Effect of Butylhydroxytoluene and Related Compounds on Permeability of the Inner Mitochondrial Membrane

A RAPID METHOD OF TOTAL LIPID EXTRACTION AND PURIFICATION

1959 • 47,127 citations

Hydroperoxide metabolism in mammalian organs.

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Oxidative stress: oxidants and antioxidants

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Substituent constants for correlation analysis in chemistry and biology

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Free Radicals in Biology

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Oxidative Stress: Oxidants and Antioxidants.

1992 • 1,193 citations

Membrane potential of mitochondria measured with an electrode sensitive to tetraphenyl phosphonium and relationship between proton electrochemical potential and phosphorylation potential in steady state

1979 • 954 citations

Mitochondria and calcium ion transport

1970 • 826 citations

The Ca2+-induced membrane transition in mitochondria

1979 • 826 citations

The Ca2+-induced membrane transition in mitochondria

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Mitochondrial calcium transport: physiological and pathological relevance

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Relationship between configuration, function, and permeability in calcium-treated mitochondria.

1976 • 610 citations

Mitochondrial calcium transport

1982 • 486 citations

Modulation of the mitochondrial cyclosporin A-sensitive permeability transition pore by the proton electrochemical gradient. Evidence that the pore can be opened by membrane depolarization.

1992 • 443 citations

Mitochondria as a source of reactive oxygen species during reductive stress in rat hepatocytes

1993 • 337 citations

On the involvement of a cyclosporin A sensitive mitochondrial pore in myocardial reperfusion injury

1993 • 295 citations

Cyclosporin and carnitine prevent the anoxic death of cultured hepatocytes by inhibiting the mitochondrial permeability transition

1993 • 294 citations

Swelling and contraction of the mitochondrial matrix. I. A structural interpretation of the relationship between light scattering and matrix volume.

1985 • 237 citations

Modulation of the mitochondrial cyclosporin A-sensitive permeability transition pore. II. The minimal requirements for pore induction underscore a key role for transmembrane electrical potential, matrix pH, and matrix Ca2+.

1993 • 225 citations

Intracellular calcium regulation

1991 • 210 citations

Mitochondrial benzodiazepine receptor linked to inner membrane ion channels by nanomolar actions of ligands.

1993 • 198 citations

Modulation of the mitochondrial cyclosporin A-sensitive permeability transition pore. I. Evidence for two separate Me2+ binding sites with opposing effects on the pore open probability.

1993 • 191 citations

The reversible Ca2+-induced permeabilization of rat liver mitochondria

1986 • 174 citations

The metabolism of menadione impairs the ability of rat liver mitochondria to take up and retain calcium.

1982 • 159 citations

Osmotic effects of polyethylene glycol

1988 • 147 citations

The permeability transition in heart mitochondria is regulated synergistically by ADP and cyclosporin A.

1992 • 146 citations

The Participation of Reactive Oxygen Species and Protein Thiols in the Mechanism of Mitochondrial Inner Membrane Permeabilization by Calcium plus Prooxidants

1993 • 139 citations

Mitochondrial regulation of superoxide by Ca2+: An alternate mechanism for the cardiotoxicity of doxorubicin

1991 • 133 citations

Intracellular calcium regulation

1990 • 123 citations

Channels in Mitochondrial Membranes: Knowns, Unknowns, and Prospects for the Future

1993 • 123 citations

Cyclosporin A-sensitive and insensitive mechanisms produce the permeability transition in mitochondria

1989 • 122 citations

Phenylarsine oxide induces the cyclosporin A-sensitive membrane permeability transition in rat liver mitochondria

1991 • 114 citations

Magnesium-Ion Modulates the Sensitivity of the Mitochondrial Permeability Transition Pore to Cyclosporine-A and ADP

1994 • 110 citations

Production of reactive oxygen by mitochondria from normoxic and hypoxic rat heart tissue

1992 • 107 citations

The effect of antimycin A on mouse liver inner mitochondrial membrane channel activity.

1992 • 95 citations

Cyclosporin a protects hepatocytes against prooxidant-induced cell killing

1992 • 94 citations

Permeability of inner mitochondrial membrane and oxidative stress

1988 • 94 citations

Cytotoxicity of butylated hydroxyanisole and butylated hydroxytoluene in isolated rat hepatocytes

1988 • 92 citations

Tert-butyl hydroperoxide-induced radical production in rat liver mitochondria

1992 • 81 citations

On the mechanism by which dicyclohexylcarbodiimide and quinine inhibit K+ transport in rat liver mitochondria.

1986 • 75 citations

Proton electrochemical potential in steady state rat liver mitochondria

1977 • 75 citations

The effect of superoxide generation on the ability of mitochondria to take up and retain Ca²⁺

1982 • 66 citations

Calcium-dependent mitochondrial oxidative damage promoted by 5-aminolevulinic acid

1992 • 65 citations

Crucial role of sulfhydryl groups in the mitochondrial inner membrane structure.

1985 • 62 citations

The role of lipid peroxidation in the induction of cation transport in rat liver mitochondria

1983 • 55 citations

Calcium-induced cytotoxicity in hepatocytes after exposure to extracellular ATP is dependent on inorganic phosphate. Effects on mitochondrial calcium.

1993 • 54 citations

Ion permeability induction by the SH cross-linking reagents in rat liver mitochondria is inhibited by the free radical scavenger, butylhydroxytoluene

1987 • 50 citations

Effects of the general anaesthetic Propofol on the Ca²⁺‐induced permeabilization of rat liver mitochondria

1991 • 45 citations

Quantitative analysis of uncoupling activity of substituted phenols with a physicochemical substituent and molecular parameters

1990 • 42 citations

Hydroperoxide-induced radical production in liver mitochondria

1986 • 40 citations

The nonspecific inner membrane pore of liver mitochondria: Modulation of cyclosporin sensitivity by ADP at carboxyatractyloside-sensitive and insensitive sites

1991 • 37 citations

Effects of monocyclic compounds on biomembranes

1977 • 36 citations

Evaluation of a procedure for the simultaneous determination of oxidized and reduced pyridine nucleotides and adenylates in organic phenol extracts from mitochondria

1992 • 35 citations

A comparison of phospholipid degradation by oxidation and hydrolysis during the mitochondrial permeability transition

1991 • 33 citations

Ca2+-induced, phospholipase-independent injury during reoxygenation of anoxic mitochondria

1993 • 31 citations

Mechanism of nitrofurantoin toxicity and oxidative stress in mitochondria

1988 • 30 citations

Calcium and magnesium ion losses in response to stimulants of efflux applied to heart, liver and kidney mitochondria

1981 • 28 citations

ATP‐synthase complex: The mechanism of control of ion fluxes induced by cumene hydroperoxide in mitochondria

1989 • 27 citations

Mechanics of swelling : from clays to living cells and tissues

1992 • 27 citations

[8] Calcium ion transport in mitochondria

1989 • 26 citations

Effects of lysophospholipids on Ca2+ transport in rat liver mitochondria incubated at physiological Ca2+ concentrations in the presence of Mg2+, phosphate and ATP at 37° C

1984 • 26 citations

Induction of electroneutral exchanges of H⁺ with Na⁺, divalent and organic cations in rat liver mitochondria

1978 • 20 citations

Mechanism accounting for the induction of nonspecific permeability of the inner mitochondrial membrane by hydroperoxides

1991 • 19 citations

Butylated hydroxytoluene and inorganic phosphate plus Ca2+ increase mitochondrial permeability via mutually exclusive mechanisms

1996 • 18 citations

The effect of butylated hydroxytoluene, an inhibitor of lipid peroxidation, on the calcium‐induced uncoupling of rat liver mitochondria

1989 • 18 citations

Inhibition by cyclosporin A and butylated hydroxytoluene of the inner mitochondrial membrane permeability transition induced by Adriamycin aglycones

1990 • 17 citations

Effects of the membrane potential upon the Ca²⁺‐ and cumene hydroperoxide‐induced permeabilization of the inner mitochondrial membrane

1991 • 14 citations

Fluorimetric Assay of Phospholipase A Acting on Biomembrane Phospholipids.

1989 • 6 citations