Adrenal Insufficiency and Colonic Inflammation after a Novel Chronic Psycho-Social Stress Paradigm in Mice: Implications and Mechanisms

Validation of open : closed arm entries in an elevated plus-maze as a measure of anxiety in the rat

1985 • 5,596 citations

The use of a plus-maze to measure anxiety in the mouse

1987 • 2,571 citations

Treatment of Murine Colitis by Lactococcus lactis Secreting Interleukin-10

2000 • 1,406 citations

Acute Stress Enhances while Chronic Stress Suppresses Cell-Mediated Immunityin Vivo:A Potential Role for Leukocyte Trafficking

1997 • 991 citations

The role of adrenocorticoids as modulators of immune function in health and disease: neural, endocrine and immune interactions

1997 • 827 citations

Normal luminal bacteria, especially Bacteroides species, mediate chronic colitis, gastritis, and arthritis in HLA-B27/human beta2 microglobulin transgenic rats.

1996 • 795 citations

Glucocorticoids in T Cell Development and Function

2000 • 783 citations

Effects of stress on immune cell distribution. Dynamics and hormonal mechanisms.

1995 • 719 citations

Inflammatory Bowel Disease and Adenomas in Mice Expressing a Dominant Negative N-Cadherin

1995 • 672 citations

Enhancing versus suppressive effects of stress hormones on skin immune function

1999 • 659 citations

Regulation of Pituitary ACTH Secretion during Chronic Stress

1994 • 530 citations

Evidence for norepinephrine-mediated collateral inhibition of locus coeruleus neurons

1977 • 490 citations

Differential regulation of corticotropin-releasing factor mRNA in rat brain regions by glucocorticoids and stress

1991 • 434 citations

Presynaptic α-autoreceptors

2005 • 355 citations

Presynaptic alpha-autoreceptors.

1987 • 350 citations

Corticotropin-releasing factor antagonist reduces emotionality in socially defeated rats via direct neurotropic action

1992 • 333 citations

The temporal dynamics of the stress response

1997 • 324 citations

Social Stress Induces Glucocorticoid Resistance in Subordinate Animals

2001 • 309 citations

Restraint stress in biomedical research: An update

1994 • 299 citations

Responses of hypothalamic and pituitary mRNA to physical and psychological stress in the rat

1989 • 297 citations

The loss of sympathetic nerve fibers in the synovial tissue of patients with rheumatoid arthritis is accompanied by increased norepinephrine release from synovial macrophages

2000 • 285 citations

Environmental stress–induced gastrointestinal permeability is mediated by endogenous glucocorticoids in the rat

2000 • 262 citations

Chronic Social Stress Alters Levels of Corticotropin-Releasing Factor and Arginine Vasopressin mRNA in Rat Brain

1997 • 254 citations

Defeat is a major stressor in males while social instability is stressful mainly in females: towards the development of a social stress model in female rats

1999 • 250 citations

Acute stress causes mucin release from rat colon: role of corticotropin releasing factor and mast cells

1996 • 249 citations

Corticotropin-releasing hormone mimics stress-induced colonic epithelial pathophysiology in the rat

1999 • 246 citations

Release of mast cell mediators into the jejunum by cold pain stress in humans

1998 • 231 citations

Corticotrophin‐releasing factor, vasopressin and pro‐opiomelanocortin mRNA responses to stress and opiates in the rat.

1988 • 217 citations

Acute stressors stimulate ion secretion and increase epithelial permeability in rat intestine

1994 • 215 citations

Anxiety enhancement in the murine elevated plus maze by immediate prior exposure to social stressors

1993 • 200 citations

Changes in Hypothalamic‐Pituitary‐Adrenal Function, Body Temperature, Body Weight and Food Intake with Repeated Social Stress Exposure in Rats

2005 • 194 citations

Stress-induced disruption of colonic epithelial barrier: role of interferon-γ and myosin light chain kinase in mice

2003 • 192 citations

Increased tyrosine hydroxylase activity in the locus coeruleus of rat brain stem after reserpine treatment and cold stress

1974 • 186 citations

Mucosal injury and inflammation in a model of chronic granulomatous colitis in rats

1993 • 181 citations

Glycoprotein Composition of Colonic Mucosa

1984 • 174 citations

Personality profile and affective state of patients with inflammatory bowel disease.

1989 • 157 citations

An opposing time‐dependent immune‐modulating effect of the sympathetic nervous system conferred by altering the cytokine profile in the local lymph nodes and spleen of mice with type II collagen–induced arthritis

2005 • 148 citations

Differential effects of social stress on central serotonergic activity and emotional reactivity in Lewis and spontaneously hypertensive rats

1997 • 146 citations

Stress-induced enhancement of colitis in rats: CRF and arginine vasopressin are not involved

1997 • 146 citations

Chronic Intermittent Psychosocial Stress (Social Defeat/Overcrowding) in Mice Increases the Severity of an Acute DSS-Induced Colitis and Impairs Regeneration

2006 • 137 citations

Modulation of tyrosine hydroxylase gene expression in rat brain and adrenals by exposure to cold

1988 • 131 citations

Stress induces the translocation of cutaneous and gastrointestinal microflora to secondary lymphoid organs of C57BL/6 mice

2005 • 129 citations

Susceptibility of Lewis and Fischer rats to stress-induced worsening of TNB-colitis: protective role of brain CRF

1999 • 127 citations

Contrasting activity of cytosin–guanosin dinucleotide oligonucleotides in mice with experimental colitis

2003 • 125 citations

Effects of stress and adrenalectomy on tyrosine hydroxylase mRNA levels in the locus ceruleus by in situ hybridization

1991 • 125 citations

Innervation of the rat thymus gland

1991 • 123 citations

Glucocorticoid-induced Apoptosis of Lymphoid Cells

1994 • 122 citations

Prenatal stress: opposite effects on anxiety and hypothalamic expression of vasopressin and corticotropin‐releasing hormone in rats selectively bred for high and low anxiety

2006 • 116 citations

Role of hypothalamic inputs in maintaining pituitary-adrenal responsiveness in repeated restraint

2003 • 116 citations

Interleukin-6 and the development of social disruption-induced glucocorticoid resistance

2002 • 113 citations

Uncoupling of the sympathetic nervous system and the hypothalamic–pituitary–adrenal axis in inflammatory bowel disease?

2002 • 109 citations

Effect of psychological stress on salt and water transport in the human jejunum

1987 • 108 citations

Tissue-specific alterations in the glucocorticoid sensitivity of immune cells following repeated social defeat in mice

2005 • 107 citations

Immobilization stress elevates gene expression for catecholamine biosynthetic enzymes and some neuropeptides in rat sympathetic ganglia: effects of adrenocorticotropin and glucocorticoids.

1996 • 104 citations

Chronic electroconvulsive shock treatment elicits up-regulation of CRF and AVP mRNA in select populations of neuroendocrine neurons

1989 • 99 citations

Social stress in laboratory rats

2001 • 91 citations

Social stress in guinea pigs

1989 • 90 citations

Social stress, dominance and blood cellular immunity

1999 • 78 citations

Effects of two stressors on behaviour in the elevated X-maze: preliminary investigation of their interaction with 8-OH-DPAT

1994 • 77 citations

Expression of Corticotropin‐Releasing Factor mRNA in Response to Stress

2007 • 75 citations

Quantification of type I and II adrenal steroid receptors in neuronal, lymphoid and pituitary tissues

1989 • 74 citations

The pituitary-adrenal axis and the different behavioral effects of buspirone and chlordiazepoxide

1996 • 68 citations

Altered Circadian Rhythms of the Stress Hormone and Melatonin Response in Lupus-prone MRL/MP-fasIpr Mice

2000 • 59 citations

Social stress and T cell maturation in male rats: transient and persistent alterations in thymic function

2003 • 58 citations

Social stress affects migration of blood T cells into lymphoid organs

2003 • 57 citations

Single exposure to social defeat increases corticotropin-releasing factor and glucocorticoid receptor mRNA expression in rat hippocampus

2005 • 57 citations

Anxiety-Like Behavior in Elevated Plus-Maze Tests in Repeatedly Cold-Stressed Mice

2001 • 56 citations

Modulation of thymocyte apoptosis by isoproterenol and prostaglandin E2

1991 • 54 citations

Intracellular signaling pathways involved in the induction of apoptosis in immature thymic T lymphocytes.

1996 • 53 citations

Long-term colony housing in Long Evans rats: immunological, hormonal, and behavioral consequences

2001 • 53 citations

Effect of cold-induced pain on salt and water transport in the human jejunum

1988 • 50 citations

The anti-inflammatory effect of leptin on experimental colitis: involvement of endogenous glucocorticoids

2003 • 50 citations

Immobilization stress elevates gene expression for catecholamine biosynthetic enzymes and some neuropeptides in rat sympathetic ganglia: effects of adrenocorticotropin and glucocorticoids

1996 • 49 citations

Colonic Mucin Composition in Primates

1985 • 46 citations

Effects of viral infection on corticosterone secretion and glucocorticoid receptor binding in immune tissues

1997 • 46 citations

NON-SPECIFIC ULCERATIVE COLITIS IN BEDOUIN ARABS

1967 • 45 citations

Psychosocial Stress and Its Pathophysiological Effects in Tree Shrews (Tupaia belangeri)

1986 • 44 citations

Reduction of colonic mucus by repeated short-term stress enhances experimental colitis in rats

2001 • 41 citations

Importance of fighting in the immune effects of social defeat

2003 • 40 citations

In vivo effects of catecholamines and glucocorticoids on mouse thymic cAMP content and thymolysis

1986 • 38 citations

Key role of the sympathetic microenvironment for the interplay of tumour necrosis factor and interleukin 6 in normal but not in inflamed mouse colon mucosa

2005 • 37 citations

TNF-α down-regulates the Na+–K+ ATPase and the Na+–K+–2Cl−cotransporter in the rat colon via PGE2

2005 • 36 citations

Mortality causes of the moustached tamarin (Saguinus mystax) in captivity

1992 • 34 citations

Anti-inflammatory effect of acute stress on experimental colitis is mediated by cholecystokinin-B receptors

2004 • 33 citations

Effect of misoprostol in preventing stress-induced intestinal fluid secretion in rats

1989 • 24 citations

Is the cotton-topped tamarin a model for behavioral research?

1985 • 20 citations

Presynaptic Autoreceptors

1982 • 8 citations

Agouti yellow mutation increases adrenal response to ACTH in mice

2004 • 7 citations