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Memantine treatment reverses anhedonia, normalizes corticosterone levels and increases BDNF levels in the prefrontal cortex induced by chronic mild stress in rats

Data up to Jan 2025

Published2012
Citations75
References64

Total Citations Per Year

Abstract

References (64)

PROTEIN MEASUREMENT WITH THE FOLIN PHENOL REAGENT

1951 • 319,299 citations

The Rat Brain in Stereotaxic Coordinates

1982 • 53,055 citations

The rat brain in stereotaxic coordinates

1983 • 28,962 citations

Antidepressant effects of ketamine in depressed patients

2000 • 3,482 citations

A Randomized Trial of an N-methyl-D-aspartate Antagonist in Treatment-Resistant Major Depression

2006 • 3,477 citations

Neurobiology of Depression

2002 • 3,057 citations

The molecular neurobiology of depression

2008 • 2,600 citations

Essential Role of BDNF in the Mesolimbic Dopamine Pathway in Social Defeat Stress

2006 • 1,997 citations

Physiology of the Neurotrophins

1996 • 1,908 citations

Stress, Depression, and Neuroplasticity: A Convergence of Mechanisms

2007 • 1,669 citations

The cellular neurobiology of depression

2001 • 1,169 citations

Adult brain neurogenesis and psychiatry: a novel theory of depression

2000 • 936 citations

Stress-induced atrophy of apical dendrites of hippocampal CA3c neurons: Involvement of glucocorticoid secretion and excitatory amino acid receptors

1995 • 849 citations

Memantine is a clinically well tolerated N-methyl-d-aspartate (NMDA) receptor antagonist—a review of preclinical data

1999 • 841 citations

Neurotrophic factors: from molecule to man

1994 • 800 citations

Neurotrophin levels in postmortem brains of suicide victims and the effects of antemortem diagnosis and psychotropic drugs

2005 • 570 citations

Neurotrophins and depression

1999 • 538 citations

Neuroimaging Abnormalities in the Amygdala in Mood Disorders

2003 • 517 citations

Mechanism of action of memantine

2005 • 440 citations

Acute administration of ketamine induces antidepressant-like effects in the forced swimming test and increases BDNF levels in the rat hippocampus

2007 • 438 citations

The stress response and the hypothalamic-pituitary-adrenal axis: from molecule to melancholia

2000 • 392 citations

Glucocortcoids mediate the stress-induced extracellular accumulation of glutamate

1994 • 377 citations

Glutamate-based antidepressants: 20 years on

2009 • 376 citations

Emerging role of glutamate in the pathophysiology of major depressive disorder

2009 • 371 citations

Correlation between plasma levels of glutamate, alanine and serine with severity of depression

2006 • 305 citations

Effects of chronic mild stress on the oxidative parameters in the rat brain

2009 • 255 citations

Effects of mood stabilizers on hippocampus BDNF levels in an animal model of mania

2006 • 241 citations

Ketamine treatment reverses behavioral and physiological alterations induced by chronic mild stress in rats

2009 • 233 citations

Animal models and human depressive disorders

1981 • 221 citations

Effects of chronic variate stress on feeding behavior and on monoamine levels in different rat brain structures

2002 • 190 citations

The N-methyl-d-aspartate receptor channel blockers memantine, MRZ 2/579 and other amino-alkyl-cyclohexanes antagonise 5-HT3 receptor currents in cultured HEK-293 and N1E-115 cell systems in a non-competitive manner

2001 • 189 citations

Increased serum glutamate in depressed patients

1982 • 186 citations

Paradigm shift in NMDA receptor antagonist drug development: Molecular mechanism of uncompetitive inhibition by memantine in the treatment of Alzheimer's disease and other neurologic disorders

2005 • 180 citations

Pharmacodynamics of Memantine: An Update

2008 • 159 citations

Potential Antidepressive Properties of Amantadine, Memantine and Bifemelane

1993 • 155 citations

The Neuroprotective Agent Memantine Induces Brain-Derived Neurotrophic Factor and trkB Receptor Expression in Rat Brain

2001 • 146 citations

The role of glutamate on the action of antidepressants

2010 • 141 citations

Increased oxidative stress in submitochondrial particles into the brain of rats submitted to the chronic mild stress paradigm

2008 • 132 citations

Chronic variable stress and partial 5-HT denervation by parachloroamphetamine treatment in the rat: effects on behavior and monoamine neurochemistry

2001 • 122 citations

Chronic Administration of Ketamine Elicits Antidepressant‐Like Effects in Rats without Affecting Hippocampal Brain‐Derived Neurotrophic Factor Protein Levels

2008 • 120 citations

Childhood and adolescent depression: Why do children and adults respond differently to antidepressant drugs?

2007 • 112 citations

An Open-label, Flexible-Dose Study of Memantine in Major Depressive Disorder

2007 • 112 citations

Stress models of depression

2003 • 111 citations

Neurochemical and behavioural effects of acute and chronic memantine administration in rats: Further support for NMDA as a new pharmacological target for the treatment of depression?

2009 • 111 citations

N-acetylcysteine for major depressive episodes in bipolar disorder

2011 • 108 citations

Effects of β-carboline harmine on behavioral and physiological parameters observed in the chronic mild stress model: Further evidence of antidepressant properties

2009 • 99 citations

Direct Inhibitory Effect of Fluoxetine on N-Methyl-D-Aspartate Receptors in the Central Nervous System

2007 • 90 citations

Possible antidepressant effects and mechanisms of memantine in behaviors and synaptic plasticity of a depression rat model

2011 • 82 citations

Anhedonia and activity deficits in rats: impact of post-stroke depression

2008 • 77 citations

Evidence for the involvement of l-arginine-nitric oxide-cyclic guanosine monophosphate pathway in the antidepressant-like effect of memantine in mice

2006 • 73 citations

Protective Effects of N-acetyl-L-cysteine on the Reduction of Dopamine Transporters in the Striatum of Monkeys Treated with Methamphetamine

2004 • 68 citations

Interaction of BDNF/TrkB signaling with NMDA receptor in learning and memory

2004 • 59 citations

Time-dependent effects of escitalopram on brain derived neurotrophic factor (BDNF) and neuroplasticity related targets in the central nervous system of rats

2010 • 57 citations

Predictability of chronic intermittent stress: Effects on sympathetic—adrenal medullary responses of laboratory rats

1990 • 57 citations

Chronic Mild Stress Paradigm Reduces Sweet Food Intake in Rats without Affecting Brain Derived Neurotrophic Factor Protein Levels

2008 • 51 citations

An involvement of BDNF and PI3-K/Akt in the anti-apoptotic effect of memantine on staurosporine-evoked cell death in primary cortical neurons

2009 • 43 citations

Expression of brain-derived neurotrophic factor is not modulated by chronic mild stress in the rat hippocampus and amygdala.

2009 • 39 citations

Repeated co-treatment with fluoxetine and amantadine induces brain-derived neurotrophic factor gene expression in rats.

2009 • 35 citations

Memantine attenuates staurosporine-induced activation of caspase-3 and LDH release in mouse primary neuronal cultures

2005 • 29 citations

Acute treatment with low doses of memantine does not impair aversive, non-associative and recognition memory in rats

2007 • 28 citations

Effect of co-administration of fluoxetine and amantadine on immunoendocrine parameters in rats subjected to a forced swimming test

2009 • 24 citations

Concomitant administration of fluoxetine and amantadine modulates the activity of peritoneal macrophages of rats subjected to a forced swimming test

2009 • 24 citations

Pigment epithelium-derived factor up-regulation induced by memantine, an N-methyl-d-aspartate receptor antagonist, is involved in increased proliferation of hippocampal progenitor cells

2010 • 24 citations

Creatine kinase levels in patients with bipolar disorder: depressive, manic, and euthymic phases

2011 • 17 citations

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