Vinca Site Agents Induce Structural Changes in Tubulin Different from and Antagonistic to Changes Induced by Colchicine Site Agents

The role of the cytoskeletal protein, tubulin, in the mode of action and mechanism of drug resistance to benzimidazoles

1988 • 548 citations

Antimitotic natural products combretastatin A-4 and combretastatin A-2: studies on the mechanism of their inhibition of the binding of colchicine to tubulin

1989 • 407 citations

Properties of colchicine binding protein from chick embryo brain. Interactions with vinca alkaloids and podophyllotoxin

1970 • 391 citations

Binding of dolastatin 10 to tubulin at a distinct site for peptide antimitotic agents near the exchangeable nucleotide and vinca alkaloid sites.

1990 • 280 citations

Interactions of colchicine with tubulin

1991 • 276 citations

The chemistry of taxol

1991 • 250 citations

Aggregation of microtubule subunit protein. Effects of divalent cations, colchicine, and vinblastine

1970 • 237 citations

Tubulin sulfhydryl groups as probes and targets for antimitotic and antimicrotubule agents

1991 • 205 citations

Natural products which interact with tubulin in the vinca domain: Maytansine, rhizoxin, phomopsin a, dolastatins 10 and 15 and halichondrin B

1992 • 186 citations

Podophyllotoxin, steganacin and combretastatin: Natural products that bind at the colchicine site of tubulin

1993 • 172 citations

Localization of the colchicine-binding site of tubulin.

1993 • 156 citations

Interactions of the catharanthus (Vinca) alkaloids with tubulin and microtubules

1991 • 145 citations

Effect of antimitotic drugs on tubulin GTPase activity and self-assembly.

1979 • 142 citations

Interaction of Vinblastine with Calf Brain Microtubule protein.

1975 • 140 citations

Conformational states of tubulin liganded to colchicine, tropolone methyl ether, and podophyllotoxin

1982 • 137 citations

SUBSTRUCTURAL ANALYSIS OF THE MICROTUBULE AND ITS POLYMORPHIC FORMS*

1975 • 121 citations

Rhizoxin binding to tubulin at the maytansine-binding site

1987 • 117 citations

Molecular mechanism of colchicine action: Induced local unfolding of .beta.-tubulin

1993 • 100 citations

Maytansine binding to the vinblastine sites of tubulin

1977 • 99 citations

Tubulin aggregation and disaggregation: mediation by two distinct vinblastine-binding sites.

1976 • 92 citations

Proteolysis of tubulin and the substructure of the tubulin dimer.

1986 • 88 citations

Interaction of vinblastine with calf brain tubulin: multiple equilibria

1986 • 82 citations

Microtubule-Macrotubule Transitions: Intermediates after Exposure to the Mitotic Inhibitor Vinblastine

1974 • 78 citations

.beta.2-Tubulin, a form of chordate brain tubulin with lesser reactivity toward an assembly-inhibiting sulfhydryl-directed cross-linking reagent

1982 • 71 citations

Purification and biochemical characterization of tubulin from the budding yeast Saccharomyces cerevisiae

1993 • 68 citations

Direct photoaffinity labeling of tubulin with guanosine 5'-triphosphate

1985 • 60 citations

Direct photoaffinity labeling of tubulin with colchicine.

1991 • 59 citations

Maytansine inhibits nucleotide binding at the exchangeable site of tubulin

1985 • 53 citations

Contrasting effects of maytansine and vinblastine on the alkylation of tubulin sulfhydryls

1981 • 51 citations

Resistance to antimitotic agents as genetic probes of microtubule structure and function

1991 • 50 citations

Photoaffinity labeling of tubulin with (2-nitro-4-azidophenyl)deacetylcolchicine: direct evidence for two colchicine binding sites

1989 • 44 citations

The interaction of vincristine with calf brain tubulin.

1983 • 44 citations

Molecular basis for determining the sensitivity of eucaryotes to the antimitotic drug rhizoxin

1990 • 42 citations

Interaction of rhizoxin with bovine brain tubulin.

1990 • 41 citations

Interaction of vinblastine with calf brain tubulin: effects of magnesium ions

1986 • 40 citations

Effect of colchicine analogs on the dissociation of .alpha..beta. tubulin into subunits: The locus of colchicine binding

1994 • 39 citations

Isolation of microtubule protein from mammalian brain frozen for extended periods of time

1991 • 37 citations

Rhizoxin resistant mutants with an altered β-tubulin gene in Aspergillus nidulans

1989 • 24 citations

Immunological detection of microtubule poison-induced conformational changes in tubulin.

1983 • 21 citations

Identification of the fragment photoaffinity-labeled with azidodansyl-rhizoxin as Met-363-Lys-379 on β-tubulin

1993 • 19 citations

The Colchicine-Induced GTPase Activity of Tubulin: State of the Product. Activation by Microtubule-Promoting Cosolvents

1994 • 14 citations

Aging of tubulin at neutral pH: The destabilizing effect of vinca alkaloids

1992 • 11 citations

Colchicine photosensitizes covalent tubulin dimerization

1992 • 8 citations

Simple and inexpensive preparation of dried polyacrylamide gels for densitometry and/or storage

1989 • 7 citations