Ketamine treatment reverses behavioral and physiological alterations induced by chronic mild stress in rats

Lifetime and 12-Month Prevalence of DSM-III-R Psychiatric Disorders in the United States

1994 • 12,456 citations

Antidepressant effects of ketamine in depressed patients

2000 • 3,482 citations

A Randomized Trial of an N-methyl-D-aspartate Antagonist in Treatment-Resistant Major Depression

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A Neurotrophic Model for Stress-Related Mood Disorders

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Physiology of the Neurotrophins

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Reduction of sucrose preference by chronic unpredictable mild stress, and its restoration by a tricyclic antidepressant

1987 • 1,858 citations

Validity, reliability and utility of the chronic mild stress model of depression: a 10-year review and evaluation

1997 • 1,773 citations

Chronic Mild Stress (CMS) Revisited: Consistency and Behavioural-Neurobiological Concordance in the Effects of CMS

2005 • 1,515 citations

Cellular Mechanisms Underlying the Antidepressant Effects of Ketamine: Role of α-Amino-3-Hydroxy-5-Methylisoxazole-4-Propionic Acid Receptors

2007 • 1,050 citations

Recurrence After Recovery From Major Depressive Disorder During 15 Years of Observational Follow-Up

1999 • 861 citations

Role of neurotrophic factors in depression

2006 • 655 citations

Glutamate as a therapeutic target in psychiatric disorders

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Critical role of brain-derived neurotrophic factor in mood disorders

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Acute administration of ketamine induces antidepressant-like effects in the forced swimming test and increases BDNF levels in the rat hippocampus

2007 • 438 citations

The Medical Management of Depression

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The stress response and the hypothalamic-pituitary-adrenal axis: from molecule to melancholia

2000 • 392 citations

Adaptation of N-Methyl-D-Aspartate (NMDA) Receptors following Antidepressant Treatment: Implications for the Pharmacotherapy of Depression

1996 • 341 citations

Decreased plasma BDNF level in depressive patients

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Behavioural and neurochemical effects induced by chronic mild stress applied to two different rat strains

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The persistent risk of chronicity in recurrent episodes of nonbipolar major depressive disorder: a prospective follow-up

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Chronic mild stress inhibits BDNF protein expression and CREB activation in the dentate gyrus but not in the hippocampus proper

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The role of glutamate in mood disorders: Results from the ketamine in major depression study and the presumed cellular mechanism underlying its antidepressant effects

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NMDA Agonists and Antagonists as Probes of Glutamatergic Dysfunction and Pharmacotherapies in Neuropsychiatric Disorders

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Neurotrophin-Mediated Rapid Signaling in the Central Nervous System: Mechanisms and Functions

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Animal models and human depressive disorders

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The neuropharmacology of serotonin and noradrenaline in depression

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Prolonged effect of an anesthetic dose of ketamine on behavioral despair

2002 • 204 citations

Effects of chronic variate stress on feeding behavior and on monoamine levels in different rat brain structures

2002 • 190 citations

The effect of escitalopram, desipramine, electroconvulsive seizures and lithium on brain-derived neurotrophic factor mRNA and protein expression in the rat brain and the correlation to 5-HT and 5-HIAA levels

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Current Trends in the Development of New Antidepressants

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Chronic variable stress and partial 5-HT denervation by parachloroamphetamine treatment in the rat: effects on behavior and monoamine neurochemistry

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Chronic Administration of Ketamine Elicits Antidepressant‐Like Effects in Rats without Affecting Hippocampal Brain‐Derived Neurotrophic Factor Protein Levels

2008 • 120 citations

Stress models of depression

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Depression, Anhedonia, and Psychomotor Symptoms:The Role of Dopaminergic Neurocircuitry

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Determinants of trapping block of N‐methyl‐<scp>d</scp>‐aspartate receptor channels

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Anxiolytic-like effects of AP7 injected into the dorsolateral or ventrolateral columns of the periaqueductal gray of rats

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Increased oxidative stress in submitochondrial particles after chronic amphetamine exposure

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The effect of CGP 37849 and CGP 39551, competitive NMDA receptor antagonists, in the forced swimming test.

1992 • 80 citations

Intravenous ketamine therapy in a patient with a treatment-resistant major depression

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Stressors in the learned helplessness paradigm: Effects on body weight and conditioned taste aversion in rats

1988 • 73 citations

Repeated intravenous ketamine therapy in a patient with treatment-resistant major depression

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Antagonism of non-NMDA receptors in the dorsal periaqueductal grey induces anxiolytic effect in the elevated plus maze

1997 • 61 citations

Predictability of chronic intermittent stress: Effects on sympathetic—adrenal medullary responses of laboratory rats

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Intra-septal infusions of excitatory amino acid receptor antagonists have differential effects in two animal models of anxiety

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Lesions of the dorsal vagal complex abolish increases in meal size induced by NMDA receptor blockade

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Visceral afferent participation in delayed satiation following NMDA receptor blockade

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Enhancement of Antidepressant-Like Effects but Not Brain-Derived Neurotrophic Factor mRNA Expression by the Novel N-Methyl-d-aspartate Receptor Antagonist Neramexane in Mice

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MK801 increases feeding and decreases drinking in nondeprived, freely feeding rats

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Effect of fluvoxamine and N-methyl-D-aspartate receptor antagonists on shock-induced depression in mice.

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Glutamate-mediated neuroplasticity in a limbic input to the hypothalamus

2006 • 10 citations