The Role of Class II Molecules in Development of Insulin-Dependent Diabetes Mellitus in Mice, Rats and Humans

Structure of the human class I histocompatibility antigen, HLA-A2

1987 • 3,453 citations

The foreign antigen binding site and T cell recognition regions of class I histocompatibility antigens

1987 • 2,403 citations

T cell tolerance by clonal elimination in the thymus

1987 • 2,248 citations

HLA-DQβ gene contributes to susceptibility and resistance to insulin-dependent diabetes mellitus

1987 • 2,045 citations

MHC-Restricted Cytotoxic T Cells: Studies on the Biological Role of Polymorphic Major Transplantation Antigens Determining T-Cell Restriction-Specificity, Function, and Responsiveness

1979 • 1,969 citations

A hypothetical model of the foreign antigen binding site of Class II histocompatibility molecules

1988 • 1,161 citations

EXACERBATIONS OF MULTIPLE SCLEROSIS IN PATIENTS TREATED WITH GAMMA INTERFERON

1987 • 1,062 citations

The Basis for the Immunoregulatory Role of Macrophages and Other Accessory Cells

1987 • 1,040 citations

Limited heterogeneity of T cell receptors from lymphocytes mediating autoimmune encephalomyelitis allows specific immune intervention

1988 • 940 citations

A Molecular Basis for MHC Class II—Associated Autoimmunity

1988 • 707 citations

Positive selection of antigen-specific T cells in thymus by restricting MHC molecules

1988 • 618 citations

Tumour necrosis factor-α in murine autoimmune 'lupus' nephritis

1988 • 599 citations

Syngeneic transfer of autoimmune diabetes from diabetic NOD mice to healthy neonates. Requirement for both L3T4+ and Lyt-2+ T cells.

1987 • 576 citations

Cytotoxicity of Human p I 7 Interleukin-1 for Pancreatic Islets of Langerhans

1986 • 525 citations

Both the Lyt-2+ and L3T4+ T cell subsets are required for the transfer of diabetes in nonobese diabetic mice.

1988 • 455 citations

HLA class II induction in human islet cells by interferon-γ plus tumour necrosis factor or lymphotoxin

1987 • 451 citations

The NOD Mouse: Recessive Diabetogenic Gene in the Major Histocompatibility Complex

1986 • 424 citations

The first external domain of the nonobese diabetic mouse class II I-A beta chain is unique.

1987 • 402 citations

Aspartic acid at position 57 of the HLA-DQ beta chain protects against type I diabetes: a family study.

1988 • 387 citations

Immunotherapy of the Nonobese Diabetic Mouse: Treatment with an Antibody to T-Helper Lymphocytes

1988 • 351 citations

Linkage map of the human major histocompatibility complex including the tumor necrosis factor genes.

1987 • 351 citations

Factors Associated with Early Remission of Type I Diabetes in Children Treated with Cyclosporine

1988 • 330 citations

Prevention of autoimmune insulitis by expression of I–E molecules in NOD mice

1987 • 308 citations

Three Recessive Loci Required for Insulin-Dependent Diabetes in Nonobese Diabetic Mice

1987 • 293 citations

Immunological self/nonself discrimination

1999 • 265 citations

Immunology of Insulin-Dependent Diabetes Mellitus

1985 • 240 citations

Identification of susceptibility loci for insulin-dependent diabetes mellitus by trans-racial gene mapping

1989 • 238 citations

IFN-gamma and tumor necrosis factor-alpha. Cytotoxicity to murine islets of Langerhans.

1988 • 235 citations

Tumour necrosis factor and lymphotoxin genes map close to H–2D in the mouse major histocompatibility complex

1987 • 230 citations

Depletion of RT6.1+ T lymphocytes induces diabetes in resistant biobreeding/Worcester (BB/W) rats.

1987 • 224 citations

Genetic control of diabetes and insulitis in the nonobese diabetic (NOD) mouse.

1987 • 222 citations

HLA-DQ is epistatic to HLA-DR in controlling the immune response to schistosomal antigen in humans

1987 • 212 citations

Defective activation of T suppressor cell function in nonobese diabetic mice. Potential relation to cytokine deficiencies.

1988 • 199 citations

Interaction between Protein-Derived Immunogenic Peptides and Ia

1986 • 180 citations

Absence of the RT-6 T cell subset in diabetes-prone BB/W rats.

1986 • 179 citations

Hyperinducibility of Ia antigen on astrocytes correlates with strain-specific susceptibility to experimental autoimmune encephalomyelitis.

1987 • 163 citations

Spontaneous diabetes mellitus syndrome in the rat. I. Association with the major histocompatibility complex.

1981 • 155 citations

Passive Transfer of Diabetes in the BB/W Rat

1983 • 155 citations

Anti-interleukin 2 receptor antibody suppresses murine diabetic insulitis and lupus nephritis.

1988 • 141 citations

Prevention of diabetes in nonobese diabetic mice by anti-I-A monoclonal antibodies: transfer of protection by splenic T cells.

1988 • 130 citations

Direct evidence for functional self-protein/Ia-molecule complexes in vivo.

1988 • 111 citations

Measuring the genetic contribution of a single locus to a multilocus disease

1984 • 108 citations

In vivo prevention of thyroid and pancreatic autoimmunity in the BB rat by antibody to class II major histocompatibility complex gene products.

1985 • 79 citations

Two genes required for diabetes in BB rats. Evidence from cyclical intercrosses and backcrosses.

1984 • 78 citations

Diabetic BioBreeding/Worcester (BB/Wor) rats need not be lymphopenic.

1986 • 74 citations

Treatment Of NZB/NZW F¹ Hybrid Mice with Mycobacterium Bovis Strain BCG or Type II Interferon Preparations Accelerates Autoimmune Disease

1981 • 69 citations

Transfusions enriched for W3/25+ helper/inducer T lymphocytes prevent spontaneous diabetes in the BB/W rat

1987 • 58 citations

The Molecular Basis of HLA—Disease Association

1989 • 55 citations

Spontaneous diabetes mellitus syndrome in the rat. IV. Immunogenetic interactions of MHC and non-MHC components of the syndrome

1983 • 52 citations

Natural killer cell number and function in the spontaneously diabetic BB/W rat.

1986 • 50 citations

Molecular characterization of MHC class II antigens (? 1 domain) in the BB diabetes-prone and -resistant rat

1989 • 41 citations

Adverse effects of interferon treatment on the life span of NZB mice.

1979 • 39 citations

Cellular typing and functional heterogeneity of MHC-encoded products

1987 • 18 citations

Association of Susceptibility to Spontaneous Diabetes in Rat With Genes of Major Histocompatibility Complex

1988 • 17 citations

Association of susceptibility to spontaneous diabetes in rat with genes of major histocompatibility complex

1988 • 7 citations

MHC‐Linked Diabetogenic Gene in the NOD Mouse Is Not Absolutely Recessive

1988 • 3 citations