On the membrane translocation of diphtheria toxin: at low pH the toxin induces ion channels on cells.

ACIDIFICATION OF THE ENDOCYTIC AND EXOCYTIC PATHWAYS

1986 • 1,977 citations

Kinetic Properties of the Plasma Membrane Na+ -H+ Exchanger

1985 • 670 citations

Diphtheria toxin entry into cells is facilitated by low pH.

1980 • 467 citations

The entry of diphtheria toxin into the mammalian cell cytoplasm: evidence for lysosomal involvement.

1980 • 372 citations

Optical probes of membrane potential

1976 • 354 citations

Ionic channels formed byStaphylococcus aureus alpha-toxin: Voltage-dependent inhibition by divalent and trivalent cations

1986 • 349 citations

Diphtheria toxin fragment forms large pores in phospholipid bilayer membranes.

1981 • 341 citations

Lymphocyte membrane potential assessed with fluorescent probes

1980 • 336 citations

Bacterial toxins: cellular mechanisms of action

1984 • 322 citations

Channels formed by botulinum, tetanus, and diphtheria toxins in planar lipid bilayers: relevance to translocation of proteins across membranes.

1985 • 309 citations

Nucleotide sequence of the structural gene for diphtheria toxin carried by corynebacteriophage beta.

1983 • 307 citations

Rapid entry of nicked diphtheria toxin into cells at low pH. Characterization of the entry process and effects of low pH on the toxin molecule.

1981 • 291 citations

Diphtheria toxin forms transmembrane channels in planar lipid bilayers.

1981 • 281 citations

The amino-acid sequence of two non-toxic mutants of diphtheria toxin: CRM45 and CRM197

1984 • 245 citations

Interleukin 2 receptor-targeted cytotoxicity. Interleukin 2 receptor-mediated action of a diphtheria toxin-related interleukin 2 fusion protein.

1988 • 220 citations

Association of diphtheria toxin with Vero cells. Demonstration of a receptor.

1978 • 195 citations

Protein unfolding and the energetics of protein translocation across biological membranes

1988 • 192 citations

Effect of pH on the conformation of diphtheria toxin and its implications for membrane penetration

1985 • 188 citations

Evidence that a Na+/Ca2+ antiport system regulates murine erythroleukemia cell differentiation.

1982 • 178 citations

Mutations in Diphtheria Toxin Separate Binding from Entry and Amplify Immunotoxin Selectivity

1987 • 173 citations

ADP-Ribosylation Reactions

1982 • 152 citations

Genetic construction, expression, and melanoma-selective cytotoxicity of a diphtheria toxin-related alpha-melanocyte-stimulating hormone fusion protein.

1986 • 136 citations

Interaction of diphtheria toxin with mammalian cell membranes.

1976 • 112 citations

The complete nucleotide sequence of the gene coding for diphtheria toxin in the corynephage omega (tox⁺) genome

1983 • 110 citations

The mechanism of ADP-ribosylation of elongation factor 2 catalyzed by fragment a from diphtheria toxin

1977 • 99 citations

On the translocation of proteins across membranes.

1987 • 95 citations

pH-dependence of the phospholipid interaction of diphtheria-toxin fragments

1985 • 89 citations

Evidence for direct insertion of fragments A and B of diphtheria toxin into model membranes.

1984 • 87 citations

Mechanism of insertion of diphtheria toxin: peptide entry and pore size determinations.

1984 • 77 citations

Cloned fragment of diphtheria toxin linked to T cell-specific antibody identifies regions of B chain active in cell entry.

1986 • 76 citations

Requirement of a transmembrane pH gradient for the entry of diphtheria toxin into cells at low pH.

1986 • 71 citations

Lipid interaction of diphtheria toxin and mutants with altered fragment B

1987 • 67 citations

A quantitative resolution of the spectra of a membrane potential indicator, diS-C3-(5), bound to cell components and to red blood cells

1978 • 60 citations

Diphtheria: studies on the biology of an infectious disease.

1980 • 56 citations

Diphtheria toxin receptor. Identification of specific diphtheria toxin-binding proteins on the surface of Vero and BS-C-1 cells.

1987 • 55 citations

Binding of diphtheria toxin to phospholipids in liposomes

1980 • 50 citations

Kinetics of adenosinediphosphoribosylation of elongation factor 2 in cells exposed to diphtheria toxin

1981 • 44 citations

Lipid interaction of diphtheria toxin and mutants with altered fragment B. 1. Liposome aggregation and fusion

1987 • 39 citations

Diphtheria toxin and its mutant crm 197 differ in their interaction with lipids

1987 • 32 citations

Methylamine facilitates demonstration of specific uptake of diphtheria toxin by CHO cell and toxin-resistant CHO cell mutants

1982 • 31 citations

Enzyme treatment of KB cells: The altered effect of diphtheria toxin

1974 • 21 citations

Gating of ion channels made by a diphtheria toxin fragment in phospholipid bilayer membranes.

1983 • 17 citations

Evidence that membrane phospholipids and protein are required for binding of diphtheria toxin in Vero cells

1985 • 14 citations