Natural products which interact with tubulin in the vinca domain: Maytansine, rhizoxin, phomopsin a, dolastatins 10 and 15 and halichondrin B

Promotion of microtubule assembly in vitro by taxol

1979 • 3,521 citations

Colchicine-binding protein of mammalian brain and its relation to microtubules

1968 • 1,140 citations

The isolation and structure of a remarkable marine animal antineoplastic constituent: dolastatin 10

1987 • 562 citations

Posttranslational Glutamylation of α-tubulin

1990 • 523 citations

Halichondrins - antitumor polyether macrolides from a marine sponge

1986 • 491 citations

Tumor inhibitors. LXXIII. Maytansine, a novel antileukemic ansa macrolide from Maytenus ovatus

1972 • 406 citations

Total synthesis of halichondrin B and norhalichondrin B

1992 • 372 citations

Halichondrin B and homohalichondrin B, marine natural products binding in the vinca domain of tubulin. Discovery of tubulin-based mechanism of action by analysis of differential cytotoxicity data

1991 • 363 citations

Antimitotic Activity of the Potent Tumor Inhibitor Maytansine

1975 • 326 citations

The clinical pharmacology and use of antimicrotubule agents in cancer chemotherapeutics

1991 • 313 citations

Biochemistry of the bacterial catabolism of aromatic compounds in anaerobic environments

1977 • 302 citations

Dolastatin 10, a powerful cytostatic peptide derived from a marine animal

1990 • 298 citations

Tubulin-nucleotide interactions during the polymerization and depolymerization of microtubules

1976 • 281 citations

Binding of dolastatin 10 to tubulin at a distinct site for peptide antimitotic agents near the exchangeable nucleotide and vinca alkaloid sites.

1990 • 280 citations

Norhalichondrin A: an antitumor polyether macrolide from a marine sponge

1985 • 273 citations

Immunoconjugates containing novel maytansinoids: promising anticancer drugs.

1992 • 255 citations

The acetylation of alpha-tubulin and its relationship to the assembly and disassembly of microtubules.

1986 • 252 citations

Characterization of posttranslational modifications in neuron-specific class III beta-tubulin by mass spectrometry.

1991 • 252 citations

Rat Brain Microtubule Protein: Purification and Determination of Covalently Bound Phosphate and Carbohydrate

1972 • 229 citations

Ansamitocin, a group of novel maytansinoid antibiotics with antitumour properties from Nocardia

1977 • 208 citations

Tubulin sulfhydryl groups as probes and targets for antimitotic and antimicrotubule agents

1991 • 205 citations

Antineoplastic agents. 219. Isolation and structure of the cell growth inhibitory constituents from the western Pacific marine sponge Axinella sp

1991 • 185 citations

Incorporation of l-Tyrosine, l-Phenylalanine and l-3,4-Dihydroxyphenylalanine as Single Units into Rat Brain Tubulin

1975 • 178 citations

Guanosinetriphosphatase activity of tubulin associated with microtubule assembly.

1977 • 174 citations

Antineoplastic agents. Part 189. The absolute configuration and synthesis of natural (-)-dolastatin 10

1989 • 174 citations

Studies on macrocyclic lactone antibiotics. VII Structure of a phytotoxin "rhizoxin" produced by Rhizopus chinensis.

1984 • 156 citations

Isolation and structure of the cytostatic linear depsipeptide dolastatin 15

1989 • 150 citations

Interactions of the catharanthus (Vinca) alkaloids with tubulin and microtubules

1991 • 145 citations

Turnover of tubulin and the N site GTP in chinese hamster ovary cells

1977 • 138 citations

Tumor inhibitors. 122. The maytansinoids. Isolation, structural elucidation, and chemical interrelation of novel ansa macrolides

1977 • 129 citations

Binding of maytansine to rat brain tubulin

1976 • 123 citations

Dolastatin 15, a potent antimitotic depsipeptide derived from Dolabella auricularia

1992 • 122 citations

Rhizoxin binding to tubulin at the maytansine-binding site

1987 • 117 citations

Rhizoxin, a macrocyclic lactone antibiotic, as a new antitumor agent against human and murine tumor cells and their vincristine-resistant sublines.

1986 • 114 citations

Structural differences between brain beta 1- and beta 2-tubulins: implications for microtubule assembly and colchicine binding.

1985 • 110 citations

Studies on macrocyclic lactone antibiotics. XI. Anti-mitotic and anti-tubulin activity of new antitumor antibiotics, rhizoxin and its homologues.

1987 • 106 citations

Maytansine binding to the vinblastine sites of tubulin

1977 • 99 citations

Tumor inhibitors. 124. Structural requirements for antileukemic activity among the naturally occurring and semisynthetic maytansinoids

1978 • 86 citations

Antineoplastic agent. 174. Isolation and structure of the cytostatic depsipeptide dolastatin 13 from the sea hare Dolabella auricularia

1989 • 82 citations

Interaction of tubulin with drugs and alkylating agents. 2. Effects of colchicine, podophyllotoxin, and vinblastine on the alkylation of tubulin

1981 • 82 citations

Plant antitumour agents: colubrinol acetate and colubrinol, antileukaemic ansa macrolides from Colubrina texensis

1973 • 80 citations

Isolation and Structure of the Cell Growth Inhibitory Depsipeptides Dolastatins 11 and 12

1989 • 76 citations

Effects of inhibitors of tubulin polymerization on GTP hydrolysis.

1981 • 75 citations

Tumor inhibitors. 96. Novel maytansinoids. Structural interrelations and requirements for antileukemic activity

1974 • 75 citations

.beta.2-Tubulin, a form of chordate brain tubulin with lesser reactivity toward an assembly-inhibiting sulfhydryl-directed cross-linking reagent

1982 • 71 citations

Interaction of estramustine phosphate with microtubule‐associated proteins

1985 • 70 citations

Isolation of Toxic Metabolites of Phomopsis leptostromiformis Responsible for Lupinosis

1977 • 69 citations

Interactions of a photoaffinity analog of GTP with the proteins of microtubules.

1977 • 68 citations

Efficient stereoselective synthesis of dolastatin 10, an antineoplastic peptide from a sea hare

1991 • 64 citations

Bis(8-anilinonaphthalene-1-sulfonate) as a probe for tubulin decay

1986 • 64 citations

Structure-activity studies with chiral isomers and with segments of the antimitotic marine peptide dolastatin 10

1990 • 62 citations

Isolation, chemical characterization and structure of ansamitocin, a new antitumor ansamycin antibiotic

1979 • 62 citations

Antineoplastic agents. 150. The structure and synthesis of dolastatin 3

1987 • 61 citations

Initial studies on the cytotoxic action of maytansine, a novel ansa macrolide

1975 • 61 citations

Direct photoaffinity labeling of tubulin with guanosine 5'-triphosphate

1985 • 60 citations

Different effects of tubulin ligands on the intrachain cross-linking of beta 1-tubulin.

1984 • 58 citations

Location of two cysteines in brain β1-tubulin that can be cross-linked after removal of exchangeable GTP

1987 • 58 citations

Antimicrotubule effects of estramustine, an antiprostatic tumor drug.

1985 • 58 citations

Studies on macrocyclic lactone antibiotics. VIII. Absolute structures of rhizoxin and a related compound.

1986 • 57 citations

Role of GTP in the Assembly of Microtubules

1977 • 56 citations

Antineoplastic agents. 220. Synthesis of natural (-)-dolastatin 15

1991 • 54 citations

Antineoplastic agents. 190. Isolation and structure of the cyclodepsipeptide dolastatin 14

1990 • 54 citations

Tumor inhibitors. 107. Novel maytansinoids. Naturally occurring and synthetic antileukemic esters of maytansinol

1975 • 53 citations

Maytansine inhibits nucleotide binding at the exchangeable site of tubulin

1985 • 53 citations

Interaction of phomopsin A and related compounds with purified sheep brain tubulin

1987 • 51 citations

Contrasting effects of maytansine and vinblastine on the alkylation of tubulin sulfhydryls

1981 • 51 citations

The X-ray structure of phomopsin A, a hexapeptide mycotoxin

1986 • 49 citations

Photoaffinity labeling of tubulin subunits with a photoactive analog of vinblastine

1987 • 48 citations

Initial studies on maytansine-induced metaphase arrest in 11210 mürine leukemia cells

1975 • 42 citations

Molecular basis for determining the sensitivity of eucaryotes to the antimitotic drug rhizoxin

1990 • 42 citations

Stoichiometry for guanine nucleotide binding to tubulin under polymerizing and nonpolymerizing conditions

1980 • 41 citations

Interaction of rhizoxin with bovine brain tubulin.

1990 • 41 citations

Studies on macrocyclic lactone antibiotics. IX. Novel macrolides from the fungus Rhizopus chinensis: Precursors of rhizoxin.

1986 • 39 citations

The interaction of phomopsin A with bovine brain tubulin

1989 • 38 citations

Interaction of dolastatin 10 with bovine brain tubulin

1992 • 38 citations

Phomopsin A, the causative agent of lupinosis, interacts with microtubules in vivo and in vitro.

1984 • 37 citations

Physical and spectroscopic methods for the evaluation of the interactions of antimitotic agents with tubulin

1991 • 33 citations

Studies on binding of GTP to the microtubule protein

1974 • 32 citations

Structure elucidation of phomopsin A, a novel cyclic hexapeptide mycotoxin produced by Phomopsis leptostromiformis

1983 • 31 citations

Nucleotides Bound to Brain Tubulin and Reconstituted Microtubules

1974 • 31 citations

Studies on macrocyclic lactone antibiotics. XIII. Anti-tubulin activity and cytotoxicity of rhizoxin derivatives: Synthesis of a photoaffinity derivative.

1991 • 29 citations

Phase I and pharmacokinetic study of rhizoxin.

1992 • 29 citations

Effects of new antimitotic antibiotics, ansamitocins, on the growth of murine tumors in vivo and on the assembly of microtubules in vitro.

1980 • 26 citations

Effect of phomopsin a on the alkylation of tubulin

1990 • 25 citations

Effects of Tau and MAP2 on the interaction of maytansine with tubulin: inhibitory effect of maytansine on vinblastine-induced aggregation of tubulin.

1985 • 25 citations

Interaction of Phomopsin a with porcine brain tubulin

1992 • 24 citations

Rhizoxin resistant mutants with an altered β-tubulin gene in Aspergillus nidulans

1989 • 24 citations

Biosynthesis of the antimitotic antitumour antibiotic rhizoxin by Rhizopus chinensis; origins of the carbon atoms

1986 • 23 citations

Intramolecular ring-opening reactions of 2-oxetanones leading to tetrahydrofuran ring formation: a Lewis-acid study

1990 • 20 citations

Interrelationships of tubulin-GDP and tubulin-GTP in microtubule assembly

1987 • 18 citations

Derivatives of 5,6-diphenylpyridazin-3-one: synthetic antimitotic agents which interact with plant and mammalian tubulin at a new drug-binding site.

1986 • 17 citations

Crystal and molecular structure and absolute configuration of maytansine (3-bromopropyl) ether

1973 • 17 citations

Results of a phase II study of maytansine in patients with breast carcinoma and melanoma.

1979 • 16 citations

Binding of maytansinoids to tubulin

1981 • 16 citations

Maytansine-resistant mutants of Chinese hamster ovary cells with an alteration in α-tubulin

1985 • 15 citations

Fluorescent and photoaffinity labeling derivatives of rhizoxin

1991 • 11 citations

Phase II study of maytansine in patients with advanced lymphomas: an Eastern Cooperative Oncology Group pilot study.

1980 • 7 citations

ALTERATION IN CELL DIVISION, MORPHOLOGY AND MOTILITY INDUCED BY THE TOXIC PRINCIPLE OF LUPINOSIS

1979 • 5 citations