Recent Advances in the Neurobiology of Depression

Neurogenesis in the adult human hippocampus

1998 • 6,181 citations

The Bcl-2 Protein Family: Arbiters of Cell Survival

1998 • 5,359 citations

The role of childhood trauma in the neurobiology of mood and anxiety disorders: preclinical and clinical studies

2001 • 2,667 citations

Causal Relationship Between Stressful Life Events and the Onset of Major Depression

1999 • 2,365 citations

Learning enhances adult neurogenesis in the hippocampal formation

1999 • 2,134 citations

The Corticosteroid Receptor Hypothesis of Depression

2000 • 2,126 citations

A Molecular and Cellular Theory of Depression

1997 • 2,091 citations

The neurobiology of stress: from serendipity to clinical relevance11Published on the World Wide Web on 22 November 2000.

2000 • 1,784 citations

Proliferation of granule cell precursors in the dentate gyrus of adult monkeys is diminished by stress

1998 • 1,386 citations

Depression Duration But Not Age Predicts Hippocampal Volume Loss in Medically Healthy Women with Recurrent Major Depression

1999 • 1,371 citations

The role of corticotropin-releasing factor in depression and anxiety disorders

1999 • 1,371 citations

Neurogenesis in the Neocortex of Adult Primates

1999 • 1,268 citations

The cellular neurobiology of depression

2001 • 1,169 citations

Distinct Mechanism for Antidepressant Activity by Blockade of Central Substance P Receptors

1998 • 1,067 citations

Adult brain neurogenesis and psychiatry: a novel theory of depression

2000 • 936 citations

Mice deficient for corticotropin-releasing hormone receptor-2 display anxiety-like behaviour and are hypersensitive to stress

2000 • 836 citations

Antidepressants and Hypothalamic-Pituitary-Adrenocortical Regulation

1996 • 829 citations

Altered Pituitary-Adrenal Axis Responses to Provocative Challenge Tests in Adult Survivors of Childhood Abuse

2001 • 733 citations

Effects of the high-affinity corticotropin-releasing hormone receptor 1 antagonist R121919 in major depression: the first 20 patients treated

2000 • 698 citations

The possibility of neurotoxicity in the hippocampus in major depression: a primer on neuron death

2000 • 690 citations

The combined dexamethasone/CRH test: A refined laboratory test for psychiatric disorders

1994 • 663 citations

Neuronal plasticity and survival in mood disorders

2000 • 658 citations

Sleep and depression — results from psychobiological studies: an overview

2001 • 622 citations

Enhancement of Hippocampal Neurogenesis by Lithium

2000 • 613 citations

The Effects of Early Rearing Environment on the Development of GABAA and Central Benzodiazepine Receptor Levels and Novelty-Induced Fearfulness in the Rat

2000 • 594 citations

Behavioural stress facilitates the induction of long-term depression in the hippocampus

1997 • 501 citations

CREB Couples Neurotrophin Signals to Survival Messages

2000 • 455 citations

Increasing the Complexity of Coactivation in Nuclear Receptor Signaling

1999 • 449 citations

Decreased Benzodiazepine Receptor Binding in Prefrontal Cortex in Combat-Related Posttraumatic Stress Disorder

2000 • 445 citations

The Mood‐Stabilizing Agent Valproate Inhibits the Activity of Glycogen Synthase Kinase‐3

2000 • 434 citations

Altered Hypothalamic-Pituitary-Adrenocortical Regulation in Healthy Subjects at High Familial Risk for Affective Disorders

1995 • 374 citations

Neuroplasticity and cellular resilience in mood disorders

2000 • 332 citations

The role of stress in the pathophysiology of the dopaminergic system

2000 • 305 citations

Effects of Corticotropin-Releasing Factor on Neuronal Activity in the Serotonergic Dorsal Raphe Nucleus

2000 • 304 citations

Decreased dorsolateral prefrontal N-acetyl aspartate in bipolar disorder

2000 • 291 citations

Genetic and pharmacological disruption of neurokinin 1 receptor function decreases anxiety-related behaviors and increases serotonergic function

2001 • 283 citations

Discovery of the antidepressant and anti-emetic efficacy of substance P receptor (NK1) antagonists

1999 • 282 citations

Stress-induced behaviors require the corticotropin-releasing hormone (CRH) receptor, but not CRH

1999 • 242 citations

Occurrence and Clinical Correlates of Psychiatric Comorbidity in Patients With Psychotic Disorders

1998 • 239 citations

Prediction of Medium-Term Outcome by Cortisol Response to the Combined Dexamethasone-CRH Test in Patients With Remitted Depression

1999 • 234 citations

Hormonal Response Pattern in the Combined DEX-CRH Test Is Stable over Time in Subjects at High Familial Risk for Affective Disorders

1998 • 210 citations

Differential behavioural effects of chronic infusion of CRH 1 and CRH 2 receptor antisense oligonucleotides into the rat brain

1999 • 192 citations

Association between depressive behavior and absence of serotonin-dopamine interaction in the nucleus accumbens

2001 • 174 citations

Antiglucocorticoid treatment of depression: double-blind ketoconazole

1999 • 168 citations

Influence of a Functional Polymorphism Within the Promoter of the Serotonin Transporter Gene on the Effects of Total Sleep Deprivation in Bipolar Depression

1999 • 167 citations

Morphological changes in the hippocampal CA3 region induced by non-invasive glucocorticoid administration: a paradox

1998 • 163 citations

Psychological Stress and Endocrine Functions

1956 • 148 citations

Modulation of synaptic plasticity by stress and antidepressants

2002 • 138 citations

Dopamine D2 receptor availability and amphetamine-induced dopamine release in unipolar depression

2001 • 132 citations

Cerebral Glucose Metabolic Response to Combined Total Sleep Deprivation and Antidepressant Treatment in Geriatric Depression

1999 • 122 citations

Neurokinin₁ Receptor Antagonists as Potential Antidepressants

2001 • 113 citations

Sleep deprivation combined with consecutive sleep phase advance as a fast-acting therapy in depression: an open pilot trial in medicated and unmedicated patients

1997 • 112 citations

Can the Placebo Be the Cure?

1999 • 107 citations

Sleep phase advance and lithium to sustain the antidepressant effect of total sleep deprivation in bipolar depression: new findings supporting the internal coincidence model?

2001 • 104 citations

How antidepressants work: New perspectives on the pathophysiology of depressive disorder

2001 • 102 citations

Transient and persistent consequences of acute stress on long-term potentiation (LTP), synaptic efficacy, theta rhythms and bursts in area CA1 of the hippocampus

1997 • 100 citations

Neurobiological similarities in antidepressant sleep deprivation and psychostimulant use: a psychostimulant theory of antidepressant sleep deprivation

1998 • 99 citations

Controlled Comparison of Electrophysiological Sleep in Families of Probands With Unipolar Depression

1998 • 92 citations

Selective serotonin reuptake inhibitors in post-traumatic stress disorder

2000 • 82 citations

Serotonergic modulation of dopamine measured with [11C]raclopride and PET in normal human subjects

1997 • 75 citations

Metyrapone displays antidepressant-like properties in preclinical paradigms

1999 • 55 citations

Changed Concentrations of Tachykinins and Neuropeptide Y in Brain of a Rat Model of Depression Lithium Treatment Normalizes Tachykinins

2001 • 52 citations

Dopamine agonist amineptine prevents the antidepressant effect of sleep deprivation

1996 • 47 citations

Pramipexole, a Dopamine Agonist, in Major Depression: Antidepressant Effects and Tolerability in an Open-Label Study with Multiple Doses

1997 • 45 citations

Dopaminergic augmentation of sleep deprivation effects in bipolar depression

2001 • 41 citations

Pharmacotherapy of Early-Onset Depression

2000 • 36 citations

Caudate Nucleus Dopamine D<sub>2</sub> Receptors in Depressed Suicide Victims

2001 • 35 citations

Neuroendocrine, polysomnographic and psychometric observations in healthy subjects at high familial risk for affective disorders: the current state of the ‘Munich vulnerability study’

2001 • 35 citations

Sleep Deprivation, EEG, and Functional MRI in Depression Preliminary Results

2001 • 32 citations

Substance P and Affective Disorders: New Treatment Opportunities by Neurokinin 1 Receptor Antagonists?

2002 • 32 citations

Stress and long-term synaptic depression

1998 • 12 citations

Towards a new model for cellular pathophysiology in affective disorder

2000 • 5 citations

260. A 1H-MRSI hippocampal study in bipolar patients with a history of alcohol abuse

2000 • 2 citations