A final common pathway for depression? Progress toward a general conceptual framework

Diagnostic and Statistical Manual of Mental Disorders (DSM-IV)

2003 • 8,902 citations

Stress and the brain: from adaptation to disease

2005 • 4,321 citations

Requirement of Hippocampal Neurogenesis for the Behavioral Effects of Antidepressants

2003 • 4,175 citations

Deep Brain Stimulation for Treatment-Resistant Depression

2005 • 3,877 citations

THE CATECHOLAMINE HYPOTHESIS OF AFFECTIVE DISORDERS: A REVIEW OF SUPPORTING EVIDENCE

1965 • 3,421 citations

A Neurotrophic Model for Stress-Related Mood Disorders

2006 • 3,154 citations

Behavioural despair in rats: A new model sensitive to antidepressant treatments

1978 • 3,035 citations

Reciprocal Limbic-Cortical Function and Negative Mood: Converging PET Findings in Depression and Normal Sadness

1999 • 2,351 citations

Neurocircuitry of stress: central control of the hypothalamo–pituitary–adrenocortical axis

1997 • 2,235 citations

Essential Role of BDNF in the Mesolimbic Dopamine Pathway in Social Defeat Stress

2006 • 1,997 citations

The Mesolimbic Dopamine Reward Circuit in Depression

2006 • 1,931 citations

The neurobiology of stress: from serendipity to clinical relevance11Published on the World Wide Web on 22 November 2000.

2000 • 1,784 citations

Validity, reliability and utility of the chronic mild stress model of depression: a 10-year review and evaluation

1997 • 1,773 citations

Sustained hippocampal chromatin regulation in a mouse model of depression and antidepressant action

2006 • 1,724 citations

Affective Style and Affective Disorders: Perspectives from Affective Neuroscience

1998 • 1,424 citations

The role of corticotropin-releasing factor in depression and anxiety disorders

1999 • 1,371 citations

Reduction of Prefrontal Cortex Glucose Metabolism Common to Three Types of Depression

1989 • 1,306 citations

Organization of the stress system and its dysregulation in melancholic and atypical depression: high vs low CRH/NE states

2002 • 1,241 citations

CRF and CRF Receptors: Role in Stress Responsivity and Other Behaviors

2004 • 1,235 citations

Neuroimaging and neuropathological studies of depression: implications for the cognitive-emotional features of mood disorders

2001 • 1,136 citations

Regional metabolic effects of fluoxetine in major depression: serial changes and relationship to clinical response

2000 • 1,113 citations

Mood disorders and allostatic load

2003 • 1,091 citations

Clinical and Biochemical Manifestations of Depression

1988 • 1,052 citations

Modulation of Cortical-Limbic Pathways in Major Depression

2004 • 1,042 citations

Inverted-U dopamine D1 receptor actions on prefrontal neurons engaged in working memory

2007 • 991 citations

Medial prefrontal cortex determines how stressor controllability affects behavior and dorsal raphe nucleus

2005 • 919 citations

Neurobiology of Executive Functions: Catecholamine Influences on Prefrontal Cortical Functions

2005 • 881 citations

Increased Amygdala and Decreased Dorsolateral Prefrontal BOLD Responses in Unipolar Depression: Related and Independent Features

2006 • 825 citations

Cerebral hemisphere regulation of motivated behavior11Published on the World Wide Web on 2 November 2000.

2000 • 823 citations

Adrenal insufficiency

2003 • 746 citations

Coordinated Expression of Dopamine Receptors in Neostriatal Medium Spiny Neurons

1996 • 743 citations

Quantitative autoradiographic localization of the D1 and D2 subtypes of dopamine receptors in rat brain

1986 • 742 citations

Neurobehavioral Aspects of Affective Disorders

1989 • 713 citations

Stressor controllability and learned helplessness: The roles of the dorsal raphe nucleus, serotonin, and corticotropin-releasing factor

2005 • 701 citations

5-Hydroxytryptamine receptors

2001 • 693 citations

Glucocorticoids, depression, and mood disorders: structural remodeling in the brain

2005 • 671 citations

The olfactory bulbectomised rat as a model of depression

2005 • 667 citations

Side Effects of Corticosteroid Therapy

2001 • 634 citations

Stress- and pharmacologically-induced behavioral sensitization increases vulnerability to acquisition of amphetamine self-administration

1990 • 574 citations

Mechanisms for selection of basic motor programs – roles for the striatum and pallidum

2005 • 569 citations

Synapsins as mediators of BDNF-enhanced neurotransmitter release

2000 • 562 citations

Stress, hypercortisolism and corticosteroid receptors in depression: implicatons for therapy

2001 • 559 citations

Elevated Monoamine Oxidase A Levels in the Brain

2006 • 540 citations

5‐Hydroxytryptamine Receptors

1993 • 524 citations

Is there a role for 5-HT1A agonists in the treatment of depression?

2003 • 519 citations

5-Hydroxytryptamine _2A serotonin receptors in the primate cerebral cortex: Possible site of action of hallucinogenic and antipsychotic drugs in pyramidal cell apical dendrites

1998 • 510 citations

A Functional Magnetic Resonance Imaging Study of Bipolar Disorder

2003 • 472 citations

Noradrenaline in the ventral forebrain is critical for opiate withdrawal-induced aversion

2000 • 455 citations

Human feelings: why are some more aware than others?

2004 • 426 citations

NEUROENDOCRINOLOGY OF STRESS

2001 • 417 citations

Effect of repeated corticosterone injections and restraint stress on anxiety and depression-like behavior in male rats

2004 • 407 citations

Corticosterone effects on corticotropin-releasing hormone mRNA in the central nucleus of the amygdala and the parvocellular region of the paraventricular nucleus of the hypothalamus

1994 • 392 citations

Multiple Dopamine Receptor Subtypes in the Medial Prefrontal Cortex of the Rat Regulate Set-Shifting

2005 • 391 citations

Selective activation of dopamine transmission in the shell of the nucleus accumbens by stress

1995 • 390 citations

Effects of Glucocorticoids and Norepinephrine on the Excitability in the Hippocampus

1989 • 383 citations

Corticotropin-Releasing Factor in Brain: A Role in Activation, Arousal, and Affect Regulation

2004 • 352 citations

Stress, genes and the mechanism of programming the brain for later life

2004 • 351 citations

Dopamine and depression

1993 • 349 citations

Functional Neuroanatomical Substrates of Altered Reward Processing in Major Depressive Disorder Revealed by a Dopaminergic Probe

2005 • 344 citations

Serial pathways from primate prefrontal cortex to autonomic areas may influence emotional expression.

2003 • 341 citations

The effect of stress doses of hydrocortisone during septic shock on posttraumatic stress disorder in survivors

2001 • 339 citations

Cytokine, Sickness Behavior, and Depression

2006 • 334 citations

Serotonin 5-HT2A receptors are expressed on pyramidal cells and interneurons in the rat cortex

1997 • 324 citations

Enlargement of the amygdala in patients with a first episode of major depression

2002 • 320 citations

Stress, depression and the mesolimbic dopamine system

1996 • 318 citations

The pathogenesis of clinical depression: Stressor- and cytokine-induced alterations of neuroplasticity

2005 • 317 citations

Typical and atypical antidepressants. Molecular mechanisms.

1982 • 315 citations

Overlap of dopaminergic, adrenergic, and serotoninergic receptors and complementarity of their subtypes in primate prefrontal cortex

1990 • 314 citations

Pathophysiology of hypercortisolism in depression

2007 • 302 citations

Dopamine receptors in human brain: Autoradiographic distribution of D2 sites

1989 • 298 citations

α1b-Adrenergic Receptors Control Locomotor and Rewarding Effects of Psychostimulants and Opiates

2002 • 287 citations

Effects of mood and subtype on cerebral glucose metabolism in treatment-resistant bipolar disorder

2001 • 286 citations

Anomalous Prefrontal-Subcortical Activation in Familial Pediatric BipolarDisorder

2004 • 285 citations

The many faces of fatigue in major depressive disorder

2005 • 268 citations

Physical activity, exercise coping, and depression in a 10-year cohort study of depressed patients

2006 • 266 citations

Social Stress in Hamsters: Defeat Activates Specific Neurocircuits within the Brain

1997 • 258 citations

Reciprocal changes in prefrontal and limbic dopamine responsiveness to aversive and rewarding stimuli after chronic mild stress: implications for the psychobiology of depression

1999 • 250 citations

Amygdala and bed nucleus of the stria terminalis: differential roles in fear and anxiety measured with the acoustic startle reflex

1997 • 250 citations

Atrophy and Impaired Muscle Protein Synthesis during Prolonged Inactivity and Stress

2006 • 246 citations

Receptor heteromerization in adenosine A _2A receptor signaling

2003 • 245 citations

Modulatory effects of norepinephrine in the lateral bed nucleus of the stria terminalis on behavioral and neuroendocrine responses to acute stress

2002 • 244 citations

α-1 noradrenergic receptor stimulation impairs prefrontal cortical cognitive function

1999 • 240 citations

Anatomical Markers of Activity in Neuroendocrine Systems: Are we all ‘Fos‐ed out’?

2002 • 239 citations

The Experience of Psychopathology: Investigating Mental Disorders in their Natural Settings

2006 • 232 citations

Acetylcholine and Depression*

1974 • 228 citations

Role of the ventral subiculum in stress integration

2006 • 224 citations

Patterns of Brain Activity Associated With Variation in Voluntary Wheel-Running Behavior.

2003 • 212 citations

Efferent projections of the nucleus of the solitary tract to peri-locus coeruleus dendrites in rat brain: Evidence for a monosynaptic pathway

1999 • 211 citations

Novelty‐related Rapid Locomotor Effects of Corticosterone in Rats

1996 • 202 citations

Adrenal Insufficiency and Colonic Inflammation after a Novel Chronic Psycho-Social Stress Paradigm in Mice: Implications and Mechanisms

2006 • 201 citations

Acute social defeat reduces neurotrophin expression in brain cortical and subcortical areas in mice

2004 • 197 citations

Role of noradrenergic projections to the bed nucleus of the stria terminalis in the regulation of the hypothalamic–pituitary–adrenal axis

2004 • 184 citations

Noradrenergic lesions differentially alter the antidepressant-like effects of reboxetine in a modified forced swim test

2002 • 184 citations

Cellular localization of serotonin2A (5HT2A) receptors in the rat brain

2000 • 182 citations

Stress-induced hyperlocomotion as a confounding factor in anxiety and depression models in mice

2005 • 181 citations

Segregation of serotonin 5-HT2A and 5-HT3 receptors in inhibitory circuits of the primate cerebral cortex

2000 • 171 citations

Topographic architecture of stress-related pathways targeting the noradrenergic locus coeruleus

2001 • 169 citations

The Role of Corticotropin-Releasing Hormone in the Dorsal Raphe Nucleus in Mediating the Behavioral Consequences of Uncontrollable Stress

2002 • 169 citations

Learning by doing versus learning by thinking: An fMRI study of motor and mental training

2005 • 169 citations

Neuroendocrinological Mechanisms of Actions of Antidepressant Drugs

2006 • 166 citations

Hypothalamic projections to locus coeruleus neurons in rat brain

2005 • 165 citations

Role of the paraventricular nucleus microenvironment in stress integration*

2002 • 165 citations

Long-term behavioral and neuronal cross-sensitization to amphetamine induced by repeated brief social defeat stress: Fos in the ventral tegmental area and amygdala

2004 • 161 citations

Stimulation of Neurogenesis in the Hippocampus of the Adult Rat by Fluoxetine Requires Rhythmic Change in Corticosterone

2005 • 161 citations

8-OH-DPAT microinjected in the region of the dorsal raphe nucleus blocks and reverses the enhancement of fear conditioning and interference with escape produced by exposure to inescapable shock.

1995 • 159 citations

The enzyme indoleamine 2,3-dioxygenase is induced in the mouse brain in response to peripheral administration of lipopolysaccharide and superantigen

2002 • 159 citations

Up‐Regulation of Immunolabeled α_2A‐Adrenoceptors,G_i Coupling Proteins, and Regulatory Receptor Kinases in the Prefrontal Cortex of Depressed Suicides

1999 • 155 citations

Repeated stress increases locomotor response to amphetamine

1984 • 153 citations

Distribution and cellular localization of the serotonin type 2C receptor messenger RNA in human brain

1999 • 152 citations

Dopamine D2-Like Receptors and the Antidepressant Response

2006 • 151 citations

Reversible inactivation of the dorsal vagal complex blocks lipopolysaccharide-induced social withdrawal and c-Fos expression in central autonomic nuclei

2003 • 150 citations

Clinical Correlates of Major Depression in Cushing’s Disease

1998 • 147 citations

Dopamine D1 receptors in the anterior cingulate cortex regulate effort-based decision making

2006 • 147 citations

Mood Symptoms during Corticosteroid Therapy: A Review

1998 • 147 citations

Modulatory effects of norepinephrine, acting on alpha1 receptors in the central nucleus of the amygdala, on behavioral and neuroendocrine responses to acute immobilization stress

2002 • 145 citations

Endotoxin- or pro-inflammatory cytokine-induced sickness behavior as an animal model of depression: focus on anhedonia

2005 • 144 citations

Distribution and pharmacology of alpha 2-adrenoceptors in the central nervous system.

1995 • 144 citations

Corticosterone regulates expression of BDNF and trkB but not NT-3 and trkC mRNA in the rat hippocampus.

1997 • 141 citations

Exploratory behaviour and grooming after repeated restraint and chronic mild stress: effect of desipramine

2000 • 141 citations

The consequences of uncontrollable stress are sensitive to duration of prior wheel running

2005 • 140 citations

Neurochemical and behavioral effects of corticotropin-releasing factor in the ventral tegmental area of the rat.

1987 • 140 citations

Dopaminergic—adrenergic interactions in the wake promoting mechanism of modafinil

2005 • 139 citations

Galanin: A Significant Role in Depression?

1998 • 139 citations

Effectiveness of pindolol plus serotonin uptake inhibitors in depression: a meta-analysis of early and late outcomes from randomised controlled trials

2002 • 138 citations

8-OH-DPAT microinjected in the region of the dorsal raphe nucleus blocks and reverses the enhancement of fear conditioning and interference with escape produced by exposure to inescapable shock.

1995 • 137 citations

Recent advances in the neurobiology of depression.

2002 • 131 citations

Effects of interleukin-1β and mild stress on alterations of norepinephrine, dopamine and serotonin neurotransmission: a regional microdialysis study

1997 • 127 citations

Repeated corticosterone administration sensitizes the locomotor response to amphetamine

1992 • 125 citations

Mood changes in response to psychosocial stress in healthy young women: Effects of pretreatment with cortisol.

2007 • 124 citations

Activation of adenosine A2A and dopamine D1 receptors stimulates cyclic AMP-dependent phosphorylation of DARPP-32 in distinct populations of striatal projection neurons

1998 • 124 citations

Regional Brain Metabolic Correlates of α-Methylparatyrosine–Induced Depressive Symptoms

2003 • 123 citations

Dexamethasone for the treatment of depression: a randomized, placebo- controlled, double-blind trial

1995 • 122 citations

Corticosterone regulates expression of BDNF and trkB but not NT-3 and trkC mRNA in the rat hippocampus

1997 • 122 citations

Identification of genes regulated by chronic psychosocial stress and antidepressant treatment in the hippocampus

2004 • 118 citations

Effects of chronic antidepressant drug administration and electroconvulsive shock on locus coeruleus electrophysiologic activity

2001 • 115 citations

Dopamine Activates Noradrenergic Receptors in the Preoptic Area

2002 • 108 citations

Acute Antidepressant Effects of Intravenous Hydrocortisone and CRH in Depressed Patients: A Double-Blind, Placebo-Controlled Study

2000 • 108 citations

The influence of specific noradrenergic and serotonergic lesions on the expression of hippocampal brain-derived neurotrophic factor transcripts following voluntary physical activity

2003 • 107 citations

Cytokines as a stressor: implications for depressive illness

2002 • 106 citations

Serotonin-Dopamine Interaction as a Focus of Novel Antidepressant Drugs

2006 • 105 citations

A Model of Anxious Depression: Persistence of Behavioral Pathology

2005 • 105 citations

Localization of the mouse α1A-adrenergic receptor (AR) in the brain: α1AAR is expressed in neurons, GABAergic interneurons, and NG2 oligodendrocyte progenitors

2006 • 102 citations

Antidepressant effects of citalopram and CRF receptor antagonist CP-154,526 in a rat model of depression

2004 • 101 citations

Involvement of catecholamine neurotransmission in the rat anterior cingulate in effort-related decision making.

2005 • 101 citations

Modeling depression: social dominance–submission gene expression patterns in rat neocortex

2005 • 101 citations

Brain‐derived neurotrophic factor regulates the expression of D₁ dopamine receptors

2006 • 99 citations

Depressive behavior and selective downregulation of serotonin receptor expression after early-life seizures: Reversal by environmental enrichment

2006 • 98 citations

Noradrenergic activation of immediate early genes in rat cerebral cortex

1991 • 96 citations

Increased corticotropin-releasing factor concentrations in the bed nucleus of the stria terminalis of anhedonic rats

2000 • 96 citations

Sleep deprivation and c‐fos expression in the rat brain

1995 • 94 citations

Physiological control of emotion-related behaviors by endogenous enkephalins involves essentially the delta opioid receptors

2005 • 87 citations

Olfactory system activation from sniffing: effects in piriform and orbitofrontal cortex

2004 • 87 citations

Behavioral sensitization to cocaine after a brief social defeat stress: c-fos expression in the PAG

1999 • 86 citations

Exploration of a novel environment leads to the expression of inducible transcription factors in barrel-related columns

2000 • 86 citations

Effects of a α2C-Adrenoreceptor Gene Polymorphism on Neural Responses to Facial Expressions in Depression

2006 • 85 citations

Monoaminergic neuronal activity up-regulates BDNF synthesis in cultured neonatal rat astrocytes

2006 • 85 citations

Mice with Mutations in the HPA-System as Models for Symptoms of Depression

2006 • 85 citations

Cytokines down-regulate α1-adrenergic receptor expression during endotoxemia

2003 • 83 citations

CRF in the paraventricular nucleus of the hypothalamus induces dose-related behavioral profile in rats

1992 • 82 citations

Dexamethasone augmentation in treatment‐resistant depression

1997 • 82 citations

The effects of CRF antagonists, antalarmin, CP154,526, LWH234, and R121919, in the forced swim test and on swim-induced increases in adrenocorticotropin in rats

2005 • 80 citations

Effects of Sleep on Wake-Induced c-fosExpression

1997 • 79 citations

5-HT1A receptor expression in pyramidal neurons of cortical and limbic brain regions

2005 • 78 citations

Environmental context and drug history modulate amphetamine-induced c-fos mrna expression in the basal ganglia, central extended amygdala, and associated limbic forebrain

2003 • 78 citations

Endocannabinoids Mediate the Effects of Acute Stress and Corticosterone on Sex Behavior

2006 • 78 citations

Testing the hypothesis that locus coeruleus hyperactivity produces depression-related changes via galanin

2005 • 77 citations

Social defeat, a paradigm of depression in rats that elicits 22-kHz vocalizations, preferentially activates the cholinergic signaling pathway in the periaqueductal gray

2007 • 77 citations

Brain monoamine receptors in a chronic unpredictable stress model in rats

2001 • 74 citations

Postsynaptic alpha-2 receptor stimulation improves memory in aged monkeys: Indirect effects of yohimbine versus direct effects of clonidine

1993 • 74 citations

Effects of galanin-like peptide (GALP) on locomotion, reproduction, and body weight in female and male mice

2005 • 73 citations

The neurobiology of bipolar disorder

2003 • 71 citations

Reversal of behavioral depression by infusion of an alpha-2 adrenergic agonist into the locus coeruleus

1986 • 71 citations

?1 Adrenoceptor subtypes: A synopsis of their pharmacology and molecular biology

1996 • 70 citations

Regulation of α and β components of noradrenergic cyclic AMP response in cortical slices

1987 • 70 citations

5-HT1A receptor and 5-HT1B receptor knockout mice in stress and anxiety paradigms.

2003 • 70 citations

Examining novel concepts of the pathophysiology of depression in the chronic psychosocial stress paradigm in tree shrews

2004 • 69 citations

Effects of antidepressant drugs injected into the amygdala on behavioral responses of rats in the forced swim test.

1986 • 69 citations

Corticosterone modulates behavioral and metabolic effects of lipopolysaccharide

1996 • 67 citations

Additive wake-promoting actions of medial basal forebrain noradrenergic α1- and β-receptor stimulation.

2003 • 66 citations

Neurotrophins

2003 • 64 citations

Severe deficits in 5‐HT_2A‐mediated neurotransmission in BDNF conditional mutant mice

2006 • 62 citations

Induction of Inducible cAMP Early Repressor Expression in Nucleus Accumbens by Stress or Amphetamine Increases Behavioral Responses to Emotional Stimuli

2006 • 62 citations

Arousal and differential Fos expression in histaminergic neurons of the ascending arousal system during a feeding‐related motivated behaviour

2005 • 61 citations

Stress, Depression, and The Role of Cytokines

1999 • 61 citations

Paraventricular nucleus bicuculline alters frequency components of sympathetic nerve discharge bursts

2001 • 59 citations

Lipopolysaccharide has indomethacin-sensitive actions on Fos expression in topographically organized subpopulations of serotonergic neurons

2006 • 59 citations

Hypothalamic paraventricular nucleus neurons regulate medullary catecholamine cell responses to restraint stress

2004 • 57 citations

Pharmacological effects of venlafaxine, a new antidepressant, given repeatedly, on the α 1 -adrenergic, dopamine and serotonin systems

1999 • 57 citations

5-HT2- and D1-mechanisms of the basolateral nucleus of the amygdala enhance conditioned fear and impair unconditioned fear

2006 • 57 citations

Mouse α_1B‐adrenergic receptor is expressed in neurons and NG2 oligodendrocytes

2004 • 56 citations

Sleep pattern in rats under different stress modalities

2005 • 54 citations

cAMP and Extracellular Signal-Regulated Kinase Signaling in Response to d-Amphetamine and Methylphenidate in the Prefrontal Cortex in Vivo: Role of β1-Adrenoceptors

2005 • 53 citations

An antidepressant mechanism of desipramine is to decrease tumor necrosis factor-α production culminating in increases in noradrenergic neurotransmission

2005 • 53 citations

Stress-induced sensitization of CRH-ir but not P-CREB-ir responsivity in the rat central nervous system

2001 • 52 citations

Astressin, a corticotropin releasing factor antagonist, reverses the anxiogenic effects of urocortin when administered into the basolateral amygdala

2000 • 52 citations

Corticosterone Controls lnterleukin‐1β Expression and Sickness Behavior in the Rat

1996 • 51 citations

Depressive Behavior in Mice Due to Immune Stimulation is Accompanied by Reduced Neural Activity in Brain Regions Involved in Positively Motivated Behavior

2006 • 50 citations

Decrease in stress-induced c-Fos-like immunoreactivity in the lateral septal nucleus of learned helpless rats

1999 • 50 citations

Time course of alterations after olfactory bulbectomy in mice

2006 • 49 citations

Agmatine, an endogenous modulator of noradrenergic neurotransmission in the rat tail artery

1996 • 48 citations

Antidepressant‐like effects of endogenous histamine and of two histamine H₁ receptor agonists in the mouse forced swim test

1998 • 48 citations

An anti-immobility effect of exogenous corticosterone in mice

2007 • 47 citations

Microstructure of sleep in depressed patients according to the cyclic alternating pattern

2002 • 45 citations

Chronic Corticosterone Impairs Inhibitory Avoidance in Rats

2000 • 44 citations

Blockade of serotonin 5-HT 1B and 5-HT 2A receptors suppresses the induction of locomotor activity by 5-HT reuptake inhibitors, citalopram and fluvoxamine, in NMRI mice exposed to a novel environment: a comparison to other 5-HT receptor subtypes

2003 • 43 citations

Hypermetabolism of paraventricular hypothalamus in the congenitally helpless rat

2001 • 42 citations

Reduced evoked fos expression in activity-related brain regions in animal models of behavioral depression

2007 • 42 citations

Pharmacological evidence for the role of central alpha 1B-adrenoceptors in the motor activity and spontaneous movement of mice

2001 • 41 citations

Calmodulin Involvement in Stress‐ and Corticosterone‐Induced Down‐Regulation of Cyclic AMP‐Generating Systems in Brain

1990 • 41 citations

Central α1-adrenergic system in behavioral activity and depression

2006 • 40 citations

Adrenoreceptors and the pharmacology of affective illness: A unifying theory

1987 • 39 citations

Effects of 5-hydroxytryptamine2 receptor antagonism on the behavioral activation and immediate early gene expression induced by dizocilpine.

1998 • 38 citations

Recent Advances in the Neurobiology of Depression

2003 • 38 citations

Stress and adenosine: I. Effect of methylxanthine and amphetamine stimulants on learned helplessness in rats.

1994 • 36 citations

Role of alpha-1-adrenergic receptors in the regulation of corticotropin-releasing hormone mRNA in the paraventricular nucleus of the hypothalamus during stress.

2000 • 35 citations

Presynaptic α-adrenoceptors and the action of tricyclic antidepressant drugs in behavioural despair in rats

1980 • 34 citations

Gross mapping of α1-adrenoceptors that regulate behavioral activation in the mouse brain

2003 • 33 citations

The cortisol response to desipramine in endogenous depressives and normal controls: Preliminary findings

1985 • 33 citations

Role of CNS α1-adrenoceptor activity in central fos responses to novelty

2006 • 32 citations

Stress and adenosine: I. Effect of methylxanthine and amphetamine stimulants on learned helplessness in rats.

1994 • 31 citations

Dopaminergic activity in transgenic mice underexpressing glucocorticoid receptors: effect of antidepressants

2001 • 31 citations

Functional effects of corticosterone on 5-HT1A and 5-HT1B receptor activity in rat brain: in vivo microdialysis studies

2001 • 28 citations

Role of catecholaminergic inputs to the medial prefrontal cortex in local and subcortical expression of Fos after psychological stress

2004 • 28 citations

Different effect of desipramine on locomotor activity in quinpiroletreated rats after repeated restraint and chronic mild stress

2000 • 28 citations

Chronic subordination stress in male tree shrews

2001 • 27 citations

Participation of histaminergic H1 and noradrenergic α1 receptors in orexin A-induced wakefulness in rats

2004 • 27 citations

Cortical 5-HT1A receptor downregulation by antidepressants in rat brain

2001 • 26 citations

Two noradrenergic systems in the brain and their interactions with other monoaminergic neurons.

1979 • 26 citations

Comparison of the effects of isoproterenol administered into the hippocampus, frontal cortex, or amygdala on behavior of rats maintained by differential reinforcement of low response rate

2001 • 25 citations

The effects of acute corticosterone on lithium chloride-induced conditioned place aversion and locomotor activity in rats

2006 • 24 citations

Role of α1-Adrenoceptors of the Locus Coeruleus in Self-Stimulation of the Medial Forebrain Bundle

2006 • 21 citations

Neural correlates to action and rewards in the rat posterior cingulate cortex

2005 • 19 citations

Repeated treatment with antidepressants enhances dopamine D1 receptor gene expression in the rat brain

2006 • 18 citations

Sympathetic and brain monoaminergic regulation of energy balance in obesity-resistant rats (Lou/C)

2003 • 18 citations

Stress-induced subsensitivity to modafinil and its prevention by corticosteroids

2002 • 17 citations

Dysphoric moods in depressed and non-depressed adolescents

1992 • 17 citations

Depressed mood, index finger force and motor cortex stimulation: A transcranial magnetic stimulation (TMS) study

2005 • 16 citations

The role of medial prefrontal cortical dopamine in spontaneous flexibility in the rat

2001 • 15 citations

ALTERATIONS IN MONOAMINE‐CONTAINING NEURONAL FUNCTION DUE TO ADMINISTRATION OF ANTIDEPRESSANTS REPEATEDLY TO RATS.

1985 • 15 citations

Signals Regulating Neurogenesis in the Adult Olfactory Bulb

2005 • 15 citations

Dysregulation of the noradrenergic system in depression.

1984 • 13 citations

Fos induction in cortical interneurons during spontaneous wakefulness of rats in a familiar or enriched environment

2002 • 11 citations

Chronobiological Dimensions of an Olfactory Bulbectomized Rodent Animal Model for Agitated Depression

2000 • 7 citations

Noradrenaline in depression: half a century of progress.

1997 • 6 citations