Role of membrane lipid asymmetry in aging

Biological Membranes as Bilayer Couples. A Molecular Mechanism of Drug-Erythrocyte Interactions

1974 • 1,362 citations

Lipid Asymmetry in Membranes

1979 • 1,245 citations

Form and function of phospholipids

1973 • 1,072 citations

Membrane Asymmetry

1977 • 965 citations

Microviscosity parameters and protein mobility in biological membranes

1976 • 686 citations

Asymmetrical Lipid Bilayer Structure for Biological Membranes

1972 • 606 citations

Electrostatic Effects on Lipid Phase Transitions: Membrane Structure and Ionic Environment

1974 • 534 citations

Lipid domains in membranes. Evidence derived from structural perturbations induced by free fatty acids and lifetime heterogeneity analysis.

1980 • 513 citations

Acidic phospholipids, unsaturated fatty acids, and limited proteolysis mimic the effect of calmodulin on the purified erythrocyte Ca2+ - ATPase.

1981 • 388 citations

The preferential interactions of cholesterol with different classes of phospholipids

1977 • 374 citations

Enzymatic methylation of phosphatidylethanolamine increases erythrocyte membrane fluidity

1978 • 356 citations

Calcium-induced phase separations in phosphatidylserine-phosphatidylcholine membranes

1974 • 354 citations

Structural aspects of the membrane of the endoplasmic reticulum

1975 • 351 citations

Spectrin as a stabilizer of the phospholipid asymmetry in the human erythrocyte membrane

1978 • 346 citations

The preference of cholesterol for phosphatidylcholine in mixed phosphatidylcholine-phosphatidylethanolamine bilayers

1976 • 338 citations

beta-Adrenergic receptor agonists increase phospholipid methylation, membrane fluidity, and beta-adrenergic receptor-adenylate cyclase coupling.

1979 • 308 citations

The increase of phospholipid bilayer rigidity after lipid peroxidation

1977 • 275 citations

Vertical displacement of membrane proteins mediated by changes in microviscosity.

1976 • 241 citations

Action of pancreatic phospholipase A2 on phosphatidylcholine bilayers in different physical states

1975 • 228 citations

Asymmetric exchange of vesicle phospholipids catalyzed by the phosphatidylcholine exchange protein. Measurement of inside-outside transitions

1975 • 222 citations

Learning and Memory Impairments in Young and Old Alcoholics: Evidence for the Premature‐Aging Hypothesis

1980 • 221 citations

Identification and properties of two methyltransferases in conversion of phosphatidylethanolamine to phosphatidylcholine.

1978 • 221 citations

Enzymatic synthesis and rapid translocation of phosphatidylcholine by two methyltransferases in erythrocyte membranes.

1978 • 199 citations

Topological Asymmetry of Phospholipids in Membranes

1977 • 197 citations

The accumulation of malonyldialdehyde, a product of fatty acid peroxidation, can disturb aminophospholipid organization in the membrane bilayer of human erythrocytes.

1984 • 196 citations

Heterogeneity in the fluidity of intact erythrocyte membrane and its homogenization upon hemolysis

1976 • 179 citations

Myelin Membrane Structure at 10 Å Resolution

1971 • 178 citations

Use of phospholipid exchange protein to measure inside-outside transposition in phosphatidylcholine liposomes

1975 • 172 citations

Isolation and characterization of subcellular membranes with altered phospholipid composition from cultured fibroblasts.

1976 • 166 citations

Glucose transport through cell membranes of modified lipid fluidity

1981 • 161 citations

Correlations between membrane viscosity, serum cholesterol, lymphocyte activation and aging in man

1980 • 160 citations

NMR differentiation of the internal and external phospholipid membrane surfaces using paramagnetic Mn2+ and Eu3+ ions

1971 • 158 citations

The Physiological Basis of Taxes in Paramecium

1982 • 157 citations

LIPID DOMAINS IN MEMBRANES*

1982 • 155 citations

Membrane asymmetry A survey and critical appraisal of the methodology II. Methods for assessing the unequal distribution of lipids

1980 • 151 citations

Age-related modification of dopaminergic and β-adrenergic receptor system: Restoration to normal activity by modifying membrane fluidity with s-adenosylmethionine

1984 • 132 citations

Testing the Theories of Aging

1983 • 132 citations

Erythrocyte Membrane Lipid Reorganization during the Sickling Process

1979 • 131 citations

Lipid translocation across the human erythrocyte membrane. Regulatory factors.

1982 • 130 citations

Degree of exposure of membrane proteins determined by fluorescence quenching

1977 • 125 citations

Hormone receptor changes during adulthood and senescence: significance for aging research.

1979 • 124 citations

Modulation of erythrocyte membrane proteins by membrane cholesterol and lipid fluidity

1979 • 123 citations

Phospholipid asymmetry in LM cell plasma membrane derivatives: polar head group and acyl chain distributions

1978 • 123 citations

The Aging Brain: Cellular and Molecular Mechanisms of Aging in the Nervous System

1983 • 123 citations

Alterations in erythrocyte membrane fluidity by phenylhydrazine-induced peroxidation of lipids

1981 • 122 citations

Phosphatidylcholine mobility in liver microsomal membranes

1978 • 122 citations

Aminophospholipid Asymmetry in Murine Synaptosomal Plasma Membrane

1980 • 117 citations

Molecular interactions between lecithin and sphingomyelin. Temperature- and composition-dependent phase separation.

1977 • 114 citations

What is the function of phospholipid N-methylation?

1983 • 114 citations

Modulation of membrane structure by Ca2+ and dibucaine as detected by 31P NMR

1979 • 112 citations

Asymmetric Transbilayer Distribution of Sterol across Plasma Membranes Determined by Fluorescence Quenching of Dehydroergosterol

1982 • 110 citations

Fluorescent sterols: Probe molecules of membrane structure and function

1984 • 104 citations

Aging brain and ergot alkaloids

1983 • 102 citations

Gross structural changes in isolated liver cell plasma membranes upon binding of insulin

1979 • 102 citations

Phospholipid unsaturation and plasma membrane organization

1975 • 100 citations

The possible functional significance of phosphatidylethanolamine methylation

1980 • 100 citations

Differential Interaction of Cholesterol with Phosphatidylcholine on the Inner and Outer Surfaces of Lipid Bilayer Vesicles

1974 • 99 citations

Kinetic model of the protein-mediated phosphatidylcholine exchange between single bilayer liposomes

1975 • 98 citations

Δ5,7,9(11)-cholestatrien-3β-ol: A fluorescent cholesterol analogue

1984 • 97 citations

Hormone action during aging: Alterations and mechanisms

1979 • 96 citations

Pitfalls and problems in studies on the methylation of phosphatidylethanolamine.

1983 • 95 citations

Molecular basis of age-dependent changes in the activity of adenine nucleotide translocase

1980 • 95 citations

The Modulation of Protein Phosphorylation and Receptor Binding in Synaptic Membranes by Changes in Lipid Fluidity: Implications for Ageing

1982 • 94 citations

Hormone-Calcium Interactions with the Plasma Membrane of Rat Liver Cells

1972 • 92 citations

Monolayer coupling in sphingomyelin bilayer systems

1978 • 92 citations

Dielectric breakdown of the erythrocyte membrane enhances transbilayer mobility of phospholipids

1983 • 84 citations

Viscosity of lymphocyte plasma membrane in aging mice and its possible relation to serum cholesterol

1979 • 84 citations

Investigation of the inside-outside distribution, intermembrane exchange and transbilayer movement of phospholipids in sonicated vesicles by shift reagent NMR

1980 • 82 citations

Asymmetry of lipid organization in cholinergic synaptic vesicle membranes

1983 • 78 citations

Outside-inside distribution and translocation of lysophosphatidylcholine in phosphatidylcholine vesicles as determined by 13C-NMR using (N-13CH3)-enriched lipids

1977 • 76 citations

Biochemical changes of rat brain membranes with aging

1983 • 74 citations

Calcium modulates the lipid dynamics of rat hepatocyte plasma membranes by direct and indirect mechanisms

1980 • 71 citations

Lipid-induced modulation of opiate receptors in mouse brain membranes

1981 • 71 citations

OCCURRENCE AND SIGNIFICANCE OF STEROL PRECURSORS OF CHOLESTEROL IN HUMAN BRAIN TUMOURS*

1964 • 68 citations

Insulin Binding to Cultured Human Fibroblasts Increases with Normal and Precocious Aging

1976 • 67 citations

Desmosterol as the Major Sterol in L-Cell Mouse Fibroblasts Grown in Sterol-Free Culture Medium

1970 • 67 citations

Uncoupling of Ca2+ transport in sarcoplasmic reticulum as a result of labeling lipid amino groups and inhibition of Ca2+-ATPase activity by modification of lysine residues of the Ca2+-ATPase polypeptide.

1982 • 67 citations

THE EFFECTS OF AGE AND ALCOHOL ON (Na⁺+ K⁺)‐ATPASE ACTIVITY OF WHOLE HOMOGENATE AND SYNAPTOSOMES PREPARED FROM MOUSE AND HUMAN BRAIN

1975 • 66 citations

Transbilayer Phospholipid Asymmetry in Plasmodium knowlesi -Infected Host Cell Membrane

1981 • 63 citations

Lysosomes, membranes and aging

1971 • 63 citations

Plasma membrane aminophospholipid distribution in transformed murine fibroblasts

1979 • 58 citations

The rate of cholesterol ‘flip‐flop’ in lipid bilayers and its relation to membrane sterol pools

1974 • 58 citations

Calcium-Induced Cell Death: Susceptibility of Cardiac Myocytes Is Age-Dependent

1981 • 57 citations

Nutritional Approaches to Aging Research

1984 • 56 citations

Recognition of different pools of phosphatidylglycerol in intact cells and isolated membranes of Acholeplasma laidlawii by phospholipase A₂

1977 • 56 citations

Fluorescence Probes as Monitors of Surface Membrane Fluidity Gradients in Murine Fibroblasts

1980 • 55 citations

Age Changes in the Lipid Composition of Whole Homogenates and Isolated Myelin Fractions of Mouse Brain

1972 • 55 citations

Calorimetric behaviour of individual phospholipid classes from human and bovine erythrocyte membranes

1976 • 54 citations

Measurement of phagocytosis usinf fluorescent latex beads

1983 • 53 citations

Biochemistry of ageing

1980 • 53 citations

Lipids of Plasmodium lophurae, and of Erythrocytes and Plasmas of Normal and P. lophurae-Infected Pekin Ducklings

1977 • 51 citations

Quantitative role of base exchange in phosphatidylethanolamine synthesis in isolated rat hepatocytes

1974 • 51 citations

Differences in fluidity between bilayer halves of tumour cell plasma membranes

1978 • 50 citations

Subcellular Biochemistry

1983 • 50 citations

Use of a flourescent sterol to probe the transbilayer distribution of sterols in biological membranes

1981 • 48 citations

Age-related decline in the activitities of erythrocyte membrane adenylate cyclase and protein kinase

1976 • 48 citations

Effect of head group on phospholipid mixing in small, unilamellar vesicles: mixtures of dimyristoylphosphatidylcholine and dimyristoylphosphatidylethanolamine

1978 • 48 citations

A model for the effect of lipid oxidation on diphenylhexatriene fluorescence in phospholipid vesicles

1981 • 48 citations

THE DESMOSTEROL REDUCTASE ACTIVITY OF RAT BRAIN DURING DEVELOPMENT¹

1971 • 46 citations

Glucagon-stimulated adenylate cyclase detects a selective perturbation of the inner half of the liver plasma-membrane bilayer achieved by the local anaesthetic prilocaine

1980 • 46 citations

Studies on brain sterols in normal and pathological conditions

1965 • 46 citations

Age-related alterations in cultured human fibroblast membrane structure and function

1984 • 46 citations

Phosphatidylcholine vesicles with thiocholesterol and a thiocholesterol-linked spin label incorporated in the vesicle wall

1970 • 45 citations

Platelet Phospholipid Asymmetry and its Significance in Hemostasis

1983 • 45 citations

Age-dependent physiochemical and biochemical studies of human red cell membranes

1979 • 45 citations

Electron spin resonance evidence for vertical asymmetry in animal cell membranes

1977 • 45 citations

Membrane alterations in cellular aging: Susceptibility of phospholipids in density (age)-separated human erythrocytes to phospholipase A2

1982 • 45 citations

Phospholipid Methylation Increases [³H]Diazepam and [³H]GABA Binding in Membrane Preparations of Rat Cerebellum

1983 • 43 citations

Phosphatidylinositol distribution and translocation in sonicated vesicles. A study with exchange protein and phospholipase C

1980 • 43 citations

Lipid and lipoprotein distributions in octo- and nonagenarians

1979 • 42 citations

Lack of transbilayer coupling in phase transitions of phosphatidylcholine vesicles

1982 • 40 citations

Endocrine Aspects of Aging

1980 • 40 citations

Modulation of electrical activity in Aplysia neurones by cholesterol

1977 • 39 citations

Neuronal membrane lipid asymmetry

1979 • 39 citations

Opposite Polarity of Filipin-Induced Deformations in the Membrane of Condensing Vacuoles and Zymogen Granules

1980 • 38 citations

EFFECT OF BRAIN CORTEX PHOSPHOLIPIDS ON ADENYLATE‐CYCLASE ACTIVITY OF MOUSE BRAIN

1978 • 37 citations

Altered phospholipid composition affects endocytosis in cultured LM fibroblasts

1981 • 36 citations

Aging and in vivo norepinephrine-uptake in mammalian brain

1976 • 36 citations

Desmosterol in developing rat brain

1965 • 35 citations

Effect of phospholipid oxidation products on transbilayer movement of phospholipids in single lamellar vesicles

1982 • 34 citations

Age dependent changes in the methylation of rat brain phospholipids

1981 • 34 citations

Asymmetric metabolism of phosphatidylethanolamine in the human red cell membrane.

1982 • 33 citations

Proton nuclear magnetic resonance study of the decay of transbilayer compositional asymmetry generated by a phosphatidylcholine exchange protein

1977 • 33 citations

Role of peroxidation in erythrocyte aging

1982 • 33 citations

Plasma membrane associated metabolic parameters and the aging of human diploid fibroblasts

1978 • 32 citations

Neurochemical Studies in Aging Brain. I. Structural Changes in Myelin Lipids

1982 • 31 citations

Fluorescence probes in metastatic B16 melanoma membranes

1984 • 30 citations

Sidedness of Phospholipid Synthesis on Brain Membranes

1982 • 29 citations

Distribution of cytochemically detectable cholesterol in the electric organ of Torpedo marmorata.

1982 • 28 citations

Fluorescence Probes Unravel Asymmetric Structure of Membranes

1985 • 27 citations

Differential effect of cholesterol on two types of 5-hydroxytryptamine binding sites

1983 • 27 citations

The function of phospholipid polar groups in membranes

1977 • 26 citations

Age related differences in binding of Concanavalin a to plasma membranes of isolated neurons

1977 • 26 citations

Determination of the electric potential at the external and internal bilayer-aqueous interfaces of the human erythrocyte membrane using spin probes

1983 • 26 citations

Determination of cholesterol asymmetry by rapid kinetics of filipin-cholesterol association: effect of modification in lipids and proteins

1981 • 26 citations

Fusion of isolated myoblast plasma membranes. An approach to the mechanism

1978 • 25 citations

Red blood cell [14C]cholesterol exchange and plasma cholesterol esterifying activity of normal and sickle cell blood

1982 • 24 citations

Cholinergic stimulation of hippocampal pyramidal cells is inhibited by increasing membrane cholesterol

1983 • 24 citations

Changes in concanavalin A capping of human lymphocytes with age

1980 • 23 citations

Changes in Rat Liver Plasma Membrane Phospholipids During Aging

1973 • 22 citations

Solubilization of adenylate cyclase of brain membranes by lipid peroxidation

1982 • 22 citations

Drug-induced surface membrane phospholipid composition in murine fibroblasts

1981 • 21 citations

How aging affects cholesterol metabolism

1978 • 21 citations

A Study on the Reaction of Human Erythrocytes with Hydrogen Peroxide

1983 • 21 citations

2-Hexanone potentiation of [14C]chloroform hepatotoxicity: Covalent interaction of a reactive intermediate with rat liver phospholipid

1984 • 20 citations

Physical properties of muscle cell membranes during fusion a fluorescence polarization study with the ionophore A23187

1976 • 20 citations

Asymmetry in the renewal of molecular classes of phosphatidylcholine in the rat-erythrocyte membrane

1979 • 19 citations

Sex and age alter plasma membranes of cultured fibroblasts

1984 • 19 citations

Relation of Cholesterol to Astrocytic Differentiation in C‐6 Glial Cells

1984 • 18 citations

DEVELOPMENT OF METASTATIC TUMORS IN ATHYMIC (NUDE) MICE FROM LM CELLS GROWN IN VITRO

1982 • 16 citations

Occurrence of desmosterol in tumors of the nervous system induced in the rat by nitrosourea derivatives.

1970 • 16 citations

The topographical distribution of phosphatidylethanolamine and phosphatidylserine in synaptosomal plasma membrane.

1976 • 16 citations

Presence of the phospholipid methylation pathway in mammalian cultured cells

1981 • 15 citations

Phagosomal membrane lipids of LM fibroblasts

1982 • 15 citations

Effect of Membrane Cholesterol on Action of Phospholipase A₂ in Mycoplasma mycoides var. Capri

1980 • 15 citations

Fatty acid and glycerol labeling of glycerolipids of leukocytes in response to ionophore A23187

1979 • 14 citations

Involvement of Calcium in the Inhibition by Insulin of the Glucagon‐Stimulated Adenylate‐Cyclase Activity

1979 • 14 citations

Influence of phospholipase treatments on ligand bindings to a benzodiazepine receptor-GABA receptor-chloride ionophore complex

1983 • 14 citations

Differences in fluidity between bilayer halves of plasma cell membranes (reply)

1980 • 13 citations

Interactions between fluorescent labeled phosphatidyl serine and cations

1977 • 13 citations

Ordering of FeNi in clear taenite from meteorites

1980 • 12 citations

Lipid composition alters phagocytosis of fluorescent latex beads

1983 • 10 citations

The displacement of phenothiazines from phospholipid binding sites by cholesterol

1983 • 10 citations

Investigations of thermotropic phase changes in peripheral nerve of frog and rat. A spin label study

1975 • 9 citations

The symmetrical distribution of cholesterol across the myelin membrane bilayer determined by deuterium labelling in vivo and neutron diffraction

1980 • 9 citations

Binding of [3H]flunitrazepam to the LM cell, a transformed murine fibroblast

1983 • 9 citations

Membrane lipids and modulation of hormone receptor expression.

1982 • 5 citations