Emerging roles of DP and CRTH2 in allergic inflammation

Anti-inflammatory cyclopentenone prostaglandins are direct inhibitors of IκB kinase

2000 • 1,337 citations

Inducible cyclooxygenase may have anti-inflammatory properties

1999 • 1,246 citations

Prostaglandin D2 Selectively Induces Chemotaxis in T Helper Type 2 Cells, Eosinophils, and Basophils via Seven-Transmembrane Receptor Crth2

2001 • 1,072 citations

Prostanoid Receptors: Subtypes and Signaling

2001 • 1,003 citations

A Critical Role for Eosinophils in Allergic Airways Remodeling

2004 • 851 citations

Pharmacology and signaling of prostaglandin receptors: Multiple roles in inflammation and immune modulation

2004 • 809 citations

Mixed messages: modulation of inflammation and immune responses by prostaglandins and thromboxanes

2001 • 733 citations

Prostaglandin D ₂ as a Mediator of Allergic Asthma

2000 • 731 citations

Defining a Link with Asthma in Mice Congenitally Deficient in Eosinophils

2004 • 701 citations

Mixed messages: modulation of inflammation and immune responses by prostaglandins and thromboxanes

2001 • 692 citations

Myeloid dendritic cells induce Th2 responses to inhaled antigen, leading to eosinophilic airway inflammation

2000 • 513 citations

15d-PGJ2: The anti-inflammatory prostaglandin?

2004 • 329 citations

Prostaglandin D2 is a potent chemoattractant for human eosinophils that acts via a novel DP receptor

2001 • 328 citations

Prostaglandin D2 Causes Preferential Induction of Proinflammatory Th2 Cytokine Production through an Action on Chemoattractant Receptor-Like Molecule Expressed on Th2 Cells

2005 • 259 citations

Peroxisome Proliferator–activated Receptors α and γ Down-regulate Allergic Inflammation and Eosinophil Activation

2003 • 250 citations

Selective modulation of chemokinesis, degranulation, and apoptosis in eosinophils through the PGD2 receptors CRTH2 and DP

2001 • 241 citations

Pronounced Eosinophilic Lung Inflammation and Th2 Cytokine Release in Human Lipocalin-Type Prostaglandin D Synthase Transgenic Mice

2002 • 225 citations

T-cell trafficking in asthma: lipid mediators grease the way

2004 • 218 citations

Activation of the Prostaglandin D2 Receptor DP2/CRTH2 Increases Allergic Inflammation in Mouse

2005 • 213 citations

INFLAMMATORY EFFECTS OF PROSTAGLANDIN D₂ IN RAT AND HUMAN SKIN

1976 • 195 citations

Molecular pharmacology of the human prostaglandin D₂ receptor, CRTH2

2002 • 190 citations

Prostaglandin D2 Inhibits Airway Dendritic Cell Migration and Function in Steady State Conditions by Selective Activation of the D Prostanoid Receptor 1

2003 • 184 citations

An Orally Bioavailable Small Molecule Antagonist of CRTH2, Ramatroban (BAY u3405), Inhibits Prostaglandin D₂-Induced Eosinophil Migration in Vitro

2003 • 158 citations

Prostaglandin D₂ mediates neuronal protection via the DP1 receptor

2004 • 153 citations

Role of Prostanoid DP Receptor Variants in Susceptibility to Asthma

2004 • 146 citations

Cutting Edge: Agonistic Effect of Indomethacin on a Prostaglandin D2 Receptor, CRTH2

2002 • 142 citations

Prevention of allergic inflammation by a novel prostaglandin receptor antagonist, S-5751.

2001 • 137 citations

The second PGD2 receptor CRTH2: structure, properties, and functions in leukocytes

2003 • 135 citations

Allergen-induced accumulation of airway dendritic cells is supported by an increase in CD31hiLy-6Cneg bone marrow precursors in a mouse model of asthma

2002 • 132 citations

Effects of prostaglandin D2 on helper T cell functions

2004 • 116 citations

Prostaglandin D2 Reinforces Th2 Type Inflammatory Responses of Airways to Low-dose Antigen through Bronchial Expression of Macrophage-derived Chemokine

2003 • 116 citations

11-Dehydro-thromboxane B2, a Stable Thromboxane Metabolite, Is a Full Agonist of Chemoattractant Receptor-homologous Molecule Expressed on TH2 Cells (CRTH2) in Human Eosinophils and Basophils

2004 • 113 citations

Monocyte-Derived Dendritic Cells Induce a House Dust Mite-Specific Th2 Allergic Inflammation in the Lung of Humanized SCID Mice: Involvement of CCR7

2002 • 111 citations

Prostaglandin D₂-Induced Eosinophilic Airway Inflammation Is Mediated by CRTH2 Receptor

2004 • 110 citations

Δ12-Prostaglandin J2, a Plasma Metabolite of Prostaglandin D2, Causes Eosinophil Mobilization from the Bone Marrow and Primes Eosinophils for Chemotaxis

2003 • 109 citations

Plasma 9 ,11 -PGF2, a PGD2 metabolite, as a sensitive marker of mast cell activation by allergen in bronchial asthma

2004 • 107 citations

Prostaglandins are powerful inducers of NGF and BDNF production in mouse astrocyte cultures

2004 • 98 citations

Identification of Indole Derivatives Exclusively Interfering with a G Protein-Independent Signaling Pathway of the Prostaglandin D2 Receptor CRTH2

2005 • 96 citations

When 7 transmembrane receptors are not G protein-coupled receptors

2005 • 95 citations

Sequence variants of the gene encoding chemoattractant receptor expressed on Th2 cells (CRTH2) are associated with asthma and differentially influence mRNA stability

2004 • 95 citations

Discovery of a new class of potent, selective, and orally active prostaglandin D2 receptor antagonists

2004 • 95 citations

Activation of the D Prostanoid Receptor 1 Regulates Immune and Skin Allergic Responses

2004 • 90 citations

Molecular cloning, chromosome mapping and characterization of the mouse CRTH2 gene, a putative member of the leukocyte chemoattractant receptor family

1999 • 87 citations

Differential modulation of human basophil functions through prostaglandin D₂ receptors DP and chemoattractant receptor‐homologous molecule expressed on Th2 cells/DP2

2004 • 85 citations

Association of a New-Type Prostaglandin D2 Receptor CRTH2 with Circulating T Helper 2 Cells in Patients with Atopic Dermatitis

2002 • 85 citations

Cutting Edge: Chemoattractant Receptor-Homologous Molecule Expressed on TH2 Cells Plays a Restricting Role on IL-5 Production and Eosinophil Recruitment

2005 • 83 citations

Minor Structural Modifications Convert the Dual TP/CRTH2 Antagonist Ramatroban into a Highly Selective and Potent CRTH2 Antagonist

2005 • 82 citations

Human basophils as effectors and immunomodulators of allergic inflammation and innate immunity

2005 • 79 citations

The DP receptor, allergic inflammation and asthma

2003 • 79 citations

Indomethacin Causes Prostaglandin D2-like and Eotaxin-like Selective Responses in Eosinophils and Basophils

2002 • 76 citations

Benzimidazoles as new potent and selective DP antagonists for the treatment of allergic rhinitis

2004 • 75 citations

15R-Methyl-Prostaglandin D₂Is a Potent and Selective CRTH2/DP₂Receptor Agonist in Human Eosinophils

2003 • 71 citations

CRTH2 is a prominent effector in contact hypersensitivity-induced neutrophil inflammation

2004 • 69 citations

Production of Prostaglandin D2 by Human Osteoblasts and Modulation of Osteoprotegerin, RANKL, and Cellular Migration by DP and CRTH2 Receptors

2005 • 69 citations

Effects of Prostaglandin D₂, 15-Deoxy-Δ^12,14-prostaglandin J₂, and Selective DP₁and DP₂Receptor Agonists on Pulmonary Infiltration of Eosinophils in Brown Norway Rats

2004 • 66 citations

Chemoattractant Receptor-Homologous Molecule Expressed on Th2 Cells Activation in Vivo Increases Blood Leukocyte Counts and Its Blockade Abrogates 13,14-Dihydro-15-keto-prostaglandin D₂-Induced Eosinophilia in Rats

2003 • 64 citations

Profile of prostaglandin levels in the rat hippocampus in pilocarpine model of epilepsy

1995 • 63 citations

Synthesis and Biological Activity of Various Derivatives of a Novel Class of Potent, Selective, and Orally Active Prostaglandin D₂ Receptor Antagonists. 2. 6,6-Dimethylbicyclo[3.1.1]heptane Derivatives

2003 • 61 citations

Prostanoid DP1 receptor agonist inhibits the pruritic activity in NC/Nga mice with atopic dermatitis

2004 • 59 citations

On the Mechanism of Interaction of Potent Surmountable and Insurmountable Antagonists with the Prostaglandin D2 Receptor CRTH2

2006 • 56 citations

Cutting Edge: Prostaglandin D2 Enhances Leukotriene C4 Synthesis by Eosinophils during Allergic Inflammation: Synergistic In Vivo Role of Endogenous Eotaxin

2006 • 52 citations

Effects of Prostaglandin D₂and 5-Lipoxygenase Products on the Expression of CD203c and CD11b by Basophils

2004 • 51 citations

Prostanoid receptor expression by human airway smooth muscle cells and regulation of the secretion of granulocyte colony-stimulating factor

2005 • 50 citations

9α,11β‐PGF₂ and its stereoisomer PGF_2α are novel agonists of the chemoattractant receptor, CRTH2

2005 • 49 citations

Indole-3-acetic Acid Antagonists of the Prostaglandin D₂ Receptor CRTH2

2005 • 48 citations

Identification of a Potent and Selective Synthetic Agonist at the CRTH2 Receptor

2005 • 45 citations

Differential Expression of Genes Involved in Skin Homing, Proliferation, and Apoptosis in CD4+ T Cells of Patients with Atopic Dermatitis

2005 • 34 citations

Gene structure and functional properties of mouse CRTH2, a prostaglandin D2 receptor

2003 • 31 citations

Eicosanoids in Rat Brain during Ischemia and Reperfusion—Correlation to DC Depolarization

1990 • 29 citations

The Th2 response as monitored by CRTH2 or CCR3 expression is severely decreased during septic shock

2004 • 26 citations

Novel Mechanism of Vasodilation in Inflammatory Bowel Disease

2005 • 26 citations

Inhibitory Effect of the 4-Aminotetrahydroquinoline Derivatives, Selective Chemoattractant Receptor-Homologous Molecule Expressed on T Helper 2 Cell Antagonists, on Eosinophil Migration Induced by Prostaglandin D₂

2005 • 25 citations

Structural Determinants of Arylacetic Acid Nonsteroidal Anti-Inflammatory Drugs Necessary for Binding and Activation of the Prostaglandin D₂Receptor CRTH2

2004 • 25 citations

3-Oxa-15-cyclohexyl prostaglandin DP receptor agonists as topical antiglaucoma agents

2002 • 25 citations

Cutting Edge: Yin-Yang: Balancing Act of Prostaglandins with Opposing Functions to Regulate Inflammation

2005 • 24 citations

Isosteric ramatroban analogs: selective and potent CRTH-2 antagonists

2005 • 24 citations

PROSTAGLANDIN D₂ IS THE PREVAILING PROSTAGLANDIN IN THE ACUTE INFLAMMATORY EXUDATE OF URATE ARTHRITIS IN THE CHICKEN

1979 • 22 citations

Development of a prostaglandin D2 receptor antagonist: discovery of a new chemical lead

2005 • 20 citations

Prostaglandin D2 and Interleukin-5 Reduce Crth2 Surface Expression on Human Eosinophils

2004 • 18 citations

Differential prostaglandin formation induced by convulsion in the brain of mice susceptible (DBA/2J) and resistant (CFLP) to acoustic stimulation

1990 • 11 citations

The α_1D-Adrenergic Receptor: Cinderella or Ugly Stepsister

2005 • 7 citations

CRTH2 expression on eosinophils from atopic patients

2004 • 2 citations