NRH:quinone reductase 2: An enzyme of surprises and mysteries

A major inducer of anticarcinogenic protective enzymes from broccoli: isolation and elucidation of structure.

1992 • 1,647 citations

Free-radical chemistry of cigarette smoke and its toxicological implications.

1985 • 1,351 citations

Broccoli sprouts: An exceptionally rich source of inducers of enzymes that protect against chemical carcinogens

1997 • 1,345 citations

Induction of phase I, II and III drug metabolism/transport by xenobiotics

2005 • 1,218 citations

Biochemical, physiological and medical aspects of ubiquinone function

1995 • 1,210 citations

Quinone chemistry and toxicity

1992 • 732 citations

Identification of the Melatonin-binding SiteMT 3 as the Quinone Reductase 2

2000 • 589 citations

Chemoprotection against cancer by Phase 2 enzyme induction

1995 • 454 citations

Chemical and molecular regulation of enzymes that detoxify carcinogens.

1993 • 426 citations

Regulation of genes encoding NAD(P)H:quinone oxidoreductases

2000 • 419 citations

Rapid detection of inducers of enzymes that protect against carcinogens.

1992 • 395 citations

Redox and addition chemistry of quinoid compounds and its biological implications

1989 • 388 citations

The three-dimensional structure of NAD(P)H:quinone reductase, a flavoprotein involved in cancer chemoprotection and chemotherapy: mechanism of the two-electron reduction.

1995 • 328 citations

Immunodetection of NAD(P)H:quinone oxidoreductase 1 (NQO1) in human tissues11This work is dedicated to the memory of Professor Lars Ernster, who provided us with enthusiastic support, scientific insight, and constant encouragement in our many interactions.

2000 • 283 citations

Antioxidant and prooxidant properties of mitochondrial Coenzyme Q

2004 • 282 citations

Antioxidant and prooxidant functions of DT-diaphorase in quinone metabolism

1995 • 273 citations

NAD(P)H:Quinone oxidoreductase1 (DT-diaphorase) expression in normal and tumor tissues

1993 • 268 citations

Disruption of the DT Diaphorase (NQO1) Gene in Mice Leads to Increased Menadione Toxicity

1998 • 262 citations

Antimalarials increase vesicle pH in Plasmodium falciparum.

1985 • 252 citations

Reversible redox energy coupling in electron transfer chains

2004 • 252 citations

Cardioprotection of red wine: role of polyphenolic antioxidants.

1999 • 248 citations

Molecular tools to study melatonin pathways and actions

2005 • 241 citations

Discovery of Novel Targets of Quinoline Drugs in the Human Purine Binding Proteome

2002 • 235 citations

Crystal Structure of Quinone Reductase 2 in Complex with Resveratrol^,

2004 • 230 citations

Mechanisms of induction of enzymes that protect against chemical carcinogenesis

1989 • 226 citations

Small Maf (MafG and MafK) Proteins Negatively Regulate Antioxidant Response Element-mediated Expression and Antioxidant Induction of the NAD(P)H:Quinone Oxidoreductase1 Gene

2000 • 205 citations

Comparative pharmacological studies of melatonin receptors: mt1, mt2 and mt3/qr2. tissue distribution of mt3/qr2 11Abbreviations: MCA-NAT, methoxy-carbonylamino-N-acetyltrypta- mine, 2-[125I]-I-MCA-NAT, 2-[125I]-iodomethoxy-carbonylamino-N-acetyltryptamine; 2-IbMT, 2-iodo-N-butanoyl-5-methoxytryptamine; 4-P-PDOT, 4-phenyl-2-propionamido-tetraline; DH97, N-pentanoyl-2-benzyltryptamine; S20760, 5-methoxy-N-cyclopropanoyl-tryptamine; S24635, N-[2-(5-carbamoylbenzofuran-3-yl)ethyl]-acetamide; …

2001 • 186 citations

Immunohistochemical detection of NAD(P)H:quinone oxidoreductase in human lung and lung tumors.

1998 • 160 citations

Catalytic Properties of NAD(P)H:Quinone Oxidoreductase-2 (NQO2), a Dihydronicotinamide Riboside Dependent Oxidoreductase

1997 • 139 citations

Soluble Diaphorase in Animal Tissues.

1958 • 138 citations

Virus-directed, enzyme prodrug therapy with nitroimidazole reductase: a phase I and pharmacokinetic study of its prodrug, CB1954.

2001 • 136 citations

Kinetic Mechanism of Quinone Oxidoreductase 2 and Its Inhibition by the Antimalarial Quinolines

2004 • 130 citations

Nucleotide and deduced amino acid sequence of a human cDNA (NQO2) corresponding to a second member of the NAD(P)H:quinone oxidoreductase gene family. Extensive polymorphism at the NQO2 gene locus on chromosome 6

1990 • 127 citations

Oxidative stress in malaria; implications for prevention and therapy

1996 • 125 citations

Characterization of the melatoninergic MT3 binding site on the NRH:quinone oxidoreductase 2 enzyme

2005 • 123 citations

An Association between Idiopathic Parkinson's Disease and Polymorphisms of Phase II Detoxification Enzymes: Glutathione S-Transferase M1 and Quinone Oxidoreductase 1 and 2

2001 • 123 citations

Unexpected genetic and structural relationships of a long-forgotten flavoenzyme to NAD(P)H:quinone reductase (DT-diaphorase)

1997 • 121 citations

Human NAD(P)H:quinone oxidoreductase2. Gene structure, activity, and tissue-specific expression.

1994 • 117 citations

Chlorophyll, chlorophyllin and related tetrapyrroles are significant inducers of mammalian phase 2 cytoprotective genes

2005 • 115 citations

Bioactivation of 5-(aziridin-1-yl)-2,4-dinitrobenzamide (CB 1954) by human NAD(P)H quinone oxidoreductase 2: a novel co-substrate-mediated antitumor prodrug therapy.

2000 • 113 citations

NRH:quinone oxidoreductase2 (NQO2)

2000 • 112 citations

Disruption of Dihydronicotinamide Riboside:Quinone Oxidoreductase 2 (NQO2) Leads to Myeloid Hyperplasia of Bone Marrow and Decreased Sensitivity to Menadione Toxicity

2002 • 109 citations

Crystal Structure of Human Quinone Reductase Type 2, a Metalloflavoprotein^,

1999 • 101 citations

NAD(P)H:quinone oxidoreductase1 (DT-diaphorase): expression, regulation, and role in cancer.

1994 • 91 citations

Organs from mice deleted for NRH:quinone oxidoreductase 2 are deprived of the melatonin binding site MT₃

2004 • 79 citations

Inhibition of melanoma cell proliferation by resveratrol is correlated with upregulation of quinone reductase 2 and p53

2005 • 77 citations

Identification and purification of resveratrol targeting proteins using immobilized resveratrol affinity chromatography

2004 • 76 citations

NAD hydrolysis: Chemical and enzymatic mechanisms

1994 • 66 citations

Differential Gene Expression ofNAD(P)H:Quinone OxidoreductaseandNRH:Quinone Oxidoreductasein Human Hepatocellular and Biliary Tissue

2002 • 65 citations

Deficiency of NRH:Quinone Oxidoreductase 2 Increases Susceptibility to 7,12-Dimethylbenz( a )anthracene and Benzo( a )pyrene-Induced Skin Carcinogenesis

2004 • 62 citations

Redox Properties of the [2Fe-2S] Center in the 24 kDa (NQO2) Subunit of NADH:Ubiquinone Oxidoreductase (Complex I)

2002 • 59 citations

Differential induction of quinone reductase by phytoestrogens and protection against oestrogen-induced DNA damage

2004 • 57 citations

Quinone reductase 2 substrate specificity and inhibition pharmacology

2005 • 52 citations

Induction of NQO1 in Cancer Cells

2004 • 51 citations

CB 1954: From the Walker Tumor to NQO2 and VDEPT

2003 • 50 citations

Antioxidant response element-mediated 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD) induction of human NAD(P)H:Quinone oxidoreductase 1 gene expression

1999 • 49 citations

Purification and Properties of a Flavoprotein Catalyzing the Oxidation of Reduced Ribosyl Nicotinamide

1962 • 47 citations

Enzymatic oxidation of some non-phosphorylated derivatives of dihydronicotinamide

1961 • 43 citations

Digestion and Absorption of NAD by the Small Intestine of the Rat

1983 • 40 citations

Sp3 repression of polymorphic human NRH:quinone oxidoreductase 2 gene promoter

2004 • 36 citations

Metabolism of nad(p)h by blood components

1992 • 35 citations

Localization of human NQO1 gene to chromosome 16q22 and NQO2???6p25 and associated polymorphisms

1999 • 34 citations

Mouse NRH:quinone oxidoreductase (NQO2): cloning of cDNA and gene- and tissue-specific expression

2000 • 34 citations

A possible association between an insertion/deletion polymorphism of the NQO2 gene and schizophrenia

2003 • 34 citations

Mitochondrial oxidation of extramitochondrial TPNH mediated by purified DT diaphorase

1960 • 31 citations

No associations between Parkinson's disease and polymorphisms of the quinone oxidoreductase (NQO1, NQO2) genes

2004 • 24 citations

Evidence for an EPR-Detectable Semiquinone Intermediate Stabilized in the Membrane-Bound Subunit NarI of Nitrate Reductase A (NarGHI) from Escherichia coli

2004 • 24 citations

Coordinated induction of the c-jun gene with genes encoding quinone oxidoreductases in response to xenobiotics and antioxidants

1999 • 23 citations

Integrated system for the screening of the specificity of protein kinase inhibitors

1993 • 20 citations

Indirect Evidences of Udp-Glucuronosyltransferase Heterogeneity: How Can it Help Purification?

1987 • 18 citations

Induction of quinone reductase by a methanol extract of Scutellaria baicalensis and its flavonoids in murine Hepa 1c1c7 cells

1998 • 17 citations

The hydrolysis of nicotinamide adenine nucleotide by brush border membranes of rat intestine

1982 • 17 citations

Inhibition of the enzymic oxidation of some dihydropyridines by polycyclic aromatic hydrocarbons

1961 • 15 citations

Potentiation of CB 1954 cytotoxicity by reduced pyridine nucleotides in human tumour cells by stimulation of DT diaphorase activity

1992 • 10 citations

Baicalin induces NAD(P)H:quinone reductase through the transactivation of AP-1 and NF-κB in Hepa 1c1c7 cells

2004 • 8 citations

Metabolism of nicotinamide mononucleotide in beef liver

1987 • 7 citations