Anti-inflammatory cyclopentenone prostaglandins are direct inhibitors of IκB kinase

THE NF-κB AND IκB PROTEINS: New Discoveries and Insights

1996 • 5,936 citations

Nuclear Factor-κB — A Pivotal Transcription Factor in Chronic Inflammatory Diseases

1997 • 4,661 citations

The peroxisome proliferator-activated receptor-γ is a negative regulator of macrophage activation

1998 • 3,517 citations

PPAR-γ agonists inhibit production of monocyte inflammatory cytokines

1998 • 2,909 citations

TNF- and Cancer Therapy-Induced Apoptosis: Potentiation by Inhibition of NF-κB

1996 • 2,665 citations

A cytokine-responsive IκB kinase that activates the transcription factor NF-κB

1997 • 2,137 citations

The anti-inflammatory agents aspirin and salicylate inhibit the activity of IκB kinase-β

1998 • 1,561 citations

Inducible cyclooxygenase may have anti-inflammatory properties

1999 • 1,246 citations

Activation of human aortic smooth-muscle cells is inhibited by PPARα but not by PPARγ activators

1998 • 1,138 citations

Complementation Cloning of NEMO, a Component of the IκB Kinase Complex Essential for NF-κB Activation

1998 • 1,070 citations

IKK-γ is an essential regulatory subunit of the IκB kinase complex

1998 • 950 citations

Positive and Negative Regulation of IκB Kinase Activity Through IKKβ Subunit Phosphorylation

1999 • 855 citations

Exploiting Chemical Libraries, Structure, and Genomics in the Search for Kinase Inhibitors

1998 • 792 citations

Cytotoxic T-cell immunity to virus-infected non-haematopoietic cells requires presentation of exogenous antigen

1999 • 586 citations

Embryonic Lethality, Liver Degeneration, and Impaired NF-κB Activation in IKK-β-Deficient Mice

1999 • 581 citations

The use of crevicular fluid prostaglandin E₂ levels as a predictor of periodontal attachment loss

1986 • 497 citations

Direct Phosphorylation of IκB by IKKα and IKKβ: Discrimination Between Free and NF-κB-Bound Substrate

1998 • 450 citations

Lipid mediator networks in cell signaling: update and impact of cytokines ¹

1996 • 401 citations

Evidence for Involvement of NF-κB in the Transcriptional Control of COX-2 Gene Expression by IL-1β

1997 • 390 citations

JNK or IKK, AP-1 or NF-κB, which are the targets for MEK kinase 1 action?

1998 • 217 citations

Inhibition of nuclear factor κB by prostaglandin A₁: An effect associated with heat shock transcription factor activation

1997 • 194 citations

Prostaglandins with antiproliferative activity induce the synthesis of a heat shock protein in human cells.

1989 • 173 citations

Prostaglandin J2--anti-tumour and anti-viral activities and the mechanisms involved.

1990 • 145 citations

Prostaglandin A Compounds as Antiviral Agents

1980 • 115 citations

Antiviral activity of cyclopentenone prostanoids

1997 • 109 citations

2-Cyclopenten-1-one, a New Inducer of Heat Shock Protein 70 with Antiviral Activity

1996 • 101 citations

Function and Regulation of Prostaglandin Synthase 2

1999 • 94 citations

Inhibition of HIV-1 replication by cyclopentenone prostaglandins in acutely infected human cells. Evidence for a transcriptional block.

1996 • 74 citations

Heat shock stimulates the release of arachidonic acid and the synthesis of prostaglandins and leukotriene B₄ in mammalian cells

1989 • 70 citations

Function and Regulation of Prostaglandin Synthase-2

1997 • 63 citations

Expression and localization of cyclooxygenase isoforms and cytosolic phospholipase A2 in anti-Thy-1 glomerulonephritis.

1998 • 60 citations

Increased in vitro bone resorption by monocytes in the hyper-immunoglobulin E syndrome.

1988 • 52 citations