Activation of the Lck Tyrosine Kinase Targets Cell Surface T Cell Antigen Receptors for Lysosomal Degradation

Green Fluorescent Protein as a Marker for Gene Expression

1994 • 6,572 citations

Discovery of a Novel, Potent, and Src Family-selective Tyrosine Kinase Inhibitor

1996 • 1,946 citations

Identification of a monoclonal antibody specific for a murine T3 polypeptide.

1987 • 1,644 citations

The small GTPase rab5 functions as a regulatory factor in the early endocytic pathway

1992 • 1,342 citations

Induction of mutant dynamin specifically blocks endocytic coated vesicle formation.

1994 • 1,206 citations

Serial triggering of many T-cell receptors by a few peptide–MHC complexes

1995 • 1,143 citations

Genetic evidence for the involvement of the lck tyrosine kinase in signal transduction through the T cell antigen receptor

1992 • 1,046 citations

T Cell Activation Determined by T Cell Receptor Number and Tunable Thresholds

1996 • 1,038 citations

Control of EGF Receptor Signaling by Clathrin-Mediated Endocytosis

1996 • 998 citations

Profound block in thymocyte development in mice lacking p56lck

1992 • 965 citations

Interaction of Tyrosine-Based Sorting Signals with Clathrin-Associated Proteins

1995 • 955 citations

Mice lacking MHC class II molecules

1991 • 869 citations

Characterization of a monoclonal antibody which detects all murine alpha beta T cell receptors.

1989 • 778 citations

T cell antigen receptor signal transduction: A tale of tails and cytoplasmic protein-tyrosine kinases

1993 • 552 citations

A novel di-leucine motif and a tyrosine-based motif independently mediate lysosomal targeting and endocytosis of CD3 chains

1992 • 540 citations

Inhibition of tyrosine phosphorylation prevents T-cell receptor-mediated signal transduction.

1990 • 526 citations

Down-regulation of T cell receptors on self-reactive T cells as a novel mechanism for extrathymic tolerance induction

1991 • 523 citations

Antigen recognition by human T lymphocytes is linked to surface expression of the T3 molecular complex

1982 • 494 citations

T cell antigen receptor signal transduction

1997 • 390 citations

The Major Histocompatibility Complex-Restricted Antigen Receptor on T Cells

1984 • 368 citations

Tyrosine phosphatase CD45 is required for T-cell antigen receptor and CD2-mediated activation of a protein tyrosine kinase and interleukin 2 production.

1991 • 349 citations

Degradation of T Cell Receptor (TCR)–CD3-ζ Complexes after Antigenic Stimulation

1997 • 316 citations

A dominant-negative transgene defines a role for p56lck in thymopoiesis.

1993 • 306 citations

Tyrosine kinases and tyrosine-based activation motifs. Current research on activation via the T cell antigen receptor.

1992 • 287 citations

Genetic and Mutational Analysis of the T-Cell Antigen Receptor

1990 • 275 citations

CD3 gamma contains a phosphoserine-dependent di-leucine motif involved in down-regulation of the T cell receptor.

1994 • 233 citations

Neoplastic transformation induced by an activated lymphocyte-specific protein tyrosine kinase (pp56lck).

1988 • 232 citations

Pre-Golgi degradation of newly synthesized T-cell antigen receptor chains: intrinsic sensitivity and the role of subunit assembly.

1989 • 228 citations

The mouse T cell receptor: Comparison of MHC-restricted receptors on two T cell hybridomas

1983 • 218 citations

Activation-Induced Ubiquitination of the T Cell Antigen Receptor

1992 • 213 citations

The major histocompatibility complex-restricted antigen receptor on T cells: Distribution on thymus and peripheral T cells

1984 • 210 citations

Mutation of a site of tyrosine phosphorylation in the lymphocyte-specific tyrosine protein kinase, p56lck, reveals its oncogenic potential in fibroblasts.

1988 • 208 citations

ZAP-70 binding specificity to T cell receptor tyrosine-based activation motifs: the tandem SH2 domains of ZAP-70 bind distinct tyrosine-based activation motifs with varying affinity.

1995 • 196 citations

Endocytosis and recycling of the T3-T cell receptor complex. The role of T3 phosphorylation.

1987 • 185 citations

CD45 tyrosine phosphatase-activated p59fyn couples the T cell antigen receptor to pathways of diacylglycerol production, protein kinase C activation and calcium influx.

1992 • 179 citations

Requirement for the Adapter Protein GRB2 in EGF Receptor Endocytosis

1996 • 178 citations

Regulation of T cell receptor expression in immature CD4+CD8+ thymocytes by p56lck tyrosine kinase: basis for differential signaling by CD4 and CD8 in immature thymocytes expressing both coreceptor molecules.

1993 • 156 citations

Syk and ZAP-70 mediate recruitment of p56lck/CD4 to the activated T cell receptor/CD3/zeta complex.

1995 • 130 citations

Expression of a hybrid immunoglobulin-T cell receptor protein in transgenic mice

1989 • 111 citations

Thy-1- and Ly-6-mediated lymphokine production and growth inhibition of a T cell hybridoma require co-expression of the T cell antigen receptor complex.

1988 • 103 citations

Mutational Analysis of Lck in CD45-Negative T Cells: Dominant Role of Tyrosine 394 Phosphorylation in Kinase Activity

1996 • 94 citations

Engagement of the CD4 molecule influences cell surface expression of the T-cell receptor on thymocytes

1988 • 84 citations

Subunit interactions within the T-cell antigen receptor: clues from the study of partial complexes.

1988 • 84 citations

The CD45 tyrosine phosphatase regulates phosphotyrosine homeostasis and its loss reveals a novel pattern of late T cell receptor-induced Ca2+ oscillations.

1992 • 81 citations

Developmental regulation of alpha beta T cell antigen receptor expression results from differential stability of nascent TCR alpha proteins within the endoplasmic reticulum of immature and mature T cells.

1994 • 76 citations

Antibody-induced modulation of the CD3/T cell receptor complex causes T cell refractoriness by inhibiting the early metabolic steps involved in T cell activation.

1987 • 74 citations

TCRα-CD3δϵ association is the initial step in αβ dimer formation in murine T cells and is limiting in immature CD4+CD8+ thymocytes

1995 • 71 citations

Novel post-translational regulation of TCR expression in CD4+CD8+ thymocytes influenced by CD4

1990 • 67 citations

Agonist‐induced T cell receptor down‐regulation: molecular requirements and dissociation from T cell activation

1997 • 66 citations

T cell receptor/CD3 complex internalization following activation of a cytolytic T cell clone: Evidence for a protein kinase C‐independent staurosporine‐sensitive step

1991 • 57 citations

Role of CD3gamma and CD3delta cytoplasmic domains in cytolytic T lymphocyte functions and TCR/CD3 down-modulation.

1997 • 41 citations

The structure and signalling functions of the invariant T cell receptor components.

1990 • 40 citations

The protein tyrosine kinase p56^ICK regulates TCR expression and T cell selection

1995 • 18 citations

Deleted Work

1955 • 0 citations