T-cell trafficking in asthma: lipid mediators grease the way

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2001 • 3,629 citations

Eosinophilic Inflammation in Asthma

1990 • 2,535 citations

Leukotriene B, a potent chemokinetic and aggregating substance released from polymorphonuclear leukocytes

1980 • 2,099 citations

Differential Expression of Chemokine Receptors and Chemotactic Responsiveness of Type 1 T Helper Cells (Th1s) and Th2s

1998 • 2,048 citations

Effects of an interleukin-5 blocking monoclonal antibody on eosinophils, airway hyper-responsìveness, and the late asthmatic response

2000 • 1,834 citations

Flexible Programs of Chemokine Receptor Expression on Human Polarized T Helper 1 and 2 Lymphocytes

1998 • 1,574 citations

Asthma

2001 • 1,547 citations

A highly efficacious lymphocyte chemoattractant, stromal cell-derived factor 1 (SDF-1)

1996 • 1,482 citations

Omalizumab, anti-IgE recombinant humanized monoclonal antibody, for the treatment of severe allergic asthma

2001 • 1,253 citations

MCP-1 and IL-8 trigger firm adhesion of monocytes to vascular endothelium under flow conditions

1999 • 1,228 citations

Prostaglandin D2 Selectively Induces Chemotaxis in T Helper Type 2 Cells, Eosinophils, and Basophils via Seven-Transmembrane Receptor Crth2

2001 • 1,072 citations

IMMUNOLOGIC BASIS OF ANTIGEN-INDUCED AIRWAY HYPERRESPONSIVENESS

1999 • 1,047 citations

Leukotrienes promote plasma leakage and leukocyte adhesion in postcapillary venules: in vivo effects with relevance to the acute inflammatory response.

1981 • 1,030 citations

A G-protein-coupled receptor for leukotriene B4 that mediates chemotaxis

1997 • 990 citations

The anti-IgE antibody omalizumab reduces exacerbations and steroid requirement in allergic asthmatics

2001 • 823 citations

Prostaglandin D ₂ as a Mediator of Allergic Asthma

2000 • 731 citations

The effect of an anti-IgE monoclonal antibody on the early- and late-phase responses to allergen inhalation in asthmatic subjects.

1997 • 719 citations

Human eotaxin is a specific chemoattractant for eosinophil cells and provides a new mechanism to explain tissue eosinophilia

1996 • 698 citations

Prominent neutrophilic inflammation in sputum from subjects with asthma exacerbation

1995 • 686 citations

Prostaglandin D2 generation after activation of rat and human mast cells with anti-IgE.

1982 • 588 citations

Sudden-Onset Fatal Asthma: A Distinct Entity with Few Eosinophils and Relatively More Neutrophils in the Airway Submucosa?

1993 • 588 citations

Targeted Disruption of the Chemokine Eotaxin Partially Reduces Antigen-induced Tissue Eosinophilia

1997 • 537 citations

Migratory Properties of Naive, Effector, and Memory Cd8+ T Cells

2001 • 514 citations

Release of Prostaglandin D₂into Human Airways during Acute Antigen Challenge

1986 • 476 citations

Humanization of an antibody directed against IgE.

1993 • 461 citations

Selective up-regulation of chemokine receptors CCR4 and CCR8 upon activation of polarized human type 2 Th cells.

1998 • 450 citations

Leukotriene B4 receptor BLT1 mediates early effector T cell recruitment

2003 • 416 citations

Effector differentiation is not prerequisite for generation of memory cytotoxic T lymphocytes

2001 • 407 citations

Development of Eosinophilic Airway Inflammation and Airway Hyperresponsiveness in Mast Cell–deficient Mice

1997 • 406 citations

Effects of Th2 Cytokines on Chemokine Expression in the Lung: IL-13 Potently Induces Eotaxin Expression by Airway Epithelial Cells

1999 • 397 citations

High Frequency of IL-4–Producing CD4+ Allergen-Specific T Lymphocytes in Atopic Dermatitis Lesional Skin

1991 • 397 citations

The murine CCR3 receptor regulates both the role of eosinophils and mast cells in allergen-induced airway inflammation and hyperresponsiveness

2002 • 385 citations

Selective Expression of a Novel Surface Molecule by Human Th2 Cells In Vivo

1999 • 383 citations

Leukotriene B4 and BLT1 control cytotoxic effector T cell recruitment to inflamed tissues

2003 • 361 citations

Cutting Edge: Selective Up-Regulation of Chemokine Receptors CCR4 and CCR8 upon Activation of Polarized Human Type 2 Th Cells

1998 • 357 citations

Prostaglandin D2 is a potent chemoattractant for human eosinophils that acts via a novel DP receptor

2001 • 328 citations

The Bronchoconstrictor Effect of Inhaled Prostaglandin D2 in Normal and Asthmatic Men

1984 • 319 citations

The importance of leukotrienes in airway inflammation in a mouse model of asthma.

1996 • 312 citations

Leukotriene B: a potential mediator of inflammation

1980 • 303 citations

Bronchial Neutrophilia in Patients with Noninfectious Status Asthmaticus

1998 • 302 citations

IL-4 Induces Eotaxin: A Possible Mechanism of Selective Eosinophil Recruitment in Helminth Infection and Atopy

1998 • 301 citations

Effect of Treatment With Zileuton, a 5-Lipoxygenase Inhibitor, in Patients With Asthma

1996 • 295 citations

Inducible Expression of a Th2-Type CC Chemokine Thymus- and Activation-Regulated Chemokine by Human Bronchial Epithelial Cells

2000 • 285 citations

Mast cell–dependent migration of effector CD8+ T cells through production of leukotriene B4

2003 • 282 citations

A Novel Human CC Chemokine, Eotaxin-3, Which Is Expressed in IL-4-Stimulated Vascular Endothelial Cells, Exhibits Potent Activity Toward Eosinophils

1999 • 269 citations

CRTH2 is the most reliable marker for the detection of circulating human type 2 Th and type 2 T cytotoxic cells in health and disease

2000 • 261 citations

CRTH2 is the most reliable marker for the detection of circulating human type 2 Th and type 2 T cytotoxic cells in health and disease

2000 • 260 citations

Mouse Monocyte-Derived Chemokine Is Involved in Airway Hyperreactivity and Lung Inflammation

1999 • 256 citations

Evidence for Elevated Levels of Histamine, Prostaglandin D₂, and Other Bronchoconstricting Prostaglandins in the Airways of Subjects with Mild Asthma

1990 • 254 citations

Effects of Arachidonic Acid, Monohydroxyeicosatetraenoic Acid and Prostaglandins on the Release of Mucous Glycoproteins from Human Airways In Vitro

1981 • 252 citations

Passive transfer of immediate hypersensitivity and airway hyperresponsiveness by allergen-specific immunoglobulin (Ig) E and IgG1 in mice.

1996 • 251 citations

Activation of eotaxin gene transcription by NF-kappa B and STAT6 in human airway epithelial cells.

1999 • 235 citations

Interleukin-5 selectively enhances the chemotactic response of eosinophils obtained from normal but not eosinophilic subjects

1992 • 226 citations

Pronounced Eosinophilic Lung Inflammation and Th2 Cytokine Release in Human Lipocalin-Type Prostaglandin D Synthase Transgenic Mice

2002 • 225 citations

Effect of 5-lipoxygenase inhibition on bronchoconstriction and airway inflammation in nocturnal asthma.

1995 • 224 citations

The major source of endogenous prostaglandin D2 production is likely antigen-presenting cells. Localization of glutathione-requiring prostaglandin D synthetase in histiocytes, dendritic, and Kupffer cells in various rat tissues.

1989 • 221 citations

Exhaled leukotrienes and prostaglandins in asthma

2002 • 220 citations

Cutting Edge: Differential Production of Prostaglandin D2 by Human Helper T Cell Subsets

2000 • 202 citations

Increased Leukotrienes in Exhaled Breath Condensate in Childhood Asthma

2002 • 201 citations

5-Lipoxygenase and FLAP

2003 • 198 citations

Bltr Mediates Leukotriene B4–Induced Chemotaxis and Adhesion and Plays a Dominant Role in Eosinophil Accumulation in a Murine Model of Peritonitis

2000 • 198 citations

INFLAMMATORY EFFECTS OF PROSTAGLANDIN D₂ IN RAT AND HUMAN SKIN

1976 • 195 citations

5-Lipoxygenase: Cellular Biology and Molecular Pharmacology

2002 • 192 citations

Activation of Eotaxin Gene Transcription by NF-κB and STAT6 in Human Airway Epithelial Cells

1999 • 186 citations

Spectrum of Prostanoid Release after Bronchoalveolar Allergen Challenge in Atopic Asthmatics and in Control Groups: An Alteration in the Ratio of Bronchoconstrictive to Bronchoprotective Mediators

1989 • 185 citations

Signal Transducer and Activator of Transcription 6 Controls Chemokine Production and T Helper Cell Type 2 Cell Trafficking in Allergic Pulmonary Inflammation

2001 • 182 citations

Interleukin-5 selectively enhances the chemotactic response of eosinophils obtained from normal but not eosinophilic subjects

1992 • 181 citations

Murine Eotaxin-2: A Constitutive Eosinophil Chemokine Induced by Allergen Challenge and IL-4 Overexpression

2000 • 173 citations

Inflammatory cells in asthma: Mechanisms and implications for therapy

2003 • 172 citations

Anaphylactic- and calcium-dependent generation of prostaglandin D2 (PGD2), thromboxane B2, and other cyclooxygenase products of arachidonic acid by dispersed human lung cells and relationship to histamine release.

1984 • 168 citations

Sequential morphologic events during apoptosis of human neutrophils. Modulation by lipoxygenase-derived eicosanoids.

1996 • 168 citations

Neutrophil–Endothelial Cell Interactions: Mechanisms of Neutrophil Adherence to Vascular Endothelium

1989 • 161 citations

Molecular and Biological Characterization of the Murine Leukotriene B4 Receptor Expressed on Eosinophils

1998 • 159 citations

An Orally Bioavailable Small Molecule Antagonist of CRTH2, Ramatroban (BAY u3405), Inhibits Prostaglandin D₂-Induced Eosinophil Migration in Vitro

2003 • 158 citations

Hematopoietic prostaglandin D synthase

2003 • 148 citations

Mast cells modulate allergic pulmonary eosinophilia in mice.

1995 • 147 citations

Genetic Variability in Pulmonary Physiological, Cellular, and Antibody Responses to Antigen in Mice

1999 • 142 citations

Release of Chemical Mediators from Partially Purified Human Lung Mast Cells

1976 • 140 citations

Prevention of allergic inflammation by a novel prostaglandin receptor antagonist, S-5751.

2001 • 137 citations

Airway hyperresponsiveness, but not airway remodeling, is attenuated during chronic pulmonary allergic responses to Aspergillus in CCR4‐/‐ mice

2002 • 136 citations

Human T-lymphocyte subset specificity of the regulatory effects of leukotriene B4.

1984 • 131 citations

Generation of leukotriene C4, leukotriene B4, and prostaglandin D2 by immunologically activated rat intestinal mucosa mast cells.

1988 • 129 citations

Stimulation of matrix metalloproteinase‐dependent migration of T cells by eicosanoids

1995 • 128 citations

Intracellular compartmentalization of leukotriene synthesis: unexpected nuclear secrets

2001 • 124 citations

Mast cells contain spleen-type prostaglandin D synthetase.

1990 • 120 citations

Prostaglandin D synthase gene is involved in the regulation of non-rapid eye movement sleep

2000 • 118 citations

Prostaglandin D2 Reinforces Th2 Type Inflammatory Responses of Airways to Low-dose Antigen through Bronchial Expression of Macrophage-derived Chemokine

2003 • 116 citations

Prostaglandin D2 potentiates airway responsiveness to histamine and methacholine.

1986 • 110 citations

Persistent increase in plasma and urinary leukotrienes after acute asthma.

1995 • 109 citations

In vitro and in vivo effects of leukotriene B4 antagonism in a primate model of asthma.

1996 • 106 citations

CCR8 Is Not Essential for the Development of Inflammation in a Mouse Model of Allergic Airway Disease

2003 • 105 citations

Increased levels of a TH2-type CC chemokine thymus and activation-regulated chemokine (TARC) in serum and induced sputum of asthmatics

2002 • 102 citations

Superoxide production of human polymorphonuclear leukocytes stimulated by leukotriene B4

1984 • 95 citations

Increased levels of a TH2-type CC chemokine thymus and activation-regulated chemokine (TARC) in serum and induced sputum of asthmatics

2002 • 92 citations

The stimulation of lysosomal enzyme secretion from human polymorphonuclear leucocytes by leukotriene B4

1981 • 88 citations

Absence of CCR8 Does Not Impair the Response to Ovalbumin-Induced Allergic Airway Disease

2003 • 87 citations

Association of a New-Type Prostaglandin D2 Receptor CRTH2 with Circulating T Helper 2 Cells in Patients with Atopic Dermatitis

2002 • 85 citations

Transcellular biosynthesis contributes to the production of leukotrienes during inflammatory responses in vivo

2002 • 78 citations

Contrasting in vitro lymphocyte chemotactic activity of the hydroxyl enantiomers of 12‐hydroxy‐5,8,10,14‐eicosatetraenoic acid

1988 • 77 citations

Secretory granule mediator release and generation of oxidative metabolites of arachidonic acid via Fc-IgG receptor bridging in mouse mast cells.

1992 • 76 citations

In vitro and in vivo pharmacological characterization of BIIL 284, a novel and potent leukotriene B(4) receptor antagonist.

2001 • 75 citations

Prostaglandin D2 causes accumulation of eosinophils in the lumen of the dog trachea

1989 • 74 citations

The relationship between airway inflammation and bronchial hyperresponsiveness

1989 • 72 citations

Transcellular biosynthesis contributes to the production of leukotrienes during inflammatory responses in vivo

2002 • 64 citations

BAY u3405, a Thromboxane A2 Antagonist, Reduces Bronchial Hyperresponsiveness in Asthmatics

1996 • 62 citations

Leukotriene and Prostanoid Pathway Enzymes in Bronchial Biopsies of Seasonal Allergic Asthmatics

2001 • 49 citations

Comparative Contractile Responses to Sulfidopeptide Leukotrienes in Normal and Asthmatic Human Subjects

1988 • 43 citations

Mediator concentrations in bronchoalveolar lavage fluid of patients with mild asymptomatic bronchial asthma

1992 • 42 citations

The monocyte‐derived chemokine is released in the bronchoalveolar lavage fluid of steady‐state asthmatics

2003 • 35 citations

GC/MS analysis of urinary excretion of 9α,11β‐PGF₂ in acute and exercise‐induced asthma in children

1998 • 33 citations

Leukotriene B4 levels in the arterial blood of asthmatic patients and the effects of prednisolone

1995 • 31 citations

The possible role of prostaglandin D₂ in the long‐lasting airways vasodilatation induced by allergen in the sensitized pig

1991 • 31 citations

Interleukin (IL)‐4 and to a lesser extent either IL‐13 or interferon‐gamma regulate the production of eotaxin‐2/CCL24 in nasal polyps

2003 • 31 citations

The inter-relation between inflammation and epidermal proliferation in normal skin following epicutaneous application of leukotriene-B4-an immunohistochemical study

1992 • 30 citations

Leukotriene Synthesis Is Increased by Transcriptional Up-Regulation of 5-Lipoxygenase, Leukotriene A₄Hydrolase, and Leukotriene C₄Synthase in Asthmatic Children

2003 • 29 citations

Recombinant interferon-gamma primes alveolar macrophages cultured in vitro for the release of leukotriene B4 in response to IgG stimulation.

1989 • 29 citations

Pathogenesis of Aspirin-Exacerbated Respiratory Disease

2003 • 27 citations

IgE Cross-Linking or Lipopolysaccharide Treatment Induces Recruitment of Th2 Cells to the Lung in the Absence of Specific Antigen

2002 • 27 citations

Kinetics of 5-lipoxygenase activation, arachidonic acid release, and leukotriene synthesis in human neutrophils: Effects of granulocyte-macrophage colony-stimulating factor

1994 • 27 citations

Direct Evidence That LTC₄and LTB₄But Not TXA₂Are Involved in Asthma Attacks in Children

1998 • 25 citations

Inflammatory mediators and cellular infiltration of the lungs in a guinea pig model of the late asthmatic reaction

1991 • 24 citations

Release of arachidonic acid metabolites and histamine from sensitized guinea‐pig lung following antigen challenge

1988 • 23 citations

Central motor conduction time and regional cerebral blood flow in patients with leuko-araiosis

1998 • 21 citations

Pharmacokinetics and pharmacodynamics of the leukotriene B₄ receptor antagonist CP‐105,696 in man following single oral administration

1998 • 21 citations

LTB₄Production and Lysosomal Enzyme Release by Rat Alveolar Macrophages: Effects of Phagocytosis, Receptor Binding, and Ionophore Stimulation

1987 • 16 citations

Immunoglobulin‐G‐dependent stimulation of guinea pig lung mast cells and macrophages

1993 • 14 citations

Deleted Work

1955 • 0 citations