Oxidative stress in malaria; implications for prevention and therapy

Human Malaria Parasites in Continuous Culture

1976 • 7,687 citations

[1] Role of free radicals and catalytic metal ions in human disease: An overview

1990 • 5,041 citations

DNA Damage and Oxygen Radical Toxicity

1988 • 1,964 citations

Continuous Monitoring ofin VztroOxidation of Human Low Density Lipoprotein

1989 • 1,824 citations

CRC handbook of methods for oxygen radical research

1985 • 1,496 citations

Antioxidant defenses and lipid peroxidation in human blood plasma.

1988 • 1,253 citations

Malaria parasites and other haemosporidia

1966 • 989 citations

TNF concentration in fatal cerebral, non-fatal cerebral, and uncomplicated Plasmodium falciparum malaria

1990 • 861 citations

Stimulation of neutrophils by tumor necrosis factor.

1986 • 847 citations

Severe and complicated malaria

1990 • 566 citations

The Pharmacological Basis of Therapeutics

1966 • 539 citations

A site-specific mechanism for free radical induced biological damage: The essential role of redox-active transition metals

1988 • 505 citations

Malaria Parasites and Other Haemosporidia

1967 • 435 citations

Qinghaosu

1993 • 410 citations

Brain injury, edema, and vascular permeability changes induced by oxygen‐derived free radicals

1984 • 387 citations

Human vascular endothelial cell adhesion receptors for Plasmodium falciparum-infected erythrocytes: roles for endothelial leukocyte adhesion molecule 1 and vascular cell adhesion molecule 1.

1992 • 383 citations

Drug Antioxidant Effects

1991 • 365 citations

Evidence for reactive oxygen intermediates causing hemolysis and parasite death in malaria

1983 • 360 citations

Microvascular Sequestration of Parasitized Erythrocytes in Human Falciparum Malaria: a Pathological Study

1991 • 317 citations

Iron-dependent free radical generation from the antimalarial agent artemisinin (qinghaosu)

1993 • 316 citations

Artemisinin (qinghaosu): the role of intracellular hemin in its mechanism of antimalarial action

1991 • 293 citations

Tumor‐Necrosis Factor and other Cytokines in Cerebral Malaria: Experimental and Clinical Data

1989 • 264 citations

Superoxide-dependent and ascorbate-dependent formation of hydroxyl radicals from hydrogen peroxide in the presence of iron. Are lactoferrin and transferrin promoters of hydroxyl-radical generation?

1987 • 253 citations

L3T4+ T lymphocytes play a major role in the pathogenesis of murine cerebral malaria.

1986 • 253 citations

Caeruloplasmin: Physiological and Pathological Perspectives

1981 • 222 citations

Origin of reactive oxygen species in erythrocytes infected with Plasmodium falciparum

1993 • 221 citations

Molecular Basis of Sequestration in Severe and Uncomplicated Plasmodium falciparum Malaria: Differential Adhesion of Infected Erythrocytes to CD36 and ICAM-l

1991 • 216 citations

Deferoxamine posttreatment reduces ischemic brain injury in neonatal rats.

1994 • 207 citations

Effect of Iron Chelation Therapy on Recovery from Deep Coma in Children with Cerebral Malaria

1992 • 206 citations

Chronic Granulomatous Disease

1987 • 204 citations

Cerebral malaria: The sequestration hypothesis

1994 • 203 citations

Efficacy trial of malaria vaccine SPf66 in Gambian infants

1995 • 192 citations

The cytokine theory of human cerebral malaria

1994 • 189 citations

The antimalarial action on Plasmodium falciparum of qinghaosu and artesunate in combination with agents which modulate oxidant stress

1987 • 177 citations

Profiles of cytokine production in relation with susceptibility to cerebral malaria.

1993 • 175 citations

Hemin-catalyzed decomposition of artemisinin (qinghaosu)

1992 • 148 citations

Tumor Necrosis Factor and Severe Malaria

1991 • 144 citations

Oxygen-derived Free Radicals in the Pathogenesis of Parasitic Disease

1986 • 143 citations

Oxidative stress and the redox status of malaria-infected erythrocytes.

1990 • 139 citations

Oxidative stress: a radical view.

1989 • 138 citations

Source of iron in neutrophil-mediated killing of endothelial cells.

1987 • 134 citations

Killing of human malaria parasites by macrophage secretory products

1984 • 130 citations

Oxygen and Living Processes: An Interdisciplinary Approach

2011 • 130 citations

Desferrioxamine inhibition of the hydroxyl radical-like reactivity of peroxynitrite: Role of the hydroxamic groups

1995 • 123 citations

Oxidative killing of the intraerythrocytic malaria parasite Plasmodium yoelii by activated macrophages.

1984 • 116 citations

The pharmacokinetics of artemisinin after oral, intramuscular and rectal administration to volunteers

1990 • 114 citations

Dietary Fish-Oil Supplementation in Experimental Gram-Negative Infection and in Cerebral Malaria in Mice

1992 • 106 citations

The antimalarial action of desferal involves a direct access route to erythrocytic (Plasmodium falciparum) parasites.

1993 • 106 citations

A Unique Histidine-rich Polypeptide from the Malaria Parasite, Plasmodium lophurae

1974 • 102 citations

Immunopathological changes in human cerebral malaria.

1993 • 101 citations

Free radicals and disease in man.

1984 • 97 citations

The redox status of malaria-infected erythrocytes: an overview with an emphasis on unresolved problems

1994 • 96 citations

The mode of action of antimalarial endoperoxides

1994 • 95 citations

Qinghaosu, dietary vitamin E, selenium, and cod-liver oil: effect on the susceptibility of mice to the malarial parasite Plasmodium yoelii

1989 • 93 citations

Suppression of malaria infection by oxidant-sensitive host erythrocytes

1976 • 93 citations

Prevention of experimental cerebral malaria by anticytokine antibodies. Interleukin 3 and granulocyte macrophage colony-stimulating factor are intermediates in increased tumor necrosis factor production and macrophage accumulation.

1988 • 92 citations

Activated oxygen mediates the antimalarial activity of qinghaosu.

1989 • 89 citations

Some roles of free radicals in malaria

1989 • 88 citations

Malaria: Living with drug resistance

1993 • 86 citations

Virulent P. berghei malaria: prolonged survival and decreased cerebral pathology in cell-dependent nude mice.

1982 • 85 citations

Primary structure and genomic organization of the histidine-rich protein of the malaria parasite Plasmodium lophurae

1984 • 84 citations

Immunological aspects of cerebral lesions in murine malaria.

1989 • 77 citations

Free radicals, lipoproteins and cardiovascular dysfunction

1992 • 75 citations

Desferrioxamine Suppresses Plasmodium falciparum in Aotus Monkeys

1987 • 75 citations

Low dosages of interleukin 1 protect mice against lethal cerebral malaria.

1990 • 73 citations

Artemisia annua L.: a source of novel antimalarial drugs

1990 • 73 citations

PREVENTION AND TREATMENT OF MALARIA

1988 • 71 citations

Dependence of plasmodial glutathione metabolism on the host cell

1979 • 69 citations

Oxidant defense enzymes of Plasmodium falciparum

1988 • 67 citations

Morphological changes in erythrocytes induced by malarial parasites

1988 • 62 citations

Glutathione reductase inhibitors as potential antimalarial drugs

1988 • 62 citations

Treatment of Malaria - 1990

1990 • 59 citations

Radical-mediated damage to parasites and erythrocytes in Plasmodium vinckei infected mice after injection of t-butyl hydroperoxide.

1984 • 57 citations

Formulation and pharmacokinetics of artemisinin and its derivatives

1991 • 57 citations

Thalassemic erythrocytes inhibit in vitro growth of Plasmodium falciparum

1987 • 56 citations

Antioxidants can prevent cerebral malaria in Plasmodium berghei-infected mice.

1989 • 56 citations

Significance of cytokine production and adhesion molecules in malarial immunopathology

1990 • 55 citations

Generation of Reactive Oxygen Radicals by Human Phagocytic Cells Activated by Plasmodium falciparum

1987 • 53 citations

Plasmodium falciparum: Thiol status and growth in normal and glucose-6-phosphate dehydrogenase deficient human erythrocytes

1984 • 52 citations

Glutathione reductase-deficient erythrocytes as host cells of malarial parasites

1988 • 51 citations

Generation of reactive oxygen species in whole blood from patients with acute falciparum malaria

1987 • 49 citations

Localization and characterization of hemoglobin-degrading aspartic proteinases from the malarial parasite Plasmodium falciparum

1992 • 49 citations

Preliminary report on the use of desferrioxamine in the treatment of Plasmodium falciparum malaria

1991 • 48 citations

Iron chelators in medicine

1992 • 47 citations

Malarial parasites and antioxidant nutrients

1993 • 47 citations

Antagonism of chloroquine with other antimalarials

1988 • 47 citations

Involvement of Tumour Necrosis Factor and Other Cytokines in Immune-Mediated Vascular Pathology

1989 • 45 citations

Evidence for a neutrophil‐mediated protective response in malaria

1988 • 44 citations

Menhaden-fish oil in a vitamin E-deficient diet: protection against chloroquine-resistant malaria in mice

1989 • 42 citations

Formation of a Histidine-peroxide Adduct by H₂O₂or Ionizing Radiation on Histidine: Chemical and Microbiological Properties

1969 • 41 citations

Protection against Murine Cerebral Malaria by Dietary-Induced Oxidative Stress

1995 • 38 citations

Protection against murine cerebral malaria by dietary-induced oxidative stress.

1995 • 36 citations

Prevention of Malaria

1990 • 35 citations

Increased cerebrospinal fluid protein and lipid peroxidation products in patients with cerebral malaria

1991 • 35 citations

The survival of Plasmodium Under oxidant stress

1991 • 34 citations

SPf66 - The first malaria vaccine

1995 • 34 citations

Plasmodium falciparum: Role of Activated Blood Monocytes in Erythrocyte Membrane Damage and Red Cell Loss during Malaria

1995 • 34 citations

Tumour necrosis factor-α and macrophages in Plasmodium berghei-induced cerebral malaria

1993 • 34 citations

Ultrastructural changes in the blood-brain barrier of mice infected with Plasmodium berghei.

1992 • 33 citations

Topographical distribution of the cerebral lesions in mice infected with Plasmodium berghei.

1983 • 33 citations

Amelioration of murine cerebral malaria by dietary restriction

1993 • 29 citations

Plasmodium yoelii: Comparative antimalarial activities of dietary fish oils and fish oil concentrates in vitamin E-deficient mice

1990 • 29 citations

Toxic Heme in Sickle Cells: an Explanation for Death of Malaria Parasites *

1985 • 27 citations

Presence of an endogenous superoxide dismutase activity in three rodent malaria species

1993 • 26 citations

The effects of ascorbate-induced free radicals on Plasmodium falciparum.

1992 • 26 citations

Cytokines in malaria, pathology and protection

1994 • 26 citations

Social and economic aspects of malaria and its control.

1988 • 25 citations

Ribose metabolism and nucleic acid synthesis in normal and glucose-6-phosphate dehydrogenase-deficient human erythrocytes infected with Plasmodium falciparum.

1986 • 23 citations

A Nonhuman Primate Model for Human Cerebral Malaria: Effects of Artesunate (Qinghaosu Derivative) on Rhesus Monkeys Experimentally Infected with Plasmodium coatneyi

1993 • 22 citations

Inhibitory effects of histidine analogues on growth and protein synthesis by Plasmodium falciparum in vitro

1986 • 21 citations

Plasmodial metabolism and related organellar function during various stages of the life-cycle: carbohydrates.

1988 • 15 citations

Generation of reactive oxygen species by blood monocytes in human Plasmodium falciparum and P. vivax infections

1991 • 14 citations

Oxygen Free Radicals in Malaria

1992 • 10 citations

Induction of Oxidant Stress by Iron Available in Advanced Forms ofPlasmodium Falciparum

1991 • 10 citations

Prostaglandin derivatives inhibit the growth of malarial parasites in mice

1989 • 10 citations

Variation in the cytoadherence characteristics of malaria parasites: is this a true virulence factor?

1992 • 8 citations

Severe and cerebral malaria

1995 • 5 citations

Generation of reactive oxygen species by blood monocytes during acutePlasmodium knowlesiinfection in rhesus monkeys

1993 • 4 citations

Erythrocytic GSH Level and Stability in Plasmodium Vivax Malaria

1992 • 4 citations

Lipid-soluble antioxidants: Biochemistry and clinical applications

1994 • 2 citations

Deleted Work

1955 • 0 citations