Anti‐tumor effects of toxins targeted to the prostate specific membrane antigen

THE ATTRACTIONS OF PROTEINS FOR SMALL MOLECULES AND IONS

1949 • 19,979 citations

Prostate-specific membrane antigen expression in normal and malignant human tissues.

1997 • 1,454 citations

pH and the recycling of transferrin during receptor-mediated endocytosis.

1983 • 1,165 citations

Five different anti-prostate-specific membrane antigen (PSMA) antibodies confirm PSMA expression in tumor-associated neovasculature.

1999 • 777 citations

A Gompertzian model of human breast cancer growth.

1988 • 685 citations

Upregulation of prostate-specific membrane antigen after androgen-deprivation therapy

1996 • 613 citations

Expression of the prostate-specific membrane antigen.

1994 • 582 citations

The kinetics of antibody binding to membrane antigens in solution and at the cell surface

1980 • 568 citations

Expression of prostate-specific membrane antigen in normal, benign, and malignant prostate tissues

1995 • 541 citations

Monoclonal antibodies to the extracellular domain of prostate-specific membrane antigen also react with tumor vascular endothelium.

1997 • 509 citations

A simplified method for production and growth of multicellular tumor spheroids.

1977 • 501 citations

Constitutive and antibody-induced internalization of prostate-specific membrane antigen.

1998 • 419 citations

Detection and characterization of the prostate‐specific membrane antigen (PSMA) in tissue extracts and body fluids

1995 • 362 citations

Multiexponential, multicompartmental, and noncompartmental modeling. II. Data analysis and statistical considerations

1984 • 345 citations

A modeling analysis of monoclonal antibody percolation through tumors: a binding-site barrier.

1990 • 343 citations

Anti-transferrin receptor monoclonal antibody and toxin–antibody conjugates affect growth of human tumour cells

1981 • 275 citations

Modeling analysis of the global and microscopic distribution of immunoglobulin G, F(ab')2, and Fab in tumors.

1989 • 257 citations

An alpha-particle emitting antibody ([213Bi]J591) for radioimmunotherapy of prostate cancer.

2000 • 254 citations

Immunotoxins in cancer therapy

1999 • 214 citations

New coupling agents for the synthesis of immunotoxins containing a hindered disulfide bond with improved stability in vivo.

1987 • 205 citations

Kinetics of cytotoxicity induced by immunotoxins. Enhancement by lysosomotropic amines and carboxylic ionophores.

1984 • 194 citations

Toxin Entry: Retrograde Transport through the Secretory Pathway

1998 • 186 citations

Expression of potential target antigens for immunotherapy on primary and metastatic prostate cancers.

1998 • 184 citations

Cloning, expression, genomic localization, and enzymatic activities of the mouse homolog of prostate-specific membrane antigen/NAALADase/folate hydrolase

2001 • 167 citations

Immunotoxins: An Update

1996 • 160 citations

Improved antitumor effects of immunotoxins prepared with deglycosylated ricin A-chain and hindered disulfide linkages.

1988 • 155 citations

Prostate cancer. An overview of an increasing dilemma

1993 • 138 citations

Immunohistochemical and pharmacokinetic characterization of the site-specific immunoconjugate CYT-356 derived from antiprostate monoclonal antibody 7E11-C5.

1990 • 136 citations

The Pharmacology of Monoclonal Antibodiesa

1987 • 129 citations

Characterization and glutamyl preferring carboxypeptidase function of prostate specific membrane antigen: A novel folate hydrolase

1997 • 121 citations

Monoclonal Antibody‐Ricin or Ricin A Chain Hybrids: Kinetic Analysis of Cell Killing for Tumor Therapy

1982 • 109 citations

Structures of Sugar Chains of Ricin D

1988 • 104 citations

Identification, purification, and subcellular localization of prostate-specific membrane antigen PSM' protein in the LNCaP prostatic carcinoma cell line.

1998 • 97 citations

Response of LNCaP spheroids after treatment with an alpha-particle emitter (213Bi)-labeled anti-prostate-specific membrane antigen antibody (J591).

2001 • 94 citations

Anti-transferrin receptor antibody linked to Pseudomonas exotoxin as a model immunotoxin in human ovarian carcinoma cell lines.

1985 • 91 citations

Bone metastases: improving the therapeutic index.

1994 • 89 citations

Indium-111 Capromab Pendetide (ProstaScint) Imaging to Detect Recurrent and Metastatic Prostate Cancer

1998 • 88 citations

Cell surface and intracellular functions for ricin galactose binding.

1992 • 82 citations

The removal of carbohydrates from ricin with endoglycosidases H, F and D and α-mannosidase

1985 • 81 citations

Carboxylic ionophores enhance the cytotoxic potency of ligand- and antibody-delivered ricin A chain.

1984 • 79 citations

Prostate-specific membrane antigen levels in sera from healthy men and patients with benign prostate hyperplasia or prostate cancer.

1999 • 54 citations

Growth and characterization of LNCaP prostate cancer cell spheroids.

1999 • 47 citations

Effect of therapeutic macromolecules in spheroids

2000 • 46 citations

A comparative study of ricin and diphtheria toxin-antibody-conjugate kinetics on protein synthesis inactivation.

1984 • 39 citations

Carrier protein-monensin conjugates: enhancement of immunotoxin cytotoxicity and potential in tumor treatment.

1990 • 36 citations

Sensitivity of human glioma cells to cytotoxic heteroconjugates

1988 • 36 citations

Internalization and intracellular fate of anti-CD5 monoclonal antibody and anti-CD5 ricin A-chain immunotoxin in human leukemic T cells

1992 • 34 citations

Heterogeneous response of individual multicellular tumour spheroids to immunotoxins and ricin toxin

1995 • 32 citations

Bioactivities of ricin retained and its immunoreactivity to anti-ricin polyclonal antibodies alleviated through pegylation

2002 • 28 citations

Self-potentiation of Ligand-Toxin Conjugates Containing Ricin A Chain Fused with Viral Structures

1995 • 28 citations

Cytoreductive effects of anti‐transferrin receptor immunotoxins in a multicellular tumor spheroid model

1994 • 15 citations

Sensitivity of human leukemia cells in exponential or stationary growth phase to anti-CD5 immunotoxins. Role of intracellular processing events.

1994 • 14 citations

Influence of Tumor Growth Kinetics on Response to Doxorubicin Treatment of C3H Mammary Carcinoma

1988 • 4 citations

The Standard Man in Relation to Internal Radiation Dose Concepts

1966 • 1 citations