Oral squamous cell carcinoma is associated with decreased bcl-2/bax expression ratio and increased apoptosis

Use of avidin-biotin-peroxidase complex (ABC) in immunoperoxidase techniques: a comparison between ABC and unlabeled antibody (PAP) procedures.

1981 • 14,396 citations

Identification of programmed cell death in situ via specific labeling of nuclear DNA fragmentation.

1992 • 9,540 citations

Mitochondria and Apoptosis

1998 • 8,909 citations

Death Receptors: Signaling and Modulation

1998 • 5,873 citations

The Bcl-2 Protein Family: Arbiters of Cell Survival

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The polypeptide encoded by the cDNA for human cell surface antigen Fas can mediate apoptosis

1991 • 2,815 citations

Involvement of the bcl -2 Gene in Human Follicular Lymphoma

1985 • 1,797 citations

A Matter of Life and Cell Death

1998 • 1,523 citations

BCL2 protein is topographically restricted in tissues characterized by apoptotic cell death.

1991 • 1,301 citations

Analysis of the structure, transcripts, and protein products of bcl-2, the gene involved in human follicular lymphoma.

1986 • 1,118 citations

Conversion of Bcl-2 to a Bax-like Death Effector by Caspases

1997 • 1,116 citations

Estimates of the worldwide frequency of sixteen major cancers in 1980

1988 • 1,073 citations

Investigation of the subcellular distribution of the bcl-2 oncoprotein: residence in the nuclear envelope, endoplasmic reticulum, and outer mitochondrial membranes.

1993 • 1,044 citations

Vascular Endothelial Growth Factor Induces Expression of the Antiapoptotic Proteins Bcl-2 and A1 in Vascular Endothelial Cells

1998 • 996 citations

Apoptosis and disease

1993 • 684 citations

Immunohistochemical determination of in vivo distribution of Bax, a dominant inhibitor of Bcl-2.

1994 • 664 citations

Expression of the bcl-2 oncogene protein is not specific for the 14;18 chromosomal translocation.

1990 • 622 citations

Immunohistochemical analysis of bcl-2, bax, bcl-X, and mcl-1 expression in prostate cancers.

1996 • 596 citations

Proapoptotic Protein Bax Heterodimerizes with Bcl-2 and Homodimerizes with Bax via a Novel Domain (BH3) Distinct from BH1 and BH2

1996 • 462 citations

Estrogen promotes chemotherapeutic drug resistance by a mechanism involving Bcl-2 proto-oncogene expression in human breast cancer cells.

1995 • 422 citations

Pathology of Tumours of the Oral Tissues

1977 • 396 citations

The genetic regulation of apoptosis

1995 • 283 citations

BCL‐2 expression in adult and embryonic non‐haematopoietic tissues

1993 • 265 citations

Structure-function analysis of the Bcl-2 oncoprotein. Addition of a heterologous transmembrane domain to portions of the Bcl-2 beta protein restores function as a regulator of cell survival

1993 • 185 citations

The role of the bcl-2/ced-9 gene family in cancer and general implications of defects in cell death control for tumourigenesis and resistance to chemotherapy

1997 • 179 citations

Pathology of Tumours of the Oral Tissues

1985 • 161 citations

Discordant expression of Bcl-x and Bcl-2 by keratinocytes in vitro and psoriatic keratinocytes in vivo.

1995 • 146 citations

bcl-2 expression in epidermal keratinocytic diseases

1994 • 131 citations

Differential expression of bcl-2 and bax in squamous cell carcinomas of the oral cavity

1996 • 131 citations

Bcl-xL and Bcl-2 expression in squamous cell carcinoma of the head and neck

1999 • 130 citations

The prevalence of bcl-2, p53, and ki-67 immunoreactivity in transitional cell bladder carcinomas and their clinicopathologic correlates

1998 • 129 citations

Tumor necrosis factor receptor p55 mediates deletion of peripheral cytotoxic T lymphocytes in vivo

1996 • 124 citations

Apoptosis and the cell cycle

1996 • 94 citations

Expression of programmed cell death regulatory p53 and bcl-2 proteins in oral lesions

1996 • 70 citations

Expression of the apoptosis-suppressing protein Bcl-2 in non-melanoma skin cancer

2006 • 69 citations

Bcl-2 expression correlates with favourable outcome in head and neck cancer treated by accelerated radiotherapy.

1996 • 54 citations

Clinical relevance of p53 and bcl-2 protein over-expression in laryngeal squamous-cell carcinoma

1998 • 54 citations

Overexpression of bcl‐2 protein inhibits terminal differentiation of oral keratinocytes in vitro

1998 • 45 citations

Expression ofbcl-2 protein in esophageal squamous cell carcinomas and its association with lymph node metastasis

1997 • 44 citations

Immunohistochemical expression of bcl-2 protein in squamous cell carcinoma and basaloid carcinoma of the esophagus

1997 • 38 citations

Suppression of Fas receptor and negative correlation of Fas ligand with differentiation and apoptosis in oral squamous cell carcinoma

1999 • 38 citations

PCNA, Ki-67, p53, bcl-2 and Prognosis in Intraoral Squamous Cell Carcinoma of the Head and Neck

1997 • 33 citations

Biological markers as indicators of pathological response to primary chemotherapy in oral-cavity cancers

1998 • 31 citations

Expression of p53 and bcl-2 and response to preoperative chemotherapy and radiotherapy for locally advanced squamous cell carcinoma of the oesophagus.

1996 • 29 citations

Expression of Bax, a pro-apoptotic member of the Bcl-2 family, in esophageal squamous cell carcinoma

1997 • 28 citations

Expression of Bcl-X(L), an antiapoptotic member of the Bcl-2 family, in esophageal squamous cell carcinoma.

1998 • 27 citations

Apoptosis‐associated proteins in oral hairy leukoplakia

1996 • 21 citations

Pre‐operative radio‐chemotherapy enhances apoptotic cell death in oral squamous cell carcinoma

1998 • 10 citations