Toxicology of Dioxins and Related Chemicals

Polychlorinated Biphenyls (PCBs), Dibenzo-p-Dioxins (PCDDs), Dibenzofurans (PCDFs), and Related Compounds: Environmental and Mechanistic Considerations Which Support the Development of Toxic Equivalency Factors (TEFs)

1990 • 1,872 citations

Principles and Methods of Toxicology

1984 • 1,459 citations

Stereospecific, high affinity binding of 2,3,7,8-tetrachlorodibenzo-p-dioxin by hepatic cytosol. Evidence that the binding species is receptor for induction of aryl hydrocarbon hydroxylase.

1976 • 1,343 citations

Results of a two-year chronic toxicity and oncogenicity study of 2,3,7,8-tetrachlorodibenzo-p-dioxin in rats

1978 • 1,054 citations

Cloning of a Factor Required for Activity of the Ah (Dioxin) Receptor

1991 • 963 citations

Cloning of the Ah-receptor cDNA reveals a distinctive ligand-activated transcription factor.

1992 • 830 citations

Identification of the Ah Receptor Nuclear Translocator Protein (Arnt) as a Component of the DNA Binding Form of the Ah Receptor

1992 • 769 citations

Cancer Mortality in Workers Exposed to 2,3,7,8-Tetrachlorodibenzo-P-Dioxin

1991 • 542 citations

Congenital Poisoning by Polychlorinated Biphenyls and Their Contaminants in Taiwan

1988 • 541 citations

Toxicology of chlorinated dibenzo-p-dioxins.

1973 • 478 citations

The DNA recognition site for the dioxin-Ah receptor complex. Nucleotide sequence and functional analysis.

1988 • 455 citations

Genetic and Molecular Aspects of 2,3,7,8-Tetra-Chlorodibenzo-P-Dioxin Action

1990 • 446 citations

2,3,7,8,-Tetrachlorodibenzo-p-dioxin: segregation of toxocity with the Ah locus.

1980 • 394 citations

Quantitative evaluation of the promotion by 2,3,7,8-tetrachlorodibenzo-p-dioxin of hepatocarcinogenesis from diethylnitrosamine.

1980 • 374 citations

In utero and lactational exposure of male rats to 2,3,7,8-tetrachlorodibenzo-p-dioxin

1992 • 363 citations

In utero and lactational exposure of male rats to 2,3,7,8-tetrachlorodibenzo-p-dioxin

1992 • 359 citations

Cloning and expression of a human Ah receptor cDNA.

1993 • 334 citations

The mechanism of dioxin toxicity: relationship to risk assessment.

1994 • 327 citations

Immunology: A Short Course

1988 • 320 citations

The fate of 2,3,7,8-tetrachlorodibenzo-p-dioxin following single and repeated oral doses to the rat

1976 • 303 citations

Cancer mortality among workers in chemical plant contaminated with dioxin

1991 • 286 citations

In utero exposure to diethylstilbestrol: Adverse effects on the reproductive tract and reproductive performance in male and female offspring

1982 • 268 citations

Estimates of the half‐life of 2,3,7,8‐tetrachlorodibenzo‐p‐dioxin in Vietnam veterans of operation ranch hand

1989 • 254 citations

2,3,7,8-Tetrachlorodibenzo-p-dioxin (TCDD): Results of a 13-week oral toxicity study in rats

1976 • 236 citations

A critical review of the developmental toxicity and teratogenicity of 2,3,7,8‐tetrachlorodibenzo‐p‐dioxin: Recent advances toward understanding the mechanism

1990 • 235 citations

Suppression of Cellular Immunity in Rats and Mice by Maternal Treatment with 2, 3, 7, 8-Tetrachlorodibenzo-<i>p</i>-Dioxin

1974 • 234 citations

Pharmacokinetics of 2,3,7,8-TCDD in man

1986 • 208 citations

Enhanced Thyroxine Metabolism and High Uptake Goiters in Rats After a Single Dose of 2,3,7,8- Tetrachlorodibenzo-p-Dioxin1¹

1977 • 201 citations

A DNA-binding factor specific for xenobiotic responsive elements of P-450c gene exists as a cryptic form in cytoplasm: its possible translocation to nucleus.

1988 • 198 citations

Accelerator mass spectrometry in biomedical dosimetry: relationship between low-level exposure and covalent binding of heterocyclic amine carcinogens to DNA.

1990 • 189 citations

2,3,7,8-Tetrachlorodibenzo-p-dioxin causes an extensive alteration of 17 beta-estradiol metabolism in MCF-7 breast tumor cells.

1990 • 187 citations

Thirty-four-year mortality follow-up of BASF employees exposed to 2,3,7,8-TCDD after the 1953 accident

1990 • 177 citations

Distribution, excretion, and metabolism of 2,3,7,8-tetrachlorodibenzo-p-dioxin in C57BL/6J, DBA/2J, and B6D2F1/J mice.

1983 • 175 citations

Toxicity of 2,3,7,8-tetrachlorodibenzo-p-dioxin in rhesus monkeys (Macaca mulatta) following a single oral dose

1978 • 167 citations

Effects of in vivo-administered 2,3,7,8-tetrachlorodibenzo-p-dioxin on receptor binding of epidermal growth factor in the hepatic plasma membrane of rat, guinea pig, mouse, and hamster.

1984 • 164 citations

Androgenic deficiency in male rats treated with 2,3,7,8-tetrachlorodibenzo-p-dioxin

1985 • 163 citations

Ovarian hormones enhance 2,3,7,8-tetrachlorodibenzo-p-dioxin-mediated increases in cell proliferation and preneoplastic foci in a two-stage model for rat hepatocarcinogenesis.

1991 • 148 citations

Suppression of B cell differentiation by 2,3,7,8-tetrachlorodibenzo-p-dioxin.

1986 • 140 citations

COMPARATIVE TOXICITY OF THREE HALOGENATED DIBENZOFURANS IN GUINEA PIGS, MICE, AND RHESUS MONKEYS

1979 • 138 citations

Modeling Receptor-Mediated Processes with Dioxin: Implications for Pharmacokinetics and Risk Assessment

1993 • 138 citations

2,3,7,8-Tetrachlorodibenzo-p-dioxin-dependent regulation of transforming growth factors-alpha and -beta 2 expression in a human keratinocyte cell line involves both transcriptional and post-transcriptional control.

1992 • 137 citations

Cytosolic receptor for 2,3,7,8-tetrachlorodibenzo-p-dioxin. Evidence for a homologous nature among various mammalian species.

1984 • 134 citations

Comparative activities of 2,3,7,8-tetrachlorodibenzo-p-dioxin and progesterone as antiestrogens in the female rat uterus

1988 • 132 citations

Toxicity of 2,3,7,8-tetrachlorodibenzo-p-dioxin in the Golden Syrian hamster

1980 • 131 citations

Differential induction of two 2,3,7,8-tetrachlorodibenzo-p-dioxin-inducible forms of cytochrome P-450 in extrahepatic versus hepatic tissues.

1984 • 127 citations

Characterization and strain distribution pattern of the murine Ah receptor specified by the Ahd and Ahb-3 alleles.

1990 • 122 citations

TOXICOPATHOLOGY CHARACTERISTICS OF THE HALOGENATED AROMATICS

1979 • 122 citations

Calculation of 2,3,7,8-TCDD equivalent concentrations of complex environmental contaminant mixtures

1986 • 120 citations

Fetal PCB syndrome: clinical features, intrauterine growth retardation and possible alteration in calcium metabolism.

1985 • 119 citations

Examination of bone marrow, immunologic parameters and host susceptibility following pre- and postnatal exposure to 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD)

1980 • 118 citations

TCDD alters medial epithelial cell differentiation during palatogenesis

1989 • 117 citations

Influence of the Ah locus on the humoral immunotoxicity of 2,3,7,8-tetrachlorodibenzo-p-dioxin: Evidence for Ah-receptor-dependent and Ah-receptor-independent mechanisms of immunosuppression

1990 • 117 citations

Tissue Distribution, Metabolism, and Excretion of ¹⁴C‐TCDD in a TCDD‐Susceptible and a TCDD‐Resistant Rat Strain^a

1990 • 115 citations

Antiestrogenic action of 2,3,7,8-tetrachlorodibenzo-p-dioxin: Tissue-specific regulation of estrogen receptor in CD1 mice

1992 • 110 citations

2,3,7,8-Tetrachlorodibenzo-p-dioxin inhibits steroidogenesis in the rat testis by inhibiting the mobilization of cholesterol to cytochrome P450scc

1991 • 107 citations

A review of the genetic toxicology of chlorinated dibenzo-p-dioxins

1977 • 100 citations

TCDD‐Induced hyperplasia of the ureteral epithelium produces hydronephrosis in murine fetuses

1987 • 98 citations

Distribution and excretion of 2,3,7,8-tetrachlorodibenzo-p-dioxin in congenic strains of mice which differ at the Ah locus.

1986 • 98 citations

Hematologic and clinical chemistry effects of 2,3,7,8-tetrachlorodibenzo-p-dioxin in laboratory animals.

1973 • 96 citations

Classification of members of the Ah gene battery

1992 • 95 citations

Studies on 2,3,7,8-tetrachlorodibenzo-p-dioxin-induced immune suppression and decreased resistance to infection: Endotoxin hypersensitivity, serum zinc concentrations and effect of thymosin treatment

1978 • 93 citations

2,3,7,8-Tetrachlorodibenzo-p-dioxin causes reduction of glucose transporting activities in the plasma membranes of adipose tissue and pancreas from the guinea pig.

1992 • 90 citations

The human cytochrome Cyp1A2 gene contains regulatory elements responsive to 3-methylcholanthrene.

1989 • 90 citations

Hormonal alterations in female rhesus monkeys fed a diet containing 2,3,7,8-tetrachlorodibenzo-p-dioxin

1979 • 90 citations

Comparative Ability of Various PCBs, PCDFs, and TCDD to Induce Cytochrome P450 1A1 and 1A2 Activity Following 4 Weeks of Treatment

1993 • 89 citations

TCDD (2,3,7,8-tetrachlorodibenzo-p-dioxin) causes increases in protein kinases particularly protein kinase C in the hepatic plasma membrane of the rat and the guinea pig

1985 • 87 citations

Residual effects of short-term, low-level exposure of nonhuman primates to polychlorinated biphenyls*1

1974 • 87 citations

Differential toxicity of 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD) in C57BL/6J mice congenic at the Ah locus

1990 • 85 citations

2,3,7,8-Tetrachlorodibenzo-p-dioxin causes increases in expression of c-erb-A and levels of protein-tyrosine kinases in selected tissues of responsive mouse strains.

1988 • 84 citations

Light and electron microscopic observations in Macaca mulatta monkeys fed toxic fat.

1967 • 83 citations

Fetal PCB Syndrome: Clinical Features, Intrauterine Growth Retardation and Possible Alteration in Calcium Metabolism

1985 • 79 citations

The effects of 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD) on the hepatic estrogen and glucocorticoid receptors in congenic strains of Ah responsive and Ah nonresponsive C57BL/6J mice

1991 • 76 citations

Ligand/Receptor Binding for 2,3,7,8-TCDD: Implications for Risk Assessment

1993 • 73 citations

Comparative Ability of Various PCBs, PCDFs, and TCDD to Induce Cytochrome P450 1A1 and 1A2 Activity Following 4 Weeks of Treatment

1993 • 72 citations

Carcinogenicity of 2,3,7,8-tetrachlorodibenzo-p-dioxin in the Syrian golden hamster

1988 • 72 citations

Effect of acute exposure to 2,3,7,8-tetrachlorodibenzo-p-dioxin on humoral antibody production in mice

1980 • 72 citations

Modulation of serum complement levels following exposure to polychlorinated dibenzo-p-dioxins

1986 • 71 citations

TCDD exposure of human embryonic palatal shelves in organ culture alters the differentiation of medial epithelial cells

1991 • 69 citations

2,3,7,8-Tetrachlorodibenzo-p-dioxin increases the potency of androgens and estrogens as feedback inhibitors of luteinizing hormone secretion in male rats

1990 • 68 citations

Chemical cross-linking of the cytosolic and nuclear forms of the Ah receptor in hepatoma cell line 1c1c7

1992 • 66 citations

Effects of TCDD on embryonic ureteric epithelial EGF receptor expression and cell proliferation

1990 • 65 citations

PRESENT STATE OF YUSHO PATIENTS

1979 • 63 citations

2,3,7,8-Tetrachlorodibenzo-p-dioxin alters embryonic palatal medial epithelial cell differentiation in vitro

1989 • 60 citations

Plasma concentrations of pituitary hormones in 2,3,7,8‐tetrachlorodibenzo‐p‐dioxin‐treated male rats

1989 • 59 citations

Comparisons of the effects of TCDD and hydrocortisone on growth factor expression provide insight into their interaction in the embryonic mouse palate

1992 • 59 citations

Cellular alterations and enhanced induction of cleft palate after coadministration of retinoic acid and TCDD

1989 • 57 citations

Influence of the Ah locus on the effects of 2,3,7,8-tetrachlorodibenzo-p-dioxin on the hepatic epidermal growth factor receptor.

1991 • 56 citations

Immunosuppression in mice induced by dioxin (TCDD) in feed.

1980 • 56 citations

Effects of TCDD-estradiol interactions in three strains of mice

1988 • 50 citations

Humans are a sensitive species to some of the biochemical effects of structural analogs of dioxin

1991 • 44 citations

Reproductive toxicity and pharmacokinetics of 2,3,7,8-tetrachlorodibenzo-p-dioxin

1989 • 41 citations

Effect of 2,3,7,8-Tetrachlorodibenzo-p-dioxin (TCDD) on Pulmonary Influenza Virus Titer and Natural Killer (NK) Activity in Rats

1994 • 39 citations

Toxicity equivalency factors for PCBs?

1991 • 37 citations

Skeletal muscle glucocorticoid receptor and glutamine synthetase activity in the wasting syndrome in rats treated with 2,3,7,8-tetrachlorodibenzo-p-dioxin

1987 • 34 citations

Ploidy and specific karyotypic changes during promotion with phenobarbital, 2,5,2',5'-tetrachlorobiphenyl, and/or 3,4,3'4'-tetrachlorobiphenyl in rat liver.

1992 • 32 citations

2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD) effects on hepatic microsomal steroid metabolism and serum estradiol of pregnant rats

1983 • 31 citations

Comparative developmental toxicity of 2,3,7,8-tetrachloro-dibenzo-p-dioxin (TCDD)

1992 • 29 citations

Response of Chickens to Prolonged Feeding of Crude "Toxic Fat".

1962 • 29 citations

Rat embryonic palatal shelves respond to TCDD in organ culture

1990 • 29 citations

2,3,7,8-TCDD: A potent & complete carcinogen in experimental animals

1992 • 24 citations

Principles and methods of toxicology

1984 • 17 citations

Induction of ethoxyresorufin-O-deethylase and inhibiyion of glucocorticoid receptor binding in skin and liver of haired and hairless HRS/J mice by topically applied 2,3,7,8-tetrachlorodibenzo-p-dioxin

1990 • 16 citations

Host Resistance to Trichinella spiralis Infection in Rats Exposed to 2,3,7,8-Tetrachlorodibenzo-p-dioxin (TCDD)

1995 • 15 citations

Selective retention of PCDDs and PCDFs in mammals: A multiple cause problem

1989 • 14 citations

Comparative ability of various PCBs, PCDFs, and TCDD to induce cytochrome P450 1A1 and 1A2 activity following 4 weeks of treatment (short communication)

1993 • 4 citations

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