Prostaglandin D₂-Induced Eosinophilic Airway Inflammation Is Mediated by CRTH2 Receptor

Prostaglandin D2 Selectively Induces Chemotaxis in T Helper Type 2 Cells, Eosinophils, and Basophils via Seven-Transmembrane Receptor Crth2

2001 • 1,072 citations

Prostaglandin D ₂ as a Mediator of Allergic Asthma

2000 • 731 citations

Cooperation between interleukin-5 and the chemokine eotaxin to induce eosinophil accumulation in vivo.

1995 • 657 citations

Selective Expression of a Novel Surface Molecule by Human Th2 Cells In Vivo

1999 • 383 citations

Relationship between interleukin-5 and eotaxin in regulating blood and tissue eosinophilia in mice.

1997 • 343 citations

Molecular Cloning and Characterization of the Human Prostanoid DP Receptor

1995 • 332 citations

Prostaglandin D2 is a potent chemoattractant for human eosinophils that acts via a novel DP receptor

2001 • 328 citations

CRTH2, an orphan receptor of T‐helper‐2‐cells, is expressed on basophils and eosinophils and responds to mast cell‐derived factor(s)

1999 • 295 citations

Selective modulation of chemokinesis, degranulation, and apoptosis in eosinophils through the PGD2 receptors CRTH2 and DP

2001 • 241 citations

Pronounced Eosinophilic Lung Inflammation and Th2 Cytokine Release in Human Lipocalin-Type Prostaglandin D Synthase Transgenic Mice

2002 • 225 citations

Eotaxin triggers eosinophil-selective chemotaxis and calcium flux via a distinct receptor and induces pulmonary eosinophilia in the presence of interleukin 5 in mice.

1996 • 180 citations

Decreased Level of Vascular Endothelial Growth Factor in Bronchoalveolar Lavage Fluid of Normal Smokers and Patients with Pulmonary Fibrosis

2002 • 154 citations

Eotaxin Triggers Eosmophil-Selective Chemotaxis and Calcium Flux via a Distinct Receptor and Induces Pulmonary Eosinophilia in the Presence of Interleukin 5 in Mice

1996 • 146 citations

Cutting Edge: Agonistic Effect of Indomethacin on a Prostaglandin D2 Receptor, CRTH2

2002 • 142 citations

Prevention of allergic inflammation by a novel prostaglandin receptor antagonist, S-5751.

2001 • 137 citations

Prostaglandin D2 Reinforces Th2 Type Inflammatory Responses of Airways to Low-dose Antigen through Bronchial Expression of Macrophage-derived Chemokine

2003 • 116 citations

Effects of prostaglandin D2 on helper T cell functions

2004 • 116 citations

Urinary excretion of inflammatory mediators during allergen‐induced early and late phase asthmatic reactions

1998 • 111 citations

Δ12-Prostaglandin J2, a Plasma Metabolite of Prostaglandin D2, Causes Eosinophil Mobilization from the Bone Marrow and Primes Eosinophils for Chemotaxis

2003 • 109 citations

Plasma 9 ,11 -PGF2, a PGD2 metabolite, as a sensitive marker of mast cell activation by allergen in bronchial asthma

2004 • 107 citations

Studies on the ocular pharmacology of prostaglandin D2.

1990 • 86 citations

Prostaglandin D2 causes accumulation of eosinophils in the lumen of the dog trachea

1989 • 74 citations

Chemoattractant Receptor-Homologous Molecule Expressed on Th2 Cells Activation in Vivo Increases Blood Leukocyte Counts and Its Blockade Abrogates 13,14-Dihydro-15-keto-prostaglandin D₂-Induced Eosinophilia in Rats

2003 • 64 citations

Cyclooxygenase-2 Expression during Allergic Inflammation in Guinea-Pig Lungs

2002 • 46 citations

Gene structure and functional properties of mouse CRTH2, a prostaglandin D2 receptor

2003 • 31 citations

The effect of a thromboxane A2 receptor antagonist BAY-u-3405 on experimental allergic reactions

1995 • 28 citations

The role of prostanoid TP‐ and DP‐receptors in the bronchoconstrictor effect of inhaled PGD₂ in anaesthetized guinea‐pigs: effect of the DP‐antagonist BW A868C

1990 • 27 citations

Prostaglandin D2 and Interleukin-5 Reduce Crth2 Surface Expression on Human Eosinophils

2004 • 18 citations

Effect of Eotaxin and Platelet-activating Factor on Airway Inflammation and Hyperresponsiveness in Guinea Pigsin Vivo

2000 • 17 citations

Pharmacokinetics and metabolism of the new thromboxane A2 receptor antagonist ramatroban in animals. 1st communication: absorption, concentrations in plasma, metabolism, and excretion after single administration to rats and dogs.

1997 • 5 citations