Ligand binding and activation of the Ah receptor

Polychlorinated Biphenyls (PCBs), Dibenzo-p-Dioxins (PCDDs), Dibenzofurans (PCDFs), and Related Compounds: Environmental and Mechanistic Considerations Which Support the Development of Toxic Equivalency Factors (TEFs)

1990 • 1,872 citations

Polychlorinated Biphenyls (PCBs): Environmental Impact, Biochemical and Toxic Responses, and Implications for Risk Assessment

1994 • 1,717 citations

PAS Domains: Internal Sensors of Oxygen, Redox Potential, and Light

1999 • 1,622 citations

The Aryl Hydrocarbon Receptor Complex

1995 • 1,586 citations

INDUCTION OF CYTOCHROME P4501A1

1999 • 1,124 citations

Immune System Impairment and Hepatic Fibrosis in Mice Lacking the Dioxin-Binding Ah Receptor

1995 • 1,064 citations

The PAS Superfamily: Sensors of Environmental and Developmental Signals

2000 • 1,030 citations

AH RECEPTOR SIGNALING PATHWAYS

1996 • 898 citations

Characterization of a murine Ahr null allele: involvement of the Ah receptor in hepatic growth and development.

1996 • 887 citations

The eicosanoids and their biochemical mechanisms of action

1989 • 882 citations

Comparative Toxicology and Mechanism of Action of Polychlorinated Dibenzo-P-Dioxins and Dibenzofurans

1986 • 707 citations

Aromatic hydrocarbon responsiveness-receptor agonists generated from indole-3-carbinol in vitro and in vivo: comparisons with 2,3,7,8-tetrachlorodibenzo-p-dioxin.

1991 • 576 citations

Aryl Hydrocarbon Receptor-Mediated Signal Transduction

1997 • 497 citations

Structure of a flavin-binding plant photoreceptor domain: Insights into light-mediated signal transduction

2001 • 462 citations

The DNA recognition site for the dioxin-Ah receptor complex. Nucleotide sequence and functional analysis.

1988 • 455 citations

Crystal Structure and Functional Analysis of the HERG Potassium Channel N Terminus

1998 • 439 citations

Inhibition of polycyclic aromatic hydrocarbon-induced neoplasia by naturally occurring indoles.

1978 • 432 citations

Dioxins and Health

1994 • 420 citations

A Novel Cytoplasmic Protein That Interacts with the Ah Receptor, Contains Tetratricopeptide Repeat Motifs, and Augments the Transcriptional Response to 2,3,7,8-Tetrachlorodibenzo-p-dioxin

1997 • 414 citations

Ligand-dependent Interaction of the Aryl Hydrocarbon Receptor with a Novel Immunophilin Homolog in Vivo

1997 • 410 citations

Species-Specific Recombinant Cell Lines as Bioassay Systems for the Detection of 2,3,7,8-Tetrachlorodibenzo-p-dioxin-like Chemicals

1996 • 407 citations

Structure of a Protein Photocycle Intermediate by Millisecond Time-Resolved Crystallography

1997 • 406 citations

Indirubin and Indigo Are Potent Aryl Hydrocarbon Receptor Ligands Present in Human Urine

2001 • 398 citations

Portosystemic shunting and persistent fetal vascular structures in aryl hydrocarbon receptor-deficient mice

2000 • 379 citations

Hepatitis B Virus X-Associated Protein 2 Is a Subunit of the Unliganded Aryl Hydrocarbon Receptor Core Complex and Exhibits Transcriptional Enhancer Activity

1998 • 375 citations

Modulation of gene expression and endocrine response pathways by 2,3,7,8-tetrachlorodibenzo-p-dioxin and related compounds

1995 • 369 citations

The aryl hydrocarbon receptor: A comparative perspective

1998 • 368 citations

Structure of a biological oxygen sensor: A new mechanism for heme-driven signal transduction

1998 • 356 citations

Certain photooxidized derivatives of tryptophan bind with very high affinity to the Ah receptor and are likely to be endogenous signal substances.

1987 • 340 citations

Dioxin binding activities of polymorphic forms of mouse and human arylhydrocarbon receptors.

1994 • 327 citations

Activation of the Ah Receptor by Tryptophan and Tryptophan Metabolites

1998 • 312 citations

The aryl hydrocarbon receptor and aryl hydrocarbon receptor nuclear translocator protein show distinct subcellular localizations in Hepa 1c1c7 cells by immunofluorescence microscopy.

1994 • 308 citations

Activation of the Ah Receptor Signal Transduction Pathway by Bilirubin and Biliverdin

1998 • 306 citations

Lipoxin formation during human neutrophil-platelet interactions. Evidence for the transformation of leukotriene A4 by platelet 12-lipoxygenase in vitro.

1990 • 297 citations

Evidence That the Co-chaperone p23 Regulates Ligand Responsiveness of the Dioxin (Aryl Hydrocarbon) Receptor

1999 • 296 citations

Analysis of the four alleles of the murine aryl hydrocarbon receptor.

1994 • 288 citations

Molecular evolution of two vertebrate aryl hydrocarbon (dioxin) receptors (AHR1 and AHR2) and the PAS family

1997 • 276 citations

Nuclear Localization and Export Signals of the Human Aryl Hydrocarbon Receptor

1998 • 275 citations

The Aromatic Hydrocarbon Receptor Modulates the Hepa 1c1c7 Cell Cycle and Differentiated State Independently of Dioxin

1996 • 273 citations

A cavity-containing mutant of T4 lysozyme is stabilized by buried benzene

1992 • 265 citations

Lipoxin A₄: A New Class of Ligand for the Ah Receptor

1999 • 257 citations

The Ah Receptor: A Regulator of the Biochemical and Toxicological Actions of Structurally Diverse Chemicals

1998 • 254 citations

Aryl Hydrocarbon Receptor-Dependent Induction of Cyp1a1 by Bilirubin in Mouse Hepatoma Hepa 1c1c7 Cells

1997 • 251 citations

Induction of cytochrome P4501A1: a model for analyzing mammalian gene transcription

1996 • 245 citations

Dual roles of the 90-kDa heat shock protein hsp90 in modulating functional activities of the dioxin receptor. Evidence that the dioxin receptor functionally belongs to a subclass of nuclear receptors which require hsp90 both for ligand binding activity and repression of intrinsic DNA binding activity.

1992 • 242 citations

Constitutive Activation of the Aromatic Hydrocarbon Receptor

1998 • 241 citations

Effect of Curcumin on the Aryl Hydrocarbon Receptor and Cytochrome P450 1A1 in MCF-7 Human Breast Carcinoma Cells

1998 • 238 citations

Photoactive yellow protein: A structural prototype for the three-dimensional fold of the PAS domain superfamily

1998 • 230 citations

Induction of CYP1A1. The AhR / DRE Paradigm Transcription, Receptor Regulation, and Expanding Biological Roles

2001 • 221 citations

Protein-DNA Interactions at Recognition Sites for the Dioxin-Ah Receptor Complex

1989 • 215 citations

Role of the aryl hydrocarbon receptor nuclear translocator protein in aryl hydrocarbon (dioxin) receptor action.

1993 • 207 citations

Structure elucidation of two tryptophan-derived, high affinity Ah receptor ligands

1995 • 202 citations

The hsp90 Chaperone Complex Regulates Intracellular Localization of the Dioxin Receptor

2001 • 197 citations

Specificity of ligand binding in a buried nonpolar cavity of T4 lysozyme: Linkage of dynamics and structural plasticity

1995 • 191 citations

Species-specific antagonism of Ah receptor action by 2,2′,5,5′-tetrachloro- and 2,2′,3,3′,4,4′-hexachlorobiphenyl

1995 • 176 citations

Structure and function of the Ah receptor for 2,3,7,8-tetrachlorodibenzo-p-dioxin. Species difference in molecular properties of the receptors from mouse and rat hepatic cytosols.

1986 • 168 citations

Complementation of Ah Receptor Deficiency in Hepatoma Cells: Negative Feedback Regulation and Cell Cycle Control by the Ah Receptor

1996 • 167 citations

Definition of a Minimal Domain of the Dioxin Receptor That Is Associated with Hsp90 and Maintains Wild Type Ligand Binding Affinity and Specificity

1995 • 164 citations

Definition of a novel ligand binding domain of a nuclear bHLH receptor: co-localization of ligand and hsp90 binding activities within the regulable inactivation domain of the dioxin receptor.

1993 • 161 citations

Photoaffinity Labeling of the Ah Receptor: Phylogenetic Survey of Diverse Vertebrate and Invertebrate Species

1994 • 156 citations

The 90-kDa heat shock protein is essential for Ah receptor signaling in a yeast expression system.

1994 • 151 citations

Three-Dimensional Quantitative Structure-Activity Relationships of Dioxins and Dioxin-like Compounds: Model Validation and Ah Receptor Characterization

1995 • 149 citations

ahr null alleles: distinctive or different?

1998 • 147 citations

Effects of canthaxanthin, astaxanthin, lycopene and lutein on liver xenobiotic-metabolizing enzymes in the rat

1996 • 143 citations

Expression of the Human Aryl Hydrocarbon Receptor Complex in Yeast

1997 • 141 citations

A cellular factor stimulates ligand-dependent release of hsp90 from the basic helix-loop-helix dioxin receptor.

1994 • 134 citations

Activation of the Ah Receptor Signaling Pathway by Prostaglandins

2001 • 132 citations

Diosmin and diosmetin are agonists of the aryl hydrocarbon receptor that differentially affect cytochrome P450 1A1 activity.

1998 • 130 citations

Omeprazole, an inducer of human CYP1A1 and 1A2, is not a ligand for the Ah receptor

1992 • 128 citations

Heat shock protein hsp90 regulates dioxin receptor function in vivo.

1995 • 120 citations

Distinct Roles of the Molecular Chaperone hsp90 in Modulating Dioxin Receptor Function via the Basic Helix-Loop-Helix and PAS Domains

1995 • 118 citations

Sustained Increase in Intracellular Free Calcium and Activation of Cyclooxygenase-2 Expression in Mouse Hepatoma Cells Treated with Dioxin

1997 • 118 citations

Physicochemical and immunocytochemical analysis of the aryl hydrocarbon receptor nuclear translocator: characterization of two monoclonal antibodies to the aryl hydrocarbon receptor nuclear translocator.

1994 • 110 citations

A Human Aryl Hydrocarbon Receptor Signaling Pathway Constructed in Yeast Displays Additive Responses to Ligand Mixtures

1999 • 109 citations

Development of a Green Fluorescent Protein-Based Cell Bioassay for the Rapid and Inexpensive Detection and Characterization of Ah Receptor Agonists

2002 • 108 citations

Regulation of CYP1A1 Transcription via the Metabolism of the Tryptophan-Derived 6-Formylindolo[3,2-b]carbazole

2000 • 107 citations

Cytochrome P450IA1 is rapidly induced in normal human keratinocytes in the absence of xenobiotics.

1994 • 107 citations

Access of ligands to cavities within the core of a protein is rapid

1996 • 105 citations

Ah Receptor-Based Chemical Screening Bioassays: Application and Limitations for the Detection of Ah Receptor Agonists

2000 • 105 citations

Ah Receptor in Embryonic Mouse Palate and Effects of TCDD on Receptor Expression

1994 • 105 citations

Characterization of the Activated Form of the Aryl Hydrocarbon Receptor in the Nucleus of HeLa Cells in the Absence of Exogenous Ligand

1996 • 101 citations

Interactions of indolo[3,2-b]carbazoles and related polycyclic aromatic hydrocarbons with specific binding sites for 2,3,7,8-tetrachlorodibenzo-p-dioxin in rat liver.

1993 • 100 citations

β-Apo-8′-carotenal, but not β-carotene, is a strong inducer of liver cytochromes P4501A1 and 1A2 in rat

1996 • 98 citations

Determination of Aryl Hydrocarbon Receptor Nuclear Translocator Protein Concentration and Subcellular Localization in Hepatic and Nonhepatic Cell Culture Lines: Development of Quantitative Western Blotting Protocols for Calculation of Aryl Hydrocarbon Receptor and Aryl Hydrocarbon Receptor Nuclear Translocator Protein in Total Cell Lysates

1997 • 98 citations

Definition of a Dioxin Receptor Mutant That Is a Constitutive Activator of Transcription

2001 • 97 citations

Transactivation Activity of Human, Zebrafish, and Rainbow Trout Aryl Hydrocarbon Receptors Expressed in COS-7 Cells: Greater Insight into Species Differences in Toxic Potency of Polychlorinated Dibenzo-p-dioxin, Dibenzofuran, and Biphenyl Congeners

1999 • 96 citations

UV-induced CYP1A1 gene expression in human cells is mediated by tryptophan

1999 • 93 citations

Suspension-mediated induction of Hepa 1c1c7 Cyp1a-1 expression is dependent on the Ah receptor signal transduction pathway.

1994 • 89 citations

Toxicology of Dioxins and Related Chemicals

1994 • 88 citations

Phototropins: A New Family of Flavin-Binding Blue Light Receptors in Plants

2001 • 87 citations

Ultraviolet photoproducts of tryptophan can act as dioxin agonists.

1991 • 86 citations

Synthesis of lipoxins and other lipoxygenase products by macrophages from the rainbow trout, Oncorhynchus mykiss

1991 • 85 citations

Marked endogenous activation of the CYP1A1 and CYP1A2 genes in the congenitally jaundiced Gunn rat.

1993 • 85 citations

Characterization of Flavonoids as Monofunctional or Bifunctional Inducers of Quinone Reductase in Murine Hepatoma Cell Lines

1998 • 83 citations

Nucleocytoplasmic Shuttling of the Aryl Hydrocarbon Receptor

2000 • 81 citations

The use of a high-volume screening procedure to assess the effects of dietary flavonoids on human cyp1a1 expression.

2001 • 77 citations

Comparative molecular field analysis of polyhalogenated dibenzo-p-dioxins, dibenzofurans, and biphenyls

1992 • 77 citations

A systematic analytical chemistry/cell assay approach to isolate activators of orphan nuclear receptors from biological extracts: characterization of peroxisome proliferator-activated receptor activators in plasma

1993 • 75 citations

Evidence That Murine Preimplantation Embryos Express Aryl Hydrocarbon Receptor

1995 • 69 citations

Species-specific binding of transformed Ah receptor to a dioxin responsive transcriptional enhancer

1992 • 64 citations

Production ofahreceptor ligands in rat fecal suspensions containing tryptophan or indole‐3‐carbinol

1991 • 63 citations

A model for recognition of polychlorinated dibenzo‐p‐dioxins by the aryl hydrocarbon receptor

2002 • 60 citations

Understanding the Congener-Specific Toxicity in Polychlorinated Dibenzo-p-dioxins: Chlorination Pattern and Molecular Quadrupole Moment

2001 • 59 citations

Identification of the Ah receptor in selected mammalian species and induction of aryl hydrocarbon hydroxylase

1985 • 59 citations

Regulation of Prostaglandin Endoperoxide H Synthase-2 Expression by 2,3,7,8-Tetrachlorodibenzo-p-dioxin

1996 • 58 citations

2,3,7,8-Tetrachlorodibenzo-p-dioxin (TCDD)-induced lipid peroxidation in genetically responsive and non-responsive mice

1988 • 58 citations

Aryl Hydrocarbon Receptor Regulation of Ceramide-induced Apoptosis in Murine Hepatoma 1c1c7 Cells

1999 • 56 citations

Phenobarbital Induction of Gene Expression in a Primary Culture of Rainbow Trout Hepatocytes

1996 • 56 citations

Additive Effects of Ultraviolet B and Crude Coal Tar on Cutaneous Carcinogen Metabolism: Possible Relevance to the Tumorigenicity of the Goeckerman Regimen

1986 • 55 citations

Differences in Inducibility of CYP1A1-mRNA by Benzimidazole Compounds between Human and Mouse Cells: Evidences of a Human-Specific Signal Transduction Pathway forCYP1A1Induction

1996 • 54 citations

Phospholipase A2 is involved in the mechanism of activation of neutrophils by polychlorinated biphenyls.

1996 • 54 citations

Electronic eigenvalue (EEVA): a new QSAR/QSPR descriptor for electronic substituent effects based on molecular orbital energies. A QSAR approach to the Ah receptor binding affinity of polychlorinated biphenyls (PCBs), dibenzo-p-dioxins (PCDDs) and dibenzofurans (PCDFs)

2000 • 52 citations

Biological sensors: More than one way to sense oxygen

1999 • 52 citations

Generation of ligand binding sites in T4 lysozyme by deficiency-creating substitutions

1998 • 49 citations

Molecular Polarizability as a Tool for Understanding the Binding Properties of Polychlorinated Dibenzo-p-Dioxins: Definition of a Reliable Computational Procedure

1996 • 45 citations

Reaction Pathways ofin vivoStereoselective Conversion of Ethylbenzene to (-)-Mandelic Acid

1976 • 45 citations

Induction of benzo[a]pyrene Mono-oxygenase in liver cell culture by the photochemical generation of active oxygen species. Evidence for the involvement of singlet oxygen and the formation of a stable inducing intermediate

1976 • 45 citations

Fix L, a haemoglobin that acts as an oxygen sensor: signalling mechanism and structural basis of its homology with PAS domains

1999 • 43 citations

Influence of UVA and UVB irradiation on hepatic and cutaneous P450 isoenzymes

1996 • 41 citations

Suppressive effects of flavonoids on dioxin toxicity

2000 • 40 citations

2,3,7,8-Tetrachlorodibenzo-p-dioxin (TCDD)-induced decrease in the fluidity of rat liver membranes

1990 • 39 citations

Preliminary Screening of the Inhibitory Effect of Food Extracts on Activation of the Aryl Hydrocarbon Receptor Induced by 2,3,7,8-Tetrachlorodibenzo-p-dioxin.

2002 • 38 citations

Influence of chronic UV-light exposure on hepatic and cutaneous monooxygenases

1983 • 37 citations

Relationship between aryl hydrocarbon receptor binding, induction of aryl hydrocarbon hydroxylase and 7-ethoxyresorufin O-deethylase enzymes, and toxic activities of aromatic xenobiotics in animals. A new model

1993 • 36 citations

The induction of benzo[a]pyrene-3-mono-oxygenase by singlet oxygen in liver cell culture is mediated by oxidation products of histidine

1980 • 34 citations

Constitutive and inducible expression of drug metabolizing enzymes in cultured human keratinocytes

1995 • 34 citations

Transient Expression of CYP1A1 in Rat Epithelial Cells Cultured in Suspension

2001 • 33 citations

2,3,7,8-Tetrachlorodibenzo-p-dioxin Induction of Cytochrome P450-Dependent Arachidonic Acid Metabolism in Mouse Liver Microsomes: Evidence for Species-Specific Differences in Responses

1998 • 31 citations

Characterization of prostaglandin-F 2alpha-binding sites on rat hepatocyte plasma membranes

1993 • 30 citations

A hypothesis on the mechanism of PCDD biological activity based on molecular electrostatic potential modeling. Part 2

1995 • 28 citations

Possible Role of Arachidonic Acid in Stress‐Induced Cytochrome P450IA1 Activity¹

1996 • 27 citations

Role of Altered Arachidonic Acid Metabolism in 2,3,7,8-Tetrachlorodibenzo-p-dioxin-Induced Immune Suppression in C57Bl/6 Mice

1998 • 22 citations

Tryptamine receptors: neurochemical and electrophysiological evidence for postsynaptic and functional binding sites

1989 • 21 citations

Different Inducibility of Cytochrome P-4501A1 mRNA of Human and Mouse by Omeprazole in Culture Cells

1995 • 20 citations

The possible role of phospholipase A2 in hepatic microsomal lipid peroxidation induced by 2,3,7,8-tetrachlorodibenzo-p-dioxin in rats

1991 • 19 citations

Toward a mechanistic understanding of PCDD biological activity based on molecular electrostatic potential modeling

1994 • 17 citations

Induction of CYP1A1 by GABA Receptor Ligands

1996 • 14 citations

The Ah Receptor Can Bind Ligand in the Absence of Receptor-Associated Heat-Shock Protein 90

1998 • 14 citations

Ocular hypotension induced by topical dopaminergic drugs and phosphodiesterase inhibitors

1994 • 12 citations

Toxicant-receptor interactions : modulation of signal transduction and gene expression

1998 • 11 citations

Crystallization and preliminary crystallographic data of the PAS domain of the NifL protein fromAzotobacter vinelandii

2001 • 6 citations

Deleted Work

1955 • 0 citations

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