Proliferative activity and loss of function of tumour suppressor genes as ‘biomarkers’ in diagnosis and prognosis of benign and preneoplastic oral lesions and oral squamous cell carcinoma

Head and Neck Cancer

1993 • 2,263 citations

Flow-cytometric and histological progression to malignancy in Barrett's esophagus: Prospective endoscopic surveillance of a cohort

1992 • 457 citations

Regulation of Proliferating Cell Nuclear Antigen during the Cell Cycle

1989 • 447 citations

Monoclonal antibodies to proliferating cell nuclear antigen (PCNA)/cyclin as probes for proliferating cells by immunofluorescence microscopy and flow cytometry

1988 • 321 citations

Defective terminal differentiation in culture as a consistent and selectable character of malignant human keratinocytes

1980 • 319 citations

Intratumoral microvessel density and L53 protein: Correlation with metastasis in head‐and‐neck squamous‐cell carcinoma

1993 • 314 citations

A comparison of immunohistochemical markers of cell proliferation with experimentally determined growth fraction

1991 • 285 citations

Activation of p53 gene expression in premalignant lesions during head and neck tumorigenesis.

1994 • 272 citations

Elevated P53 expression correlates with a history of heavy smoking in squamous cell carcinoma of the head and neck

1991 • 259 citations

Expression of p53 in premalignant and malignant squamous epithelium.

1991 • 237 citations

Assessment of p53 protein expression in normal, benign, and malignant oral mucosa

1992 • 187 citations

Biomarkers as Intermediate End Points in Chemoprevention Trials

1990 • 186 citations

Sequential Increases in Proliferating Cell Nuclear Antigen Expression in Head and Neck Tumorigenesis: A Potential Biomarker

1993 • 158 citations

Gene mutations and increased levels of p53 protein in human squamous cell carcinomas and their cell lines

1993 • 127 citations

Overexpression of p53 protein in betel‐ and tobacco‐related human oral dysplasia and squamous‐cell carcinoma in India

1994 • 119 citations

Expression of p53 mutant nuclear phosphoprotein in oral carcinoma and potentially malignant oral lesions

1992 • 117 citations

Overexpression of P53 in head and neck cancer

1992 • 91 citations

Proliferating cell nuclear antigen in malignant and pre-malignant lesions of epithelial origin in the oral cavity and the skin: an immunohistochemical study

1992 • 90 citations

Expression of the tumour suppressor gene p53 in oral cancer

1992 • 88 citations

Advanced methods in the evaluation of premalignant lesions and carcinomas of the oral mucosa

1985 • 88 citations

Proliferating cell nuclear antigen expression in non-cycling cells may be induced by growth factors in vivo

1994 • 83 citations

HAS THE CELLULAR PROLIFERATION MARKER KI67 ANY CLINICAL RELEVANCE IN SQUAMOUS CELL CARCINOMA OF THE HEAD AND NECK?

1994 • 74 citations

p53 and Ki 67 expression in preneoplastic and neoplastic lesions of the oral mucosa

1993 • 72 citations

Ki-67 Staining as a Means to Simplify Analysis of Tumor Cell Proliferation

1991 • 71 citations

The presence of p53 protein in relation to Ki-67 as cellular proliferation marker in head and neck squamous cell carcinoma and adjacent dysplastic mucosa

1994 • 67 citations

EGFR and PCNA experession in oral squamous cell carcinomas—a valuable tool in estimating the patient's prognosis

1993 • 67 citations

Measurement of proliferating cell nuclear antigen (PCNA) and its clinical application in oral cancers

1992 • 56 citations

Immunohistochemical Detection of p53 Oncoprotein in Human Oral Squamous Cell Carcinomas and Leukoplakias: Comparison with Proliferating Cell Nuclear Antigen Staining and Correlation with Clinicopathological Findings

1993 • 50 citations

Mutations in the conserved regions of p53 are infrequent in betel-associated oral cancers from Papua New Guinea.

1994 • 50 citations

p53 and PCNA expression in carcinogenesis of the oropharyngeal mucosa

1994 • 47 citations

Correlation between p53 gene expression and tumor‐cell proliferation in oropharyngeal cancer

1994 • 39 citations

Relationship of tobacco/alcohol use to p53 expression in patients with lingual squamous cell carcinomas

1993 • 38 citations

Relationship between immunohistochemically detectable p53 protein and prognostic factors in head and neck tumors.

1993 • 32 citations

Molecular Screening: Prospects for a New Approach

1993 • 32 citations

Two binding sites for Ki67 related to quiescent and cycling cells in human epidermis.

1989 • 31 citations

Improved immunohistochemical detection of p53 protein in paraffin--embedded tissues reveals elevated levels in most head and neck and lung carcinomas: correlation with clinicopathological parameters.

1992 • 30 citations

Some oral carcinomas from Sri Lankan betel/tobacco chewers overexpress p53 oncoprotein but lack mutations in exons 5-9.

1993 • 29 citations

DNA content and PCNA immunoreactivity in oral precancerous and cancerous lesions

1993 • 26 citations

Human squamous carcinoma cells express complex defects in the control of proliferation and differentiation.

1988 • 26 citations

Proliferating cell nuclear antigen counts as markers of cell proliferation in head and neck cancer

1994 • 25 citations

p⁵³ Expression in the carcinogenesis in the oral mucosa

1994 • 23 citations

Biology and chemoprevention of head and neck cancer

1994 • 21 citations

Proliferative pattern of head and neck cancer

1991 • 16 citations

Changes in the Ki-67 Labeling Rates of Head and Neck Squamous Cell Carcinomas during Preoperative Radiation Therapy

1992 • 12 citations

p53 protein expression in squamocellular carcinomas of the lip.

1993 • 9 citations

Prognostic value of PCNA and cytokeratins for radiation therapy of oral squamous cell carcinoma

1993 • 7 citations

Correlation between p53 gene expression and tumor cell proliferation in oropharyngeal cancer

1993 • 5 citations

[Significance of aberrant p53 protein in head-neck tumors and its effect on proliferation and differentiation].

1993 • 4 citations

[Expression of tumor suppressor gene p53 and Rb in patients with epidermoid carcinoma of the head and neck].

1994 • 4 citations

Deleted Work

1955 • 0 citations