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Memantine is a clinically well tolerated N-methyl-d-aspartate (NMDA) receptor antagonist—a review of preclinical data

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Functional antagonists at the NMDA receptor complex exhibit antidepressant actions

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2002 • 509 citations

Failures and successes of NMDA receptor antagonists: Molecular basis for the use of open-channel blockers like memantine in the treatment of acute and chronic neurologic insults

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Antidepressants for the new millennium

1999 • 358 citations

Roles of NMDA receptor activity and nitric oxide production in brain development

2000 • 337 citations

Dementia of Alzheimer’s disease and other neurodegenerative disorders—memantine, a new hope

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Elevated plasma nitrate levels in depressive states

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Nitric oxide synthase inhibitors have antidepressant-like properties in mice

1999 • 228 citations

Involvement of NMDA receptors and l-arginine-nitric oxide pathway in the antidepressant-like effects of zinc in mice

2003 • 186 citations

Synergistic effect of uncompetitive NMDA receptor antagonists and antidepressant drugs in the forced swimming test in rats

2002 • 173 citations

Antidepressant-like effect of 7-nitroindazole in the forced swimming test in rats

2000 • 168 citations

Antidepressant- and anxiolytic-like effects of selective neuronal NOS inhibitor 1-(2-trifluoromethylphenyl)-imidazole in mice

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Nitric oxide synthase inhibitors augment the effects of serotonin re-uptake inhibitors in the forced swimming test

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Potential Antidepressive Properties of Amantadine, Memantine and Bifemelane

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Serotonergic mediation of the antidepressant-like effects of nitric oxide synthase inhibitors

2003 • 155 citations

Reduction of cGMP and nitric oxide has antidepressant-like effects in the forced swimming test in rats

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Evidence for dual effects of nitric oxide in the forced swimming test and in the tail suspension test in mice

2000 • 124 citations

Effects of potassium channel inhibitors in the forced swimming test: Possible involvement of l-arginine-nitric oxide-soluble guanylate cyclase pathway

2005 • 102 citations

Involvement of nitric oxide–cGMP pathway in the antidepressant-like effects of adenosine in the forced swimming test

2005 • 88 citations

Acute treatments with GMP produce antidepressant-like effects in mice

2000 • 84 citations

Memantine hydrochloride

2004 • 82 citations

Specific localized expression of cGMP PDEs in Purkinje neurons and macrophages

2004 • 69 citations

Dual effects of nitric oxide in the mouse forced swimming test: possible contribution of nitric oxide-mediated serotonin release and potassium channel modulation

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Augmentation of the NO-cGMP cascade induces anxiogenic-like effect in mice.

2003 • 67 citations

Species differences in the localization of cGMP‐producing and NO‐responsive elements in the mouse and rat hippocampus using cGMP immunocytochemistry

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A comparison of the predictive therapeutic and undesired side-effects of the NMDA receptor antagonist, memantine, in mice

2005 • 52 citations

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2003 • 49 citations

Involvement of PKA, MAPK/ERK and CaMKII, but not PKC in the acute antidepressant-like effect of memantine in mice

2005 • 49 citations

Effect of NOS inhibitor on forced swim test and neurotransmitters turnover in the mouse brain.

2002 • 42 citations

Involvement of NO/cGMP pathway in toluene-induced locomotor hyperactivity in female rats

2004 • 23 citations