Heterogeneous response of individual multicellular tumour spheroids to immunotoxins and ricin toxin

Cell and Environment Interactions in Tumor Microregions: The Multicell Spheroid Model

1988 • 1,755 citations

EXPERIMENTAL EVALUATION OF POTENTIAL ANTICANCER AGENTS. XIII. ON THE CRITERIA AND KINETICS ASSOCIATED WITH "CURABILITY" OF EXPERIMENTAL LEUKEMIA.

1964 • 763 citations

The interaction of Ricinus communis agglutinin with normal and tumor cell surfaces

1972 • 514 citations

A simplified method for production and growth of multicellular tumor spheroids.

1977 • 501 citations

Multiexponential, multicompartmental, and noncompartmental modeling. II. Data analysis and statistical considerations

1984 • 345 citations

Immunotoxins: magic bullets or misguided missiles?

1993 • 209 citations

Improved tumor-specific immunotoxins in the treatment of CNS and leptomeningeal neoplasia

1989 • 111 citations

Chimeric toxins

1981 • 108 citations

Early intervention in cancer using monoclonal antibodies and other biological ligands: micropharmacology and the "binding site barrier".

1992 • 101 citations

Implications of kinetic heterogeneity in clinical oncology.

1985 • 84 citations

An exponential-Gompertzian description of LoVo cell tumor growth from in vivo and in vitro data.

1989 • 59 citations

THE GOMPERTZ EQUATION AND THE CONSTRUCTION OF TUMOUR GROWTH CURVES

1980 • 51 citations

Response to chemotherapy of EMT6 spheroids as measured by growth delay and cell survival

1980 • 47 citations

Immunotoxins: magic bullets or misguided missiles?

1993 • 45 citations

Growth of testicular neoplasm lung metastases: Tumor-specific relation between two Gompertzian parameters

1980 • 45 citations

Uptake kinetics of monoclonal antibodies by human malignant melanoma multicell spheroids.

1988 • 41 citations

Estimation of tumor cell kill from Gompertz growth curves.

1975 • 35 citations

A tumour spheroid model for antibody-targeted therapy of micrometastases

1988 • 27 citations

Diffusion and Binding of Monoclonal Antibody TNT-1 in Multicellular Tumor Spheroids

1991 • 26 citations

Growth and radiation sensitivity of the MLS human ovarian carcinoma cell line grown as multicellular spheroids and xenografted tumours

1989 • 22 citations

Blocking effect of human serum but not of cerebrospinal fluid on ricin A chain immunotoxin potentiation by monensin or carrier protein-monensin conjugates.

1992 • 18 citations

The Exponential-Gompertzian Tumor Growth Model: Data from Six Tumor Cell Lines in Vitro and in Vivo. Estimate of the Transition point from Exponential to Gompertzian Growth and Potential Cinical Implications

1991 • 18 citations

Cytoreductive effects of anti‐transferrin receptor immunotoxins in a multicellular tumor spheroid model

1994 • 15 citations

Sensitivity of human leukemia cells in exponential or stationary growth phase to anti-CD5 immunotoxins. Role of intracellular processing events.

1994 • 14 citations

Penetration of anti-melanoma immunotoxin into multicellular tumor spheroids and cell kill effects

1992 • 7 citations

Influence of Tumor Growth Kinetics on Response to Doxorubicin Treatment of C3H Mammary Carcinoma

1988 • 4 citations