Overexpression of the STE4 gene leads to mating response in haploid Saccharomyces cerevisiae.

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2001 • 133,517 citations

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1979 • 7,824 citations

Transformation of intact yeast cells treated with alkali cations

1983 • 7,688 citations

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1985 • 7,573 citations

G PROTEINS: TRANSDUCERS OF RECEPTOR-GENERATED SIGNALS

1987 • 6,374 citations

[19] Rapid and efficient site-specific mutagenesis without phenotypic selection

1987 • 5,413 citations

[12] One-step gene disruption in yeast

1983 • 3,302 citations

The βγ subunits of GTP-binding proteins activate the muscarinic K+ channel in heart

1987 • 1,186 citations

A Saccharomyces cerevisiae genomic plasmid bank based on a centromere-containing shuttle vector

1987 • 1,181 citations

Transformation in yeast: Development of a hybrid cloning vector and isolation of the can1 gene

1979 • 1,080 citations

G Proteins: A Family of Signal Transducers

1986 • 975 citations

Single-stranded DNA ‘blue’ T7 promoter plasmids: a versatile tandem promoter system for cloning and protein engineering

1986 • 816 citations

Roles of G protein subunits in transmembrane signalling

1988 • 794 citations

Isolation of a yeast centromere and construction of functional small circular chromosomes

1980 • 788 citations

G protein involvement in receptor-effector coupling.

1988 • 618 citations

A family of yeast expression vectors containing the phage f1 intergenic region1

1987 • 514 citations

The STE4 and STE18 genes of yeast encode potential β and γ subunits of the mating factor receptor-coupled G protein

1989 • 491 citations

G-protein βγ-subunits activate the cardiac muscarinic K+-channel via phospholipase A2

1989 • 438 citations

The yeast SCG1 gene: A Gα-like protein implicated in the a- and α-factor response pathway

1987 • 431 citations

GPA1, a haploid-specific essential gene, encodes a yeast homolog of mammalian G protein which may be involved in mating factor signal transduction

1987 • 365 citations

Nucleotide sequences of STE2 and STE3 , cell type-specific sterile genes from Saccharomyces cerevisiae

1985 • 351 citations

Stimulation of phospholipase A2 activity in bovine rod outer segments by the beta gamma subunits of transducin and its inhibition by the alpha subunit.

1987 • 344 citations

The yeast α-factor receptor: structural properties deduced from the sequence of theSTE2gene

1985 • 318 citations

Evidence the yeast STE3 gene encodes a receptor for the peptide pheromone a factor: gene sequence and implications for the structure of the presumed receptor.

1986 • 305 citations

The C-terminus of the S. cerevisiae α-pheromone receptor mediates an adaptive response to pheromone

1988 • 214 citations

Constitutive mutants in the yeast pheromone response: Ordered function of the gene products

1989 • 143 citations

Mutations in a gene encoding the alpha subunit of a Saccharomyces cerevisiae G protein indicate a role in mating pheromone signaling.

1988 • 121 citations

Stimulation of phospholipase A_2 activity in bovine rod outer segments by the βγ subunits of transducin and its inhibition by the α subunit

1987 • 97 citations

Use of Unpurified Synthetic Deoxynucleotide Primers for Rapid Dideoxynucleotide Chain Termination Sequencing

1984 • 96 citations

A Monoclonal Antibody to the α Subunit of G _k Blocks Muscarinic Activation of Atrial K ⁺ Channels

1988 • 85 citations

Regulation by the Yeast Mating-Type Locus of STE12, a Gene Required for Cell-Type-Specific Expression

1987 • 72 citations

GPA1Val-50 mutation in the mating-factor signaling pathway in Saccharomyces cerevisiae.

1989 • 61 citations

[22] Cloning of yeast STE genes in 2 μm vectors

1983 • 54 citations

Structure of the Trinuclear Basic Acetates

1960 • 50 citations

Transcriptional Regulation of the Cell Cycle-Dependent Thymidylate Synthase Gene of Saccharomyces cerevisiae

1988 • 33 citations

Expression of MFα1 in MATa cells supersensitive to α-factor leads to self-arrest

1988 • 23 citations