Promiscuous binding of proinsulin peptides to Type 1 diabetes-permissive and -protective HLA class II molecules

MHC-dependent antigen processing and peptide presentation: Providing ligands for T lymphocyte activation

1994 • 1,448 citations

Specificity and promiscuity among naturally processed peptides bound to HLA-DR alleles.

1993 • 900 citations

Predominant naturally processed peptides bound to HLA-DR1 are derived from MHC-related molecules and are heterogeneous in size

1992 • 763 citations

Several Common HLA-DR Types Share Largely Overlapping Peptide Binding Repertoires

1998 • 647 citations

Development of high potency universal DR-restricted helper epitopes by modification of high affinity DR-blocking peptides

1994 • 516 citations

Cellular immunity to a determinant common to glutamate decarboxylase and coxsackie virus in insulin-dependent diabetes.

1994 • 452 citations

Protection of nonobese diabetic mice from diabetes by intranasal or subcutaneous administration of insulin peptide B-(9-23).

1996 • 415 citations

Structure of a human insulin peptide–HLA-DQ8 complex and susceptibility to type 1 diabetes

2001 • 386 citations

Promiscuous and allele-specific anchors in HLA-DR-binding peptides

1993 • 383 citations

Susceptibility to type I diabetes: HLA-DQ and DR revisited

1996 • 324 citations

Invited anniversary review: HLA associated diseases

1997 • 278 citations

HLA supertypes and supermotifs: a functional perspective on HLA polymorphism

1998 • 244 citations

On the interaction of promiscuous antigenic peptides with different DR alleles. Identification of common structural motifs.

1991 • 242 citations

Purification and characterization of class II histocompatibility antigens from a homozygous human B cell line.

1987 • 222 citations

The class II MHC I-Ag7 molecules from non-obese diabetic mice are poor peptide binders.

1996 • 217 citations

A disease-associated cellular immune response in type 1 diabetics to an immunodominant epitope of insulin

2001 • 210 citations

A Unified Hypothesis for the Complex Genetics of HLA Associations With IDDM

1990 • 190 citations

Naturally processed and presented epitopes of the islet cell autoantigen IA-2 eluted from HLA-DR4

1999 • 159 citations

Antigen processing in the endocytic compartment

2001 • 156 citations

HLA DR4w4-binding motifs illustrate the biochemical basis of degeneracy and specificity in peptide-DR interactions.

1993 • 154 citations

Determinant capture as a possible mechanism of protection afforded by major histocompatibility complex class II molecules in autoimmune disease.

1993 • 146 citations

Major Histocompatibility Complex Class II Molecules Can Protect from Diabetes by Positively Selecting T Cells with Additional Specificities

1998 • 109 citations

A New Look at MHC and Autoimmune Disease

1999 • 105 citations

A Peptide Binding Motif for HLA-DQA1*0102/DQB1*0602, the Class II MHC Molecule Associated with Dominant Protection in Insulin-Dependent Diabetes Mellitus

1998 • 79 citations

Large Protein Fragments as Substrates for Endocytic Antigen Capture by MHC Class II Molecules

1998 • 73 citations

Dissecting the genetics of Type 1 diabetes: relevance for familial clustering and differences in incidence

1998 • 63 citations

Binding of conserved islet peptides by human and murine MHC class II molecules associated with susceptibility to type I diabetes

2000 • 63 citations

HLA-DR binding analysis of peptides from islet antigens in IDDM.

1998 • 63 citations

Antigen‐specific immunotherapy for autoimmune disease: fighting fire with fire?

2001 • 59 citations

Different modes of peptide interaction enable HLA-DQ and HLA-DR molecules to bind diverse peptide repertoires.

1997 • 57 citations

Use of Complete Eluted Peptide Sequence Data from HLA-DR and -DQ Molecules to Predict T Cell Epitopes, and the Influence of the Nonbinding Terminal Regions of Ligands in Epitope Selection

1998 • 48 citations

T Cell Recognition of Human Pre-Proinsulin Peptides Depends on the Polymorphism at HLA DQ Locus: A Study Using HLA DQ8 and DQ6 Transgenic Mice

1997 • 41 citations

The T-cell repertoire available for recognition of self-antigens

2001 • 32 citations

Dissecting the genetics of Type 1 diabetes: relevance for familial clustering and differences in incidence

1998 • 10 citations