Prognostic relevance of molecular markers of oral cancer—A review

Skp2 is oncogenic and overexpressed in human cancers

2001 • 498 citations

Constitutive activation of signal transducers and activators of transcription 3 correlates with cyclin D1 overexpression and may provide a novel prognostic marker in head and neck squamous cell carcinoma.

2002 • 376 citations

A Two-Stage, p16^INK4A- and p53-Dependent Keratinocyte Senescence Mechanism That Limits Replicative Potential Independent of Telomere Status

2002 • 334 citations

Combination of EGFR, HER-2/neu, and HER-3 is a stronger predictor for the outcome of oral squamous cell carcinoma than any individual family members.

1999 • 293 citations

Genetic aberrations in oral or head and neck squamous cell carcinoma (SCCHN): 1. Carcinogen metabolism, DNA repair and cell cycle control

2000 • 283 citations

Expression of MMPS, MT-MMP, and TIMPs in squamous cell carcinoma of the oral cavity: Correlations with tumor invasion and metastasis

1999 • 256 citations

Prognostic Significance of Vascular Endothelial Growth Factor Protein Levels in Oral and Oropharyngeal Squamous Cell Carcinoma

2000 • 249 citations

Up-Regulation of Bcl-2 in microvascular endothelial cells enhances intratumoral angiogenesis and accelerates tumor growth.

2001 • 234 citations

Is the invasive front of an oral carcinoma the most important area for prognostication?

1998 • 209 citations

p53 expression above the basal cell layer in oral mucosa is an early event of malignant transformation and has predictive value for developing oral squamous cell carcinoma

1998 • 199 citations

Matrix metalloproteinases and oral cancer

1999 • 183 citations

Expression of matrix metalloproteinases (MMP-1 and -2) and their inhibitors (TIMP-1, -2 and -3) in oral lichen planus, dysplasia, squamous cell carcinoma and lymph node metastasis

1998 • 183 citations

Genetic aberrations in oral or head and neck squamous cell carcinoma 2: chromosomal aberrations

2000 • 179 citations

Immunohistochemical study of tumour angiogenesis in oral squamous cell carcinoma

1997 • 166 citations

The number of intratumoral dendritic cells and ?-chain expression in T cells as prognostic and survival biomarkers in patients with oral carcinoma

2001 • 158 citations

Strong correlation between c-erbB-2 overexpression and overall survival of patients with oral squamous cell carcinoma.

1997 • 155 citations

The prognostic value of spontaneous apoptosis, Bax, Bcl-2, and p53 in oral squamous cell carcinoma of the tongue

1999 • 154 citations

High expression of S-phase kinase-interacting protein 2, human F-box protein, correlates with poor prognosis in oral squamous cell carcinomas.

2001 • 152 citations

αvβ6integrin promotes invasion of squamous carcinoma cells through up-regulation of matrix metalloproteinase-9

2001 • 149 citations

Absent or low expression of the zeta chain in T cells at the tumor site correlates with poor survival in patients with oral carcinoma.

1998 • 147 citations

Prognostic and predictive factors in oral cancer: the role of the invasive tumour front

2000 • 135 citations

Possible contribution of active MMP2 to lymph-node metastasis and secreted cathepsin L to bone invasion of newly established human oral-squamous-cancer cell lines

1997 • 134 citations

Expression of vascular endothelial growth factor and microvessel density in head and neck tumorigenesis.

2000 • 133 citations

Expression of matrix metalloproteinase-2 and -9 in oral squamous cell carcinomas with regard to the metastatic potential

2000 • 132 citations

NODAL METASTASES

1998 • 122 citations

pRb and p16 protein alterations in human oral tumorigenesis

1998 • 119 citations

Cell cycle proteins and the development of oral squamous cell carcinoma

1999 • 118 citations

Comparison of integrin, cadherin, and catenin expression in squamous cell carcinomas of the oral cavity

1998 • 116 citations

Peritumoral CD1a-Positive Dendritic Cells Are Associated With Improved Survival in Patients With Tongue Carcinoma

1998 • 115 citations

p53 and Ki‐67 as markers of radioresistance in head and neck carcinoma

2002 • 113 citations

P53 codon 72 polymorphism and risk of squamous cell carcinoma of the head and neck: a case-control study

2002 • 107 citations

Prognostic significance of Ki-67 (MIB1), PCNA and p53 in cancer of the oropharynx and oral cavity

1999 • 105 citations

Gelatinolytic activity of matrix metalloproteinase in tumor tissues correlates with the invasiveness of oral cancer.

1999 • 103 citations

Clinicopathological significance of p16 gene expression in the surgical treatment of head and neck squamous cell carcinomas

2002 • 99 citations

p27Kip1 accumulation by inhibition of proteasome function induces apoptosis in oral squamous cell carcinoma cells.

2000 • 98 citations

Immunohistochemical study of desmosomes in oral squamous cell carcinoma: correlation with cytokeratin and E-cadherin staining, and with tumour behaviour

1998 • 98 citations

Expression of cell cycle control proteins in normal epithelium, premalignant and malignant lesions of oral cavity

2002 • 94 citations

Cell Adhesion Molecules and Oral Cancer

2001 • 94 citations

p53 gene mutations in sequential oral epithelial dysplasias and squamous cell carcinomas

2000 • 92 citations

Role of p16/MTS1, cyclin D1 and RB in primary oral cancer and oral cancer cell lines

1999 • 91 citations

Tumor angiogenesis as a prognostic indicator in T2-T4 oral cavity squamous cell carcinoma: A clinical-pathologic correlation

1997 • 90 citations

Induction of apoptosis by abrogation of HSP70 expression in human oral cancer cells

2000 • 87 citations

Aberrant expression of cyclin A and cyclin B1 proteins in oral carcinoma

1999 • 87 citations

Integrins and oral cancer

1997 • 86 citations

Proliferative activity and loss of function of tumour suppressor genes as ‘biomarkers’ in diagnosis and prognosis of benign and preneoplastic oral lesions and oral squamous cell carcinoma

1998 • 86 citations

Prognostic value of histobiological factors (malignancy grading and AgNOR content) assessed at the invasive tumour front of oral squamous cell carcinomas

1997 • 85 citations

Oral squamous cell carcinoma is associated with decreased bcl-2/bax expression ratio and increased apoptosis

1999 • 85 citations

p53 expression in oral precancer as a marker for malignant potential

1998 • 82 citations

Vascular endothelial growth factor (VEGF) expression in oral tissues: possible relevance to angiogenesis, tumour progression and field cancerisation

2001 • 82 citations

Expression of c-erbB proto-oncogene family members in squamous cell carcinoma of the head and neck.

1998 • 81 citations

Cyclin D1 overexpression and p53 inactivation immortalize primary oral keratinocytes by a telomerase-independent mechanism

2001 • 81 citations

Variable expression of cathepsin B and D correlates with highly invasive and metastatic phenotype of oral cancer

2000 • 78 citations

Cyclin D1 overexpression and p53 inactivation immortalize primary oral keratinocytes by a telomerase-independent mechanism

2001 • 76 citations

Apoptosis-associated proteins and the development of oral squamous cell carcinoma

1999 • 76 citations

Expression of p27 is associated with Bax expression and spontaneous apoptosis in oral and oropharyngeal carcinoma

1999 • 75 citations

Active-MMP2 in cancer cell nests of oral cancer patients: correlation with lymph node metastasis.

1998 • 73 citations

Markers for Nodal Metastasis in Head and Neck Squamous Cell Cancer

2002 • 72 citations

Clinical relevance of erbB-1 and -2 oncogenes in oral carcinomas

2000 • 72 citations

Expression of p16, Rb, and cyclin D1 gene products in oral and laryngeal squamous carcinoma: Biological and clinical implications

1999 • 72 citations

Prevalence of p53, bcl-2, and Ki-67 immunoreactivity and of apoptosis in normal oral epithelium and in premalignant and malignant lesions of the oral cavity

2002 • 71 citations

Enhanced production and activation of progelatinase A mediated by membrane-type 1 matrix metalloproteinase in human oral squamous cell carcinomas: implications for lymph node metastasis.

2000 • 71 citations

Expression of programmed cell death regulatory p53 and bcl-2 proteins in oral lesions

1996 • 70 citations

Alterations of Rb, p16INK4A and cyclin D1 in the tumorigenesis of oral squamous cell carcinomas

2000 • 69 citations

Adhesive Mechanisms Regulating Invasion and Metastasis in Oral Cancer

2001 • 69 citations

Frequent cyclin D1 gene amplification and protein overexpression in oral epithelial dysplasias

2001 • 69 citations

Circulating p53 antibodies as early markers of oral cancer: correlation with p53 alterations.

1998 • 68 citations

Beta- and gamma-catenin expression in oral squamous cell carcinomas.

2000 • 68 citations

Alterations of p53, pRb, cyclin D1 and cdk4 in human oral and pharyngeal squamous cell carcinomas

2000 • 67 citations

Ets-1: a plausible marker of invasive potential and lymph node metastasis in human oral squamous cell carcinomas

1999 • 65 citations

Expression of p21/waf1 in oral squamous cell carcinomas—correlation with p53 and mdm2 and cellular proliferation index

1999 • 65 citations

p53, p21 and p27 protein expression in head and neck cancer and their prognostic value.

2001 • 65 citations

Prognostic significance of proliferative and apoptotic markers in oral tongue squamous cell carcinomas

1999 • 64 citations

Prognostic significance of apoptosis and associated factors in oral squamous cell carcinoma

2000 • 64 citations

Overexpression of the ERK/MAP kinases in oral squamous cell carcinoma.

1998 • 63 citations

Ets‐1: a plausible marker of invasive potential and lymph node metastasis in human oral squamous cell carcinomas

1999 • 63 citations

Molecular marker expression in oral and oropharyngeal squamous cell carcinoma.

2001 • 61 citations

Patterns of p53 and Ki-67 protein expression in epithelial dysplasia from the floor of the mouth

1997 • 60 citations

Suprabasal expression of Ki-67 antigen as a marker for the presence and severity of oral epithelial dysplasia

2000 • 60 citations

Evaluation of the anti-tumor and anti-angiogenic effect of paclitaxel and thalidomide on the xenotransplanted oral squamous cell carcinoma

2001 • 58 citations

Apoptosis, mitosis, PCNA and bcl-2 in normal, leukoplakic and malignant epithelia of the human oral cavity: Prospective, in vivo study

1997 • 58 citations

Reduced expression of p27Kip1 correlates with an early stage of cancer invasion in oral squamous cell carcinoma

2000 • 56 citations

Expression of Integrins in Squamous Cell Carcinoma of the Oral Cavity: Correlations with Tumor Invasion and Metastasis

1999 • 56 citations

p53 and Ki-67 as predictive markers for radiosensitivity in squamous cell carcinoma of the oral cavity? an immunohistochemical and clinicopathologic study

2001 • 53 citations

Diagnostic and prognostic value of nucleolar organizer regions in normal epithelium, dysplasia, and squamous cell carcinoma of the oral cavity

1997 • 52 citations

Telomerase components as a diagnostic tool in human oral lesions

1999 • 52 citations

Cyclin D1 expression in oral squamous cell carcinomas: clinicopathological relevance and correlation with p53 expression

2000 • 51 citations

Oral and Maxillofacial Pathology: MMP and TIMP gene expression in head and neck squamous cell carcinomas and adjacent tissues

2000 • 51 citations

Type II nitric oxide synthase (NOS2) expression correlates with lymph node status in oral squamous cell carcinoma

2001 • 51 citations

Expression of cyclin D1 is correlated with poor prognosis in patients with areaca quid chewing‐related oral squamous cell carcinomas in Tiwan

1999 • 49 citations

Prognostic role of p27Kip1 expression in oral squamous cell carcinoma in Taiwan

2002 • 49 citations

Association between polymorphism in p21(Waf1/Cip1) cyclin-dependent kinase inhibitor gene and human oral cancer.

2000 • 48 citations

Angiogenesis during tumor progression in the oral cavity is related to reduced apoptosis and high tumor cell proliferation

1998 • 48 citations

Reduction of p12DOC-1 expression is a negative prognostic indicator in patients with surgically resected oral squamous cell carcinoma.

2001 • 47 citations

Expression of p21WAF1/CIP1 is unrelated to p53 tumour suppressor gene status in oral squamous cell carcinomas

1998 • 47 citations

Experimental oral carcinoma of the tongue and buccal mucosa: possible biologic markers linked to cancers at two anatomic sites

2000 • 47 citations

Prognostic value of p53 expression and histopathological parameters in squamous cell carcinoma of oral tongue

1999 • 47 citations

Activation of fibroblast collagenase-1 expression by tumor cells of squamous cell carcinomas is mediated by p38 mitogen-activated protein kinase and c-Jun NH2-terminal kinase-2.

2000 • 46 citations

Down‐regulation of desmosomal molecules in oral and pharngeal squamous cell carcinomas as a marker for tumour growth and distant metastasis

1999 • 46 citations

Expression of cyclin dependent kinase inhibitor p21waf1/cip1 in premalignant and malignant oral lesions: relationship with p53 status

1998 • 44 citations

Expression of E1AF, an ets-family transcription factor, is correlated with the invasive phenotype of oral squamous cell carcinoma

1997 • 44 citations

Biomarkers predictive of lymph node metastases in oral squamous cell carcinoma

2002 • 44 citations

Microvessel density (MVD) and vascular endothelial growth factor expression (VEGF) in human oral squamous cell carcinoma.

2001 • 44 citations

De novo programmed cell death in oral cancer

1999 • 43 citations

BAG-1 expression correlates highly with the malignant potential in early lesions (T1 and T2) of oral squamous cell carcinoma

2000 • 43 citations

Abnormalities of the ARF-p53 pathway in oral squamous cell carcinoma

2001 • 40 citations

Telomerase activity in oral and maxillofacial tumors

2000 • 40 citations

Telomerase activity and in situ telomerase RNA expression in oral carcinogenesis

1999 • 39 citations

Relationship of p53 overexpression to other cell cycle regulatory proteins in oral squamous cell carcinoma

1998 • 39 citations

Immunohistochemical study of the expression of human chorionic gonadotropin-? in oral squamous cell carcinoma

1999 • 38 citations

Suppression of Fas receptor and negative correlation of Fas ligand with differentiation and apoptosis in oral squamous cell carcinoma

1999 • 38 citations

Heat shock protein and p53 expression in head and neck squamous cell carcinoma☆☆☆★

1998 • 38 citations

Alteration of pRb expression in the development of rat tongue carcinoma induced by 4-nitroquinoline 1-oxide

2001 • 37 citations

Cyclin D1 overexpression associates with radiosensitivity in oral squamous cell carcinoma

2001 • 36 citations

Cytokeratin expression in precancerous lesions of the human oral cavity

1998 • 35 citations

Conversion of Normal To Malignant Phenotype: Telomere Shortening, Telomerase Activation, and Genomic Instability During Immortalization of Human Oral Keratinocytes

2001 • 35 citations

Diagnostic and prognostic value of nucleolar organizer regions in normal epithelium, dysplasia, and squamous cell carcinoma of the oral cavity

1997 • 34 citations

Differential expression of heat shock protein 27 in normal oral mucosa, oral epithelial dysplasia and squamous cell carcinoma

2002 • 34 citations

Up-regulation of Fas ligand and down-regulation of Fas expression in oral carcinogenesis

1999 • 33 citations

Prognostic factors in oral squamous cell carcinoma. A review of the literature.

2000 • 33 citations

Immunohistochemical analysis of the oncoprotein c-erbB-2 expression in oral benign and malignant lesions

1998 • 33 citations

Expression of p53 protein correlates with decreased survival in patients with areca quid chewing and smoking‐associated oral squamous cell carcinomas in Taiwan

1999 • 33 citations

Integrin- and Cadherin-Mediated Induction of the Matrix Metalloprotease Matrilysin in Cocultures of Malignant Oral Squamous Cell Carcinoma Cells and Dermal Fibroblasts

2001 • 32 citations

Increased expression of c-erbB-3 protein and proliferating cell nuclear antigen during development of verrucous carcinoma of the oral mucosa

2000 • 32 citations

Deregulated Bag‐1 protein expression in human oral squamous cell carcinomas and lymph node metastases

2002 • 32 citations

Predicting tumor metastasis in patients with oral cancer by means of the proliferation marker Ki67.

1999 • 31 citations

Angiogenesis and Expression of Platelet-Derived Endothelial Cell Growth Factor in Oral Squamous Cell Carcinoma

1997 • 30 citations

Mapping of resection margins of oral cancer for p53 overexpression and chromosome instability to detect residual (pre)malignant cells

2001 • 30 citations

Cytokeratin alterations as diagnostic and prognostic markers of oral and pharyngeal carcinomas. A prospective study.

1999 • 30 citations

An immunohistochemical study of p53 and PCNA in inflammatory papillary hyperplasia of the palate: a dilemma of interpretation

1998 • 29 citations

Apoptosis, angiogenesis and proliferation: trifunctional measure of tumour response to radiotherapy for oral cancer

2001 • 28 citations

Enhanced apoptosis of squamous cell carcinoma cells by interleukin-2-activated cytotoxic lymphocytes combined with radiation and anticancer drugs

2000 • 26 citations

Fas antigen expression and outcome of oral squamous cell carcinoma

2000 • 25 citations

Potentially malignant and malignant lesions of the lip. Role of silver staining nucleolar organizer regions, proliferating cell nuclear antigen, p53, and c‐myc in differentiation and prognosis

1999 • 25 citations

Cyclin-dependent kinase inhibitor p27 is related to cell proliferation and prognosis in laryngeal squamous cell carcinomas

2001 • 25 citations

P-glycoprotein is positively correlated with p53 in human oral pre-malignant and malignant lesions and is associated with poor prognosis

1999 • 25 citations

Association of Preoperative Radiation Effect with Tumor Angiogenesis and Vascular Endothelial Growth Factor in Oral Squamous Cell Carcinoma

2000 • 24 citations

Localization of Fas antigen in oral squamous cell carcinoma

1999 • 24 citations

Evaluation of argyrophilic nucleolar organizer regions in tongue squamous cell carcinomas

1999 • 23 citations

Predictive value of cathepsin‐D for cervical lymph node metastasis in head and neck squamous cell carcinoma

1999 • 22 citations

p53, cyclin‐D1, PCNA, AgNOR expression in squamous cell cancer of the lip: a multicenter study

2000 • 21 citations

Correlation between type II nitric oxide synthase and p53 expression in oral squamous cell carcinoma

2000 • 21 citations

Expression of type 2 nitric oxide synthase and p21 in oral squamous cell carcinoma

2002 • 21 citations

Reduced Expression of Cyclin-Dependent Kinase Inhibitor p27<sup>Kip1</sup> in Oral Malignant Tumors

1999 • 21 citations

Matrix metalloproteinases expressed in squamous cell carcinoma of the oral cavity: correlation with clinicopathologic features and neo-adjuvant chemotherapy response.

1999 • 20 citations

Enhanced cell death in NR-S1 tumor by photodynamic therapy: Possible involvement of Fas and Fas ligand system

2000 • 20 citations

Angiogenic inhibition for the treatment of head and neck cancer.

1998 • 20 citations

Zinc-α2-glycoprotein expression as a marker of differentiation in human oral tumors

1999 • 19 citations

Prognosis value of the expression of Ki-67 for squamous cell carcinoma of the oral cavity.

1996 • 19 citations

Aberrations of erbB-1 and erbB-2 oncogenes in non-dysplastic leukoplakias of the oral cavity

1999 • 19 citations

AgNORs in hyperplasia, papilloma and oral squamous cell carcinoma.

2000 • 19 citations

Immunohistochemical inactivation of p14ARF concomitant with MDM2 overexpression inversely correlates with p53 overexpression in oral squamous cell carcinoma

2000 • 18 citations

p120cat delocalization in cell lines of oral cancer

2002 • 18 citations

Nitric oxide and apoptosis during human head and neck squamous cell carcinoma development

2002 • 18 citations

Expression of nitric oxide synthase-2 in cutaneous squamous cell carcinoma of the head and neck

2002 • 17 citations

S100⊕ cell response to squamous cell carcinoma of the lip: inverse correlation with metastasis

1998 • 16 citations

Expression of Fas (CD95) ligand is correlated with IL-10 and granulocyte colony-stimulating factor expression in oral and oropharyngeal squamous cell carcinoma

2000 • 16 citations

Prognosis in lower lip squamous cell carcinoma: assessment of tumor factors

1998 • 15 citations

Cell-surface expression of complement restriction factors and sialyl Lewis antigens in oral carcinoma: relevance to chemo-immunotherapy.

2000 • 15 citations

Correlation of E-cadherin and alpha-catenin expression with differentiation of oral squamous cell carcinoma.

1999 • 15 citations

Correlation between p53 gene mutation, p53 protein labeling and PCNA expression in oral squamous cell carcinomas.

1998 • 15 citations

Markers of neck failure in oral cavity and oropharyngeal carcinomas treated with radiotherapy

2001 • 15 citations

Does type II nitric oxide synthase expression correlate with cellular proliferation in oral squamous cell carcinoma and dysplasia?

2001 • 15 citations

Participation of Fas-mediated apoptotic pathway in KB, a human head and neck squamous cell carcinoma cell line, after irradiation

2002 • 12 citations

p120 and AgNOR nucleolar protein expression

1998 • 12 citations

Does type II nitric oxide synthase expression correlate with cellular proliferation in oral squamous cell carcinoma and dysplasia?

2001 • 10 citations

Fas expression and Fas monoclonal antibody‐induced apoptosis in a human squamous cell carcinoma cell line, SCC‐25

2000 • 10 citations

Correlation between the expression of cyclin A protein and p53 activity in oral squamous cell carcinomas.

2001 • 9 citations

Nucleolar protein p120 expression in oral carcinoma.

1999 • 9 citations

Telomerase Activity in Oral Squamous Cell Carcinoma and Leukoplakia.

2001 • 6 citations

Lack of specific inhibition of DNA repair in WI-38 human diploid fibroblasts by sodium saccharin

1985 • 4 citations

Alteration of Fas/FasL expression of oral squamous cell carcinoma cell line Tca83 induced by retinoic acid.

2000 • 4 citations