Free Fatty Acid Effects on Mitochondrial Permeability: An Overview

PROTEIN MEASUREMENT WITH THE FOLIN PHENOL REAGENT

1951 • 319,299 citations

The mitochondrial permeability transition

1995 • 2,412 citations

Mechanisms by which mitochondria transport calcium

1990 • 1,630 citations

Fatty acid-induced β cell apoptosis: A link between obesity and diabetes

1998 • 1,142 citations

Uncoupling: new approaches to an old problem of bioenergetics

1998 • 877 citations

Inhibition by cyclosporin A of a Ca2+-dependent pore in heart mitochondria activated by inorganic phosphate and oxidative stress.

1988 • 846 citations

Cyclosporin A is a potent inhibitor of the inner membrane permeability transition in liver mitochondria

1989 • 699 citations

From calcium signaling to cell death: two conformations for the mitochondrial permeability transition pore. Switching from low- to high-conductance state

1998 • 568 citations

Recent progress on regulation of the mitochondrial permeability transition pore; a cyclosporin-sensitive pore in the inner mitochondrial membrane

1994 • 561 citations

Effect of small molecules on the dipalmitoyl lecithin liposomal bilayer: III. Phase transition in lipid bilayer

1977 • 490 citations

Potentiation of NMDA receptor currents by arachidonic acid

1992 • 428 citations

Effect of fatty acids on energy coupling processes in mitochondria

1993 • 352 citations

Inhibition of Carnitine Palmitoyltransferase I Augments Sphingolipid Synthesis and Palmitate-induced Apoptosis

1997 • 349 citations

Action of cyclosporine on mitochondrial calcium fluxes

1987 • 329 citations

Fatty acid transport: difficult or easy?

1998 • 315 citations

Mitochondrial calcium transport

1980 • 304 citations

The osmotic behavior and permeability to non-electrolytes of mitochondria

1955 • 293 citations

Fatty Acids Decrease IDX-1 Expression in Rat Pancreatic Islets and Reduce GLUT2, Glucokinase, Insulin, and Somatostatin Levels

1997 • 286 citations

Inhibition of the mitochondrial permeability transition by cyclosporin A during long time frame experiments: relationship between pore opening and the activity of mitochondrial phospholipases

1995 • 224 citations

Modulation of dihydropyridine-sensitive calcium channels in heart cells by fish oil fatty acids.

1992 • 211 citations

The Peptide Mastoparan Is a Potent Facilitator of the Mitochondrial Permeability Transition

1995 • 207 citations

Dexamethasone Induces Posttranslational Degradation of GLUT2 and Inhibition of Insulin Secretion in Isolated Pancreatic β Cells

1997 • 151 citations

Spermine Inhibition of the Permeability Transition of Isolated Rat Liver Mitochondria: An Investigation of Mechanism

1993 • 124 citations

Fatty acid‐induced uncoupling of oxidative phosphorylation is partly due to opening of the mitochondrial permeability transition pore

1998 • 120 citations

Fatty acid‐promoted mitochondrial permeability transition by membrane depolarization and binding to the ADP/ATP carrier

1997 • 108 citations

Prooxidants Open Both the Mitochondrial Permeability Transition Pore and a Low-Conductance Channel in the Inner Mitochondrial Membrane

2000 • 99 citations

A Heterocomplex Formed by the Calcium-binding Proteins MRP8 (S100A8) and MRP14 (S100A9) Binds Unsaturated Fatty Acids with High Affinity

1997 • 94 citations

Palmitic Acid Opens a Novel Cyclosporin A-Insensitive Pore in the Inner Mitochondrial Membrane

2001 • 89 citations

EGTA inhibits reverse uniport-dependent Ca2+ release from uncoupled mitochondria. Possible regulation of the Ca2+ uniporter by a Ca2+ binding site on the cytoplasmic side of the inner membrane.

1988 • 81 citations

Permeability transition pore of the inner mitochondrial membrane can operate in two open states with different selectivities

1996 • 79 citations

Proton Selective Substate of the Mitochondrial Permeability Transition Pore: Regulation by the Redox State of the Electron Transport Chain

1998 • 76 citations

The effect of free fatty acids on the thermotropic phase transition of dimyristoyl glycerophosphocholine

1978 • 75 citations

Regulation of Ca²⁺ Efflux from Kidney and Liver Mitochondria by Unsaturated Fatty Acids and Na⁺ Ions

1979 • 72 citations

Time Course of Changes in Lactate and Free Fatty Acids after Experimental Brain Injury and Relationship to Morphologic Damage

1997 • 67 citations

Perspectives on the mitochondrial multiple conductance channel

1996 • 64 citations

Protonophoric Activity of Fatty Acid Analogs and Derivatives in the Inner Mitochondrial Membrane: A Further Argument for the Fatty Acid Cycling Model

1998 • 61 citations

Mechanisms of fatty acid effects on sarcoplasmic reticulum. III. The effects of palmitic and oleic acids on sarcoplasmic reticulum function–a model for fatty acid membrane interactions.

1984 • 58 citations

Definition of the Specific Roles of Lysolecithin and Palmitic Acid in Altering the Susceptibility of Dipalmitoylphosphatidylcholine Bilayers to Phospholipase A₂

1998 • 52 citations

Phospholipase A2 and 3H-hemicholinium-3 binding sites in rat brain: a potential second-messenger role for fatty acids in the regulation of high-affinity choline uptake

1990 • 46 citations

Refsum disease diagnostic marker phytanic acid alters the physical state of membrane proteins of liver mitochondria

1999 • 45 citations

Influence of fatty acids on the binding of calcium to human albumin. Correlation of binding and conformation studies and evidence for distinct differences between unsaturated fatty acids and saturated fatty acids.

1982 • 43 citations

cis-Unsaturated Free Fatty Acids Block Growth Hormone and Prolactin Secretion in Thyrotropin-Releasing Hormone-Stimulated GH₃Cells by Perturbing the Function of Plasma Membrane Integral Proteins¹

1997 • 40 citations

A Mitochondrial Signal Peptide fromNeurospora crassaIncreases the Permeability of Isolated Rat Liver Mitochondria

1996 • 39 citations

Signal Presequences Increase Mitochondrial Permeability and Open the Multiple Conductance Channel

1999 • 37 citations

Thyroxine induces cyclosporin A‐insensitive, Ca²⁺‐dependent reversible permeability transition pore in rat liver mitochondria

1997 • 35 citations

Divalent cation binding to phospholipid vesicles. Dependence on temperature and lipid fluidity

1979 • 33 citations

Fatty Acid-mediated Calcium Sequestration within Intracellular Calcium Pools

1998 • 29 citations

Effect of Butylhydroxytoluene and Related Compounds on Permeability of the Inner Mitochondrial Membrane

1997 • 26 citations

Lipid Domains in Biological Membranes: Their Structural and Functional Perturbation by Free Fatty Acids and the Regulation of Receptor Mobility

1979 • 18 citations

Butylated hydroxytoluene and inorganic phosphate plus Ca2+ increase mitochondrial permeability via mutually exclusive mechanisms

1996 • 18 citations

Carboxyatractyloside increases the effect of oleate on mitochondrial permeability transition

1999 • 18 citations

Fatty acid-induced Ca(2+)-dependent uncoupling and activation of external pathway of NADH oxidation are coupled to cyclosporin A-sensitive mitochondrial permeability transition.

1994 • 17 citations

Release of fatty acid-binding protein and long chain fatty acids from isolated rat heart after ischemia and subsequent calcium paradox

1993 • 16 citations

The role of fatty acids in ischemic tissue injury: difference between oleic and palmitic acid

1986 • 12 citations

Fatty acids as modulators of cytochrome c oxidase in proteoliposomes

1996 • 11 citations

Effect of cyclosporin A and trifluoperazine on rat liver mitochondria swelling and lipid peroxidation.

1993 • 9 citations

Ligation, inhibition, and activation of cytochrome <I>c</I> oxidase by fatty acids

1997 • 5 citations

Ligation, inhibition, and activation of cytochromecoxidase by fatty acids

1997 • 5 citations