Association of a New-Type Prostaglandin D2 Receptor CRTH2 with Circulating T Helper 2 Cells in Patients with Atopic Dermatitis

TH1 and TH2 Cells: Different Patterns of Lymphokine Secretion Lead to Different Functional Properties

1989 • 7,558 citations

Diagnostic Features of Atopic Dermatitis

1980 • 4,910 citations

Functional diversity of helper T lymphocytes

1996 • 4,512 citations

Lymphocyte Homing and Homeostasis

1996 • 2,934 citations

Prostanoid Receptors: Structures, Properties, and Functions

1999 • 2,395 citations

Differential Expression of Chemokine Receptors and Chemotactic Responsiveness of Type 1 T Helper Cells (Th1s) and Th2s

1998 • 2,048 citations

Flexible Programs of Chemokine Receptor Expression on Human Polarized T Helper 1 and 2 Lymphocytes

1998 • 1,574 citations

The chemokine receptors CXCR3 and CCR5 mark subsets of T cells associated with certain inflammatory reactions.

1998 • 1,382 citations

Lymphokine Production by Human T Cells in Disease States

1994 • 1,351 citations

Inducible cyclooxygenase may have anti-inflammatory properties

1999 • 1,246 citations

The Role of Chemokine Receptors in Primary, Effector, and Memory Immune Responses

2000 • 1,077 citations

Selective Expression of the Eotaxin Receptor CCR3 by Human T Helper 2 Cells

1997 • 1,073 citations

Prostaglandin D2 Selectively Induces Chemotaxis in T Helper Type 2 Cells, Eosinophils, and Basophils via Seven-Transmembrane Receptor Crth2

2001 • 1,072 citations

Chemokines and chemokine receptors in T-cell priming and Th1/Th2-mediated responses

1998 • 918 citations

CCR5⁺and CXCR3⁺T cells are increased in multiple sclerosis and their ligands MIP-1α and IP-10 are expressed in demyelinating brain lesions

1999 • 839 citations

Differential in situ cytokine gene expression in acute versus chronic atopic dermatitis.

1994 • 780 citations

P- and E-selectin mediate recruitment of T-helper-1 but not T-helper-2 cells into inflamed tissues

1997 • 735 citations

Prostaglandin D ₂ as a Mediator of Allergic Asthma

2000 • 731 citations

A role for Th1 and Th2 cells in the immunopathogenesis of atopic dermatitis

1998 • 721 citations

Selective recruitment of CCR4-bearing Th2 cells toward antigen-presenting cells by the CC chemokines thymus and activation-regulated chemokine and macrophage-derived chemokine

1999 • 710 citations

Prostaglandin D2 generation after activation of rat and human mast cells with anti-IgE.

1982 • 588 citations

The cutaneous lymphocyte antigen is a skin lymphocyte homing receptor for the vascular lectin endothelial cell-leukocyte adhesion molecule 1.

1991 • 557 citations

Rules of chemokine receptor association with T cell polarization in vivo

2001 • 472 citations

Selective up-regulation of chemokine receptors CCR4 and CCR8 upon activation of polarized human type 2 Th cells.

1998 • 450 citations

Grading of the severity of atopic dermatitis.

1989 • 419 citations

Biphasic response against aeroallergen in atopic dermatitis showing a switch from an initial TH2 response to a TH1 response in situ: An immunocytochemical study

1996 • 407 citations

Lesional expression of interferon-γ in atopic eczema

1994 • 404 citations

Selective Expression of a Novel Surface Molecule by Human Th2 Cells In Vivo

1999 • 383 citations

In vivo expression of IL-12 and IL-13 in atopic dermatitis

1996 • 380 citations

Cutting Edge: Selective Up-Regulation of Chemokine Receptors CCR4 and CCR8 upon Activation of Polarized Human Type 2 Th Cells

1998 • 357 citations

A Th2 Chemokine, TARC, Produced by Keratinocytes May Recruit CLA+CCR4+ Lymphocytes into Lesional Atopic Dermatitis Skin

2000 • 342 citations

Molecular Cloning and Characterization of the Human Prostanoid DP Receptor

1995 • 332 citations

Bacterial superantigens induce T cell expression of the skin-selective homing receptor, the cutaneous lymphocyte-associated antigen, via stimulation of interleukin 12 production.

1995 • 316 citations

CRTH2, an orphan receptor of T‐helper‐2‐cells, is expressed on basophils and eosinophils and responds to mast cell‐derived factor(s)

1999 • 295 citations

Circulating allergen-reactive T cells from patients with atopic dermatitis and allergic contact dermatitis express the skin-selective homing receptor, the cutaneous lymphocyte-associated antigen.

1995 • 291 citations

Analysis of the Cytokine Pattern Expressed In Situ in Inhalant Allergen Patch Test Reactions of Atopic Dermatitis Patients

1995 • 284 citations

Role of the Parasite-Derived Prostaglandin D2 in the Inhibition of Epidermal Langerhans Cell Migration during Schistosomiasis Infection

2001 • 273 citations

CRTH2 is the most reliable marker for the detection of circulating human type 2 Th and type 2 T cytotoxic cells in health and disease

2000 • 261 citations

CRTH2 is the most reliable marker for the detection of circulating human type 2 Th and type 2 T cytotoxic cells in health and disease

2000 • 260 citations

Transcript imaging of the development of human T helper cells using oligonucleotide arrays

2000 • 230 citations

Enhanced Expression of Eotaxin and CCR3 in Atopic Dermatitis

1999 • 217 citations

Skin-homing, CLA+ memory T cells are activated in atopic dermatitis and regulate IgE by an IL-13-dominated cytokine pattern: IgG4 counter-regulation by CLA- memory T cells.

1997 • 196 citations

INFLAMMATORY EFFECTS OF PROSTAGLANDIN D₂ IN RAT AND HUMAN SKIN

1976 • 195 citations

Skin Levels of Arachidonic Acid-Derived Inflammatory Mediators and Histamine in Atopic Dermatitis and Psoriasis

1986 • 191 citations

The biology and pharmacology of PGD2

1988 • 174 citations

Cyclooxygenase-2-derived prostaglandin D₂is an early anti-inflammatory signal in experimental colitis

2000 • 163 citations

Th1/Th2 subsets: distinct differences in homing and chemokine receptor expression?

1999 • 145 citations

A human homolog of Drosophila warts tumor suppressor, h‐warts, localized to mitotic apparatus and specifically phosphorylated during mitosis

1999 • 104 citations

Predominance of type 2 cytokine–producing CD4+ and CD8+ cells in patients with atopic dermatitis

1997 • 101 citations

Increased circulating skin-homing cutaneous lymphocyte-associated antigen (CLA)+ type 2 cytokine-producing cells, and decreased CLA+ type 1 cytokine-producing cells in atopic dermatitis

2000 • 87 citations

Independent regulation of cutaneous lymphocyte-associated antigen expression and cytokine synthesis phenotype during human CD4+ memory T cell differentiation.

1997 • 73 citations

Functional characterization of skin-infiltrating lymphocytes in atopic dermatitis

1991 • 61 citations

A novel surface molecule of Th2- and Tc2-type cells, CRTH2 expression on human peripheral and decidual CD4+ and CD8+ T cells during the early stage of pregnancy

2001 • 57 citations

Expression of cutaneous lymphocyte-associated antigen on human CD4+ and CD8+ Th2 cells

2000 • 57 citations

Reversal of human allergen-specific CRTH2+ TH2 cells by IL-12 or the PS-DSP30 oligodeoxynucleotide

2001 • 45 citations

The release of prostaglandin D₂ from human skin in vivo and in vitro during immediate allergic reactions

1988 • 40 citations

Prostaglandin D2 and histamine during the immediate and the late-phase components of allergic cutaneous responses

1988 • 33 citations

Cutaneous late‐phase response in food‐allergic children and adolescents with atopic dermatitis

1993 • 25 citations