Response of LNCaP spheroids after treatment with an alpha-particle emitter (213Bi)-labeled anti-prostate-specific membrane antigen antibody (J591).

Longitudinal Data Analysis for Discrete and Continuous Outcomes

1986 • 7,710 citations

Cell and Environment Interactions in Tumor Microregions: The Multicell Spheroid Model

1988 • 1,755 citations

Report of the task group on reference man

1979 • 1,754 citations

LNCaP model of human prostatic carcinoma.

1983 • 1,749 citations

Prostate-specific membrane antigen expression in normal and malignant human tissues.

1997 • 1,454 citations

Mechanisms of heterogeneous distribution of monoclonal antibodies and other macromolecules in tumors: significance of elevated interstitial pressure.

1988 • 703 citations

Identification and characterization of the blood vessels of solid tumors that are leaky to circulating macromolecules.

1988 • 680 citations

Radiolabeled-Antibody Therapy of B-Cell Lymphoma with Autologous Bone Marrow Support

1993 • 665 citations

Microvascular permeability of normal and neoplastic tissues

1986 • 601 citations

Expression of the prostate-specific membrane antigen.

1994 • 582 citations

The kinetics of antibody binding to membrane antigens in solution and at the cell surface

1980 • 568 citations

Phase I/II Trial of IDEC-Y2B8 Radioimmunotherapy for Treatment of Relapsed or Refractory CD20⁺B-Cell Non-Hodgkin's Lymphoma

1999 • 563 citations

Radioimmunotherapy of B-Cell Lymphoma with [¹³¹I]Anti-B1 (Anti-CD20) Antibody

1993 • 557 citations

Monoclonal antibodies to the extracellular domain of prostate-specific membrane antigen also react with tumor vascular endothelium.

1997 • 509 citations

A simplified method for production and growth of multicellular tumor spheroids.

1977 • 501 citations

Constitutive and antibody-induced internalization of prostate-specific membrane antigen.

1998 • 419 citations

Radioimmunotherapy with alpha-emitting nuclides

1998 • 398 citations

Relationships between tumor size and curability for uniformly targeted therapy with beta-emitting radionuclides.

1995 • 366 citations

Selection of highly metastatic variants of different human prostatic carcinomas using orthotopic implantation in nude mice.

1996 • 365 citations

A modeling analysis of monoclonal antibody percolation through tumors: a binding-site barrier.

1990 • 343 citations

Non-Hodgkin's lymphoma

1995 • 342 citations

Bone marrow dosimetry for radioimmunotherapy: theoretical considerations.

1993 • 295 citations

Drug and radiation resistance in spheroids: cell contact and kinetics

1994 • 268 citations

An alpha-particle emitting antibody ([213Bi]J591) for radioimmunotherapy of prostate cancer.

2000 • 254 citations

Pharmacokinetics and dosimetry of an alpha-particle emitter labeled antibody: 213Bi-HuM195 (anti-CD33) in patients with leukemia.

1999 • 203 citations

Astatine-211-Labeled Radiotherapeutics An Emerging Approach to Targeted Alpha-Particle Radiotherapy

2000 • 195 citations

Alpha-emitting bismuth cyclohexylbenzyl DTPA constructs of recombinant humanized anti-CD33 antibodies: pharmacokinetics, bioactivity, toxicity and chemistry.

1999 • 172 citations

Radioimmunotherapy with Alpha-Particle-Emitting Immunoconjugates

1988 • 155 citations

An 225Ac/213Bi generator system for therapeutic clinical applications: construction and operation

1999 • 128 citations

High-linear energy transfer (LET) alpha versus low-LET beta emitters in radioimmunotherapy of solid tumors: therapeutic efficacy and dose-limiting toxicity of 213Bi- versus 90Y-labeled CO17-1A Fab' fragments in a human colonic cancer model.

1999 • 124 citations

Radioimmunotherapy with α-Particle Emitting Radioimmunoconjugates

1996 • 116 citations

Synthesis of C-functionalized trans-cyclohexyldiethylenetriaminepenta-acetic acids for labelling of monoclonal antibodies with the bismuth-212 α-particle emitter

1992 • 112 citations

Preparation of alpha-emitting 213Bi-labeled antibody constructs for clinical use.

1999 • 110 citations

Interstitial transport of rabbit and sheep antibodies in normal and neoplastic tissues.

1990 • 108 citations

Monoclonal antibody M195: a diagnostic marker for acute myelogenous leukemia.

1989 • 102 citations

Restricted expression of an early myeloid and monocytic cell surface antigen defined by monoclonal antibody M195.

1989 • 96 citations

A Model of Cell Inactivation by Alpha-Particle Internal Emitters

1993 • 90 citations

Bone metastases: improving the therapeutic index.

1994 • 89 citations

Rat prostate adenocarcinoma cells disseminate to bone and adhere preferentially to bone marrow-derived endothelial cells.

1992 • 86 citations

Radioimmunotherapy of neoplastic meningitis in rats using an alpha-particle-emitting immunoconjugate.

1994 • 79 citations

Vascular Targeted Radioimmunotherapy with 213Bi—An α-Particle Emitter

1998 • 67 citations

An effective chelating agent for labelling of monoclonal antibody with²¹²Bi for α-particle mediated radioimmunotherapy

1991 • 51 citations

Radiotoxicity of Bismuth-213 Bound to Membranes of Monolayer and Spheroid Cultures of Tumor Cells

1999 • 50 citations

Growth and characterization of LNCaP prostate cancer cell spheroids.

1999 • 47 citations

Modeling and dosimetry of monoclonal antibody M195 (anti-CD33) in acute myelogenous leukemia.

1993 • 40 citations

Plasmapheresis in radioimmunotherapy of micrometastases: a mathematical modeling and dosimetrical analysis.

1992 • 37 citations

Parametric images of antibody pharmacokinetics in Bi213-HuM195 therapy of leukemia.

2001 • 35 citations

Studies on the red marrow dosimetry in radioimmunotherapy: an experimental investigation of factors influencing the radiation-induced myelotoxicity in therapy with beta-, Auger/conversion electron-, or alpha-emitters.

1999 • 34 citations

Use of multi‐cell spheroids of ovarian carcinoma as an intraperitoneal radio‐immunotherapy model: Uptake, retention kinetics and dosimetric evaluation

1992 • 31 citations

131I-anticarcinoembryonic antigen therapy of LS174T human colon adenocarcinoma spheroids.

1989 • 28 citations

A tumour spheroid model for antibody-targeted therapy of micrometastases

1988 • 27 citations

Radiation effects in spheroids of cells exposed to alpha emitters

2000 • 23 citations

Optimization of radioimmunotherapy using human malignant melanoma multicell spheroids as a model.

1989 • 21 citations

Growth of prostatic cancer cells, DU 145, as multicellular spheroids and effects of estramustine.

1993 • 14 citations