The Src family kinase Hck couples BCR/ABL to STAT5 activation in myeloid leukemia cells

Effects of a selective inhibitor of the Abl tyrosine kinase on the growth of Bcr–Abl positive cells

1996 • 3,649 citations

Induction of Chronic Myelogenous Leukemia in Mice by the P210 ^bcr/abl Gene of the Philadelphia Chromosome

1990 • 2,207 citations

SH2 and SH3 Domains: Elements that Control Interactions of Cytoplasmic Signaling Proteins

1991 • 1,931 citations

TRANSCRIPTIONAL RESPONSES TO POLYPEPTIDE LIGANDS: The JAK-STAT Pathway

1995 • 1,826 citations

SH2 and SH3 domains: From structure to function

1992 • 977 citations

Binding of a high affinity phosphotyrosyl peptide to the Src SH2 domain: Crystal structures of the complexed and peptide-free forms

1993 • 758 citations

Acute leukaemia in bcr/abl transgenic mice

1990 • 701 citations

Prolactin induces phosphorylation of Tyr694 of Stat5 (MGF), a prerequisite for DNA binding and induction of transcription.

1994 • 599 citations

Transformation of hematopoietic cells by BCR/ABL requires activation of a PI-3k/Akt-dependent pathway

1997 • 591 citations

STAT5 as a molecular regulator of proliferation, differentiation and apoptosis in hematopoietic cells

1999 • 503 citations

Tyrosyl phosphorylation and DNA binding activity of signal transducers and activators of transcription (STAT) proteins in hematopoietic cell lines transformed by Bcr/Abl.

1996 • 501 citations

P210 and P190 Induce the Tyrosine Phosphorylation and DNA Binding Activity of Multiple Specific STAT Family Members

1996 • 498 citations

Alternative splicing of RNAs transcribed from the human abl gene and from the bcr-abl fused gene

1986 • 489 citations

Constitutive activation of STAT5 by the BCR-ABL oncogene in chronic myelogenous leukemia.

1996 • 452 citations

Phosphatidylinositol-3 kinase activity is regulated by BCR/ABL and is required for the growth of Philadelphia chromosome-positive cells

1995 • 419 citations

Suppression of interleukin-3-induced gene expression by a C-terminal truncated Stat5: role of Stat5 in proliferation.

1996 • 414 citations

BCR sequences essential for transformation by the BCR-ABL oncogene bind to the ABL SH2 regulatory domain in a non-phosphotyrosine-dependent manner

1991 • 375 citations

ErbB Receptor-induced Activation of Stat Transcription Factors Is Mediated by Src Tyrosine Kinases

1999 • 365 citations

Blockade of the Bcr-Abl Kinase Activity Induces Apoptosis of Chronic Myelogenous Leukemia Cells by Suppressing Signal Transducer and Activator of Transcription 5–Dependent Expression of Bcl-XL

2000 • 362 citations

Combined deficiencies of Src, Fyn, and Yes tyrosine kinases in mutant mice.

1994 • 317 citations

BCR/ABL Regulates Mammalian RecA Homologs, Resulting in Drug Resistance

2001 • 315 citations

Signal Transducer and Activator of Transcription (STAT)5 Activation by BCR/ABL Is Dependent on Intact Src Homology (SH)3 and SH2 Domains of BCR/ABL and Is Required for Leukemogenesis

1999 • 283 citations

Constitutive activation of JAKs and STATs in BCR-Abl-expressing cell lines and peripheral blood cells derived from leukemic patients.

1997 • 283 citations

Expression of a Distinctive BCR-ABL Oncogene in Ph ¹ -Positive Acute Lymphocytic Leukemia (ALL)

1988 • 252 citations

STAT5 activation contributes to growth and viability in Bcr/Abl-transformed cells

2000 • 235 citations

Functional overlap in the src gene family: inactivation of hck and fgr impairs natural immunity.

1994 • 232 citations

IL-3 signaling and the role of Src kinases, JAKs and STATs: a covert liaison unveiled

2000 • 225 citations

The state of the STATs: recent developments in the study of signal transduction to the nucleus

1997 • 212 citations

Granulocyte macrophage-colony stimulating factor stimulates both association and activation of phosphoinositide 3OH-kinase and src-related tyrosine kinase(s) in human myeloid derived cells.

1993 • 208 citations

SH3-mediated Hck Tyrosine Kinase Activation and Fibroblast Transformation by the Nef Protein of HIV-1

1997 • 201 citations

STAT5 Activation by BCR-Abl Contributes to Transformation of K562 Leukemia Cells

1999 • 191 citations

Antiapoptotic activity ofStat5required during terminal stages of myeloid differentiation

2000 • 188 citations

Activation of Src kinases p53/56lyn and p59hck by p210bcr/abl in myeloid cells.

1996 • 185 citations

Lyn Physically Associates With the Erythropoietin Receptor and May Play a Role in Activation of the Stat5 Pathway

1998 • 174 citations

Initiation of deregulated growth of multipotent progenitor cells by bcr-abl in vitro

1992 • 170 citations

Src-Related Protein Tyrosine Kinases in Hematopoiesis

1999 • 166 citations

Phosphatidylinositol-3 kinase inhibitors enhance the anti-leukemia effect of STI571

2002 • 154 citations

Reduced lymphomyeloid repopulating activity from adult bone marrow and fetal liver of mice lacking expression of STAT5

2002 • 153 citations

Src kinases and not JAKs activate STATs during IL-3 induced myeloid cell proliferation

1998 • 151 citations

Differential Control of the Phosphorylation State of Proline-juxtaposed Serine Residues Ser725 of Stat5a and Ser730 of Stat5b in Prolactin-sensitive Cells

1998 • 143 citations

Involvement of Jak2 tyrosine phosphorylation in Bcr–Abl transformation

2001 • 140 citations

Selective pyrrolo-pyrimidine inhibitors reveal a necessary role for Src family kinases in Bcr–Abl signal transduction and oncogenesis

2002 • 134 citations

Transcriptional Responses to Polypeptide Ligands: The JAK-STAT Pathway

1995 • 129 citations

Structure-Function Analysis of SH3 Domains: SH3 Binding Specificity Altered by Single Amino Acid Substitutions

1995 • 126 citations

The Src Family Kinase Hck Interacts with Bcr-Abl by a Kinase-independent Mechanism and Phosphorylates the Grb2-binding Site of Bcr

1997 • 124 citations

Deficiency of the Hck and Src tyrosine kinases results in extreme levels of extramedullary hematopoiesis

1996 • 119 citations

Transformation of Myeloid Leukemia Cells to Cytokine Independence by Bcr-Abl Is Suppressed by Kinase-defective Hck

2000 • 117 citations

Complementary functions of the antiapoptotic protein A1 and serine/threonine kinase pim-1 in the BCR/ABL-mediated leukemogenesis

2002 • 116 citations

SH3-dependent stimulation of Src-family kinase autophosphorylation without tail release from the SH2 domain in vivo

2002 • 115 citations

Differential Effects of Prolactin andsrc/abl Kinases on the Nuclear Translocation of STAT5B and STAT5A

1999 • 113 citations

The Bmx Tyrosine Kinase Induces Activation of the Stat Signaling Pathway, Which Is Specifically Inhibited by Protein Kinase Cδ

1997 • 112 citations

Dominant Negative Mutants Implicate STAT5 in Myeloid Cell Proliferation and Neutrophil Differentiation

1999 • 110 citations

Functional Cooperation among Ras, STAT5, and Phosphatidylinositol 3-Kinase Is Required for Full Oncogenic Activities of BCR/ABL in K562 Cells

2002 • 109 citations

Signal transduction by wild-type and leukemogenic Abl proteins

1997 • 107 citations

Signaling Pathways Activated by Oncogenic Forms of Abl Tyrosine Kinase

1999 • 106 citations

Src-Related Protein Tyrosine Kinases in Hematopoiesis

1999 • 103 citations

Src directly tyrosine-phosphorylates STAT5 on its activation site and is involved in erythropoietin-induced signaling pathway

2001 • 93 citations

SH2-containing phosphotyrosine phosphatase Syp is a target of p210bcr-abl tyrosine kinase.

1994 • 90 citations

Regulation of the Src tyrosine kinase and Syp tyrosine phosphatase by their cellular association.

1995 • 80 citations

The SH3 Domain Contributes to BCR/ABL-Dependent Leukemogenesis In Vivo: Role in Adhesion, Invasion, and Homing

1998 • 77 citations

Mechanisms of Transformation by the BCR/ABL Oncogene

2001 • 74 citations

Activation of STAT3 by the c-Fes Protein-tyrosine Kinase

1998 • 73 citations

Molecular Biology of Chronic Myeloid Leukemia

2001 • 59 citations

Platelet-derived growth factor (PDGF)-induced activation of signal transducer and activator of transcription (Stat) 5 is mediated by PDGF beta-receptor and is not dependent on c-src, fyn, jak1 or jak2 kinases.

2000 • 52 citations

Intramolecular interactions of the regulatory domains of the Bcr–Abl kinase reveal a novel control mechanism

1996 • 39 citations

Signaling Domains of the βc Chain of the GM‐CSF/IL‐3/IL‐5 Receptor

1999 • 33 citations

The SH3 Domain Contributes to BCR/ABL-Dependent Leukemogenesis In Vivo: Role in Adhesion, Invasion, and Homing

1998 • 22 citations

Lyn Physically Associates With the Erythropoietin Receptor and May Play a Role in Activation of the Stat5 Pathway

1998 • 15 citations

Platelet-derived growth factor (PDGF)-induced activation of signal transducer and activator of transcription (Stat) 5 is mediated by PDGF β-receptor and is not dependent on c-Src, Fyn, Jak1 or Jak2 kinases

2000 • 13 citations

Dominant Negative Mutants Implicate STAT5 in Myeloid Cell Proliferation and Neutrophil Differentiation

1999 • 7 citations