Prostaglandin D2 mediates neuronal protection via the DP1 receptor

Inhibition of forskolin-induced neurite outgrowth and protein phosphorylation by a newly synthesized selective inhibitor of cyclic AMP-dependent protein kinase, N-[2-(p-bromocinnamylamino)ethyl]-5-isoquinolinesulfonamide (H-89), of PC12D pheochromocytoma cells.

1990 • 1,507 citations

Expression of a mitogen-inducible cyclooxygenase in brain neurons: Regulation by synaptic activity and glucocorticoids

1993 • 1,222 citations

Nonsteroidal Antiinflammatory Drugs and the Risk of Alzheimer's Disease

2001 • 1,183 citations

Risk of Alzheimer's disease and duration of NSAID use

1997 • 1,113 citations

Prostaglandin D2 Selectively Induces Chemotaxis in T Helper Type 2 Cells, Eosinophils, and Basophils via Seven-Transmembrane Receptor Crth2

2001 • 1,072 citations

K-252 compounds, novel and potent inhibitors of protein kinase C and cyclic nucleotide-dependent protein kinases

1987 • 947 citations

Induction of apoptosis in cerebellar granule neurons by low potassium: inhibition of death by insulin-like growth factor I and cAMP.

1993 • 886 citations

Prostaglandin D ₂ as a Mediator of Allergic Asthma

2000 • 731 citations

Cyclo-Oxygenase-2 Gene Expression in Neurons Contributes to Ischemic Brain Damage

1997 • 728 citations

Cyclooxygenase-2 is instrumental in Parkinson's disease neurodegeneration

2003 • 634 citations

Is CREB a key to neuronal survival?

2000 • 516 citations

Ligand binding specificities of the eight types and subtypes of the mouse prostanoid receptors expressed in Chinese hamster ovary cells

1997 • 511 citations

Prostaglandin and thromboxane biosynthesis

1991 • 444 citations

Neuroprotective Function of the PGE₂EP2 Receptor in Cerebral Ischemia

2004 • 353 citations

Cyclooxygenase-2 inhibition prevents delayed death of CA1 hippocampal neurons following global ischemia

1998 • 343 citations

Prostaglandin D2 is a potent chemoattractant for human eosinophils that acts via a novel DP receptor

2001 • 328 citations

cAMP analogs promote survival and neurite outgrowth in cultures of rat sympathetic and sensory neurons independently of nerve growth factor.

1988 • 312 citations

Cyclooxygenase 2 inhibition protects motor neurons and prolongs survival in a transgenic mouse model of ALS

2002 • 305 citations

Cyclooxygenase-2 Regulates Prostaglandin E₂Signaling in Hippocampal Long-Term Synaptic Plasticity

2002 • 290 citations

Prostaglandin H Synthase and Xenobiotic Oxidation

1990 • 276 citations

Peroxisome proliferator-activated receptor-gamma ligands reduce neuronal inducible nitric oxide synthase expression and cell death in vivo.

2000 • 257 citations

Dominant expression of mRNA for prostaglandin D synthase in leptomeninges, choroid plexus, and oligodendrocytes of the adult rat brain.

1993 • 239 citations

Lack of tactile pain (allodynia) in lipocalin-type prostaglandin D synthase-deficient mice

1999 • 234 citations

Identification of prostaglandin D2 as a major prostaglandin in homogenates of rat brain

1977 • 232 citations

Molecular characterization of a mouse prostaglandin D receptor and functional expression of the cloned gene.

1994 • 226 citations

Peroxisome Proliferator-Activated Receptor-γ Ligands Reduce Neuronal Inducible Nitric Oxide Synthase Expression and Cell DeathIn Vivo

2000 • 218 citations

Cyclic AMP Elevation Is Sufficient to Promote the Survival of Spinal Motor NeuronsIn Vitro

1998 • 216 citations

Additive neuroprotective effects of creatine and cyclooxygenase 2 inhibitors in a transgenic mouse model of amyotrophic lateral sclerosis

2003 • 199 citations

Prostaglandin D2 in rat brain, spinal cord and pituitary: Basal level and regional distribution

1982 • 197 citations

Molecular pharmacology of the human prostaglandin D₂ receptor, CRTH2

2002 • 190 citations

Dominant localization of prostaglandin D receptors on arachnoid trabecular cells in mouse basal forebrain and their involvement in the regulation of non-rapid eye movement sleep

2001 • 190 citations

Neuronal overexpression of cyclooxygenase‐2 increases cerebral infarction

2003 • 171 citations

Prostaglandin D2 and sleep regulation

1999 • 162 citations

Cyclooxygenase-2-deficient mice are resistant to 1-methyl-4-phenyl1, 2, 3, 6-tetrahydropyridine-induced damage of dopaminergic neurons in the substantia nigra

2002 • 160 citations

Glutamate and non-glutamate receptor mediated toxicity caused by oxygen and glucose deprivation in organotypic hippocampal cultures

1995 • 148 citations

A therapeutic role for cyclooxygenase‐2 inhibitors in a transgenic mouse model of amyotrophic lateral sclerosis

2003 • 141 citations

Prostanoids, not reactive oxygen species, mediate COX‐2–dependent neurotoxicity

2004 • 140 citations

The second PGD2 receptor CRTH2: structure, properties, and functions in leukocytes

2003 • 135 citations

Cellular localization of lipocalin-type prostaglandin D synthase (?-trace) in the central nervous system of the adult rat

2000 • 135 citations

Protection by prostaglandins from glutamate toxicity in cortical neurons☆

1994 • 127 citations

PGE₂ receptors rescue motor neurons in a model of amyotrophic lateral sclerosis

2004 • 123 citations

Role of PPAR-γ Ligands In Neuroprotection against Glutamate-Induced Cytotoxicity in Retinal Ganglion Cells

2003 • 111 citations

15-Deoxy-Δ12,14-prostaglandin J2, a specific ligand for peroxisome proliferator-activated receptor-γ, induces neuronal apoptosis

2001 • 100 citations

Different responsiveness of prostaglandin D₂‐sensitive systems to prostaglandin D₂ and its analogues

1985 • 96 citations

Molecular cloning, chromosome mapping and characterization of the mouse CRTH2 gene, a putative member of the leukocyte chemoattractant receptor family

1999 • 87 citations

Neuroprotective effects of prostaglandin E₂ or cAMP against microglial and neuronal free radical mediated toxicity associated with inflammation

2002 • 85 citations

Formation and Function of Eicosanoids in the Central Nervous System

1989 • 84 citations

Additive Neuroprotective Effects of Creatine and a Cyclooxygenase 2 Inhibitor Against Dopamine Depletion in the 1-Methyl-4-Phenyl-1,2,3,6-Tetrahydropyridine (MPTP) Mouse Model of Parkinson's Disease

2003 • 83 citations

Pharmacological and cardiovascular properties of a hydantoin derivative, BW 245 C, with high affinity and selectivity for PGD2 receptors

1983 • 81 citations

Discovery of Three Novel Orphan G-Protein-Coupled Receptors

1999 • 79 citations

Platelet and cardiovascular activity of the hydantoin BW245C, a potent prostaglandin analogue

1983 • 77 citations

Expression and Molecular Pharmacology of the Mouse CRTH2 Receptor

2003 • 75 citations

The Cycloxygenase-2 inhibitor SC58236 is neuroprotective in an in vivo model of focal ischemia in the rat

2001 • 72 citations

Lipid-Derived Mediators in Endogenous Anti-Inflammation and Resolution: Lipoxins and Aspirin-Triggered 15-epi-Lipoxins

2002 • 71 citations

Profile of prostaglandin levels in the rat hippocampus in pilocarpine model of epilepsy

1995 • 63 citations

Expression of messenger RNA for the prostaglandin D receptor in the leptomeninges of the mouse brain

1997 • 63 citations

Hematopoietic prostaglandin D synthase is expressed in microglia in the developing postnatal mouse brain

2003 • 63 citations

Profile of prostaglandin levels in the rat hippocampus in pilocarpine model of epilepsy

1995 • 56 citations

Neurotoxicity of Acute Glutamate Transport Blockade Depends on Coactivation of Both NMDA and AMPA/Kainate Receptors in Organotypic Hippocampal Cultures

1995 • 53 citations

Prostaglandin DP receptors positively coupled to adenylyl cyclase in embryonic bovine tracheal (EBTr) cells: pharmacological characterization using agonists and antagonists

1999 • 52 citations

Dominant Expression of Rat Prostanoid DP Receptor mRNA in Leptomeninges, Inner Segments of Photoreceptor Cells, Iris Epithelium, and Ciliary Processes

1998 • 52 citations

Selective prostaglandin D2 receptor stimulation elicits ocular hypotensive effects in rabbits and cats

1995 • 34 citations

Eicosanoids in Rat Brain during Ischemia and Reperfusion—Correlation to DC Depolarization

1990 • 29 citations

Microdialysis measurements of PGD2, TXB2 and 6-keto-PGF1α in rat CA1 hippocampus during transient cerebral ischemia

1993 • 27 citations

The formation and regional distribution of prostaglandins D2 and F2α in the brain of spontaneously convulsing gerbils

1985 • 25 citations

Prostaglandin D synthase is the key enzyme in the promotion of physiological sleep.

1993 • 20 citations

Targeted gene disruption of the prostaglandin e2 ep2 receptor

2002 • 13 citations

Differential prostaglandin formation induced by convulsion in the brain of mice susceptible (DBA/2J) and resistant (CFLP) to acoustic stimulation

1990 • 11 citations

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