Protein toxins acting on intracellular targets: cellular uptake and translocation to the cytosol

Tetanus and botulinum-B neurotoxins block neurotransmitter release by proteolytic cleavage of synaptobrevin

1992 • 1,792 citations

RNA N-glycosidase activity of ricin A-chain. Mechanism of action of the toxic lectin ricin on eukaryotic ribosomes.

1987 • 943 citations

Anthrax toxin edema factor: a bacterial adenylate cyclase that increases cyclic AMP concentrations of eukaryotic cells.

1982 • 929 citations

Roles of G protein subunits in transmembrane signalling

1988 • 794 citations

Site of action of a Vero toxin (VT2) from Escherichia coli O157:H7 and of Shiga toxin on eukaryotic ribosomes

1988 • 774 citations

The crystal structure of diphtheria toxin

1992 • 663 citations

NAD-dependent inhibition of protein synthesis by Pseudomonas aeruginosa toxin,.

1975 • 619 citations

G protein involvement in receptor-effector coupling.

1988 • 618 citations

Protein Tyrosine Phosphatase Activity of an Essential Virulence Determinant in Yersinia

1990 • 566 citations

Expression cloning of a diphtheria toxin receptor: Identity with a heparin-binding EGF-like growth factor precursor

1992 • 552 citations

Structure of exotoxin A of Pseudomonas aeruginosa at 3.0-Angstrom resolution.

1986 • 517 citations

Botulinum C2 toxin ADP-ribosylates actin

1986 • 503 citations

Subunit structure of islet-activating protein, pertussis toxin, in conformity with the A-B model

1982 • 497 citations

Identification of the carbohydrate receptor for Shiga toxin produced by Shigella dysenteriae type 1.

1987 • 448 citations

The alpha 2-macroglobulin receptor/low density lipoprotein receptor-related protein binds and internalizes Pseudomonas exotoxin A.

1992 • 444 citations

Mechanism of action of the toxic lectins abrin and ricin

1974 • 443 citations

Retrograde transport of endocytosed Shiga toxin to the endoplasmic reticulum

1992 • 429 citations

Acidification of the cytosol inhibits endocytosis from coated pits.

1987 • 345 citations

ADP-ribosylation of elongation factor 2 by diphtheria toxin. NMR spectra and proposed structures of ribosyl-diphthamide and its hydrolysis products.

1980 • 323 citations

Inhibition of coated pit formation in Hep2 cells blocks the cytotoxicity of diphtheria toxin but not that of ricin toxin.

1985 • 309 citations

Rapid entry of nicked diphtheria toxin into cells at low pH. Characterization of the entry process and effects of low pH on the toxin molecule.

1981 • 291 citations

The mechanism of action of cholera toxin in pigeon erythrocyte lysates

1975 • 279 citations

Pseudomonas exotoxin contains a specific sequence at the carboxyl terminus that is required for cytotoxicity.

1990 • 267 citations

Crystallographic refinement of ricin to 2.5 Å

1991 • 262 citations

Nucleotide sequence of the Shiga-like toxin genes of Escherichia coli.

1987 • 261 citations

Ligands internalized through coated or noncoated invaginations follow a common intracellular pathway.

1987 • 254 citations

Endocytosis from coated pits of Shiga toxin: a glycolipid-binding protein from Shigella dysenteriae 1.

1989 • 251 citations

The Ways of Endocytosis

1989 • 237 citations

Processing of Pseudomonas exotoxin by a cellular protease results in the generation of a 37,000-Da toxin fragment that is translocated to the cytosol

1990 • 233 citations

Effect of diphtheria toxin on protein synthesis: Inactivation of one of the transfer factors

1967 • 232 citations

Estimation of the amount of internalized ricin that reaches the trans-Golgi network

1988 • 212 citations

Globotetraosylceramide Is Recognized by the Pig Edema Disease Toxin

1989 • 203 citations

The cytotoxic activity of Shigella toxin. Evidence for catalytic inactivation of the 60 S ribosomal subunit.

1981 • 201 citations

Pathogenesis of Shigella diarrhea. IX. Simplified high yield purification of Shigella toxin and characterization of subunit composition and function by the use of subunit-specific monoclonal and polyclonal antibodies.

1984 • 187 citations

Receptor-mediated internalization of pseudomonas toxin by mouse fibroblasts

1980 • 176 citations

Subunit structure of Shigella cytotoxin.

1981 • 174 citations

Bordetella pertussis invasive adenylate cyclase. Partial resolution and properties of its cellular penetration.

1985 • 163 citations

Subunit number and arrangement in Escherichia coli heat-labile enterotoxin

1981 • 156 citations

Disruption of the Golgi apparatus by brefeldin A inhibits the cytotoxicity of ricin, modeccin, and Pseudomonas toxin

1991 • 156 citations

Ricin transport in brefeldin A-treated cells: correlation between Golgi structure and toxic effect.

1991 • 152 citations

A deleted variant of Bacillus anthracis protective antigen is non-toxic and blocks anthrax toxin action in vivo

1989 • 151 citations

Ricin — a potent inhibitor of protein synthesis

1972 • 134 citations

ADP-ribosylation of actin by clostridial toxins.

1989 • 133 citations

Pasteurella multocida toxin: potent mitogen for cultured fibroblasts.

1990 • 131 citations

The 27-kD diphtheria toxin receptor-associated protein (DRAP27) from vero cells is the monkey homologue of human CD9 antigen: expression of DRAP27 elevates the number of diphtheria toxin receptors on toxin-sensitive cells.

1992 • 106 citations

Action of viscumin, a toxic lectin from mistletoe, on cells in culture.

1982 • 104 citations

Diphtheria toxin-induced channels in Vero cells selective for monovalent cations.

1988 • 89 citations

Peptides fused to the amino-terminal end of diphtheria toxin are translocated to the cytosol.

1991 • 86 citations

Tight folding of acidic fibroblast growth factor prevents its translocation to the cytosol with diphtheria toxin as vector.

1992 • 86 citations

Low pH-induced release of diphtheria toxin A-fragment in Vero cells. Biochemical evidence for transfer to the cytosol.

1988 • 85 citations

On the membrane translocation of diphtheria toxin: at low pH the toxin induces ion channels on cells.

1988 • 84 citations

Cellular internalisation of Clostridium difficile toxin A

1987 • 83 citations

Insertion of diphtheria toxin B-fragment into the plasma membrane at low pH. Characterization and topology of inserted regions

1991 • 78 citations

Properties of volkensin, a toxic lectin from Adenia volkensii.

1985 • 78 citations

Cell-mediated reduction of the interfragment disulfide in nicked diphtheria toxin. A new system to study toxin entry at low pH.

1987 • 75 citations

Requirement of a transmembrane pH gradient for the entry of diphtheria toxin into cells at low pH.

1986 • 71 citations

Evidence that diphtheria toxin and modeccin enter the cytosol from different vesicular compartments.

1984 • 71 citations

Barnase toxin: A new chimeric toxin composed of pseudomonas exotoxin A and barnase

1991 • 69 citations

Inhibition of protein synthesis by Shiga toxin

1980 • 68 citations

Inhibition of Peptide Chain Elongation

1972 • 64 citations

Replacement of negative by positive charges in the presumed membrane-inserted part of diphtheria toxin B fragment. Effect on membrane translocation and on formation of cation channels.

1992 • 54 citations

Modeccin — A plant toxin inhibiting protein synthesis

1977 • 53 citations

Ability of inhibitors of glycosylation and protein synthesis to sensitize cells to abrin, ricin, Shigella toxin, and Pseudomonas toxin.

1986 • 49 citations

Conformation and model membrane interactions of diphtheria toxin fragment A.

1988 • 46 citations

Membrane translocation of diphtheria toxin carrying passenger protein domains

1992 • 37 citations

Effects of eliminating a disulfide bridge within domain II of Pseudomonas aeruginosa exotoxin A

1989 • 35 citations

Interactions between diphtheria toxin entry and anion transport in Vero cells. IV. Evidence that entry of diphtheria toxin is dependent on efficient anion transport.

1986 • 33 citations

Permeabilization of the plasma membrane by deletion mutants of diphtheria toxin.

1989 • 19 citations

Role of Anions in Low pH-induced Translocation of Diphtheria Toxin

1989 • 11 citations

Evidence that the adenylate cyclase secreted from Bordetella pertussis does not enter animal cells by receptor‐mediated endocytosis

1990 • 11 citations