apoptosis, reactive oxygen species production, and glutathione depletion induced by transforming growth factor beta in fetal rat hepatocytes in primary culture

1997 • 29 citations

Mitochondrial superoxide anion production and release into intermembrane space

2002 • 29 citations

Attenuating effects of heat shock against TGF-β1-induced apoptosis in cultured rat hepatocytes

2002 • 25 citations

Cytochemical localization of glutaraldehyde-resistant NAD(P)H-oxidase in rat hepatocytes

1983 • 16 citations