Linking Protein Kinase C to Cell‐Cycle Control

WAF1, a potential mediator of p53 tumor suppression

1993 • 8,360 citations

The p21 Cdk-interacting protein Cip1 is a potent inhibitor of G1 cyclin-dependent kinases

1993 • 5,680 citations

The retinoblastoma protein and cell cycle control

1995 • 4,873 citations

Intracellular Signaling by Hydrolysis of Phospholipids and Activation of Protein Kinase C

1992 • 4,480 citations

p21 is a universal inhibitor of cyclin kinases

1993 • 3,408 citations

Inhibitors of mammalian G1 cyclin-dependent kinases.

1995 • 3,258 citations

G1 phase progression: Cycling on cue

1994 • 2,706 citations

Protein kinase C and lipid signaling for sustained cellular responses

1995 • 2,527 citations

G ₁ Events and Regulation of Cell Proliferation

1989 • 2,203 citations

Cloning of p27Kip1, a cyclin-dependent kinase inhibitor and a potential mediator of extracellular antimitogenic signals

1994 • 2,154 citations

Cyclins and cancer II: Cyclin D and CDK inhibitors come of age

1994 • 2,122 citations

p27, a novel inhibitor of G1 cyclin-Cdk protein kinase activity, is related to p21

1994 • 2,071 citations

Early Signals in the Mitogenic Response

1986 • 1,498 citations

Cyclin A is required at two points in the human cell cycle.

1992 • 1,380 citations

Cloning of Senescent Cell-Derived Inhibitors of DNA Synthesis Using an Expression Screen

1994 • 1,368 citations

Protein kinase Cα activates RAF-1 by direct phosphorylation

1993 • 1,282 citations

Protein kinase C isoenzymes: divergence in signal transduction?

1993 • 1,237 citations

Correlation of Terminal Cell Cycle Arrest of Skeletal Muscle with Induction of p21 by MyoD

1995 • 1,154 citations

p53-Independent Expression of p21 ^Cip1 in Muscle and Other Terminally Differentiating Cells

1995 • 1,058 citations

MAP kinase pathways in yeast: For mating and more

1995 • 1,009 citations

Phosphorylation of the retinoblastoma gene product is modulated during the cell cycle and cellular differentiation

1989 • 990 citations

Protein kinase C - a question of specificity

1994 • 958 citations

p57KIP2, a structurally distinct member of the p21CIP1 Cdk inhibitor family, is a candidate tumor suppressor gene.

1995 • 956 citations

Cloning of p57KIP2, a cyclin-dependent kinase inhibitor with unique domain structure and tissue distribution.

1995 • 910 citations

Inhibition of CDK2 activity in vivo by an associated 20K regulatory subunit

1993 • 778 citations

Interaction of myogenic factors and the retinoblastoma protein mediates muscle cell commitment and differentiation

1993 • 734 citations

A novel cyclin associates with M015/CDK7 to form the CDK-activating kinase

1994 • 636 citations

Ordering S phase and M phase in the cell cycle

1994 • 596 citations

An essential G1 function for cyclin-like proteins in yeast

1989 • 574 citations

Overexpression of protein kinase C-delta and -epsilon in NIH 3T3 cells induces opposite effects on growth, morphology, anchorage dependence, and tumorigenicity.

1993 • 546 citations

Negative regulation of the growth-promoting transcription factor E2F-1 by a stably bound cyclin A-dependent protein kinase

1994 • 493 citations

Overproduction of protein kinase C causesdisordered growth control in rat fibroblasts

1988 • 492 citations

Joining the complex: Cyclin-dependent kinase inhibitory proteins and the cell cycle

1994 • 460 citations

The polyphosphoinositide cycle exists in the nuclei of Swiss 3T3 cells under the control of a receptor (for IGF-I) in the plasma membrane, and stimulation of the cycle increases nuclear diacylglycerol and apparently induces translocation of protein kinase

1991 • 454 citations

Protein kinase C isozymes and substrates

1996 • 440 citations

A candidate protein kinase C gene, PKC1, is required for the S. cerevisiae cell cycle

1990 • 422 citations

Amplification and expression of the human cyclin D gene in esophageal cancer.

1992 • 411 citations

CLB5: a novel B cyclin from budding yeast with a role in S phase.

1992 • 391 citations

Protein kinase C ζ isoform is critical for mitogenic signal transduction

1993 • 383 citations

A yeast mitogen-activated protein kinase homolog (Mpk1p) mediates signalling by protein kinase C.

1993 • 373 citations

Mutants in the S. cerevisiae PKC1 gene display a cell cycle-specific osmotic stability defect.

1992 • 371 citations

Immunocytochemical Localization of Eight Protein Kinase C Isozymes Overexpressed in NIH 3T3 Fibroblasts

1995 • 302 citations

Allosteric activation of latent p53 tetramers

1994 • 302 citations

Cell division arrest induced by phorbol ester in CHO cells overexpressing protein kinase C-delta subspecies.

1992 • 300 citations

Role of Diacylglycerol-Regulated Protein Kinase C Isotypes in Growth Factor Activation of the Raf-1 Protein Kinase

1997 • 292 citations

Characterization of the tumor suppressor protein p53 as a protein kinase C substrate and a S100b-binding protein.

1992 • 289 citations

Activation of the c-Raf protein kinase by protein kinase C phosphorylation.

1992 • 288 citations

Cyclin-B homologs in Saccharomyces cerevisiae function in S phase and in G2.

1992 • 281 citations

The decision to enter mitosis

1994 • 270 citations

MCF-7 breast cancer cells transfected with protein kinase C-alpha exhibit altered expression of other protein kinase C isoforms and display a more aggressive neoplastic phenotype.

1995 • 269 citations

A cyclin associated with the CDK-activating kinase MO15

1994 • 267 citations

Rules to replicate by

1994 • 252 citations

Phorbol ester-induced myeloid differentiation is mediated by protein kinase C-alpha and -delta and not by protein kinase C-beta II, -epsilon, -zeta, and -eta.

1993 • 251 citations

Intracellular free calcium rise triggers nuclear envelope breakdown in the sea urchin embryo

1988 • 243 citations

A p53-independent Pathway for Activation of WAF1/CIP1 Expression Following Oxidative Stress

1995 • 242 citations

Regulation of p21WAF1/CIP1 expression by p53-independent pathways.

1996 • 240 citations

E2F and Cell Proliferation: A World Turned Upside Down

1996 • 234 citations

The osmotic integrity of the yeast cell requires a functional PKC1 gene product.

1992 • 229 citations

More on target with protein phosphorylation: conferring specificity by location.

1996 • 225 citations

A Dominant Negative Protein Kinase C ζ Subspecies Blocks NF-κ B Activation

1993 • 223 citations

The epsilon isoform of protein kinase C is an oncogene when overexpressed in rat fibroblasts.

1993 • 222 citations

Protein kinase C and calcium ion in mitogenic response of macrophage-depleted human peripheral lymphocytes.

1985 • 220 citations

Protein kinase C-mediated serine phosphorylation directly activates Raf-1 in murine hematopoietic cells.

1994 • 218 citations

The Role of the Transcription Factor Sp1 in Regulating the Expression of the WAF1/CIP1 Gene in U937 Leukemic Cells

1996 • 215 citations

The Petinoblastoma Tumor Suppressor Protein

1994 • 215 citations

Inositides and the nucleus and inositides in the nucleus

1993 • 209 citations

Protein kinase C isotypes in human erythroleukemia (K562) cell proliferation and differentiation. Evidence that beta II protein kinase C is required for proliferation

1993 • 202 citations

Regulation of the Sequence-specific DNA Binding Function of p53 by Protein Kinase C and Protein Phosphatases

1995 • 199 citations

The retinoblastoma protein and the regulation of cell cycling

1992 • 198 citations

The Role of Carboxyl-terminal Basic Amino Acids in Gqα-dependent Activation, Particulate Association, and Nuclear Localization of Phospholipase C-β1

1996 • 198 citations

The SLT2 (MPK1) MAP kinase homolog is involved in polarized cell growth in Saccharomyces cerevisiae.

1993 • 197 citations

Identification of nuclear beta II protein kinase C as a mitotic lamin kinase.

1994 • 195 citations

Active involvement of Ca2+ in mitotic progression of Swiss 3T3 fibroblasts.

1990 • 183 citations

Inhibition of growth of human tumor cell lines in nude mice by an antisense of oligonucleotide inhibitor of protein kinase C-alpha expression.

1996 • 178 citations

Mitotic role for the Cdc28 protein kinase of Saccharomyces cerevisiae.

1990 • 169 citations

Phosphoinositide signalling enzymes in rat liver nuclei: phosphoinositidase C isoform β1 is specifically, but not predominantly, located in the nucleus

1993 • 165 citations

DP and E2F proteins: components of a heterodimeric transcription factor implicated in cell cycle control

1994 • 152 citations

Control of the yeast cell cycle is associated with assembly/disassembly of the Cdc28 protein kinase complex

1988 • 148 citations

Saccharomyces cerevisiae PKC1 encodes a protein kinase C (PKC) homolog with a substrate specificity similar to that of mammalian PKC

1994 • 147 citations

Cyclin-dependent kinase 7: at the cross-roads of transcription, DNA repair and cell cycle control?

1996 • 145 citations

βII Protein Kinase C Is Required for the G2/M Phase Transition of Cell Cycle

1996 • 143 citations

Identification of protein kinase C (PKC) phosphorylation sites on human lamin B. Potential role of PKC in nuclear lamina structural dynamics.

1993 • 139 citations

Apoptosis in 7-hydroxystaurosporine-treated T lymphoblasts correlates with activation of cyclin-dependent kinases 1 and 2.

1995 • 137 citations

Growth inhibition by protein kinase C late in mitogenesis

1987 • 133 citations

Cell Cycle Kinases

2013 • 131 citations

Highly synchronous culture of fibroblasts from G2 block caused by staurosporine, a potent inhibitor of protein kinases

1991 • 129 citations

A dominant negative protein kinase C zeta subspecies blocks NF-kappa B activation.

1993 • 128 citations

A New Phospholipase C δ4 Is Induced at S-phase of the Cell Cycle and Appears in the Nucleus

1996 • 124 citations

Uncoupled cell cycle without mitosis induced by a protein kinase inhibitor, K-252a.

1991 • 121 citations

Transformed mammalian cells are deficient in kinase-mediated control of progression through the G1 phase of the cell cycle.

1991 • 119 citations

Nuclear diacylglycerol is increased during cell proliferation in vivo

1993 • 119 citations

Differential localization of protein kinase C isozymes in U937 cells: evidence for distinct isozyme functions during monocyte differentiation

1995 • 117 citations

Different effects of staurosporine, an inhibitor of protein kinases, on the cell cycle and chromatin structure of normal and leukemic lymphocytes.

1992 • 115 citations

Two Distinct Signaling Pathways Activate the Latent DNA Binding Function of p53 in a Casein Kinase II-independent Manner

1995 • 109 citations

Two Closely Related Isoforms of Protein Kinase C Produce Reciprocal Effects on the Growth of Rat Fibroblasts

1995 • 101 citations

Treatment of glioblastoma U-87 by systemic administration of an antisense protein kinase C-alpha phosphorothioate oligodeoxynucleotide.

1996 • 100 citations

Phorbol Ester Inhibits the Phosphorylation of the Retinoblastoma Protein without Suppressing Cyclin D-associated Kinase in Vascular Smooth Muscle Cells

1996 • 96 citations

Characterization of a Protein Kinase C-δ (PKC-δ) ATP Binding Mutant

1995 • 95 citations

More on target with protein phosphorylation: conferring specificity by location

1996 • 93 citations

Effect of UCN-01, a selective inhibitor of protein kinase C, on the cell-cycle distribution of human epidermoid carcinoma, A431 cells

1994 • 92 citations

Protein kinase C in yeast. Characteristics of the Saccharomyces cerevisiae PKC1 gene product

1994 • 89 citations

New insights into p53 function from structural studies.

1996 • 88 citations

Protein kinase C-mediated bidirectional regulation of DNA synthesis, RB protein phosphorylation, and cyclin-dependent kinases in human vascular endothelial cells.

1993 • 87 citations

Activation of novel protein kinases C delta and C epsilon upon mitogenic stimulation of quiescent rat 3Y1 fibroblasts

1994 • 80 citations

Overexpression of protein kinase C alpha-subtype in Swiss/3T3 fibroblasts causes loss of both high and low affinity receptor numbers for epidermal growth factor.

1990 • 76 citations

The Polyether Bistratene A Activates Protein Kinase C–δ and Induces Growth Arrest in HL60 Cells

1996 • 75 citations

A pathway in the yeast cell division cycle linking protein kinase C (Pkc1) to activation of Cdc28 at START.

1996 • 75 citations

Protein Kinase C-Mediated Inhibition of Vascular Smooth Muscle Cell Proliferation: The Isoforms That May Mediate G1/S Inhibition

1993 • 69 citations

Phorbol esters induce death in MCF-7 breast cancer cells with altered expression of protein kinase C isoforms. Role for p53-independent induction of gadd-45 in initiating death.

1995 • 68 citations

Linking protein kinase C to the cell cycle: ectopic expression of PKC eta in NIH3T3 cells alters the expression of cyclins and Cdk inhibitors and induces adipogenesis.

1996 • 66 citations

G1 arrest and down-regulation of cyclin E/cyclin-dependent kinase 2 by the protein kinase inhibitor staurosporine are dependent on the retinoblastoma protein in the bladder carcinoma cell line 5637.

1996 • 60 citations

Biological response to phorbol ester determined by alternative G1 pathways.

1995 • 59 citations

Cell cycle arrest in the G2 phase induced by phorbol ester and diacylglycerol in vascular endothelial cells

1996 • 56 citations

More on target with proteinphosphorylation: conferring specificity by location

1996 • 55 citations

Identification of novel phosphorylation sites in murine A‐type lamins

1993 • 52 citations

The Catalytic Domain of Protein Kinase C-δ in Reciprocal δ and ∊ Chimeras Mediates Phorbol Ester-induced Macrophage Differentiation of Mouse Promyelocytes

1997 • 49 citations

The protein kinase C activator, phorbol ester, cooperates with the wild-type p53 species of Ras-transformed embryo fibroblasts growth arrest.

1994 • 48 citations

Protein kinase C isoform ? overexpression in C6 glioma cells and its role in cell proliferation

1995 • 48 citations

Murine p53 is phosphorylated within the PAb421 epitope by protein kinase C in vitro, but not in vivo, even after stimulation with the phorbol ester o-tetradecanoylphorbol 13-acetate.

1996 • 39 citations

The Protein Kinase C Inhibitor Ilmofosine (BM 41 440) Arrests Cells in G2 Phase and Suppresses CDC2 Kinase Activation Through a Mechanism Different from That of DNA Damaging Agents

1994 • 38 citations

E2F1, B-MYB and Selective Members of Cyclin/CDK Subunits Are Targets for Protein Kinase C-Mediated Bimodal Growth Regulation in Vascular Endothelial Cells

1994 • 37 citations

12-O-tetradecanoylphorbol-13-acetate induces transient cell cycle arrest in G1 and G2 in metastatic melanoma cells: inhibition of phosphorylation of p34cdc2.

1992 • 37 citations

Specific role for protein kinase C beta in cell differentiation.

1994 • 37 citations

A Protein Kinase C Isozyme, NPKC-ϵ, Is Involved in the Activation of NF-κ-B by 12-O-Tetradecanoylphorbol-13-Acetate (TPA) in Rat 3Y1 Fibroblasts

1995 • 34 citations

Protein kinase C-α regulates proliferation but not apoptosis in rat coronary vascular smooth muscle cells

1996 • 33 citations

Protein kinase C--an enzyme and its relatives.

1994 • 31 citations

Tumor-promoting phorbol ester transiently down-modulates the p53 level and blocks the cell cycle.

1994 • 30 citations

Protein kinase C inhibits the CAK-CDK2 cyclin-dependent kinase cascade and G1/S cell cycle progression in human diploid fibroblasts

1996 • 30 citations

Altered expression of cyclins and c-fos in R6 cells that overproduce PKCε

1995 • 29 citations

Phorbol ester-induced monocytic differentiation is associated with G2 delay and down-regulation of cdc25 expression.

1993 • 29 citations

Differential Effects of Overexpression of PKCα and PKCδ/ϵ on Cellular E2F Activity in Late G1 Phase

1996 • 29 citations

Phorbol Ester TPA Rapidly Prevents Activation of p34cdc2 Histone H1 Kinase and Concomitantly the Transition from G2 Phase to Mitosis in Synchronized HeLa Cells

1994 • 26 citations

Involvement of the α Isoenzyme of Protein Kinase C in the Growth Inhibition Induced by Phorbol Esters in MH1C1 Hepatoma Cells

1994 • 26 citations

Protein Kinase C-Mediated Inhibition of Cyclin A Expression in Human Vascular Endothelial Cells

1993 • 22 citations

Induction of Tumor Suppressor P21 Protein by Kinase Inhibitors in MCF-7 Cells

1995 • 19 citations

TPA-Induced Differentiation of Human Rhabdomyosarcoma Cells Involves Dephosphorylation and Nuclear Accumulation of Mutant p53

1994 • 13 citations

PMA Inhibits the Growth of Human Fibroblasts after the Induction of Immediate-Early Genes

1994 • 12 citations

Phorbol ester stimulated Cip1 expression in p53-negative leukemic cells

1996 • 2 citations