BCR/ABL Regulates Mammalian RecA Homologs, Resulting in Drug Resistance

DNA Repair and Mutagenesis

2006 • 4,725 citations

Effects of a selective inhibitor of the Abl tyrosine kinase on the growth of Bcr–Abl positive cells

1996 • 3,649 citations

Chronic Myeloid Leukemia

1999 • 1,639 citations

Association of BRCA1 with Rad51 in Mitotic and Meiotic Cells

1997 • 1,466 citations

XRCC3 promotes homology-directed repair of DNA damage in mammalian cells

1999 • 1,322 citations

BRCA2 Is Required for Homology-Directed Repair of Chromosomal Breaks

2001 • 980 citations

Rad51-deficient vertebrate cells accumulate chromosomal breaks prior to cell death

1998 • 793 citations

Role of BRCA2 in Control of the RAD51 Recombination and DNA Repair Protein

2001 • 691 citations

Transformation of hematopoietic cells by BCR/ABL requires activation of a PI-3k/Akt-dependent pathway

1997 • 591 citations

The Breast Cancer Susceptibility Gene BRCA1 Is Required for Subnuclear Assembly of Rad51 and Survival following Treatment with the DNA Cross-linking Agent Cisplatin

2000 • 565 citations

Chromosome Instability and Defective Recombinational Repair in Knockout Mutants of the Five Rad51 Paralogs

2001 • 519 citations

The P190, P210, and P230 Forms of the BCR/ABL Oncogene Induce a Similar Chronic Myeloid Leukemia–like Syndrome in Mice but Have Different Lymphoid Leukemogenic Activity

1999 • 503 citations

BCR-ABL maintains resistance of chronic myelogenous leukemia cells to apoptotic cell death [published erratum appears in Blood 1994 Jun 15;83(12):3835]

1994 • 495 citations

Alternative splicing of RNAs transcribed from the human abl gene and from the bcr-abl fused gene

1986 • 489 citations

Antibody to HER-2/neu receptor blocks DNA repair after cisplatin in human breast and ovarian cancer cells.

1994 • 439 citations

Phosphatidylinositol-3 kinase activity is regulated by BCR/ABL and is required for the growth of Philadelphia chromosome-positive cells

1995 • 419 citations

Suppression of interleukin-3-induced gene expression by a C-terminal truncated Stat5: role of Stat5 in proliferation.

1996 • 414 citations

BRCA2 is required for ionizing radiation-induced assembly of Rad51 complex in vivo.

1999 • 406 citations

BCR-ABL maintains resistance of chronic myelogenous leukemia cells to apoptotic cell death [published erratum appears in Blood 1994 Jun 15;83(12):3835]

1994 • 378 citations

Synergistic actions of Rad51 and Rad52 in recombination and DNA repair

1998 • 367 citations

BCR-ABL-mediated inhibition of apoptosis with delay of G2/M transition after DNA damage: a mechanism of resistance to multiple anticancer agents

1995 • 363 citations

Bcr-Abl Exerts Its Antiapoptotic Effect Against Diverse Apoptotic Stimuli Through Blockage of Mitochondrial Release of Cytochrome C and Activation of Caspase-3

1998 • 319 citations

Overexpression of Rad51 protein stimulates homologous recombination and increases resistance of mammalian cells to ionizing radiation

1998 • 314 citations

Signal Transducer and Activator of Transcription (STAT)5 Activation by BCR/ABL Is Dependent on Intact Src Homology (SH)3 and SH2 Domains of BCR/ABL and Is Required for Leukemogenesis

1999 • 283 citations

Radiation-induced Assembly of Rad51 and Rad52 Recombination Complex Requires ATM and c-Abl

1999 • 272 citations

Expression of a Distinctive BCR-ABL Oncogene in Ph ¹ -Positive Acute Lymphocytic Leukemia (ALL)

1988 • 252 citations

Xrcc3 Is Required for Assembly of Rad51 Complexes in Vivo

1998 • 251 citations

Homologous recombination and the roles of double-strand breaks

1995 • 234 citations

Coupled Homologous and Nonhomologous Repair of a Double-Strand Break Preserves Genomic Integrity in Mammalian Cells

2000 • 233 citations

Regulation of Rad51 Function by c-Abl in Response to DNA Damage

1998 • 217 citations

DNA repair and recombination factor Rad51 is over-expressed in human pancreatic adenocarcinoma

2000 • 209 citations

Role of oncogenes in resistance and killing by cancer therapeutic agents

1997 • 167 citations

JAK-STAT signaling activated by Abl oncogenes

2000 • 144 citations

Sequestration of Mammalian Rad51-Recombination Protein into Micronuclei

1999 • 143 citations

Signaling mismatch repair in cancer

1999 • 133 citations

Homologous-pairing activity of the human DNA-repair proteins Xrcc3⋅Rad51C

2001 • 129 citations

Links between replication, recombination and genome instability in eukaryotes

2000 • 116 citations

In Vitroandin VivoPotentiation of Radiosensitivity of Malignant Gliomas by Antisense Inhibition of the RAD51 Gene

1998 • 115 citations

Ribozyme minigene-mediated RAD51 down-regulation increases radiosensitivity of human prostate cancer cells

2001 • 106 citations

BCR-ABL Delays Apoptosis Upstream of Procaspase-3 Activation

1998 • 100 citations

The two major sites of cbl tyrosine phosphorylation in abl-transformed cells select the crkL SH2 domain.

1996 • 97 citations

ts BCR-ABL kinase activation confers increased resistance to genotoxic damage via cell cycle block.

1996 • 88 citations

Role for Caspase-Mediated Cleavage of Rad51 in Induction of Apoptosis by DNA Damage

1999 • 82 citations

Homologous recombination as a mechanism of carcinogenesis

2001 • 75 citations

Chlorambucil induction of HsRad51 in B-cell chronic lymphocytic leukemia.

1999 • 57 citations

v-src induces cisplatin resistance by increasing the repair of cisplatin-DNA interstrand cross-links in human gallbladder adenocarcinoma cells

1999 • 53 citations

Characterization of the human Rad51 genomic locus and examination of tumors with 15q14-15 loss of heterozygosity (LOH).

1999 • 47 citations