Characterization of a Protein Kinase C-δ (PKC-δ) ATP Binding Mutant

The role of protein kinase C in cell surface signal transduction and tumour promotion

1984 • 7,521 citations

Intracellular Signaling by Hydrolysis of Phospholipids and Activation of Protein Kinase C

1992 • 4,480 citations

Purification of a RAS-responsive adenylyl cyclase complex from Saccharomyces cerevisiae by use of an epitope addition method.

1988 • 983 citations

Lipid activation of protein kinase C.

1991 • 566 citations

The Cln3-Cdc28 kinase complex of S. cerevisiae is regulated by proteolysis and phosphorylation.

1992 • 414 citations

Cytokine-dependent granulocytic differentiation. Regulation of proliferative and differentiative responses in a murine progenitor cell line.

1987 • 369 citations

Phorbol ester-induced myeloid differentiation is mediated by protein kinase C-alpha and -delta and not by protein kinase C-beta II, -epsilon, -zeta, and -eta.

1993 • 251 citations

Signal Transduction Through the EGF Receptor Transfected in IL-3-Dependent Hematopoietic Cells

1988 • 238 citations

A Dominant Negative Protein Kinase C ζ Subspecies Blocks NF-κ B Activation

1993 • 223 citations

Tyrosine phosphorylation of protein kinase C-delta in response to its activation.

1994 • 169 citations

In vivo regulation of protein kinase C by trans-phosphorylation followed by autophosphorylation.

1994 • 159 citations

Requirement for negative charge on “activation loop” of protein kinase C.

1994 • 153 citations

Development of a highly efficient expression cDNA cloning system: application to oncogene isolation.

1991 • 145 citations

A point mutation at the putative ATP-binding site of protein kinase C alpha abolishes the kinase activity and renders it down-regulation-insensitive. A molecular link between autophosphorylation and down-regulation.

1990 • 145 citations

Structural and functional diversities of a family of signal transducing protein kinases, protein kinase C family; two distinct classes of PKC, conventional cPKC and novel nPKC

1991 • 134 citations

Macrophage-colony-stimulating factor (CSF-1) induces proliferation, chemotaxis, and reversible monocytic differentiation in myeloid progenitor cells transfected with the human c-fms/CSF-1 receptor cDNA.

1990 • 112 citations

Ras-dependent signal transduction is indispensable but not sufficient for the activation of AP1/Jun by PKC delta.

1994 • 111 citations

Structure and properties of a ubiquitously expressed protein kinase C, nPKCδ

1991 • 105 citations

Stimulation of the Platelet-Derived Growth Factor β Receptor Signaling Pathway Activates Protein Kinase C-δ

1994 • 101 citations

Phosphorylation of Thr642 is an early event in the processing of newly synthesized protein kinase C beta 1 and is essential for its activation.

1994 • 56 citations

Downregulation of protein kinase C‐γ is independent of a functional kinase domain

1991 • 37 citations

Down‐regulation of a kinase defective PKC‐α

1991 • 33 citations