Gene silencing as an adaptive defence against viruses

Potent and specific genetic interference by double-stranded RNA in Caenorhabditis elegans

1998 • 14,674 citations

Role for a bidentate ribonuclease in the initiation step of RNA interference

2001 • 4,804 citations

RNA interference is mediated by 21- and 22-nucleotide RNAs

2001 • 3,271 citations

An RNA-directed nuclease mediates post-transcriptional gene silencing in Drosophila cells

2000 • 2,945 citations

RNAi

2000 • 2,596 citations

Introduction of a Chimeric Chalcone Synthase Gene into Petunia Results in Reversible Co-Suppression of Homologous Genes in trans.

1990 • 2,386 citations

Cytosine methylation and the ecology of intragenomic parasites

1997 • 1,906 citations

Nested Retrotransposons in the Intergenic Regions of the Maize Genome

1996 • 1,392 citations

Delay of Disease Development in Transgenic Plants That Express the Tobacco Mosaic Virus Coat Protein Gene

1986 • 1,324 citations

The rde-1 Gene, RNA Interference, and Transposon Silencing in C. elegans

1999 • 1,286 citations

Flavonoid genes in petunia: addition of a limited number of gene copies may lead to a suppression of gene expression.

1990 • 1,182 citations

Virus resistance and gene silencing in plants can be induced by simultaneous expression of sense and antisense RNA

1998 • 1,121 citations

Use of dsRNA-Mediated Genetic Interference to Demonstrate that frizzled and frizzled 2 Act in the Wingless Pathway

1998 • 1,116 citations

Arabidopsis SGS2 and SGS3 Genes Are Required for Posttranscriptional Gene Silencing and Natural Virus Resistance

2000 • 1,082 citations

Viral pathogenicity determinants are suppressors of transgene silencing in Nicotiana benthamiana

1998 • 1,073 citations

An RNA-Dependent RNA Polymerase Gene in Arabidopsis Is Required for Posttranscriptional Gene Silencing Mediated by a Transgene but Not by a Virus

2000 • 1,061 citations

Plant Retrotransposons

1999 • 1,011 citations

Total silencing by intron-spliced hairpin RNAs

2000 • 968 citations

Transcriptional silencing and promoter methylation triggered by double-stranded RNA

2000 • 866 citations

A Similarity Between Viral Defense and Gene Silencing in Plants

1997 • 821 citations

A Counterdefensive Strategy of Plant Viruses

1998 • 815 citations

Isolation and Analysis of Double-Stranded RNA from Virus-Infected Plant and Fungal Tissue

1979 • 781 citations

Antisense gene that inhibits synthesis of the hormone ethylene in transgenic plants

1990 • 780 citations

Systemic acquired silencing: transgene-specific post-transcriptional silencing is transmitted by grafting from silenced stocks to non-silenced scions

1997 • 777 citations

mut-7 of C. elegans, Required for Transposon Silencing and RNA Interference, Is a Homolog of Werner Syndrome Helicase and RNaseD

1999 • 745 citations

Transposable element contributions to plant gene and genome evolution.

2000 • 742 citations

Systemic Spread of Sequence-Specific Transgene RNA Degradation in Plants Is Initiated by Localized Introduction of Ectopic Promoterless DNA

1998 • 694 citations

A Viral Movement Protein Prevents Spread of the Gene Silencing Signal in Nicotiana benthamiana

2000 • 677 citations

Gene silencing in Neurospora crassa requires a protein homologous to RNA-dependent RNA polymerase

1999 • 653 citations

Fast forward genetics based on virus-induced gene silencing

1999 • 630 citations

Mobilization of transposons by a mutation abolishing full DNA methylation in Arabidopsis

2001 • 626 citations

AGO1, QDE-2, and RDE-1 are related proteins required for post-transcriptional gene silencing in plants, quelling in fungi, and RNA interference in animals

2000 • 555 citations

EGO-1 is related to RNA-directed RNA polymerase and functions in germ-line development and RNA interference in C. elegans

2000 • 546 citations

Macromolecular Trafficking Indicated by Localization and Turnover of Sucrose Transporters in Enucleate Sieve Elements

1997 • 455 citations

Gene Silencing without DNA: RNA-Mediated Cross-Protection between Viruses

1999 • 444 citations

Domains in gene silencing and cell differentiation proteins: the novel PAZ domain and redefinition of the Piwi domain

2000 • 426 citations

Plant Transposable Elements

1986 • 394 citations

Plants combat infection by gene silencing

1997 • 384 citations

RNA Replication: Function and Structure of QBeta-Replicase

1979 • 376 citations

Suppression of Virus Accumulation in Transgenic Plants Exhibiting Silencing of Nuclear Genes.

1996 • 375 citations

Disruption of an RNA helicase/RNAse III gene in Arabidopsis causes unregulated cell division in floral meristems

1999 • 368 citations

Listening to the silent genes: transgene silencing, gene regulation and pathogen control

1999 • 367 citations

Phloem long-distance transport ofCmNACPmRNA: implications for supracellular regulation in plants

1999 • 366 citations

SDE3 encodes an RNA helicase required for post-transcriptional gene silencing in Arabidopsis

2001 • 365 citations

Virus-encoded suppressor of posttranscriptional gene silencing targets a maintenance step in the silencing pathway

2000 • 363 citations

Translational control of IS10 transposition

1983 • 362 citations

A Calmodulin-Related Protein That Suppresses Posttranscriptional Gene Silencing in Plants

2000 • 351 citations

Untranslatable transcripts of the tobacco etch virus coat protein gene sequence can interfere with tobacco etch virus replication in transgenic plants and protoplasts

1992 • 315 citations

Robertson's Mutator transposons in A. thaliana are regulated by the chromatin-remodeling gene Decrease in DNA Methylation (DDM1)

2001 • 314 citations

Silencing of Retrotransposons in Arabidopsis and Reactivation by the ddm1 Mutation

2000 • 312 citations

HC-Pro Suppression of Transgene Silencing Eliminates the Small RNAs but Not Transgene Methylation or the Mobile Signal

2001 • 310 citations

RNA-Mediated RNA Degradation and Chalcone Synthase A Silencing in Petunia

1997 • 308 citations

Suppression of beta-1,3-glucanase transgene expression in homozygous plants.

1992 • 303 citations

Posttranscriptional Gene Silencing in Neurospora by a RecQ DNA Helicase

1999 • 252 citations

Gene silencing in worms and fungi

2000 • 251 citations

A single copy of a virus‐derived transgene encoding hairpin RNA gives immunity to barley yellow dwarf virus

2000 • 247 citations

PLASMODESMATA IN RELATION TO VIRAL MOVEMENT WITHIN LEAF TISSUES

1994 • 244 citations

Evidence that processed small dsRNAs may mediate sequence-specific mRNA degradation during RNAi in Drosophila embryos

2000 • 239 citations

DNA methylation and chromatin structure affect transcriptional and post-transcriptional transgene silencing in Arabidopsis

2000 • 238 citations

Strong host resistance targeted against a viral suppressor of the plant gene silencing defence mechanism

1999 • 235 citations

Transgene and gene suppression: telling us something new?

1995 • 218 citations

The contributions of retroelements to plant genome organization, function and evolution

1996 • 217 citations

A model for RNA-mediated gene silencing in higher plants.

1998 • 213 citations

De novomethylation and co-suppression induced by a cytoplasmically replicating plant RNA virus

1998 • 195 citations

Alu transcripts: cytoplasmic localisation and regulation by DNA methylation

1994 • 162 citations

High-efficiency silencing of a beta-glucuronidase gene in rice is correlated with repetitive transgene structure but is independent of DNA methylation.

2000 • 152 citations

A Link Between RNA Interference and Nonsense-Mediated Decay in Caenorhabditis elegans

2000 • 145 citations

Retraction: ‘Viral pathogenicity determinants are suppressors of transgene silencing in Nicotiana benthamiana’

2015 • 144 citations

Cell‐to‐cell movement of potato spindle tuber viroid

1997 • 134 citations

Suppression of Virus Accumulation in Transgenic Plants Exhibiting Silencing of Nuclear Genes

1996 • 128 citations

Detection of Several mRNA Species in Rice Phloem Sap

1998 • 126 citations

The MAR-Mediated Reduction in Position Effect Can Be Uncoupled from Copy Number-Dependent Expression in Transgenic Plants.

1995 • 122 citations

The Mutator Transposable Element System of Maize

1996 • 119 citations

Replication of tobacco mosaic virus RNA

1999 • 117 citations

Plant Transposable Elements

1997 • 116 citations

Stable and heritable inhibition of the expression of nopaline synthase in tobacco expressing antisense RNA

1987 • 106 citations

Replicating satellite RNA induces sequence-specific DNA methylation and truncated transcripts in plants

2001 • 97 citations

Distinct features of post‐transcriptional gene silencing by antisense transgenes in single copy and inverted T‐DNA repeat loci

2000 • 89 citations

Post‐transcriptional silencing of a neomycin phosphotransferase II transgene correlates with the accumulation of unproductive RNAs and with increased cytosine methylation of 3′ flanking regions

1997 • 87 citations

Characterization of the major transcripts encoded by the regulatory MuDR transposable element of maize.

1995 • 85 citations

Epigenetic regulation of the maize Spm transposable element: Novel activation of a methylated promoter by TnpA

1994 • 85 citations

Characterization of Post-Transcriptionally Suppressed Transgene Expression That Confers Resistance to Tobacco Etch Virus Infection in Tobacco.

1997 • 79 citations

Somatic inactivation and reactivation of Ac associated with changes in cytosine methylation and transposase expression.

1994 • 74 citations

Molecular cloning and characterization of a rabbit eIF2C protein

1998 • 69 citations

Detailed characterization of the posttranscriptional gene-silencing-related small RNA in a GUS gene-silenced tobacco

2000 • 66 citations

Virus-induced cell death in plants expressing the mammalian 2′,5′ oligoadenylate system

1996 • 62 citations

Stochastic and Nonstochastic Post-Transcriptional Silencing of Chitinase and β-1,3-Glucanase Genes Involves Increased RNA Turnover—Possible Role for Ribosome-Independent RNA Degradation

1999 • 51 citations

Post‐transcriptional gene silencing of ACC synthase in tomato results from cytoplasmic RNA degradation

1997 • 45 citations

Plant viral suppressors of post‐transcriptional silencing do not suppress transcriptional silencing

2000 • 37 citations

Developments in plant virus taxonomy since the publication of the 6th ICTV Report

1999 • 30 citations

Characterization of Post-Transcriptionally Suppressed Transgene Expression That Confers Resistance to Tobacco Etch Virus Infection in Tobacco

1997 • 23 citations