SGV1 encodes a CDC28/cdc2-related kinase required for a Gα subunit-mediated adaptive response to pheromone in S. cerevisiae

DNA sequencing with chain-terminating inhibitors

1977 • 69,181 citations

Improved tools for biological sequence comparison.

1988 • 11,455 citations

Transformation of intact yeast cells treated with alkali cations

1983 • 7,688 citations

G PROTEINS: TRANSDUCERS OF RECEPTOR-GENERATED SIGNALS

1987 • 6,374 citations

The Protein Kinase Family: Conserved Features and Deduced Phylogeny of the Catalytic Domains

1988 • 5,115 citations

ras GENES

1987 • 3,818 citations

[12] One-step gene disruption in yeast

1983 • 3,302 citations

High-frequency transformation of yeast: autonomous replication of hybrid DNA molecules.

1979 • 1,504 citations

A Saccharomyces cerevisiae genomic plasmid bank based on a centromere-containing shuttle vector

1987 • 1,181 citations

Complementation used to clone a human homologue of the fission yeast cell cycle control gene cdc2

1987 • 1,153 citations

G Proteins: A Family of Signal Transducers

1986 • 975 citations

An electrophoretic karyotype for yeast.

1985 • 787 citations

An essential G1 function for cyclin-like proteins in yeast

1989 • 574 citations

The WHI1+ gene of Saccharomyces cerevisiae tethers cell division to cell size and is a cyclin homolog.

1988 • 563 citations

The STE4 and STE18 genes of yeast encode potential β and γ subunits of the mating factor receptor-coupled G protein

1989 • 491 citations

G1-specific cyclins of S. cerevisiae: Cell cycle periodicity, regulation by mating pheromone, and association with the p34CDC28 protein kinase

1990 • 449 citations

DAF1, a mutant gene affecting size control, pheromone arrest, and cell cycle kinetics of Saccharomyces cerevisiae.

1988 • 445 citations

Two genes required for cell fusion during yeast conjugation: evidence for a pheromone-induced surface protein.

1987 • 439 citations

FUS3 encodes a cdc2+/CDC28-related kinase required for the transition from mitosis into conjugation

1990 • 437 citations

The yeast SCG1 gene: A Gα-like protein implicated in the a- and α-factor response pathway

1987 • 431 citations

A family of cyclin homologs that control the G1 phase in yeast.

1989 • 416 citations

Identification of a gene necessary for cell cycle arrest by a negative growth factor of yeast: FAR1 is an inhibitor of a G1 cyclin, CLN2

1990 • 401 citations

THE SELECTION OF S. CEREVISIAE MUTANTS DEFECTIVE IN THE START EVENT OF CELL DIVISION

1980 • 391 citations

Mutants of Saccharomyces cerevisiae unresponsive to cell division control by polypeptide mating hormone.

1980 • 368 citations

GPA1, a haploid-specific essential gene, encodes a yeast homolog of mammalian G protein which may be involved in mating factor signal transduction

1987 • 365 citations

Primary structure homology between the product of yeast cell division control gene CDC28 and vertebrate oncogenes

1984 • 354 citations

Nucleotide sequences of STE2 and STE3 , cell type-specific sterile genes from Saccharomyces cerevisiae

1985 • 351 citations

The yeast α-factor receptor: structural properties deduced from the sequence of theSTE2gene

1985 • 318 citations

The carboxy-terminal segment of the yeast α-factor receptor is a regulatory domain

1988 • 317 citations

Sequence of the cell division gene CDC2 from Schizosaccharomyces pombe; patterns of splicing and homology to protein kinases

1984 • 313 citations

One-Step Gene Disruption in Yeast

1989 • 310 citations

Evidence the yeast STE3 gene encodes a receptor for the peptide pheromone a factor: gene sequence and implications for the structure of the presumed receptor.

1986 • 305 citations

A putative protein kinase overcomes pheromone-induced arrest of cell cycling in S. cerevisiae

1989 • 298 citations

Identification and regulation of a gene required for cell fusion during mating of the yeast Saccharomyces cerevisiae.

1987 • 253 citations

Conjugation in Saccharomyces cerevisiae

1988 • 248 citations

Physiological characterization of Saccharomyces cerevisiae mutants supersensitive to G1 arrest by a factor and alpha factor pheromones.

1982 • 216 citations

The C-terminus of the S. cerevisiae α-pheromone receptor mediates an adaptive response to pheromone

1988 • 214 citations

Recovery of S. cerevisiae a cells from G1 arrest by α factor pheromone requires endopeptidase action

1979 • 193 citations

Occurrence in Saccharomyces cerevisiae of a gene homologous to the cDNA coding for the alpha subunit of mammalian G proteins.

1987 • 170 citations

Dual regulation of the yeast CDC28-p40 protein kinase complex: Cell cycle, pheromone, and nutrient limitation effects

1987 • 166 citations

Control of the yeast cell cycle is associated with assembly/disassembly of the Cdc28 protein kinase complex

1988 • 148 citations

Constitutive mutants in the yeast pheromone response: Ordered function of the gene products

1989 • 143 citations

PHO85, a negative regulator of the PHO system, is a homolog of the protein kinase gene, CDC28, of Saccharomyces cerevisiae

1988 • 141 citations

Mutations in a gene encoding the alpha subunit of a Saccharomyces cerevisiae G protein indicate a role in mating pheromone signaling.

1988 • 121 citations

Regulation of the yeast pheromone response pathway by G protein subunits.

1990 • 116 citations

Role of STE genes in the mating factor signaling pathway mediated by GPA1 in Saccharomyces cerevisiae.

1988 • 107 citations

Yeast cells recover from mating pheromone alpha factor-induced division arrest by desensitization in the absence of alpha factor destruction.

1984 • 98 citations

Pheromone-induced phosphorylation of a G protein β subunit in S. cerevisiae is associated with an adaptive response to mating pheromone

1991 • 96 citations

Molecular cloning and sequence analysis of mutant alleles of the fission yeast cdc2 protein kinase gene: Implications for cdc2 + protein structure and function

1989 • 88 citations

GPA1Val-50 mutation in the mating-factor signaling pathway in Saccharomyces cerevisiae.

1989 • 61 citations

G protein mutations that alter the pheromone response in Saccharomyces cerevisiae.

1990 • 46 citations