Cytoreductive effects of anti‐transferrin receptor immunotoxins in a multicellular tumor spheroid model

Cell and Environment Interactions in Tumor Microregions: The Multicell Spheroid Model

1988 • 1,755 citations

Mechanisms of heterogeneous distribution of monoclonal antibodies and other macromolecules in tumors: significance of elevated interstitial pressure.

1988 • 703 citations

Ubiquitous cell-surface glycoprotein on tumor cells is proliferation-associated receptor for transferrin.

1981 • 699 citations

The interaction of Ricinus communis agglutinin with normal and tumor cell surfaces

1972 • 514 citations

A simplified method for production and growth of multicellular tumor spheroids.

1977 • 501 citations

Immunotoxins: magic bullets or misguided missiles?

1993 • 209 citations

Improved tumor-specific immunotoxins in the treatment of CNS and leptomeningeal neoplasia

1989 • 111 citations

Dynamics of growth in tumors and in normal organisms.

1969 • 109 citations

Chimeric toxins

1981 • 108 citations

Early intervention in cancer using monoclonal antibodies and other biological ligands: micropharmacology and the "binding site barrier".

1992 • 101 citations

Growth equations: A general equation and a survey of special cases

1980 • 87 citations

Antibody Conjugates for the Treatment of Cancer

1992 • 84 citations

Membrane-mediated cytotoxicity

1986 • 73 citations

An exponential-Gompertzian description of LoVo cell tumor growth from in vivo and in vitro data.

1989 • 59 citations

Immunocytochemical characterization of extracellular matrix proteins expressed by cultured glioma cells.

1989 • 45 citations

Uptake kinetics of monoclonal antibodies by human malignant melanoma multicell spheroids.

1988 • 41 citations

A comparative study of ricin and diphtheria toxin-antibody-conjugate kinetics on protein synthesis inactivation.

1984 • 39 citations

Estimation of tumor cell kill from Gompertz growth curves.

1975 • 35 citations

Diffusion and Binding of Monoclonal Antibody TNT-1 in Multicellular Tumor Spheroids

1991 • 26 citations

Growth and radiation sensitivity of the MLS human ovarian carcinoma cell line grown as multicellular spheroids and xenografted tumours

1989 • 22 citations

Blocking effect of human serum but not of cerebrospinal fluid on ricin A chain immunotoxin potentiation by monensin or carrier protein-monensin conjugates.

1992 • 18 citations

Efficacy and selectivity of monoclonal‐antibody‐targeted drugs and free methotrexate in fluorescence‐labelled mixed tumour‐cell monolayer cultures and multicellular spheroids

1991 • 10 citations