Antioxidant and prooxidant functions of DT-diaphorase in quinone metabolism

Molecular mechanisms of quinone cytotoxicity

1991 • 1,002 citations

The metabolism of menadione (2-methyl-1,4-naphthoquinone) by isolated hepatocytes. A study of the implications of oxidative stress in intact cells.

1982 • 893 citations

Transcriptional Regulator of Oxidative Stress-Inducible Genes: Direct Activation by Oxidation

1990 • 869 citations

Identification of a common chemical signal regulating the induction of enzymes that protect against chemical carcinogenesis.

1988 • 589 citations

DT-diaphorase as a quinone reductase: A cellular control device against semiquinone and superoxide radical formation

1982 • 530 citations

Dt diaphorase I. Purification from the soluble fraction of rat-liver cytoplasm, and properties

1962 • 484 citations

Chemical and molecular regulation of enzymes that detoxify carcinogens.

1993 • 426 citations

Alterations in intracellular thiol homeostasis during the metabolism of menadione by isolated rat hepatocytes

1984 • 411 citations

Detection of superoxide generated by endothelial cells.

1984 • 398 citations

Redox and addition chemistry of quinoid compounds and its biological implications

1989 • 388 citations

Menadione-induced cytotoxicity is associated with protein thiol oxidation and alteration in intracellular Ca2+ homeostasis

1984 • 376 citations

Superoxide as an intracellular radical sink

1993 • 356 citations

[30] DT-diaphorase: Purification, properties, and function

1990 • 316 citations

Oxidative stress in mitochondria: Its relationship to cellular Ca2+ homeostasis, cell death, proliferation, and differentiation

1991 • 307 citations

Redox cycling and sulphydryl arylation; Their relative importance in the mechanism of quinone cytotoxicity to isolated hepatocytes

1988 • 296 citations

DT-diaphorase and cancer chemotherapy

1992 • 284 citations

Metabolism and reactions of quinoid anticancer agents

1987 • 273 citations

NAD(P)H:Quinone oxidoreductase1 (DT-diaphorase) expression in normal and tumor tissues

1993 • 268 citations

Glutathione conjugation: Mechanisms and biological significance

1989 • 267 citations

Role of hydrogen peroxide and hydroxyl radical formation in the killing of Ehrlich tumor cells by anticancer quinones.

1986 • 263 citations

Metabolism of mitomycin C by DT-diaphorase: role in mitomycin C-induced DNA damage and cytotoxicity in human colon carcinoma cells.

1990 • 222 citations

Potential bioreductive alkylating agents. 1. Benzoquinone derivatives

1972 • 200 citations

The role of calcium in cell killing

1990 • 199 citations

DT-diaphorase in activation and detoxification of quinones

1993 • 188 citations

On the mechanism of the Mn3+-induced neurotoxicity of dopamine: Prevention of quinone-derived oxygen toxicity by DT diaphorase and superoxide dismutase

1989 • 187 citations

Hepatic low-level chemiluminescence during redox cycling of menadione and the menadione-glutathione conjugate: Relation to glutathione and NAD(P)H:quinone reductase (DT-diaphorase) activity

1983 • 180 citations

DT-diaphorase-catalysed reduction of 1,4-naphthoquinone derivatives and glutathionyl-quinone conjugates. Effect of substituents on autoxidation rates

1989 • 170 citations

Quinone toxicity in hepatocytes without oxidative stress

1986 • 166 citations

Sequential oxidation and glutathione addition to 1,4-benzoquinone: correlation of toxicity with increased glutathione substitution.

1988 • 165 citations

Bioreductive activation of mitomycin C by DT-diaphorase

1992 • 158 citations

Oxidation of polyunsaturated fatty acids and lipids through thiyl and sulfonyl radicals: Reaction kinetics, and influence of oxygen and structure of thiyl radicals

1992 • 155 citations

Purification and some properties of a highly dicumarol-sensitive liver diaphorase

1960 • 154 citations

Relationship of the single-electron reduction potential of quinones to their reduction by flavoproteins

1980 • 154 citations

Generation of reactive oxygen radicals through bioactivation of mitomycin antibiotics.

1986 • 144 citations

Soluble Diaphorase in Animal Tissues.

1958 • 138 citations

DNA strand scission and free radical production in menadione-treated cells. Correlation with cytotoxicity and role of NADPH quinone acceptor oxidoreductase.

1992 • 136 citations

Molecular Biology of the Carcinogen, 4-Nitroquinoline 1-Oxide

1976 • 130 citations

Toxicology of Quinone-Thioethers

1992 • 130 citations

Induction of dna damage by menadione (2-methyl-1,4-naphthoquinone) in primary cultures of rat hepatocytes

1984 • 124 citations

Mechanisms of toxicity of naphthoquinones to isolated hepatocytes

1986 • 122 citations

The Role of NAD(P)H: Quinone Reductase (EC 1.6.99.2, DT-Diaphorase) in the Reductive Bioactivation of the Novel Indoloquinone Antitumor Agent E09

1991 • 122 citations

Cytochrome c reduction by semiquinone radicals can be indirectly inhibited by superoxide dismutase

1981 • 108 citations

Metabolism of Xenobiotics

2016 • 107 citations

Metabolism of Xenobiotics

2002 • 106 citations

Active oxygens, lipid peroxides and antioxidants

1993 • 105 citations

Induction of glutathione transferases and NAD(P)H:quinone reductase by fumaric acid derivatives in rodent cells and tissues.

1990 • 99 citations

Extracellular glutathione and γ-glutamyl transpeptidase prevent H2O2-induced injury by 2,3-dimethoxy-1,4-naphthoquinone

1993 • 98 citations

Formation of glutathione-conjugated semiquinones by the reaction of quinones with glutathione: An ESR study

1987 • 98 citations

The addition and substitution chemistry of quinones

2010 • 97 citations

Bioreductive Activation of Quinones: Redox Properties and Thiol Reactivity

1990 • 95 citations

Intermediates in the aerobic autoxidation of 6-hydroxydopamine: Relative importance under different reaction conditions

1989 • 84 citations

Pro‐ and Antioxidant Functions of Quinones and Quinone Reductases in Mammalian Cells

1992 • 82 citations

The one-electron reduction potential of several substrates can be related to their reduction rates by cytochrome P-450 reductase

1993 • 82 citations

Bone marrow stromal cell bioactivation and detoxification of the benzene metabolite hydroquinone: comparison of macrophages and fibroblastoid cells.

1990 • 81 citations

Effect of superoxide dismutase on the autoxidation of substituted hydro- and semi-naphthoquinones

1990 • 80 citations

Role of the glutathione-glutathione peroxidase cycle in the cytotoxicity of the anticancer quinones

1990 • 77 citations

The sensitivity of human tumour cells to quinone bioreductive drugs: What role for DT-diaphorase?

1992 • 77 citations

Relationship between DT-diaphorase-mediated metabolism of a series of aziridinylbenzoquinones and DNA damage and cytotoxicity.

1992 • 75 citations

A note on the inhibition of DT-diaphorase by dicoumarol

1991 • 74 citations

One-electron reduction of 2- and 6-methyl-1,4-naphthoquinone bioreductive alkylating agents

1986 • 73 citations

Auto-oxidation of dialuric acid, divicine and isouramil

1989 • 70 citations

Bioactivation of Mitomycin C by Xanthine Dehydrogenase From EMT6 Mouse Mammary Carcinoma Tumors

1992 • 67 citations

Semiquinone anion radicals formed by the reaction of quinones with glutathione or amino acids

1986 • 67 citations

Unusually marked hypoxic sensitization to indoloquinone E09 and mitomycin C in a human colon‐tumour cell line that lacks DT‐diaphorase activity

1994 • 66 citations

Mechanisms of toxicity of 2‐ and 5‐hydroxy‐1,4‐naphthoquinone; absence of a role for redox cycling in the toxicity of 2‐hydroxy‐1,4‐naphthoquinone to isolated hepatocytes

1987 • 66 citations

Active Oxygens, Lipid Peroxides and Antioxidants

1993 • 64 citations

Free radical formation from anthracycline antitumour

1984 • 64 citations

2-Bromo-(diglutathion-S-yl)hydroquinone nephrotoxicity: physiological, biochemical, and electrochemical determinants.

1988 • 63 citations

A thermodynamic appraisal of the radical sink hypothesis

1993 • 62 citations

The toxicity of menadione (2-methyl-1,4-naphthoquinone) and two thioether conjugates studied with isolated renal epithelial cells

1991 • 60 citations

Identification of a glycine-rich sequence as an NAD(P)H-binding site and tyrosine 128 as a dicumarol-binding site in rat liver NAD(P)H:quinone oxidoreductase by site-directed mutagenesis.

1992 • 58 citations

Inhibition of NAD(P)H:Quinone Acceptor Oxidoreductase by Flavones: A Structure-Activity Study

1993 • 57 citations

Rat liver NAD(P)H: Quinone reductase

1989 • 55 citations

DT-diaphorase-catalyzed two electron reduction of quinone epoxides

1987 • 54 citations

DT-diaphorase activity correlates with sensitivity to the indoloquinone EO9 in mouse and human colon carcinomas

1992 • 54 citations

Interconversion of NAD(H) TO NADP(H)

1989 • 52 citations

Cell-specific metabolism in mouse bone marrow stroma: studies of activation and detoxification of benzene metabolites.

1992 • 52 citations

Alteration in DNA cross-linking and sequence selectivity of a series of aziridinylbenzoquinones after enzymic reduction by DT-diaphorase

1992 • 52 citations

Alterations in hepatocyte cytoskeleton caused by redox cycling and alkylating quinones

1988 • 48 citations

Quinoneimines as substrates for quinone reductase (NAD(P)H : (Quinone-acceptor)oxidoreductase) and the effect of dicumarol on their cytotoxicity

1987 • 48 citations

In Vitro Cytotoxicities of 1,4‐Naphthoquinone and Hydroxylated 1,4‐Naphthoquinones to Replicating Cells

1993 • 46 citations

Reactions of glutathione and glutathione radicals with benzoquinones

1992 • 46 citations

The cytotoxic effects of 5-OH-1,4-naphthoquinone and 5,8-diOH-1,4-naphthoquinone on doxorubicin-resistant human leukemia cells (HL-60)

1992 • 45 citations

Formation of benzo[a]pyrene-3,6-quinol mono- and diglucuronides in rat liver microsomes

1985 • 44 citations

The reduction of anti-tumour diaziridinyl benzoquinones

1987 • 43 citations

The role of human and rodent DT-diaphorase in the reductive metabolism of hypoxic cell cytotoxins

1992 • 43 citations

DT-diaphorase-catalyzed two-electron reduction of various p-benzoquinone- and 1,4-naphthoquinone epoxides

1988 • 43 citations

Role of NAD(P)H:(quinone acceptor) oxidoreductase (DT-diaphorase) in activation of mitomycin C under hypoxia.

1992 • 41 citations

Oxidation by superoxide ion of catechols, ascorbic acid, dihydrophenazine, and reduced flavins to their respective anion radicals. A common mechanism via a combined proton-hydrogen atom transfer

1985 • 41 citations

Menadione (2-methyl-1,4-naphthoquinone)-induced Ca²⁺release from rat-liver mitochondria is caused by NAD(P)H oxidation

1986 • 40 citations

NAD(P)H (quinone acceptor) oxidoreductase (DT-diaphorase)-mediated two-electron reduction of anthraquinone-based antitumour agents and generation of hydroxyl radicals

1992 • 38 citations

The enzymology of doxorubicin quinone reduction in tumour tissue

1992 • 38 citations

Two structurally related diaziridinylbenzoquinones preferentially cross-link DNA at different sites upon reduction with DT-diaphorase

1993 • 38 citations

Possible role of DT-diaphorase in the bioactivation of antitumor quinones

1983 • 37 citations

Induction of Antioxidant Enzymes and DT-Diaphorase in Human Blood Mononuclear Cells by Light Stress

1993 • 36 citations

Free radical formation and DNA strand breakage during metabolism of diaziquone by NAD(P)H quinone-acceptor oxidoreductase (DT-diaphorase) and NADPH cytochrome c reductase

1991 • 36 citations

Study of the redox properties of naphthazarin (5,8-dihydroxy-1,4-naphthoquinone) and its glutathionyl conjugate in biological reactions: One- and two-electron enzymatic reduction

1989 • 34 citations

Role of sulfhydryl groups in benzoquinone-induced Ca2+ release by rat liver mitochondria

1988 • 34 citations

Peroxidase activation of 1-naphthol to naphthoxy or naphthoxy-derived radicals and their reaction with glutathione

1986 • 34 citations

Characterization of a glutathione conjugate of the 1,4-benzosemiquinone-free radical formed in rat hepatocytes.

1988 • 33 citations

Enhancement of xanthine dehydrogenase mediated mitomycin C metabolism by dicumarol.

1992 • 32 citations

Dicoumarol-sensitive glucuronidation of benzo(a)pyrene metabolites in rat liver microsomes

1986 • 31 citations

Induction of cell damage by menadione and benzo(a)-pyrene-3,6-quinone in cultures of adult rat hepatocytes and human fibroblasts

1985 • 31 citations

The reductive metabolism of diaziquone (AZQ) in the S9 fraction of MCF-7 cells: Free radical formation and NAD(P)H: Quinone-acceptor oxidoreductase (DT-diaphorase) activity

1991 • 30 citations

One- and two-electron reduction of 2-methyl-1,4-naphthoquinone bioreductive alkylating agents: kinetic studies, free-radical production, thiol oxidation and DNA-strand-break formation

1994 • 30 citations

Reductive activation of diaziquone and possible involvement of free radicals and the hydroquinone dianion.

1986 • 27 citations

Kinetics and mechanism of mitomycin C bioactivation by xanthine dehydrogenase under aerobic and hypoxic conditions.

1993 • 26 citations

Purified NAD(P)H‐quinone oxidoreductase enhances the mutagenicity of dinitropyrenes in vitro

1991 • 26 citations

Glutathionyl- and hydroxyl radical formation coupled to the redox transitions of 1,4-naphthoquinone bioreductive alkylating agents during glutathione two-electron reductive addition

1991 • 26 citations

Carcinogenic Aromatic Hydrocarbons: Special Vulnerability of Rats

1965 • 25 citations

Studies on the reaction mechanism of DT diaphorase

1975 • 25 citations

Reductive metabolism of diaziquone (AZQ) in the S9 fraction of MCF-7 cells

1992 • 25 citations

Role of metabolism and oxidation-reduction cycling in the cytotoxicity of antitumor quinoneimines and quinonediimines.

1987 • 24 citations

Thiol oxidation coupled to DT-diaphorase-catalysed reduction of diaziquone. Reductive and oxidative pathways of diaziquone semiquinone modulated by glutathione and superoxide dismutase

1992 • 23 citations

Mechanistic Toxicology: A Radical Perspective

1989 • 23 citations

Diaziquone-induced cytotoxicity in isolated rat hepatocytes.

1989 • 21 citations

Effect of the superoxide dismutase inhibitor, diethyldithiocarbamate, on the cytotoxicity of mitomycin antibiotics.

1989 • 20 citations

Role of NAD(P)H:(quinone acceptor) oxidoreductase (DT-diaphorase) in activation of mitomycin C under acidic conditions.

1993 • 19 citations

Effect of treatment duration and glutathione depletion on mitomycin C cytotoxicity in vitro.

1992 • 19 citations

Effect Of Glutathione On The Redox Transitions Of Naphthohydroquinone Derivatives Formed During Dt-Diaphorase Catalysis

1990 • 18 citations

Inhibition of mouse glutathione transferases and glutathione peroxidase II by dicumarol and other ligands

1992 • 17 citations

The effects of 2,3,5-(triglutathion-S-yl)hydroquinone on renal mitochondrial respiratory function in vivo and in vitro: Possible role in cytotoxicity

1992 • 17 citations

Synthesis of the photoaffinity probe 3-(p-azidobenzyl)-4-hydroxycoumarin and identification of the dicoumarol binding site in rat liver NAD(P)H:quinone reductase (EC 1.6.99.2).

1991 • 16 citations

A comparison of free radical formation by quinone anti-tumour agents in MCF-7 cells and the role of NAD(P)H (quinone-acceptor) oxidoreductase (DT-diaphorase)

1993 • 15 citations

Differential cytotoxicity of diaziquone toward Chinese hamster ovary cells under hypoxic and aerobic exposure conditions.

1990 • 15 citations

Reduction Of Adrenochrome By Rat Liver And Brain Dt-Diaphorase

1990 • 14 citations

Does lung NAD(P)H: quinone reductase (DT-diaphorase) play an antioxidant enzyme role in protection from hyperoxia?

1993 • 14 citations

Oxygen radical generation and alkylating ability of mitomycin C bioactivated by xanthine dehydrogenase.

1992 • 13 citations

Biochemical characterization of a mitomycin C resistant colon cancer cell line variant

1993 • 13 citations

Redox cycling of potential antitumor aziridinyl quinones

1992 • 11 citations

Developmental Toxicity of Bromohydroquinone (BHQ) and BHQ-Glutathione Conjugates in Vivo and in Whole Embryo Culture

1993 • 11 citations

Advances in research on DT-diaphorase--catalytic properties, regulation of activity and significance in the detoxication of foreign compounds.

1990 • 10 citations

Superoxide anion production and toxicity in V79 cells of six hydroxy-anthraquinones.

1991 • 10 citations

Role of DT diaphorase the cytotoxicity of menadione and 4-nitroquinoline-1-oxide in cultured mammalian fibroblastic cells

1990 • 8 citations

Molecular mechanisms of trenimon-induced cytotoxicity in resistant L5178Y/HBM10 cells

1992 • 7 citations

Modulation of trenimon-induced cytotoxicity by DT-diaphorase in isolated rat hepatocytes under aerobic versus hypoxic conditions.

1992 • 7 citations

Rat liver DT-diaphorase as a nitroso-reductase.

1990 • 5 citations