Structural elements of Gα subunits that interact with Gβγ, receptors, and effectors

The GTPase superfamily: conserved structure and molecular mechanism

1991 • 3,365 citations

The GTPase superfamily: a conserved switch for diverse cell functions

1990 • 2,330 citations

Diversity of G Proteins in Signal Transduction

1991 • 1,990 citations

The βγ subunits of GTP-binding proteins activate the muscarinic K+ channel in heart

1987 • 1,186 citations

Refined crystal structure of the triphosphate conformation of H-ras p21 at 1.35 A resolution: implications for the mechanism of GTP hydrolysis.

1990 • 1,077 citations

Molecular Switch for Signal Transduction: Structural Differences Between Active and Inactive Forms of Protooncogenic ras Proteins

1990 • 1,037 citations

Structure of the guanine-nucleotide-binding domain of the Ha-ras oncogene product p21 in the triphosphate conformation

1989 • 881 citations

Substitution of three amino acids switches receptor specificity of Gqα to that of Giα

1993 • 702 citations

Gustducin is a taste-cell-specific G protein closely related to the transducins

1992 • 662 citations

Isozyme-selective stimulation of phospholipase C-β2 by G protein βγ-subunits

1992 • 630 citations

Hormonal stimulation of adenylyl cyclase through Gi-protein βγ subunits

1992 • 623 citations

Regulation of Gi and Go by mastoparan, related amphiphilic peptides, and hydrophobic amines. Mechanism and structural determinants of activity.

1990 • 600 citations

Purification and properties of the inhibitory guanine nucleotide regulatory unit of brain adenylate cyclase.

1984 • 585 citations

Subunits βγ of heterotrimeric G protein activate β2 isoform of phospholipase C

1992 • 506 citations

Characterization of transducin from bovine retinal rod outer segments. I. Separation and reconstitution of the subunits.

1983 • 492 citations

Site of G Protein Binding to Rhodopsin Mapped with Synthetic Peptides from the α Subunit

1988 • 491 citations

The STE4 and STE18 genes of yeast encode potential β and γ subunits of the mating factor receptor-coupled G protein

1989 • 491 citations

Time-resolved X-ray crystallographic study of the conformational change in Ha-Ras p21 protein on GTP hydrolysis

1990 • 489 citations

Structural basis of β‐adrenergic receptor function

1989 • 480 citations

G Proteins in Signal Transduction

1990 • 479 citations

In vitro mutagenesis and the search for structure-function relationships among G protein-coupled receptors

1992 • 470 citations

Pertussis toxin-catalyzed ADP-ribosylation of transducin. Cysteine 347 is the ADP-ribose acceptor site.

1985 • 457 citations

Regulation of purified subtypes of phosphatidylinositol-specific phospholipase C beta by G protein alpha and beta gamma subunits

1993 • 444 citations

Receptor-to-effector signaling through G proteins: Roles for βγ dimers as well as α subunits

1992 • 441 citations

Rhodopsin, photoreceptor of the rod cell. An emerging pattern for structure and function.

1992 • 439 citations

G-protein βγ-subunits activate the cardiac muscarinic K+-channel via phospholipase A2

1989 • 438 citations

Phospholipase C-β1 is a GTPase-activating protein for Gq/11, its physiologic regulator

1992 • 430 citations

G proteins control diverse pathways of transmembrane signaling ¹

1989 • 399 citations

Adenylyl cyclases

1992 • 397 citations

Selectivity in Signal Transduction Determined by γ Subunits of Heterotrimeric G Proteins

1993 • 393 citations

Different β-subunits determine G-protein interaction with transmembrane receptors

1992 • 390 citations

Rhodopsin Mutants That Bind But Fail to Activate Transducin

1990 • 377 citations

Gi2 mediates alpha 2-adrenergic inhibition of adenylyl cyclase in platelet membranes: in situ identification with G alpha C-terminal antibodies.

1989 • 374 citations

The G protein coupled to the thromboxane A2 receptor in human platelets is a member of the novel Gq family

1991 • 373 citations

Adrenergic Receptors as Models for G Protein-Coupled Receptors

1992 • 340 citations

Signal sorting and amplification through G protein-coupled receptors

1989 • 338 citations

Rhodopsin and phototransduction: a model system for G protein‐linked receptors

1992 • 332 citations

Characterization of transducin from bovine retinal rod outer segments. II. Evidence for distinct binding sites and conformational changes revealed by limited proteolysis with trypsin.

1983 • 331 citations

Regulation of deactivation of photoreceptor G protein by its target enzyme and cGMP

1992 • 324 citations

Antibodies to the alpha q subfamily of guanine nucleotide-binding regulatory protein alpha subunits attenuate activation of phosphatidylinositol 4,5-bisphosphate hydrolysis by hormones.

1991 • 320 citations

Simultaneous coupling of alpha 2-adrenergic receptors to two G-proteins with opposing effects. Subtype-selective coupling of alpha 2C10, alpha 2C4, and alpha 2C2 adrenergic receptors to Gi and Gs.

1992 • 319 citations

G-protein alpha-subunit expression, myristoylation, and membrane association in COS cells.

1990 • 277 citations

Lipid modifications of G protein subunits.

1991 • 274 citations

G _z -Mediated Hormonal Inhibition of Cyclic AMP accumulation

1992 • 258 citations

Identification of receptor contact site involved in receptor–G protein coupling

1987 • 249 citations

The NPXY internalization signal of the LDL receptor adopts a reverse-turn conformation

1991 • 246 citations

Lipid modification at the N terminus of photoreceptor G-protein α-subunit

1992 • 228 citations

Myristoylation of an inhibitory GTP-binding protein alpha subunit is essential for its membrane attachment.

1990 • 225 citations

Mutant α subunits of Gi2 inhibit cyclic AMP accumulation

1991 • 224 citations

Physical and immunological characterization of a guanine nucleotide-binding protein purified from bovine cerebral cortex.

1985 • 205 citations

Beta gamma-subunit activation of G-protein-regulated phospholipase C.

1992 • 197 citations

Family of G protein α chains: amphipathic analysis and predicted structure of functional domains

1986 • 197 citations

Mutagenesis of the beta2-Adrenergic Receptor: How Structure Elucidates Function

1992 • 192 citations

Activation of cytosolic phosphoinositide phospholipase C by G-protein beta gamma subunits

1992 • 188 citations

The biology and medicine of signal transduction

1991 • 185 citations

Mechanisms of muscarinic receptor action on Go in reconstituted phospholipid vesicles

1989 • 180 citations

Identification of effector-activating residues of Gsα

1992 • 180 citations

A mutation that prevents GTP-dependent activation of the α chain of Gs

1988 • 176 citations

Recombinant Gq alpha. Mutational activation and coupling to receptors and phospholipase C.

1992 • 156 citations

Influence of gamma subunit prenylation on association of guanine nucleotide-binding regulatory proteins with membranes.

1992 • 152 citations

The G226A mutant of Gs alpha highlights the requirement for dissociation of G protein subunits.

1992 • 148 citations

Selective tissue distribution of G protein gamma subunits, including a new form of the gamma subunits identified by cDNA cloning.

1992 • 140 citations

Mastoparan interacts with the carboxyl terminus of the alpha subunit of Gi.

1990 • 138 citations

X-ray crystal structures of transforming p21 ras mutants suggest a transition-state stabilization mechanism for GTP hydrolysis.

1992 • 132 citations

Common Modifications of Trimeric G Proteins and ras Protein: Involvement of Polyisoprenylation

1990 • 122 citations

G protein diversity is increased by associations with a variety of gamma subunits.

1990 • 119 citations

Membrane-bound conformation of mastoparan-X, a G-protein-activating peptide

1992 • 113 citations

The amino terminus of G protein alpha subunits is required for interaction with beta gamma.

1988 • 104 citations

A site on rod G protein alpha subunit that mediates effector activation

1992 • 101 citations

Effects of guanyl nucleotides and rhodopsin on ADP-ribosylation of the inhibitory GTP-binding component of adenylate cyclase by pertussis toxin.

1984 • 100 citations

Rhodopsin/transducin interactions. I. Characterization of the binding of the transducin-beta gamma subunit complex to rhodopsin using fluorescence spectroscopy.

1992 • 100 citations

Diversity among the beta subunits of heterotrimeric GTP-binding proteins: Characterization of a novel beta-subunit cDNA

1992 • 99 citations

Gαi-αs chimeras define the function of α chain domains in control of G protein activation and βγ subunit complex interactions

1990 • 95 citations

Isoprenylation of C-terminal cysteine in a G-protein gamma subunit.

1990 • 95 citations

Structural analysis of rod GTP-binding protein, Gt. Limited proteolytic digestion pattern of Gt with four proteases defines monoclonal antibody epitope

1991 • 93 citations

Rhodopsin and the retinal G-protein distinguish among G-protein beta gamma subunit forms

1991 • 87 citations

Mapping of the mastoparan-binding site on G proteins. Cross-linking of [125I-Tyr3,Cys11]mastoparan to Go

1991 • 86 citations

Molecular model of the G protein alpha subunit based on the crystal structure of the HRAS protein.

1989 • 82 citations

Expression and analysis of Gs alpha mutants with decreased ability to activate adenylylcyclase

1991 • 79 citations

GTPase domains of ras p21 oncogene protein and elongation factor Tu: analysis of three-dimensional structures, sequence families, and functional sites.

1991 • 76 citations

Mutagenesis of the amino terminus of the alpha subunit of the G protein Go. In vitro characterization of alpha o beta gamma interactions.

1992 • 75 citations

G protein-bound conformation of mastoparan-X, a receptor-mimetic peptide.

1992 • 73 citations

Rhodopsin/transducin interactions. II. Influence of the transducin-beta gamma subunit complex on the coupling of the transducin-alpha subunit to rhodopsin.

1992 • 70 citations

Topographic analysis of antigenic determinants recognized by monoclonal antibodies to the photoreceptor guanyl nucleotide-binding protein, transducin.

1987 • 68 citations

Transducin inhibition of light-dependent rhodopsin phosphorylation: evidence for beta gamma subunit interaction with rhodopsin.

1988 • 61 citations

A new RAS mutation that suppresses the CDC25 gene requirement for growth of Saccharomyces cerevisiae.

1988 • 52 citations

Deletion within the amino-terminal region of Gs alpha impairs its ability to interact with beta gamma subunits and to activate adenylate cyclase

1991 • 50 citations

Immunoprecipitation of alpha 2a-adrenergic receptor-GTP-binding protein complexes using GTP-binding protein selective antisera. Changes in receptor/GTP-binding protein interaction following agonist binding.

1992 • 46 citations

Promotion of the GTP-liganded state of the Go alpha protein by deletion of the C terminus.

1992 • 46 citations

The carboxyl terminus of Scg1, the G alpha subunit involved in yeast mating, is implicated in interactions with the pheromone receptors.

1991 • 42 citations

Mapping of the carboxyl terminus within the tertiary structure of transducin's alpha subunit using the heterobifunctional cross-linking reagent, 125I-N-(3-iodo-4-azidophenylpropionamido-S-(2-thiopyridyl) cysteine.

1988 • 36 citations

A truncated recombinant alpha subunit of Gi3 with a reduced affinity for beta gamma dimers and altered guanosine 5'-3-O-(thio)triphosphate binding.

1992 • 33 citations

Molecular interactions between the photoreceptor G protein and rhodopsin

1991 • 27 citations

The identification of a domain in Escherichia coli elongation factor Tu that interacts with elongation factor Ts.

1992 • 26 citations

Effect of monoclonal antibody binding on .alpha.-.beta..gamma. subunit interactions in the rod outer segment G protein, Gt

1989 • 26 citations

Genetic and structural analysis of G protein α subunit regulatory domains

1991 • 19 citations

Membrane attachment of recombinant G-protein α-subunits in excess of βγ subunits in a eukaryotic expression system

1989 • 19 citations

Recombinant Gq?: mutational activation and coupling to receptors and phospholipase

1992 • 17 citations

Surfaces of interaction between Gt and rhodopsin in the GDP-bound and empty-pocket configurations.

1990 • 7 citations