Modulation of microtubule dynamics during the cell cycle

Dynamic instability of microtubule growth

1984 • 3,187 citations

Cyclin synthesis drives the early embryonic cell cycle

1989 • 1,223 citations

Dynamic instability of individual microtubules analyzed by video light microscopy: rate constants and transition frequencies.

1988 • 985 citations

Modulation of the dynamic instability of tubulin assembly by the microtubule-associated protein tau.

1992 • 936 citations

Human cyclins A and B1 are differentially located in the cell and undergo cell cycle-dependent nuclear transport.

1991 • 858 citations

Altered microtubule organization in small-calibre axons of mice lacking tau protein

1994 • 742 citations

Polewards microtubule flux in the mitotic spindle: evidence from photoactivation of fluorescence.

1989 • 603 citations

γ-Tubulin is a highly conserved component of the centrosome

1991 • 566 citations

Visualization of the dynamic instability of individual microtubules by dark-field microscopy

1986 • 547 citations

Microtubule dynamics and microtubule caps: a time-resolved cryo-electron microscopy study.

1991 • 544 citations

XKCM1: A Xenopus Kinesin-Related Protein That Regulates Microtubule Dynamics during Mitotic Spindle Assembly

1996 • 539 citations

Identification of katanin, an ATPase that severs and disassembles stable microtubules

1993 • 490 citations

Tubulin dynamics in cultured mammalian cells.

1984 • 489 citations

In vitro reconstitution of centrosome assembly and function: The central role of γ-tubulin

1994 • 457 citations

γ-Tubulin is a centrosomal protein required for cell cycle-dependent microtubule nucleation

1992 • 447 citations

Real-time visualization of cell cycle-dependent changes in microtubule dynamics in cytoplasmic extracts

1990 • 444 citations

Structure of growing microtubule ends: two-dimensional sheets close into tubes at variable rates.

1995 • 429 citations

Sites of microtubule assembly and disassembly in the mitotic spindle

1986 • 410 citations

γ-Tubulin is present in Drosophila melanogaster and homo sapiens and is associated with the centrosome

1991 • 405 citations

Role of GTP hydrolysis in microtubule dynamics: information from a slowly hydrolyzable analogue, GMPCPP.

1992 • 376 citations

Real-time observations of microtubule dynamic instability in living cells.

1988 • 364 citations

A microtubule-associated protein from Xenopus eggs that specifically promotes assembly at the plus-end.

1987 • 338 citations

Direct observation of microtubule dynamics in living cells

1988 • 318 citations

Chromosomes move poleward in anaphase along stationary microtubules that coordinately disassemble from their kinetochore ends.

1987 • 314 citations

A novel pool of protein phosphatase 2A is associated with microtubules and is regulated during the cell cycle.

1995 • 305 citations

Kinetochore microtubule dynamics and the metaphase-anaphase transition.

1995 • 292 citations

Cyclin B interaction with microtubule-associated protein 4 (MAP4) targets p34cdc2 kinase to microtubules and is a potential regulator of M-phase microtubule dynamics.

1995 • 279 citations

Poleward kinetochore fiber movement occurs during both metaphase and anaphase-A in newt lung cell mitosis.

1992 • 271 citations

Microtubule Severing by Elongation Factor 1α

1994 • 252 citations

Kinetic stabilization of microtubule dynamic instability in vitro by vinblastine

1993 • 240 citations

INH, a negative regulator of MPF, is a form of protein phosphatase 2A

1991 • 231 citations

Centrosome assembly in vitro: role of gamma-tubulin recruitment in Xenopus sperm aster formation

1994 • 228 citations

Antibodies to the kinesin motor domain and CENP-E inhibit microtubule depolymerization-dependent motion of chromosomes in vitro.

1995 • 222 citations

XMAP from Xenopus eggs promotes rapid plus end assembly of microtubules and rapid microtubule polymer turnover.

1994 • 209 citations

Observation and quantification of individual microtubule behavior in vivo: microtubule dynamics are cell-type specific.

1993 • 197 citations

Severing of stable microtubules by a mitotically activated protein in xenopus egg extracts

1991 • 196 citations

Microtubule-nucleating activity of centrosomes in Chinese hamster ovary cells is independent of the centriole cycle but coupled to the mitotic cycle.

1981 • 191 citations

Localization of an Exchangeable GTP BZinding Site at the Plus End of Microtubules

1993 • 180 citations

Gamma-tubulin is required for the structure and function of the microtubule organizing centre in Drosophila neuroblasts.

1995 • 179 citations

Brain microtubule-associated proteins modulate microtubule dynamic instability in vitro: Real-time observations using video microscopy

1992 • 166 citations

Recruitment of antigenic gamma-tubulin during mitosis in animal cells: presence of gamma-tubulin in the mitotic spindle

1994 • 152 citations

Microtubule dynamics and chromosome motion visualized in living anaphase cells.

1988 • 147 citations

Regulation of the microtubule nucleating activity of centrosomes in Xenopus egg extracts: role of cyclin A-associated protein kinase.

1992 • 135 citations

Mitogen‐activated‐protein‐kinase‐catalyzed phosphorylation of microtubule‐associated proteins, microtubule‐associated protein 2 and microtubule‐associated protein 4, induces an alteration in their function

1992 • 128 citations

Microtubule dependency of p34cdc2 inactivation and mitotic exit in mammalian cells.

1994 • 126 citations

Role of the centrosome in organizing the interphase microtubule array: properties of cytoplasts containing or lacking centrosomes.

1984 • 121 citations

Widespread distribution of a 210,000 mol wt microtubule-associated protein in cells and tissues of primates.

1980 • 104 citations

How the transition frequencies of microtubule dynamic instability (nucleation, catastrophe, and rescue) regulate microtubule dynamics in interphase and mitosis: analysis using a Monte Carlo computer simulation.

1993 • 95 citations

Microtubules of the kinetochore fiber turn over in metaphase but not in anaphase.

1989 • 93 citations

Microtubule-associated protein 2 alters the dynamic properties of microtubule assembly and disassembly

1993 • 91 citations

A microtubule-associated protein in Drosophila melanogaster: identification, characterization, and isolation of coding sequences.

1986 • 87 citations

Stability of microtubule attachment to metaphase kinetochores in PTK1 cells

1990 • 86 citations

Quantitative determination of the proportion of microtubule polymer present during the mitosis-interphase transition

1994 • 76 citations

Microtubule dynamics in fish melanophores.

1994 • 76 citations

Microtubule flux in mitosis is independent of chromosomes, centrosomes, and antiparallel microtubules.

1994 • 67 citations

Buffer conditions and non‐tubulin factors critically affect the microtubule dynamic instability of sea urchin egg tubulin

1992 • 56 citations

Microtubule-Stabilizing Activity of Microtubule-Associated Proteins (MAPs) Is Due to Increase in Frequency of Rescue in Dynamic Instability: Shortening Length Decreases with Binding of MAPs onto Microtubules.

1994 • 56 citations

Modulation of microtubule stability by kinetochores in vitro.

1990 • 54 citations

A novel homo-oligomeric protein responsible for an MPF-dependent microtubule-severing activity.

1992 • 51 citations

Microtubule-severing activity in M phase

1995 • 19 citations