Karyopherins and kissing cousins

CRM1 Is an Export Receptor for Leucine-Rich Nuclear Export Signals

1997 • 2,062 citations

Nuclear targeting sequences — a consensus?

1991 • 1,908 citations

Exportin 1 (Crm1p) Is an Essential Nuclear Export Factor

1997 • 1,144 citations

Nucleocytoplasmic Transport

1996 • 1,071 citations

Nucleocytoplasmic transport: signals, mechanisms and regulation

1997 • 987 citations

Shuttling of pre-mRNA binding proteins between nucleus and cytoplasm

1992 • 825 citations

Protein import into nuclei: association and dissociation reactions involving transport substrate, transport factors, and nucleoporins

1995 • 767 citations

The GTP-binding protein Ran/TC4 is required for protein import into the nucleus

1993 • 760 citations

Evidence for a Role of CRM1 in Signal-Mediated Nuclear Protein Export

1997 • 716 citations

A Novel Receptor-Mediated Nuclear Protein Import Pathway

1996 • 669 citations

Leptomycin B is an inhibitor of nuclear export: inhibition of nucleo-cytoplasmic translocation of the human immunodeficiency virus type 1 (HIV-1) Rev protein and Rev-dependent mRNA

1997 • 654 citations

The asymmetric distribution of the constituents of the Ran system is essential for transport into and out of the nucleus

1997 • 628 citations

Export of Importin α from the Nucleus Is Mediated by a Specific Nuclear Transport Factor

1997 • 613 citations

Genes involved in sister chromatid separation are needed for b-type cyclin proteolysis in budding yeast

1995 • 561 citations

Inhibition of nuclear protein import by nonhydrolyzable analogues of GTP and identification of the small GTPase Ran/TC4 as an essential transport factor [published erratum appears in J Cell Biol 1994 Jan;124(1-2):217]

1993 • 544 citations

A nuclear export signal in hnRNP A1: A signal-mediated, temperature-dependent nuclear protein export pathway

1995 • 529 citations

A nuclear localization domain in the hnRNP A1 protein.

1995 • 510 citations

The human homologue of yeast CRM1 is in a dynamic subcomplex with CAN/Nup214 and a novel nuclear pore component Nup88

1997 • 480 citations

Identification of a protein complex that is required for nuclear protein import and mediates docking of import substrate to distinct nucleoporins.

1995 • 430 citations

A Novel Class of RanGTP Binding Proteins

1997 • 427 citations

Dominant-negative mutants of importin-beta block multiple pathways of import and export through the nuclear pore complex

1997 • 365 citations

A Distinct Nuclear Import Pathway Used by Ribosomal Proteins

1997 • 335 citations

Multiple DNA and protein sequence alignment based on segment-to-segment comparison.

1996 • 310 citations

Kap104p: A Karyopherin Involved in the Nuclear Transport of Messenger RNA Binding Proteins

1996 • 306 citations

The Yeast La Protein Is Required for the 3′ Endonucleolytic Cleavage That Matures tRNA Precursors

1997 • 253 citations

Transportin-mediated Nuclear Import of Heterogeneous Nuclear RNP Proteins

1997 • 252 citations

A Role for the M9 Transport Signal of hnRNP A1 in mRNA Nuclear Export

1997 • 249 citations

Higher order chromosome structure is affected by cold-sensitive mutations in a Schizosaccharomyces pombe gene crm1+ which encodes a 115-kD protein preferentially localized in the nucleus and its periphery.

1989 • 246 citations

A GTPase Controlling Nuclear Trafficking: Running the Right Way or Walking RANdomly?

1996 • 211 citations

The GLFG repetitive region of the nucleoporin Nup116p interacts with Kap95p, an essential yeast nuclear import factor.

1995 • 206 citations

Importin Provides a Link between Nuclear Protein Import and U snRNA Export

1996 • 189 citations

Nuclear pore proteins are involved in the biogenesis of functional tRNA.

1996 • 175 citations

Cloning and characterization of a cellular apoptosis susceptibility gene, the human homologue to the yeast chromosome segregation gene CSE1.

1995 • 171 citations

Role of the Nuclear Transport Factor p10 in Nuclear Import

1996 • 166 citations

Yrb4p, a yeast Ran-GTP-binding protein involved in import of ribosomal protein L25 into the nucleus

1997 • 163 citations

Karyopherin β2 mediates nuclear import of a mRNA binding protein

1997 • 160 citations

Isolation and characterization of Saccharomyces cerevisiae mRNA transport-defective (mtr) mutants [published erratum appears in J Cell Biol 1994 Sep;126(6):1627]

1994 • 159 citations

Nuclear import of hnRNP A1 is mediated by a novel cellular cofactor related to karyopherin-β

1997 • 146 citations

Nuclear import of U snRNPs requires importin beta

1997 • 141 citations

Importin/karyopherin protein family members required for mRNA export from the nucleus

1997 • 138 citations

CSE1 and CSE2, two new genes required for accurate mitotic chromosome segregation in Saccharomyces cerevisiae.

1993 • 138 citations

Cloning and characterization of human karyopherin β3

1997 • 124 citations

Fission yeast pap1-dependent transcription is negatively regulated by an essential nuclear protein, crm1.

1992 • 116 citations

Transportin: Nuclear Transport Receptor of a Novel Nuclear Protein Import Pathway

1996 • 114 citations

Nuclear protein import: Ran-GTP dissociates the karyopherin alphabeta heterodimer by displacing alpha from an overlapping binding site on beta.

1996 • 105 citations

A Distinct and Parallel Pathway for the Nuclear Import of an mRNA-binding Protein

1997 • 104 citations

Cloning and Characterization of LOS1, a Saccharomyces cerevisiae Gene That Affects tRNA Splicing

1987 • 104 citations

Potential RNA Binding Proteins in Saccharomyces cerevisiae Identified as Suppressors of Temperature-Sensitive Mutations in NPL3

1996 • 91 citations

Functional domains in nuclear import factor p97 for binding the nuclear localization sequence receptor and the nuclear pore.

1997 • 87 citations

Different Binding Domains for Ran-GTP and Ran-GDP/RanBP1 on Nuclear Import Factor p97

1997 • 86 citations

A Nuclear Import Pathway for a Protein Involved in tRNA Maturation

1997 • 85 citations

A Nuclear Export Signal in Kap95p Is Required for Both Recycling the Import Factor and Interaction with the Nucleoporin GLFG Repeat Regions of Nup116p and Nup100p

1997 • 84 citations

RanGTP-mediated nuclear export of karyopherin α involves its interaction with the nucleoporin Nup153

1997 • 65 citations

Cloning and characterization of LOS1, a Saccharomyces cerevisiae gene that affects tRNA splicing.

1987 • 65 citations

Screening and identification of a gene, PSE-1, that affects protein secretion in Saccharomyces cerevisiae

1992 • 40 citations

Expression in yeast of binding regions of karyopherins α and β inhibits nuclear import and cell growth

1996 • 20 citations

Loslp, Involved in Yeast Pre-tRNA Splicing, Positively Regulates Members of the SOL Gene Family

1996 • 16 citations